{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:47:27Z","timestamp":1780476447277,"version":"3.54.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,9,1]]},"DOI":"10.1093\/alcalc\/agh085","type":"journal-article","created":{"date-parts":[[2004,8,11]],"date-time":"2004-08-11T01:12:36Z","timestamp":1092186756000},"page":"450-454","source":"Crossref","is-referenced-by-count":32,"title":["ACETALDEHYDE-INDUCED CARDIAC CONTRACTILE DYSFUNCTION MAY BE ALLEVIATED BY VITAMIN B1 BUT NOT BY VITAMINS B6 OR B12"],"prefix":"10.1093","volume":"39","author":[{"suffix":"II","given":"Nicholas S.","family":"Aberle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Burd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie H.","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,7,10]]},"reference":[{"key":"key\n\t\t\t\t20171011015100_B1","doi-asserted-by":"crossref","unstructured":"Aberle, N. S. and Ren, J. (2003) Short-term acetaldehyde exposure depresses ventricular myocyte contraction: role of cytochrome P450 oxidase, xanthine oxidase, and lipid peroxidation. Alcoholism: Clinical and Experimental Research27, 577\u2013583.","DOI":"10.1111\/j.1530-0277.2003.tb04393.x"},{"key":"key\n\t\t\t\t20171011015100_B2","doi-asserted-by":"crossref","unstructured":"Aberle, N. S. II, Privratsky, J. R., Burd, L. and Ren, J. (2003) Combined acetaldehyde and nicotine exposure depresses cardiac contraction in ventricular myocytes: prevention by folic acid. Neurotoxicology and Teratology25, 731\u2013736.","DOI":"10.1016\/j.ntt.2003.07.008"},{"key":"key\n\t\t\t\t20171011015100_B3","doi-asserted-by":"crossref","unstructured":"Ba, A., Seri, B. V. and Han, S. H. (1996) Thiamine administration during chronic alcohol intake in pregnant and lactating rats: effects on the offspring neurobehavioural development. Alcohol and Alcoholism31, 27\u201340.","DOI":"10.1093\/oxfordjournals.alcalc.a008113"},{"key":"key\n\t\t\t\t20171011015100_B4","doi-asserted-by":"crossref","unstructured":"Ba, A., Seri, B. V., Aka, K. J., Glin, L. and Tako, A. (1999) Comparative effects of developmental thiamine deficiencies and ethanol exposure on the morphometry of the CA3 pyramidal cells. Neurotoxicology and Teratology21, 579\u2013586.","DOI":"10.1016\/S0892-0362(99)00014-8"},{"key":"key\n\t\t\t\t20171011015100_B5","doi-asserted-by":"crossref","unstructured":"Hintz, K. K., Relling, D. P., Saari, J. T., Borgerding, A. J., Duan, J., Ren, B. H., Kato, K., Epstein, P. N. and Ren, J. (2003). Cardiac overexpression of alcohol dehydrogenase exacerbates cardiac contractile dysfunction, lipid peroxidation, and protein damage after chronic ethanol ingestion. Alcoholism: Clinical and Experimental Research27, 1090\u20131098.","DOI":"10.1097\/01.ALC.0000075823.73536.DD"},{"key":"key\n\t\t\t\t20171011015100_B6","doi-asserted-by":"crossref","unstructured":"Laposata, E. A. and Lange, L. G. (1986) Presence of nonoxidative ethanol metabolism in human organs commonly damaged by ethanol abuse. Science231, 497\u2013499.","DOI":"10.1126\/science.3941913"},{"key":"key\n\t\t\t\t20171011015100_B7","doi-asserted-by":"crossref","unstructured":"Preedy, V. R. and Richardson, P. J. (1994) Ethanol induced cardiovascular disease. British Medical Bulletin50, 152\u2013163.","DOI":"10.1093\/oxfordjournals.bmb.a072873"},{"key":"key\n\t\t\t\t20171011015100_B8","unstructured":"Preedy, V. R., Patel, V. B., Reilly, M. E., Richardson, P. J., Falkous, G. and Mantle, D. (1999) Oxidants, antioxidants and alcohol: implications for skeletal and cardiac muscle. Frontiers in Bioscience4, e58\u2013e66."},{"key":"key\n\t\t\t\t20171011015100_B9","doi-asserted-by":"crossref","unstructured":"Ren, J. and Brown, R. A. (2000) Influence of chronic alcohol ingestion on acetaldehyde-induced depression of rat cardiac contractile function. Alcohol and Alcoholism35, 554\u2013560.","DOI":"10.1093\/alcalc\/35.6.554"},{"key":"key\n\t\t\t\t20171011015100_B10","unstructured":"Ren, J., Davidoff, A. J. and Brown, R. A. (1997) Acetaldehyde depresses shortening and intracellular Ca2+ transients in adult rat ventricular myocytes. Cellular and Molecular Biology43, 825\u2013834."