{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:02:48Z","timestamp":1792785768572,"version":"4.5.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2021\/GNT200985"],"award-info":[{"award-number":["2021\/GNT200985"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Australian Government Research Training Program","id":[{"id":"https:\/\/ror.org\/0314h5y94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To examine the effects of cannabidiol (CBD) on psychophysiological responding and risky decision-making in individuals with alcohol use disorder (AUD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a double-blind, placebo-controlled crossover trial, 18 participants with AUD completed the Columbia Card Task (CCT) following administration of CBD and placebo. Skin conductance responses (SCR) and high-frequency heart rate variability (HF-HRV) were assessed as indices of autonomic responding during task performance. Risk-taking was indexed by the number of cards selected on the CCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CBD did not significantly affect SCR (P\u2009=\u2009.16, pBH\u2009=\u2009.326) or risky decision-making on the CCT (P\u2009&amp;gt;\u2009.63, pBH\u2009=\u20090.67). However, CBD significantly increased HF-HRV (\u03b2\u2009=\u20090.53, SE\u2009=\u20090.19, P\u2009=\u2009.005; pBH\u2009=\u20090.020). There was no evidence that the relationships between HF-HRV or SCR and risky decision-making differed between CBD and placebo conditions (drug \u00d7 HF-HRV: P\u2009=\u2009.92; drug \u00d7 SCR: P\u2009=\u2009.958; both pBH\u2009=\u2009.958).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>CBD increased HF-HRV but did not significantly alter SCR, risky decision-making, or the relationship between autonomic responses and risky decision-making. These findings suggest that CBD influences autonomic responding during task performance, although the functional significance of this effect remains uncertain. The modest sample size and relatively healthy, non-treatment-seeking sample may have limited the ability to detect broader physiological and behavioural effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/alcalc\/agag068","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:16:15Z","timestamp":1790334975000},"source":"Crossref","is-referenced-by-count":0,"title":["Effects of cannabidiol on risky decision-making and autonomic function in alcohol use disorder"],"prefix":"10.1093","volume":"61","author":[{"given":"Ellen","family":"McGuire","sequence":"first","affiliation":[{"name":"Edith Collins Centre for Translational Research (Alcohol, Drugs & Toxicology), Royal Prince Alfred Hospital , Sydney Local Health District, Camperdown, NSW 2050 ,","place":["Australia"]},{"name":"Leiden University, Faculty of Medicine, Leiden University Medical Centre , Leiden, Zuid-Holland, Albinusdreef 2, 2333 ZA Leiden ,","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Hurzeler","sequence":"additional","affiliation":[{"name":"Edith Collins Centre for Translational Research (Alcohol, Drugs & Toxicology), Royal Prince Alfred Hospital , Sydney Local Health District, Camperdown, NSW 2050 ,","place":["Australia"]},{"name":"Specialty of Addiction Medicine, Sydney Medical School, Faculty of Medicine and Health, University of Sydney , Camperdown NSW 2050 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren","family":"Logge","sequence":"additional","affiliation":[{"name":"Edith Collins Centre for Translational Research (Alcohol, Drugs & Toxicology), Royal Prince Alfred Hospital , Sydney Local Health District, Camperdown, NSW 2050 ,","place":["Australia"]},{"name":"Specialty of Addiction Medicine, Sydney Medical School, Faculty of Medicine and Health, University of Sydney , Camperdown NSW 2050 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Watt","sequence":"additional","affiliation":[{"name":"Edith Collins Centre for Translational Research (Alcohol, Drugs & Toxicology), Royal Prince Alfred Hospital , Sydney Local Health District, Camperdown, NSW 2050 ,","place":["Australia"]},{"name":"Specialty of Addiction Medicine, Sydney Medical School, Faculty of Medicine and Health, University of Sydney , Camperdown NSW 2050 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain S","family":"McGregor","sequence":"additional","affiliation":[{"name":"Lambert Initiative for Cannabinoid Therapeutics, University of Sydney , Camperdown NSW 2050 ,","place":["Australia"]},{"name":"Faculty of Science, School of Psychology, University of Sydney , Camperdown NSW 2050 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Suraev","sequence":"additional","affiliation":[{"name":"Lambert Initiative for Cannabinoid Therapeutics, University of Sydney , Camperdown NSW 2050 ,","place":["Australia"]},{"name":"Faculty of Science, School of Psychology, University of Sydney , Camperdown NSW 2050 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S","family":"Haber","sequence":"additional","affiliation":[{"name":"Edith Collins Centre for Translational Research (Alcohol, Drugs & Toxicology), Royal Prince Alfred Hospital , Sydney Local Health District, Camperdown, NSW 2050 ,","place":["Australia"]},{"name":"Specialty of Addiction Medicine, Sydney Medical School, Faculty of Medicine and Health, University of Sydney , Camperdown NSW 2050 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0868-9928","authenticated-orcid":false,"given":"Kirsten C","family":"Morley","sequence":"additional","affiliation":[{"name":"Edith Collins Centre for Translational Research (Alcohol, Drugs & Toxicology), Royal Prince Alfred Hospital , Sydney Local Health District, Camperdown, NSW 2050 ,","place":["Australia"]},{"name":"Specialty of Addiction Medicine, Sydney Medical School, Faculty of Medicine and Health, University of Sydney , Camperdown NSW 2050 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"2026101411455946000_ref1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American","year":"2022"},{"key":"2026101411455946000_ref2","doi-asserted-by":"publisher","first-page":"2943","DOI":"10.3390\/jcm12082943","article-title":"Risky decision-making in adults with alcohol use disorder\u2014a systematic and meta-analytic review","volume":"12","author":"Ariesen","year":"2023","journal-title":"J Clin Med"},{"key":"2026101411455946000_ref3","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2025.1517308","article-title":"Exposure to subtle dominance cues activates the stress response and affects decision-making","volume":"16","author":"Bamshad","year":"2025","journal-title":"Front Psychol"},{"key":"2026101411455946000_ref4","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1093\/arclin\/acx038","article-title":"Test-retest reliability of common behavioral decision making tasks","volume":"33","author":"Buelow","year":"2018","journal-title":"Arch Clin Neuropsychol"},{"key":"2026101411455946000_ref5","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1207\/s15326942dn2503_2","article-title":"Developmental changes in real life decision making: performance on a gambling task previously shown to depend on the ventromedial prefrontal cortex","volume":"25","author":"Crone","year":"2004","journal-title":"Dev Neuropsychol"},{"key":"2026101411455946000_ref6","volume-title":"SoftwareX","author":"Cruz"},{"key":"2026101411455946000_ref7","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1037\/a0022619","article-title":"The skin conductance response, anticipation, and decision-making","volume":"4","author":"Dawson","year":"2011","journal-title":"J Neurosci Psychol Econ"},{"key":"2026101411455946000_ref8","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1097\/j.pain.0000000000001386","article-title":"Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain","volume":"160","author":"De Gregorio","year":"2019","journal-title":"Pain"},{"key":"2026101411455946000_ref9","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.13390","article-title":"Event-related potentials in response to feedback following risk-taking in the hot version of the Columbia Card Task","volume":"56","author":"De Groot","year":"2019","journal-title":"Psychophysiology"},{"key":"2026101411455946000_ref10","volume-title":"A Handbook of Process Tracing Methods for Decision Research","author":"Figner","year":"2011"},{"key":"2026101411455946000_ref11","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1037\/a0014983","article-title":"Affective and deliberative processes in risky choice: age differences in risk taking in the Columbia Card Task","volume":"35","author":"Figner","year":"2009","journal-title":"J Exp Psychol Learn Mem Cogn"},{"key":"2026101411455946000_ref12","doi-asserted-by":"publisher","first-page":"109549","DOI":"10.1016\/j.neuropharm.2023.109549","article-title":"Cannabidiol regulates behavioral and brain alterations induced by spontaneous alcohol