{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T20:46:17Z","timestamp":1789159577649,"version":"build-2803163510"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Safety and tolerability data from the first open-label feasibility study of 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for alcohol use disorder was recently published. This paper presents a Bayesian analysis of the impact of MDMA-assisted psychotherapy on treatment success, defined as 2-level reduction in the World Health Organization (WHO) drinking risk at the 3\u00a0months follow-up. We also examined the impact on drinking behavior and psychosocial measures at 3\u00a0months compared to baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fourteen participants with a diagnosis of alcohol use disorder who had recently undergone detoxification completed an eight-week course of ten psychotherapy sessions, including two sessions with MDMA. Measures assessing drinking behavior, quality of life, sleep, self-compassion, and empathy were collected. Bayesian analysis using flat and skeptical priors was performed to determine treatment success defined as a 2-level reduction in WHO drinking risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Bayesian analysis suggested that the probability of a 2-level reduction in WHO drinking risk from baseline to 3\u00a0months post-treatment is 55%\u201363%, based upon either a flat or skeptical prior respectively. We present preliminary findings suggesting reductions in alcohol craving (measured by the Penn Alcohol Craving Scale and Obsessive Compulsive Drinking Scale) and improvements in sleep and aspects of psychosocial functioning at 3\u00a0months follow-up compared to baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The Bayesian analysis provides a useful harm reduction endpoint interpretation of drinking in terms of a 2-level reduction in WHO drinking risk. Further findings provide preliminary insights into the potential impact of MDMA-assisted psychotherapy on quality of life and well-being in addition to reductions in drinking.<\/jats:p>\n                    <jats:p>ClinicalTrials.gov ID: NCT04158778.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/alcalc\/agaf031","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T09:42:21Z","timestamp":1747993341000},"source":"Crossref","is-referenced-by-count":7,"title":["MDMA-assisted psychotherapy for AUD: Bayesian analysis of WHO drinking risk level and exploratory analysis of drinking behavior and psychosocial functioning at 3\u00a0months follow-up"],"prefix":"10.1093","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7714-3446","authenticated-orcid":false,"given":"Hannah","family":"Thurgur","sequence":"first","affiliation":[{"name":"Division of Psychiatry, Department of Brain Sciences, Imperial College London , The Commonwealth Building, Du Cane Road, London, W12 0NN ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Sessa","sequence":"additional","affiliation":[{"name":"Independent Consultant"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"Higbed","sequence":"additional","affiliation":[{"name":"Division of Psychiatry, Department of Brain Sciences, Imperial College London , The Commonwealth Building, Du Cane Road, London, W12 0NN ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Division of Psychiatry, Department of Brain Sciences, Imperial College London , The Commonwealth Building, Du Cane Road, London, W12 0NN ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Durant","sequence":"additional","affiliation":[{"name":"Division of Psychiatry, Department of Brain Sciences, Imperial College London , The Commonwealth Building, Du Cane Road, London, W12 0NN ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Wilson","sequence":"additional","affiliation":[{"name":"Division of Psychiatry, Department of Brain Sciences, Imperial College London , The Commonwealth Building, Du Cane Road, London, W12 0NN ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs","family":"Szigeti","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioural Sciences, University of California , 675 18th St, San Francisco, CA 94107 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia J A","family":"Morgan","sequence":"additional","affiliation":[{"name":"Psychopharmacology and Addiction Research Centre, University of Exeter , Stocker Road, EX4 4PY ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Nutt","sequence":"additional","affiliation":[{"name":"Division of Psychiatry, Department of Brain Sciences, Imperial College London , The Commonwealth Building, Du Cane Road, London, W12 0NN ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"key":"2025061007020825300_ref1","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1097\/ADM.0000000000000925","article-title":"The relationship between reductions in WHO risk drinking levels during treatment and subsequent healthcare costs for the ACTIVE workgroup","volume":"16","author":"Aldridge","year":"2022","journal-title":"J Addict Med"},{"key":"2025061007020825300_ref2","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1111\/add.12328","article-title":"Commentary on Subbaraman et\u00a0al. 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