},{"key":"key\n\t\t\t\t20171011015100_B11","doi-asserted-by":"crossref","unstructured":"Ren, J., Wold, L. E., Natavio, M., Ren, B. H., Hannigan, J. H. and Brown, R. A. (2002) Influence of prenatal alcohol exposure on myocardial contractile function in adult rat hearts: role of intracellular calcium and apoptosis. Alcohol and Alcoholism37, 30\u201337.","DOI":"10.1093\/alcalc\/37.1.30"},{"key":"key\n\t\t\t\t20171011015100_B12","doi-asserted-by":"crossref","unstructured":"Ren, J., Roughead, Z. K., Wold, L. E., Norby, F. L., Rakoczy, S., Mabey, R. L. and Brown-Borg, H. M. (2003) Increases in insulin-like growth factor-1 level and peroxidative damage after gestational ethanol exposure in rats. Pharmacological Research47, 341\u2013347.","DOI":"10.1016\/S1043-6618(03)00005-7"},{"key":"key\n\t\t\t\t20171011015100_B13","doi-asserted-by":"crossref","unstructured":"Rindi, G., Imarisio, L. and Patrini, C. (1986) Effects of acute and chronic ethanol administration on regional thiamin pyrophosphokinase activity of the rat brain. Biochemical Pharmacology35, 3903\u20133908.","DOI":"10.1016\/0006-2952(86)90002-X"},{"key":"key\n\t\t\t\t20171011015100_B14","doi-asserted-by":"crossref","unstructured":"Singleton, C. K. and Martin, P. R. (2001) Molecular mechanisms of thiamine utilization. Current Molecular Medicine1, 197\u2013207.","DOI":"10.2174\/1566524013363870"},{"key":"key\n\t\t\t\t20171011015100_B15","doi-asserted-by":"crossref","unstructured":"Spies, C. D., Sander, M., Stangl, K., Fernandez-Sola, J., Preedy, V. R., Rubin, E., Andreasson, S., Hanna, E. Z. and Kox, W. J. (2001) Effects of alcohol on the heart. Current Opinion in Critical Care7, 337\u2013343.","DOI":"10.1097\/00075198-200110000-00004"},{"key":"key\n\t\t\t\t20171011015100_B16","doi-asserted-by":"crossref","unstructured":"Takabe, M. and Itokawa, Y. (1983) Thiamin depletion after ethanol and acetaldehyde administration to rabbits. Journal of Nutritional Science and Vitaminology29, 509\u2013514.","DOI":"10.3177\/jnsv.29.509"},{"key":"key\n\t\t\t\t20171011015100_B17","doi-asserted-by":"crossref","unstructured":"Telford, W. G., King, L. E. and Fraker, P. J. (1994) Rapid quantitation of apoptosis in pure and heterogeneous cell populations using flow cytometry. Journal of Immunological Methods172, 1\u201316.","DOI":"10.1016\/0022-1759(94)90373-5"},{"key":"key\n\t\t\t\t20171011015100_B18","doi-asserted-by":"crossref","unstructured":"Thomas, A. P., Rozanski, D. J., Renard, D. C. and Rubin, E. (1994) Effects of ethanol on the contractile function of the heart: a review. Alcoholism: Clinical and Experimental Research18, 121\u2013131.","DOI":"10.1111\/j.1530-0277.1994.tb00891.x"},{"key":"key\n\t\t\t\t20171011015100_B19","doi-asserted-by":"crossref","unstructured":"Tillotson, L. G., Carter, E. A., Inui, K. I. and Isselbacher, K. J. (1981) Inhibition of Na+-stimulated glucose transport function and perturbation of intestinal microvillus membrane vesicles by ethanol and acetaldehyde. Archives of Biochemistry and Biophysics207, 360\u2013370.","DOI":"10.1016\/0003-9861(81)90043-6"},{"key":"key\n\t\t\t\t20171011015100_B20","unstructured":"Tobias, S. L., van der Westhuyzen, J., Davis, R. E., Icke, G. C. and Atkinson, P. M. (1989) Alcohol intakes and deficiencies in thiamine and vitamin B6 in black patients with cardiac failure. South African Medical Journal76, 299\u2013302."},{"key":"key\n\t\t\t\t20171011015100_B21","doi-asserted-by":"crossref","unstructured":"Whyte, K. F., Dunnigan, M. G. and McIntosh, W. B. (1982) Excessive beer consumption and beri-beri. Scottish Medical Journal27, 288\u2013291.","DOI":"10.1177\/003693308202700405"}],"container-title":["Alcohol and Alcoholism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/alcalc\/article-pdf\/39\/5\/450\/529092\/agh085.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T05:52:15Z","timestamp":1507701135000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/alcalc\/article\/39\/5\/450\/204019\/ACETALDEHYDEINDUCED-CARDIAC-CONTRACTILE"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7,10]]},"references-count":21,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2004,7,10]]},"published-print":{"date-parts":[[2004,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/alcalc\/agh085","relation":{},"ISSN":["1464-3502","0735-0414"],"issn-type":[{"value":"1464-3502","type":"electronic"},{"value":"0735-0414","type":"print"}],"subject":[],"published-other":{"date-parts":[[2004,9]]},"published":{"date-parts":[[2004,7,10]]}}}