withdrawal","volume":"233","author":"Gasparyan","year":"2023","journal-title":"Neuropharmacology"},{"key":"2026101411455946000_ref13","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.1038\/s41386-018-0050-8","article-title":"Unique treatment potential of cannabidiol for the prevention of relapse to drug use: preclinical proof of principle","volume":"43","author":"Gonzalez-Cuevas","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"2026101411455946000_ref14","volume-title":"Medical Journal of Australia","author":"Haber"},{"key":"2026101411455946000_ref15","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1017\/S1930297500005106","article-title":"Risky choice in younger versus older adults: affective context matters","volume":"8","author":"Huang","year":"2013","journal-title":"Judgm Decis Mak"},{"key":"2026101411455946000_ref16","volume":"176","author":"Hurd","journal-title":"American Journal of Psychiatry"},{"key":"2026101411455946000_ref17","doi-asserted-by":"publisher","first-page":"101341","DOI":"10.1016\/j.conctc.2024.101341","article-title":"The neurobehavioural effects of cannabidiol in alcohol use disorder: study protocol for a double-blind, randomised, cross over, placebo-controlled trial","volume":"41","author":"Hurzeler","year":"2024","journal-title":"Contemporary Clinical Trials Communications"},{"key":"2026101411455946000_ref18","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1007\/s00406-025-01983-4","article-title":"Cannabidiol attenuates precuneus activation during appetitive cue exposure in individuals with alcohol use disorder","volume":"275","author":"Hurzeler","year":"2025","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"2026101411455946000_ref19","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/acer.15514","article-title":"Cannabidiol alters psychophysiological, craving and anxiety responses in an alcohol cue reactivity task: a cross-over randomized controlled trial","volume":"49","author":"Hurzeler","year":"2025","journal-title":"Alcohol Clin Exp Res"},{"key":"2026101411455946000_ref20","doi-asserted-by":"publisher","first-page":"e453","DOI":"10.1038\/tp.2014.103","article-title":"Genetic markers associated with abstinence length in alcohol-dependent subjects treated with acamprosate","volume":"4","author":"Karpyak","year":"2014","journal-title":"Transl Psychiatry"},{"key":"2026101411455946000_ref21","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1038\/s41386-025-02141-z","article-title":"The neural and psychophysiological effects of cannabidiol in youth with alcohol use disorder: a randomized controlled clinical trial","volume":"50","author":"Kirkland","year":"2025","journal-title":"Neuropsychopharmacology"},{"key":"2026101411455946000_ref22","doi-asserted-by":"publisher","first-page":"E89","DOI":"10.1017\/sjp.2015.81","article-title":"Assessing affective and deliberative decision-making: adaptation of the Columbia Card Task to Brazilian Portuguese","volume":"18","author":"Kluwe-Schiavon","year":"2015","journal-title":"Span J Psychol"},{"key":"2026101411455946000_ref23","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1042\/cs0870225","article-title":"Acute alcohol intake decreases short-term heart rate variability in healthy subjects","volume":"87","author":"Koskinen","year":"1994","journal-title":"Clin Sci"},{"key":"2026101411455946000_ref24","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/s10964-024-02072-w","article-title":"Combined effects of social exclusion and social rank feedback on risky decision-making across adolescence","volume":"54","author":"Lorenz","year":"2025","journal-title":"J Youth Adolesc"},{"key":"2026101411455946000_ref25","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2019.02466","article-title":"Anxiolytic effects of repeated cannabidiol treatment in teenagers with social anxiety disorders","volume":"10","author":"Masataka","year":"2019","journal-title":"Front Psychol"},{"key":"2026101411455946000_ref26","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1002\/dta.3419","article-title":"How long does a single oral dose of cannabidiol persist in plasma? Findings from three clinical trials","volume":"15","author":"Mccartney","year":"2023","journal-title":"Drug Test Anal"},{"key":"2026101411455946000_ref27","doi-asserted-by":"publisher","first-page":"46","DOI":"10.7453\/gahmj.2014.073","article-title":"Heart rate variability: new perspectives on physiological