{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T18:56:14Z","timestamp":1768416974961,"version":"3.49.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,1]]},"DOI":"10.1093\/alcalc\/agu047","type":"journal-article","created":{"date-parts":[[2014,7,26]],"date-time":"2014-07-26T00:58:22Z","timestamp":1406336302000},"page":"498-504","source":"Crossref","is-referenced-by-count":37,"title":["Increase in Nucleus Accumbens Dopamine Levels Following Local Ethanol Administration Is Not Mediated by Acetaldehyde"],"prefix":"10.1093","volume":"49","author":[{"given":"Rhona B.C.","family":"Clarke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Adermark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PeiPei","family":"Chau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"S\u00f6derpalm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia","family":"Ericson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,7,25]]},"reference":[{"key":"key\n\t\t\t\t20171010180515_AGU047C1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1369-1600.2010.00206.x","article-title":"Implications for glycine receptors and astrocytes in ethanol-induced elevation of dopamine levels in the nucleus accumbens","volume":"16","year":"2011","journal-title":"Addict Biol"},{"key":"key\n\t\t\t\t20171010180515_AGU047C2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0376-8716(77)90049-7","article-title":"Possible involvement of acetaldehyde, norepinephrine and their tetrahydroisoquinoline derivatives in the regulation of ethanol self-administration","volume":"2","year":"1977","journal-title":"Drug Alcohol Depend"},{"key":"key\n\t\t\t\t20171010180515_AGU047C3","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0091-3057(93)90165-P","article-title":"Differences in ethanol-induced behaviors in normal and acatalasemic mice: systematic examination using a biobehavioral approach","volume":"44","year":"1993","journal-title":"Pharmacol Biochem Behav"},{"key":"key\n\t\t\t\t20171010180515_AGU047C4","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0014-2999(93)90434-J","article-title":"The mesolimbic dopamine-activating properties of ethanol are antagonized by mecamylamine","volume":"249","year":"1993","journal-title":"Eur J Pharmacol"},{"key":"key\n\t\t\t\t20171010180515_AGU047C5","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1471-4159.1981.tb02411.x","article-title":"Regional distribution of catalase in the adult rat brain","volume":"36","year":"1981","journal-title":"J Neurochem"},{"key":"key\n\t\t\t\t20171010180515_AGU047C6","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.neubiorev.2011.07.009","article-title":"Piecing together the puzzle of acetaldehyde as a neuroactive agent","volume":"36","year":"2012","journal-title":"Neurosci Biobehav Rev"},{"key":"key\n\t\t\t\t20171010180515_AGU047C7","first-page":"485","article-title":"Acute ethanol increases taurine but neither glutamate nor GABA in the nucleus accumbens of male rats: a microdialysis study","volume":"29","year":"1994","journal-title":"Alcohol Alcohol"},{"key":"key\n\t\t\t\t20171010180515_AGU047C8","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1111\/acer.12034","article-title":"Microinjections of acetaldehyde or salsolinol into the posterior ventral tegmental area increase dopamine release in the nucleus accumbens shell","volume":"37","year":"2013","journal-title":"Alcohol Clin Exp Res"},{"key":"key\n\t\t\t\t20171010180515_AGU047C9","doi-asserted-by":"crossref","first-page":"557","DOI":"10.15288\/jsa.2004.65.557","article-title":"Acetaldehyde: deja vu du jour","volume":"65","year":"2004","journal-title":"J Stud Alcohol"},{"key":"key\n\t\t\t\t20171010180515_AGU047C10","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1111\/j.1530-0277.2009.01055.x","article-title":"Ethanol is self-administered into the nucleus accumbens shell, but not the core: evidence of genetic sensitivity","volume":"33","year":"2009","journal-title":"Alcohol Clin Exp Res"},{"key":"key\n\t\t\t\t20171010180515_AGU047C11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.drugalcdep.2008.10.010","article-title":"Acetaldehyde sequestering prevents ethanol-induced stimulation of mesolimbic dopamine transmission","volume":"100","year":"2009","journal-title":"Drug Alcohol