{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T06:14:35Z","timestamp":1764656075393,"version":"3.41.2"},"reference-count":42,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>This open-label study in patients with alcohol dependence and evidence of elevated liver stiffness and\/or hepatic steatosis was designed to explore the efficacy of nalmefene (18\u00a0mg) in reducing alcohol consumption and its subsequent effects on a variety of clinically relevant liver parameters.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Adult patients with a diagnosis of alcohol dependence and evidence of elevated liver stiffness and\/or hepatic steatosis (liver stiffness &gt;6\u00a0kPa or controlled attenuation parameter (CAP) &gt;215\u00a0dB\/m as measured by transient elastography) were recruited at two study sites in Germany. During the 12-week treatment period, patients were instructed to take nalmefene each day they perceived a risk of drinking alcohol.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>All 45 enrolled patients took at least one dose of nalmefene and 39 completed the study. After 12\u00a0weeks of study treatment with nalmefene patients showed a reduction in alcohol consumption of \u221213.5\u00a0days\/month heavy drinking days and \u221245.8\u00a0g\/day total alcohol consumption. Most liver parameters showed modest changes at Week 12; there was a 13% decrease in liver stiffness and 10% reduction in CAP values. Results indicated non-significant negative associations between alcohol consumption and liver stiffness and\/or CAP over this 12-week study. Nalmefene was generally well tolerated, and most adverse events were mild or moderate, the most frequent being dizziness.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Patients treated with nalmefene for 12\u00a0weeks had reductions in alcohol consumption by ~50% relative to baseline and showed trends to improvement in liver stiffness and CAP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/alcalc\/agz078","type":"journal-article","created":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T11:34:56Z","timestamp":1567942496000},"source":"Crossref","is-referenced-by-count":9,"title":["Open-label Study with Nalmefene as Needed Use in Alcohol-Dependent Patients with Evidence of Elevated Liver Stiffness and\/or Hepatic Steatosis"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5655-6778","authenticated-orcid":false,"given":"Sebastian","family":"Mueller","sequence":"first","affiliation":[{"name":"Department of Medicine and Centre for Alcohol Research, Salem Medical Centre, University of Heidelberg, Zeppelinstra\u00dfe 11--33, 69121 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Luderer","sequence":"additional","affiliation":[{"name":"Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J 5 68159 Mannheim, Germany"},{"name":"Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Heinrich-Hoffmann-Str. 10 60528 Frankfurt\/Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doris","family":"Zhang","sequence":"additional","affiliation":[{"name":"H. 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