mechanisms, assessment of self-regulatory capacity, and health risk","volume":"4","author":"Mccraty","year":"2015","journal-title":"Global Adv Health Med"},{"key":"2026101411455946000_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2020.11.001","volume-title":"Neurobiology of Addiction and Co-Morbid Disorders","author":"Melugin","year":"2021"},{"key":"2026101411455946000_ref29","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01365","article-title":"A systematic review on the pharmacokinetics of cannabidiol in humans","volume":"9","author":"Millar","year":"2018","journal-title":"Front Pharmacol"},{"key":"2026101411455946000_ref30","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1080\/14656566.2021.1892641","article-title":"New approved and emerging pharmacological approaches to alcohol use disorder: a review of clinical studies","volume":"22","author":"Morley","year":"2021","journal-title":"Expert Opin Pharmacother"},{"key":"2026101411455946000_ref31","volume-title":"Methods in Mind","author":"Naqvi","year":"2006"},{"key":"2026101411455946000_ref32","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-025-06860-5","article-title":"CBD attenuates amygdala response to negative emotional stimuli in individuals with alcohol use disorder\u2013a randomized controlled trial","volume":"243","author":"Pfisterer","journal-title":"Psychopharmacology"},{"key":"2026101411455946000_ref33","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1037\/0893-164X.8.1.29","article-title":"Effects of alcohol administration on psychophysiological and subjective-emotional responses to aversive stimulation in anxiety-sensitive women","volume":"8","author":"Stewart","year":"1994","journal-title":"Psychol Addict Behav"},{"key":"2026101411455946000_ref34","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1109\/MEMB.2002.1032635","article-title":"Neurovisceral integration in cardiac and emotional regulation","volume":"21","author":"Thayer","year":"2002","journal-title":"IEEE Eng Med Biol Mag"},{"key":"2026101411455946000_ref35","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/adb.12495","article-title":"Cannabidiol reduces ethanol consumption, motivation and relapse in mice","volume":"23","author":"Viudez-Mart\u00ednez","year":"2018","journal-title":"Addict Biol"},{"key":"2026101411455946000_ref36","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3390\/ph14010035","article-title":"Comparison of five oral cannabidiol preparations in adult humans: pharmacokinetics, body composition, and heart rate variability","volume":"14","author":"Williams","year":"2021","journal-title":"Pharmaceuticals"},{"key":"2026101411455946000_ref37","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.13563","volume-title":"Global Status Report on Alcohol and Health 2018","author":"World Health Organization","year":"2018"},{"key":"2026101411455946000_ref38","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s00406-023-01602-0","article-title":"Computational markers of risky decision-making predict for relapse to alcohol","volume":"274","author":"Yuan","year":"2024","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"2026101411455946000_ref39","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.1038\/s41380-024-02869-y","article-title":"Acute cannabidiol administration reduces alcohol craving and cue-induced nucleus accumbens activation in individuals with alcohol use disorder: the double-blind randomized controlled ICONIC trial","volume":"30","author":"Zimmermann","year":"2025","journal-title":"Mol Psychiatry"}],"container-title":["Alcohol and Alcoholism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/alcalc\/article-pdf\/61\/6\/agag068\/71947635\/agag068.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/alcalc\/article-pdf\/61\/6\/agag068\/71947635\/agag068.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:46:04Z","timestamp":1791992764000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/alcalc\/article\/doi\/10.1093\/alcalc\/agag068\/8916537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,20]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,9,20]]}},"URL":"https:\/\/doi.org\/10.1093\/alcalc\/agag068","relation":{},"ISSN":["0735-0414","1464-3502"],"issn-type":[{"value":"0735-0414","type":"print"},{"value":"1464-3502","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,11]]},"published":{"date-parts":[[2026,9,20]]},"article-number":"agag068"}}