Depend"},{"key":"key\n\t\t\t\t20171010180515_AGU047C12","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0014-2999(98)00602-5","article-title":"Voluntary ethanol intake in the rat and the associated accumbal dopamine overflow are blocked by ventral tegmental mecamylamine","volume":"358","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"key\n\t\t\t\t20171010180515_AGU047C13","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1111\/j.1460-9568.2006.04868.x","article-title":"Taurine elevates dopamine levels in the rat nucleus accumbens; antagonism by strychnine","volume":"23","year":"2006","journal-title":"Eur J Neurosci"},{"key":"key\n\t\t\t\t20171010180515_AGU047C14","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1369-1600.2010.00245.x","article-title":"Rising taurine and ethanol concentrations in nucleus accumbens interact to produce dopamine release after ethanol administration","volume":"16","year":"2011","journal-title":"Addict Biol"},{"key":"key\n\t\t\t\t20171010180515_AGU047C15","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/sj.npp.1300326","article-title":"Acetaldehyde increases dopaminergic neuronal activity in the VTA","volume":"29","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"key\n\t\t\t\t20171010180515_AGU047C16","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1097\/01.ALC.0000171945.30494.AF","article-title":"Prevention of ethanol-induced behavioral stimulation by d-Penicillamine: a sequestration agent for acetaldehyde","volume":"29","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"key":"key\n\t\t\t\t20171010180515_AGU047C17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.neuropharm.2014.03.010","article-title":"The involvement of accumbal glycine receptors in the dopamine-elevating effects of addictive drugs","volume":"82","year":"2014","journal-title":"Neuropharmacology"},{"key":"key\n\t\t\t\t20171010180515_AGU047C18","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/j.1530-0277.2011.01439.x","article-title":"Ethanol as a prodrug: brain metabolism of ethanol mediates its reinforcing effects","volume":"35","year":"2011","journal-title":"Alcohol Clin Exp Res"},{"key":"key\n\t\t\t\t20171010180515_AGU047C19","article-title":"Long-term inhibition of ethanol intake by the administration of an aldehyde dehydrogenase-2 (Aldh2)-coding lentiviral vector into the ventral tegmental area of rats","year":"2014","journal-title":"Addict Biol"},{"key":"key\n\t\t\t\t20171010180515_AGU047C20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00726-003-0057-1","article-title":"Ethanol but not acetaldehyde induced changes in brain taurine: a microdialysis study","volume":"26","year":"2004","journal-title":"Amino Acids"},{"key":"key\n\t\t\t\t20171010180515_AGU047C21","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ejphar.2006.10.055","article-title":"Characterization of ethanol-induced dopamine elevation in the rat nucleus accumbens","volume":"555","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"key\n\t\t\t\t20171010180515_AGU047C22","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.neulet.2010.07.081","article-title":"Systemic administration of d-penicillamine prevents the locomotor activation after intra-VTA ethanol administration in rats","volume":"483","year":"2010","journal-title":"Neurosci Lett"},{"key":"key\n\t\t\t\t20171010180515_AGU047C23","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1111\/j.1530-0277.2001.tb02163.x","article-title":"Does acetaldehyde mediate ethanol action in the central nervous system?","volume":"25","year":"2001","journal-title":"Alcohol Clin Exp Res"},{"key":"key\n\t\t\t\t20171010180515_AGU047C24","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1111\/j.1460-9568.2007.05887.x","article-title":"Acetaldehyde mediates alcohol activation of the mesolimbic dopamine system","volume":"26","year":"2007","journal-title":"Eur J Neurosci"},{"key":"key\n\t\t\t\t20171010180515_AGU047C25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/01.ALC.0000150012.09608.81","article-title":"Accumbal strychnine-sensitive glycine receptors: an access point for ethanol to the brain reward system","volume":"29","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"key":"key\n\t\t\t\t20171010180515_AGU047C26","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/01.ALC.0000150009.78622.E0","article-title":"Involvement