{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:24:11Z","timestamp":1755224651940,"version":"3.43.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"The Standardizing Care for Neuropsychiatric Symptoms and Quality of Life in Dementia"},{"DOI":"10.13039\/100009408","name":"Brain Canada Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009408","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019829","name":"Centre for Aging and Brain Health Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Excessive alcohol use (EAU) elevates the risk of dementia through various mechanisms, yet its impact on the behavioural and psychological symptoms of dementia (BPSDs) remains uncertain.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this exploratory cross-sectional analysis of baseline data from the Standardizing Care for Neuropsychiatric Symptoms and Quality of Life in Dementia (StaN) study (ClinicalTrials.gov\/NCT03672201), we included individuals with Alzheimer\u2019s disease and related dementias requiring BPSD treatment. We compared demographic characteristics and presentation of BPSDs (using the total and domain scores on the Neuropsychiatric Inventory-Clinician) in those with and without a lifetime history of EAU.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 193 participants [mean (SD) age: 80.6 (9.7) years, male: 48.4%], those in the EAU group (n\u2009=\u200917) and in the comparator group (n\u2009=\u2009176) had severe and comparable cognitive impairment, with a median Functional Assessment Staging Tool for Dementia score of 6e. Participants with EAU were significantly younger than comparators [mean age (SD): 72.9 (7.1) years vs. 81.4 (9.5) years] (t\u2009=\u2009\u22123.678, df\u2009=\u2009181, P\u2009&amp;lt;\u2009.001), and were more frequently male (76.5% [13 of 17] vs. 46.6% [82 of 176]; P\u2009=\u2009.036). In a sensitivity analysis, there were no differences in the Neuropsychiatric Inventory-Clinician total or individual domain scores between those with EAU and a subsample of those without EAU matched for age, sex, and recruitment site.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This exploratory study found that among individuals with Alzheimer\u2019s disease and related dementias and BPSDs, lifetime history of EAU is more frequent in younger males. Future studies may further examine the impact of EAU in individuals with BPSDs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/alcalc\/agaf048","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T22:43:57Z","timestamp":1755038637000},"source":"Crossref","is-referenced-by-count":0,"title":["The impact of lifetime excessive alcohol use on behavioural and psychological symptoms of dementia"],"prefix":"10.1093","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6378-0505","authenticated-orcid":false,"given":"Emytis","family":"Tavakoli","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University Health Network , 200 Elizabeth Street, Toronto, ON, M5G 2C4 ,","place":["Canada"]},{"name":"Centre for Addiction and Mental Health , 1st Floor, 250 College Street, Toronto, ON, M5T 1R8 ,","place":["Canada"]},{"name":"Department of Psychiatry, University of Toronto , 8th Floor, 250 College Street, Toronto, ON, M5T 1R8 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaina","family":"Niciforos","sequence":"additional","affiliation":[{"name":"Department of Research & Academics, Ontario Shores Centre for Mental Health Sciences , 700 Gordon Street, Whitby, ON, L1N 5S9 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parmida","family":"Amid","sequence":"additional","affiliation":[{"name":"Department of Research & Academics, Ontario Shores Centre for Mental Health Sciences , 700 Gordon Street, Whitby, ON, L1N 5S9 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ari B","family":"Cuperfain","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Toronto , 8th Floor, 250 College Street, Toronto, ON, M5T 1R8 ,","place":["Canada"]},{"name":"Department of Psychiatry, Centre for Addiction and Mental Health , 80 Workman Way, Toronto, ON, M6J 1H4 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amer M","family":"Burhan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Toronto , 8th Floor, 250 College Street, Toronto, ON, M5T 1R8 ,","place":["Canada"]},{"name":"Department of Psychiatry, Ontario Shores Centre for Mental Health Sciences , 700 Gordon Street, Whitby, ON, L1N 5S9 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Colman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Toronto , 8th Floor, 250 College Street, Toronto, ON, M5T 1R8 ,","place":["Canada"]},{"name":"Department of Psychiatry, Centre for Addiction and Mental Health , 80 Workman Way, Toronto, ON, M6J 1H4 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Toronto , 8th Floor, 250 College Street, Toronto, ON, M5T 1R8 ,","place":["Canada"]},{"name":"Department of Psychiatry, Centre for Addiction and Mental Health , 80 Workman Way, Toronto, ON, M6J 1H4 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon J C","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Toronto , 8th Floor, 250 College Street, Toronto, ON, M5T 1R8 ,","place":["Canada"]},{"name":"Department of Psychiatry, Centre for Addiction and Mental Health , 80 Workman Way, Toronto, ON, M6J 1H4 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Derkach","sequence":"additional","affiliation":[{"name":"Ukrainian Canadian Care Centre , 60 Richview Road, Etobicoke, Toronto, ON M9A 5E4 ,","place":["Canada"]},{"name":"West Park Long-Term Care Centre , 82 Buttonwood Avenue, York, Toronto, ON M6M 2J5 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