{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:03:41Z","timestamp":1790337821645,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,1]]},"DOI":"10.1093\/alcalc\/agy013","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T19:10:15Z","timestamp":1522091415000},"page":"611-618","source":"Crossref","is-referenced-by-count":21,"title":["Insomnia in Alcohol-Dependent Patients: Prevalence, Risk Factors and Acamprosate Effect: An Individual Patient Data Meta-Analysis"],"prefix":"10.1093","volume":"53","author":[{"given":"Pascal","family":"Perney","sequence":"first","affiliation":[{"name":"Service d\u2019Addictologie, H\u00f4pital Caremeau, Place du Pr Debr\u00e9, N\u00eemes, France"},{"name":"universit\u00e9 Montpellier 1, 2 rue de l'\u00e9cole de M\u00e9decine, Montpellier, France"},{"name":"CESP, UMR 1018, INSERM, UPS, UVSQ. P. Descartes. H\u00f4pital Paul Brousse \u2013 Bat 15\/16 \u2013 16 avenue PV Couturier 6 Villejuif Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lehert","sequence":"additional","affiliation":[{"name":"Statistics Department, Faculty of Economics, University of Louvain, 181 chauss\u00e9e de Binche, Mons, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"key":"key\n\t\t\t\t20180822100420_agy013C1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1300\/J069v26n04_06","article-title":"Treatment options for sleep disturbances during alcohol recovery","volume":"26","author":"Arnedt","year":"2007","journal-title":"J Addict Dis"},{"key":"key\n\t\t\t\t20180822100420_agy013C2","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.15288\/qjsa.1974.35.1230","article-title":"Clinical correlates of reported sleep in alcoholics","volume":"35","author":"Baekeland","year":"1974","journal-title":"Q J Stud Alcohol"},{"key":"key\n\t\t\t\t20180822100420_agy013C3","first-page":"149","article-title":"Acamprosate: multicenter Portuguese efficacy and tolerance evaluation study","volume":"18","author":"Barrias","year":"1997","journal-title":"Psiquiatria Clinica"},{"key":"key\n\t\t\t\t20180822100420_agy013C4","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1530-0277.1998.tb04295.x","article-title":"Combined efficacy of acamprosate and disulfiram in the treatment of alcoholism: a controlled study","volume":"22","author":"Besson","year":"1998","journal-title":"Alcohol Clin Exp Res"},{"key":"key\n\t\t\t\t20180822100420_agy013C5","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1159\/000077944","article-title":"Pharmacodynamic effects of acamprosate on markers of cerebral function in alcohol-dependent subjects administered as pretreatment and during alcohol abstinence","volume":"50","author":"Boeijinga","year":"2004","journal-title":"Neuropsychobiology"},{"key":"key\n\t\t\t\t20180822100420_agy013C6","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S1087-0792(03)90005-0","article-title":"Insomnia, alcoholism and relapse","volume":"7","author":"Brower","year":"2003","journal-title":"Sleep Med Rev"},{"key":"key\n\t\t\t\t20180822100420_agy013C7","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1176\/appi.ajp.158.3.399","article-title":"Insomnia, self-medication, and relapse to alcoholism","volume":"158","author":"Brower","year":"2001","journal-title":"Am J Psychiatry"},{"key":"key\n\t\t\t\t20180822100420_agy013C8","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1111\/j.1530-0277.2008.00706.x","article-title":"A randomized double-blind pilot trial of gabapentin versus placebo to treat alcohol dependence and comorbid insomnia","volume":"32","author":"Brower","year":"2008","journal-title":"Alcohol Clin Exp Res"},{"key":"key\n\t\t\t\t20180822100420_agy013C9","first-page":"73","article-title":"Prevalence, trends, and incidence of alcohol withdrawal symptoms: analysis of general population and clinical samples","volume":"22","author":"Caetano","year":"1998","journal-title":"Alcohol Health Res World"},{"key":"key\n\t\t\t\t20180822100420_agy013C10","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1111\/acer.13217","article-title":"Alcohol dependence and its relationship with insomnia and other sleep disorders","volume":"40","author":"Chakravorty","year":"2016","journal-title":"Alcohol Clin Exp Res"},{"key":"key\n\t\t\t\t20180822100420_agy013C11","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1521-0391.2012.12009.x","article-title":"Insomnia in alcohol dependence: predictors of symptoms in a sample of veterans referred from primary care","volume":"22","author":"Chakravorty","year":"2013","journal-title":"Am J Addict"},{"key":"key\n\t\t\t\t20180822100420_agy013C12","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1093\/alcalc\/35.2.176","article-title":"United Kingdom Multicentre Acamprosate Study (UKMAS): a 6-month prospective study of acamprosate versus placebo in preventing relapse after withdrawal from alcohol","volume":"35","author":"Chick","year":"2000","journal-title":"Alcohol Alcohol"},{"key":"key\n\t\t\t\t20180822100420_agy013C13","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"key":"key\n\t\t\t\t20180822100420_agy013C14","first-page":"1796","article-title":"The