{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T02:28:53Z","timestamp":1793845733926,"version":"4.6.1"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","award":["FRANCE 2030"],"award-info":[{"award-number":["FRANCE 2030"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019979","name":"Grenoble Alpes University Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019979","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sleep Health-AI chair"},{"name":"MIAI Cluster","award":["ANR-23-IACL-0006"],"award-info":[{"award-number":["ANR-23-IACL-0006"]}]},{"DOI":"10.13039\/100017647","name":"ResMed","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Coexisting chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) is known as overlap syndrome. This may represent a distinct clinical phenotype that shows different responses after being initiated on noninvasive ventilation (NIV) for hypercapnic chronic respiratory failure. However, current data remain scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective(s)<\/jats:title>\n                    <jats:p>This study estimated the impact of overlap syndrome versus COPD without OSA on transitions between 3 states (without\/recovery from severe exacerbation, severe exacerbation and death) in patients initiated on domiciliary NIV therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multistate model data came from the French national health insurance reimbursement system database for individuals with COPD aged\u2009\u226540\u2009years and\u2009\u22651 NIV reimbursement in 2015-2019. Outcomes in the overlap syndrome and COPD without OSA groups were compared using a Cox model and inverse probability of treatment weighting analysis, adjusted for patient characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data from 54,545 patients were included (median age 70\u2009years, 51.2% male). Probabilities of transitioning from severe exacerbation to death (10% vs. 22%) and without severe exacerbation to death (5% vs. 18%) were lower in the overlap syndrome versus COPD without OSA group. The rate of transition from severe exacerbation to without exacerbation\/recovery was also higher in the overlap syndrome group. After NIV initiation, the mortality rate was 33% lower in people with overlap syndrome vs COPD without OSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>For people with COPD started on domiciliary NIV, those with overlap syndrome might benefit from NIV to a greater extent than those without OSA. This highlights the need for OSA screening in people with COPD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/annalsats\/aaoaf043","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T09:02:55Z","timestamp":1769158975000},"page":"597-606","source":"Crossref","is-referenced-by-count":2,"title":["Mortality impact of long-term home non-invasive ventilation in COPD patients with versus without obstructive sleep apnea"],"prefix":"10.1093","volume":"23","author":[{"given":"Jean-Louis","family":"Pepin","sequence":"first","affiliation":[{"name":"Grenoble Alpes University, Inserm U1300, CHU Grenoble Alpes, HP2 Laboratory , Grenoble,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonore","family":"Herquelot","sequence":"additional","affiliation":[{"name":"HEVA , 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