of accumbal glycine receptors in the regulation of voluntary ethanol intake in the rat","volume":"29","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"key":"key\n\t\t\t\t20171010180515_AGU047C27","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1177\/43.12.8537642","article-title":"Immunocytochemical localization of catalase in the central nervous system of the rat","volume":"43","year":"1995","journal-title":"J Histochem Cytochem"},{"key":"key\n\t\t\t\t20171010180515_AGU047C28","article-title":"Alterations in ethanol-induced accumbal transmission after acute and long-term zinc depletion","year":"2013","journal-title":"Addict Biol"},{"key":"key\n\t\t\t\t20171010180515_AGU047C29","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0091-3057(82)90364-1","article-title":"Intravenous self-administration of acetaldehyde in the rat as a function of schedule, food deprivation and photoperiod","volume":"17","year":"1982","journal-title":"Pharmacol Biochem Behav"},{"key":"key\n\t\t\t\t20171010180515_AGU047C30","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1021\/jm00210a019","article-title":"2,5,5-Trimethylthiazolidine-4-carboxylic acid, a d(\u2212)-penicillamine-directed pseudometabolite of ethanol. Detoxication mechanism for acetaldehyde","volume":"21","year":"1978","journal-title":"J Med Chem"},{"key":"key\n\t\t\t\t20171010180515_AGU047C31","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1021\/jm00176a007","article-title":"Structural requirements for the sequestration of metabolically generated acetaldehyde","volume":"23","year":"1980","journal-title":"J Med Chem"},{"key":"key\n\t\t\t\t20171010180515_AGU047C32","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0741-8329(99)00022-1","article-title":"Brain ethanol levels after voluntary ethanol drinking in AA and Wistar rats","volume":"19","year":"1999","journal-title":"Alcohol"},{"key":"key\n\t\t\t\t20171010180515_AGU047C33","volume-title":"The Rat Brain in Stereotaxic Coordinates","year":"2007"},{"key":"key\n\t\t\t\t20171010180515_AGU047C34","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1530-0277.2007.00574.x","article-title":"Key role of ethanol-derived acetaldehyde in the motivational properties induced by intragastric ethanol: a conditioned place preference study in the rat","volume":"32","year":"2008","journal-title":"Alcohol Clin Exp Res"},{"key":"key\n\t\t\t\t20171010180515_AGU047C35","first-page":"23","article-title":"Acetaldehyde-reinforcing effects: a study on oral self-administration behavior","volume":"1","year":"2010","journal-title":"Front Psychiatry"},{"key":"key\n\t\t\t\t20171010180515_AGU047C36","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0091-3057(00)00486-X","article-title":"Conditioned stimulus preference after acetaldehyde but not ethanol injections","volume":"68","year":"2001","journal-title":"Pharmacol Biochem Behav"},{"key":"key\n\t\t\t\t20171010180515_AGU047C37","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.pneurobio.2005.03.003","article-title":"The role of acetaldehyde in the neurobehavioral effects of ethanol: a comprehensive review of animal studies","volume":"75","year":"2005","journal-title":"Prog Neurobiol"},{"key":"key\n\t\t\t\t20171010180515_AGU047C38","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1530-0277.2011.01606.x","article-title":"Reward and relapse: complete gene-induced dissociation in an animal model of alcohol dependence","volume":"36","year":"2012","journal-title":"Alcohol Clin Exp Res"},{"key":"key\n\t\t\t\t20171010180515_AGU047C39","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0091-3057(01)00733-X","article-title":"The reinforcing effects of acetaldehyde in the posterior ventral tegmental area of alcohol-preferring rats","volume":"72","year":"2002","journal-title":"Pharmacol Biochem Behav"},{"key":"key\n\t\t\t\t20171010180515_AGU047C40","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0741-8329(99)00016-6","article-title":"The catalase inhibitor sodium azide reduces ethanol-induced locomotor activity","volume":"19","year":"1999","journal-title":"Alcohol"},{"key":"key\n\t\t\t\t20171010180515_AGU047C41","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1002\/rcm.2951","article-title":"Liquid