sleep of abstinent pure primary alcoholic patients: natural course and relationship to relapse","volume":"22","author":"Drummond","year":"1998","journal-title":"Alcohol Clin Exp Res"},{"key":"key\n\t\t\t\t20180822100420_agy013C15","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1590\/S1516-44462009000300013","article-title":"Complaints of insomnia in hospitalized alcoholics","volume":"31","author":"Escobar-Cordoba","year":"2009","journal-title":"Rev Bras Psiquiatr"},{"key":"key\n\t\t\t\t20180822100420_agy013C16","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1111\/j.1530-0277.1999.tb04223.x","article-title":"Impaired sleep in alcohol misusers and dependent alcoholics and the impact upon outcome","volume":"23","author":"Foster","year":"1999","journal-title":"Alcohol Clin Exp Res"},{"key":"key\n\t\t\t\t20180822100420_agy013C17","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1111\/j.1530-0277.2008.00742.x","article-title":"Trazodone for sleep disturbance after alcohol detoxification: a double-blind, placebo-controlled trial","volume":"32","author":"Friedmann","year":"2008","journal-title":"Alcohol Clin Exp Res"},{"key":"key\n\t\t\t\t20180822100420_agy013C18","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000259166","article-title":"Acamprosate and prevention of relapse in alcoholics. Results of a randomized, placebo-controlled, double-blind study in out-patient alcoholics in The Netherlands, Belgium and Luxembourg","volume":"3","author":"Geerlings","year":"1997","journal-title":"Eur Addict Res"},{"key":"key\n\t\t\t\t20180822100420_agy013C19","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/alcalc\/36.5.413","article-title":"Acamprosate during and after acute alcohol withdrawal: a double-blind placebo-controlled study in Spain","volume":"36","author":"Gual","year":"2001","journal-title":"Alcohol Alcohol"},{"key":"key\n\t\t\t\t20180822100420_agy013C20","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1111\/acer.13106","article-title":"Missing data in alcohol clinical trials with binary outcomes","volume":"40","author":"Hallgren","year":"2016","journal-title":"Alcohol Clin Exp Res"},{"key":"key\n\t\t\t\t20180822100420_agy013C21","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1093\/alcalc\/agv046","article-title":"The association of alcohol severity and sleep quality in problem drinkers","volume":"50","author":"Hartwell","year":"2015","journal-title":"Alcohol Alcohol"},{"key":"key\n\t\t\t\t20180822100420_agy013C22","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1002\/sim.918","article-title":"Meta-analysis of continuous outcome data from individual patients","volume":"20","author":"Higgins","year":"2001","journal-title":"Stat Med"},{"key":"key\n\t\t\t\t20180822100420_agy013C23","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0","author":"Higgins","year":"2011"},{"key":"key\n\t\t\t\t20180822100420_agy013C24","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1001\/jama.2014.3628","article-title":"Pharmacotherapy for adults with alcohol use disorders in outpatient settings: a systematic review and meta-analysis","volume":"311","author":"Jonas","year":"2014","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20180822100420_agy013C25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0163-7258(03)00054-8","article-title":"N-methyl-D-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability","volume":"99","author":"Krystal","year":"2003","journal-title":"Pharmacol Ther"},{"key":"key\n\t\t\t\t20180822100420_agy013C26","first-page":"182","article-title":"Acamprosate\u2014a stabilizing factor in long-term withdrawal of alcoholic patients","volume":"50","author":"Ladewig","year":"1993","journal-title":"Ther Umsch"},{"key":"key\n\t\t\t\t20180822100420_agy013C27","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/01.ALC.0000108656.81563.05","article-title":"The efficacy of acamprosate in the maintenance of abstinence in alcohol-dependent individuals: results of a meta-analysis","volume":"28","author":"Mann","year":"2004","journal-title":"Alcohol Clin Exp Res"},{"key":"key\n\t\t\t\t20180822100420_agy013C28","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jpsychires.2006.02.002","article-title":"Effect of oral acamprosate on abstinence in patients with alcohol dependence in a double-blind, placebo-controlled trial: the role of patient motivation","volume":"40","author":"Mason","year":"2006","journal-title":"J Psychiatr Res"},{"key":"key\n\t\t\t\t20180822100420_agy013C29","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1530-0277.2011.01616.x","article-title":"Acamprosate for alcohol dependence: a sex-specific meta-analysis based on individual patient data","volume":"36","author":"Mason","year":"2012","journal-title":"Alcohol Clin Exp Res"},{"key":"key\n\t\t\t\t20180822100420_agy013C30","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"key":"key\n\t\t\t\t20180822100420_agy013C31","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/978-1-4612-2878-3_44","volume-title":"Novel