{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:42:48Z","timestamp":1753875768349,"version":"3.41.2"},"reference-count":40,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T00:00:00Z","timestamp":1571097600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Mount Sinai International Exchange Program for Minority Students","award":["MD001452"],"award-info":[{"award-number":["MD001452"]}]},{"name":"Foundation for Formation and Research"},{"name":"Murcia\u2019s Drug Commissioner Office"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>In current clinical practice, prenatal alcohol exposure is usually assessed by interviewing the pregnant woman by applying questionnaires. An alternative method for detecting alcohol use is to measure the biomarker carbohydrate-deficient transferrin (CDT). However, few studies measure CDT during pregnancy. This study examines the utility of CDT biomarker in the screening of alcohol exposure during early pregnancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A cohort of 91, first-trimester pregnant women assigned to a public reference maternity hospital, was screened using the Green Page (GP) questionnaire, an environmental exposure tool. CDT levels and other biomarkers of alcohol use were measured and compared with questionnaire data.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>About 70% of the mothers in the study consumed alcohol during early pregnancy and 22% met high-risk criteria for prenatal exposure to alcohol. CDT measurement showed a statistically significant area under the receiver operating characteristic curve with a value of 0.70. For a value of 0.95% of CDT, a specificity of 93% was observed. The most significant predictors of CDT were the number of binge drinking episodes, women\u2019s body mass index and European white race.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Pregnant women with a CDT value &gt;0.95% would be good candidates for the performance of the GP questionnaire during early pregnancy in order to detect potential high-risk pregnancy due to alcohol exposure.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/alcalc\/agz073","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T15:12:39Z","timestamp":1565277159000},"source":"Crossref","is-referenced-by-count":0,"title":["An Integrative Screening Tool of Alcohol Exposure During Early Pregnancy: Combining of the CDT Biomarker with Green Page Questionnaire"],"prefix":"10.1093","author":[{"given":"Mar\u00eda Luisa","family":"Azurmendi-Funes","sequence":"first","affiliation":[{"name":"Pediatric Environmental Health Speciality Unit, Department of Paediatrics, Laboratory of Environmental and Human Health (A5) Institute of Biomedical Research, IMIB-Arrixaca, Virgen de la Arrixaca University Hospital, University of Murcia, Ctra. Madrid-Cartagena, s\/n, 30120 El Palmar, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Mart\u00ednez-Villanueva","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, University Clinical Hospital Virgen de la Arrixaca, Ctra. Madrid-Cartagena, s\/n, 30120 El Palmar, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Lu\u00eds","family":"Delgado-Mar\u00edn","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Department of Obstetrics and Gynecology, Virgen de la Arrixaca University Hospital, Ctra. Madrid-Cartagena, s\/n, 30120 El Palmar, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Ramis","sequence":"additional","affiliation":[{"name":"Cancer and Environmental Epidemiology Unit, National Epidemiology Centre, Carlos III Health Institute and Centre for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiolog\u00eda y Salud P\u00fablica \u2212 CIBERESP), Avda. Monforte de Lemos 5, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel Felipe","family":"S\u00e1nchez-Sauco","sequence":"additional","affiliation":[{"name":"Pediatric Environmental Health Speciality Unit, Department of Paediatrics, Laboratory of Environmental and Human Health (A5) Institute of Biomedical Research, IMIB-Arrixaca, Virgen de la Arrixaca University Hospital, University of Murcia, Ctra. Madrid-Cartagena, s\/n, 30120 El Palmar, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando Antonio","family":"L\u00f3pez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departamento de M\u00e9todos Cuantitativos e Inform\u00e1ticos, Universidad Polit\u00e9cnica de Cartagena, C\/ Real, 3; 30201 Cartagena, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"S\u00e1nchez-Sol\u00eds","sequence":"additional","affiliation":[{"name":"Pediatric Environmental Health Speciality Unit, Department of Paediatrics, Laboratory of Environmental and Human Health (A5) Institute of Biomedical Research, IMIB-Arrixaca, Virgen de la Arrixaca University Hospital, University of Murcia, Ctra. Madrid-Cartagena, s\/n, 30120 El Palmar, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Monteagudo-Piqueras","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n General de Salud de P\u00fablica, Consejer\u00eda de Salud, Regi\u00f3n de Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Antonio","family":"Noguera-Velasco","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, University Clinical Hospital Virgen de la Arrixaca, Ctra. Madrid-Cartagena, s\/n, 30120 El Palmar, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luz","family":"Claudio","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine and Public Health, Mount Sinai School of Medicine, One Gustave L. 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