chromatography\/tandem mass spectrometry determination of (4S,2RS)-2,5,5-trimethylthiazolidine-4-carboxylic acid, a stable adduct formed between d-(\u2212)-penicillamine and acetaldehyde (main biological metabolite of ethanol), in plasma, liver and brain rat tissues","volume":"21","year":"2007","journal-title":"Rapid Commun Mass Spectrom"},{"key":"key\n\t\t\t\t20171010180515_AGU047C42","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1111\/j.1530-0277.2010.01416.x","article-title":"l-Cysteine prevents ethanol-induced stimulation of mesolimbic dopamine transmission","volume":"35","year":"2011","journal-title":"Alcohol Clin Exp Res"},{"key":"key\n\t\t\t\t20171010180515_AGU047C43","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0741-8329(84)90097-1","article-title":"Conditioned place preference induced by intraventricular infusions of acetaldehyde","volume":"1","year":"1984","journal-title":"Alcohol"},{"key":"key\n\t\t\t\t20171010180515_AGU047C44","first-page":"127","article-title":"Neurocircuitry involved in the development of alcohol addiction: the dopamine system and its access points","volume":"13","year":"2013","journal-title":"Curr Top Behav Neurosci"},{"issue":"Suppl 1","key":"key\n\t\t\t\t20171010180515_AGU047C45","first-page":"S87","article-title":"Mechanistic studies of ethanol's interaction with the mesolimbic dopamine reward system","volume":"42","year":"2009","journal-title":"Pharmacopsychiatry"},{"key":"key\n\t\t\t\t20171010180515_AGU047C46","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1152\/physrev.00013.2008","article-title":"Alcoholism: a systems approach from molecular physiology to addictive behavior","volume":"89","year":"2009","journal-title":"Physiol Rev"},{"key":"key\n\t\t\t\t20171010180515_AGU047C47","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.tins.2004.08.007","article-title":"Gabaergic microcircuits in the neostriatum","volume":"27","year":"2004","journal-title":"Trends Neurosci"},{"key":"key\n\t\t\t\t20171010180515_AGU047C48","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0306-4522(80)90071-8","article-title":"Biochemical evidence for gamma-aminobutyrate containing fibres from the nucleus accumbens to the substantia nigra and ventral tegmental area in the rat","volume":"5","year":"1980","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20171010180515_AGU047C49","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0028-3908(97)00007-5","article-title":"Acetaldehyde-induced changes in the monoamine and amino acid extracellular microdialysate content of the nucleus accumbens","volume":"36","year":"1997","journal-title":"Neuropharmacology"},{"key":"key\n\t\t\t\t20171010180515_AGU047C50","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.neuron.2012.03.017","article-title":"Whole-brain mapping of direct inputs to midbrain dopamine neurons","volume":"74","year":"2012","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20171010180515_AGU047C51","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/oxfordjournals.alcalc.a008128","article-title":"Distribution of catalase in rat brain: aminergic neurons as possible targets for ethanol effects","volume":"31","year":"1996","journal-title":"Alcohol Alcohol"},{"key":"key\n\t\t\t\t20171010180515_AGU047C52","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1111\/j.1530-0277.2006.00181.x","article-title":"Enzymatic mechanisms of ethanol oxidation in the brain","volume":"30","year":"2006","journal-title":"Alcohol Clin Exp Res"}],"container-title":["Alcohol and Alcoholism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/alcalc\/article-pdf\/49\/5\/498\/9357802\/agu047.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T20:36:32Z","timestamp":1507667792000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/alcalc\/article\/49\/5\/498\/2888136\/Increase-in-Nucleus-Accumbens-Dopamine-Levels"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,25]]},"references-count":52,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,7,25]]},"published-print":{"date-parts":[[2014,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/alcalc\/agu047","relation":{},"ISSN":["0735-0414","1464-3502"],"issn-type":[{"value":"0735-0414","type":"print"},{"value":"1464-3502","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,25]]}}}