Pharmacological Interventions for Alcoholism","author":"Pelc","year":"1992"},{"key":"key\n\t\t\t\t20180822100420_agy013C32","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1192\/bjp.171.1.73","article-title":"Efficacy and safety of acamprosate in the treatment of detoxified alcohol-dependent patients. A 90-day placebo-controlled dose-finding study","volume":"171","author":"Pelc","year":"1997","journal-title":"Br J Psychiatry"},{"key":"key\n\t\t\t\t20180822100420_agy013C33","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/alcalc\/agr160","article-title":"Sleep disturbance in alcoholism: proposal of a simple measurement, and results from a 24-week randomized controlled study of alcohol-dependent patients assessing acamprosate efficacy","volume":"47","author":"Perney","year":"2012","journal-title":"Alcohol Alcohol"},{"key":"key\n\t\t\t\t20180822100420_agy013C34","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/ADM.0000000000000063","article-title":"Measuring sleep disturbance in patients with alcohol use disorders: a short questionnaire suitable for routine practice","volume":"9","author":"Perney","year":"2015","journal-title":"J Addict Med"},{"key":"key\n\t\t\t\t20180822100420_agy013C35","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1111\/j.1360-0443.1997.tb02873.x","article-title":"Acamprosate treatment in a long-term community-based alcohol rehabilitation programme","volume":"92","author":"Poldrugo","year":"1997","journal-title":"Addiction"},{"key":"key\n\t\t\t\t20180822100420_agy013C36","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3758\/BRM.40.3.879","article-title":"Asymptomatic and resampling strategies for assessing and comparing indirect effects in multiple mediator models","volume":"40","author":"Preacher","year":"2008","journal-title":"Behav Res Methods"},{"key":"key\n\t\t\t\t20180822100420_agy013C37","first-page":"CD004332","article-title":"Acamprosate for alcohol dependence","volume":"9","author":"R\u00f6sner","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"key\n\t\t\t\t20180822100420_agy013C38","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1111\/j.1530-0277.2006.00180.x","article-title":"Effects of acamprosate on sleep during alcohol withdrawal: a double-blind placebo-controlled polysomnographic study in alcohol-dependent subjects","volume":"30","author":"Staner","year":"2006","journal-title":"Alcohol Clin Exp Res"},{"key":"key\n\t\t\t\t20180822100420_agy013C39","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/alcalc\/agq087","article-title":"Perception of sleep and dreams in alcohol-dependent patients during detoxification and abstinence","volume":"46","author":"Steinig","year":"2011","journal-title":"Alcohol Alcohol"},{"key":"key\n\t\t\t\t20180822100420_agy013C40","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/alcalc\/35.2.202","article-title":"Acamprosate and relapse prevention in the treatment of alcohol dependence: a placebo-controlled study","volume":"35","author":"Tempesta","year":"2000","journal-title":"Alcohol Alcohol"},{"key":"key\n\t\t\t\t20180822100420_agy013C41","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1097\/PSY.0b013e3181de7ff8","article-title":"It\u2019s more than sex: exploring the dyadic nature of sleep and implications for health","volume":"72","author":"Troxel","year":"2010","journal-title":"Psychosom Med"},{"key":"key\n\t\t\t\t20180822100420_agy013C42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v036.i03","article-title":"Conducting meta-analyses in R with the metafor package","volume":"36","author":"Viechtbauer","year":"2010","journal-title":"J Stat Soft"},{"key":"key\n\t\t\t\t20180822100420_agy013C43","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/S0140-6736(96)91682-7","article-title":"Comparison of acamprosate and placebo in long-term treatment of alcohol dependence","volume":"347","author":"Whitworth","year":"1996","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180822100420_agy013C44","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1111\/j.1530-0277.2012.01771.x","article-title":"Prevalence and correlates of insomnia in a Polish sample of alcohol-dependent patients","volume":"36","author":"Zhabenko","year":"2012","journal-title":"Alcohol Clin Exp Res"}],"container-title":["Alcohol and Alcoholism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/alcalc\/article-pdf\/53\/5\/611\/25526246\/agy013.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T01:20:38Z","timestamp":1660699238000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/alcalc\/article\/53\/5\/611\/4956705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,30]]},"references-count":44,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,3,30]]},"published-print":{"date-parts":[[2018,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/alcalc\/agy013","relation":{},"ISSN":["1464-3502"],"issn-type":[{"value":"1464-3502","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,9]]},"published":{"date-parts":[[2018,3,30]]}}}