{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:05:27Z","timestamp":1793419527144,"version":"4.5.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"5","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA24136"],"award-info":[{"award-number":["DA24136"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AA10788"],"award-info":[{"award-number":["AA10788"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Senior Career Research Scientists Award from the Veterans Health Administration"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Low-level alcohol consumption at or below current guidelines (\u22641 standard drink equivalent\/day for females, \u22642 standard drink equivalents\/day for males) has been indicated to carry minimal systemic health risks. This study assessed the relationships between alcohol consumption over 1- and 3-years prior to study and over lifetime and measures of manual dexterity and postural stability in healthy adults with low-level alcohol consumption.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Healthy, non-smoking adults (n\u2009=\u200983; 21\u201369\u00a0years old) completed measures of dominant and non-dominant hand dexterity, complex motor coordination and motor speed (Lafayette Grooved Peg Board), and static postural stability (Sharpened Romberg Test; eyes open and eyes closed conditions). Alcohol consumption over 1- and 3-years prior to study, and over lifetime, was acquired via the Lifetime Drinking History.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The greater multiplicative product of age and total lifetime drinks was related to poorer dexterity, complex motor coordination and motor speed for the dominant hand, and for the summed performance across the dominant and non-dominant hands. Greater lifetime average drinks\/month was related to poorer static postural stability, with eyes closed. Males and females showed equivalent performance across dependent measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Findings indicated higher lifetime alcohol consumption, at a level that has been historically regarded as low risk for adverse functional consequences, was associated with poorer performance on established clinical and research measures of manual dexterity, complex motor coordination and motor speed, and static postural stability. These results may have implications for current alcohol consumption public health guidelines and associated policies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/alcalc\/agag055","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T16:59:11Z","timestamp":1784912351000},"source":"Crossref","is-referenced-by-count":1,"title":["In healthy adults with low-level alcohol intake greater age and lifetime alcohol consumption are associated with poorer manual dexterity and higher lifetime consumption is related to worse postural stability"],"prefix":"10.1093","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5969-9544","authenticated-orcid":false,"given":"Timothy C","family":"Durazzo","sequence":"first","affiliation":[{"name":"War Related Illness and Injury Study Center, VA Palo Alto Health Care System , 3801 Miranda Ave, Palo Alto, CA 94304 ,","place":["United States"]},{"name":"Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine , 401 Quarry Rd., Stanford, CA 94305 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole D","family":"Evangelista","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine , 401 Quarry Rd., Stanford, CA 94305 ,","place":["United States"]},{"name":"Sierra-Pacific Mental Illness Research and Education Clinical Centers, VA Palo Alto Health Care System , 3801 Miranda Ave, Palo Alto, CA 94304 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Windy","family":"McNerney","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine , 401 Quarry Rd., Stanford, CA 94305 ,","place":["United States"]},{"name":"Sierra-Pacific Mental Illness Research and Education Clinical Centers, VA Palo Alto Health Care System , 3801 Miranda Ave, Palo Alto, CA 94304 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansgar J","family":"Furst","sequence":"additional","affiliation":[{"name":"War Related Illness and Injury Study Center, VA Palo Alto Health Care System , 3801 Miranda Ave, Palo Alto, CA 94304 ,","place":["United States"]},{"name":"Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine , 401 Quarry Rd., Stanford, CA 94305 ,","place":["United States"]},{"name":"Polytrauma System of Care, VA Palo Alto Health Care System , 3801 Miranda Ave, Palo Alto, CA 94304 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maheen M","family":"Adamson","sequence":"additional","affiliation":[{"name":"Women\u2019s Operational Military Exposure Network Center of Excellence, VA Palo Alto Health Care System , 3801 Miranda Ave, Palo Alto, CA 94304 ,","place":["United States"]},{"name":"Department of 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