{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T04:31:50Z","timestamp":1769920310952,"version":"3.49.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"am","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Bronchiectasis, a condition defined by radiographic evidence of abnormally widened airways, is increasing in prevalence. Previous studies have demonstrated increased morbidity and health care utilization among patients with bronchiectasis, but there is a dearth of recent data regarding the current rates and outcomes of persons hospitalized with bronchiectasis in the United States.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A retrospective cohort analysis was performed of the 2022 HCUP National Inpatient Sample (NIS) dataset, focusing on persons admitted with bronchiectasis via ICD-10 codes. Demographic and clinical and cost characteristics were evaluated. Patients were classified as having bronchiectasis with asthma, chronic obstructive pulmonary disease, or none of these. Multivariable regression models with a priori covariates were constructed for outcomes of in hospital mortality, length of stay and cost. Sex-stratified analyses were also conducted. All analyses were run at a two-sided p value of 0.05 using R.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n We identified 99,755 weighted hospitalizations (29.9 per 100,000), 57.6% female, median age 75 years. Admissions were highest among older females, but mortality was greater in males (adjusted OR 1.37, 95% CI 1.22\u20131.54) and in bronchiectasis-alone versus bronchiectasis\u2013asthma (aOR 2.38, 95% CI 1.85\u20133.07). Most hospitalizations occurred in the Southwestern United States, but the Western United States region had the highest mortality and costs. Median cost was $58,582 and median length of stay was 5 days; respiratory failure occurred in 53.7% of admissions. Income and race were not independently associated with mortality.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Nearly 100,000\u2009U.S. hospitalizations for bronchiectasis occurred in 2022, with the highest rates in older females but the greatest mortality in males and in bronchiectasis-alone phenotypes. Mortality remains substantial, particularly in these high-risk groups, underscoring the need for targeted prevention, earlier recognition, and phenotype-specific management strategies to curb the growing inpatient burden of bronchiectasis.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/annalsats\/aaoag018","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T16:14:04Z","timestamp":1769876044000},"source":"Crossref","is-referenced-by-count":0,"title":["Rates and Characteristics of Bronchiectasis-Related Hospitalizations in the United States in 2022: A Population-Based Cohort Study"],"prefix":"10.1093","author":[{"given":"Meagan","family":"Deviaene","sequence":"first","affiliation":[{"name":"University of Calgary Cumming School of Medicine, , 3330 Hospital Dr NW, Calgary, AB T2N 2T8"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Haldane","sequence":"additional","affiliation":[{"name":"University of Calgary Cumming School of Medicine, , 3330 Hospital Dr NW, Calgary, AB T2N 2T8"},{"name":"University of Toronto Institute of Health Policy, Management & Evaluation, , 155 College St 4th Floor, Toronto, ON M5T 3M6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason E","family":"Black","sequence":"additional","affiliation":[{"name":"University of Calgary Department of Community Health Sciences, Cumming School of Medicine, , Calgary, Alberta,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina S","family":"Thornton","sequence":"additional","affiliation":[{"name":"University of Calgary Department of Medicine, , Calgary, AB,","place":["Canada"]},{"name":"University of Calgary Department Microbiology, Immunology and Infectious Diseases, , Calgary, AB,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjani","family":"Somayaji","sequence":"additional","affiliation":[{"name":"University of Calgary Department of Community Health Sciences, Cumming School of Medicine, , Calgary, Alberta,","place":["Canada"]},{"name":"University of Calgary Department of Medicine, , Calgary, AB,","place":["Canada"]},{"name":"University of Calgary Department Microbiology, Immunology and Infectious Diseases, , Calgary, AB,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,30]]},"container-title":["Annals of the American Thoracic Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/annalsats\/advance-article-pdf\/doi\/10.1093\/annalsats\/aaoag018\/66676000\/aaoag018.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/annalsats\/advance-article-pdf\/doi\/10.1093\/annalsats\/aaoag018\/66676000\/aaoag018.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T16:14:04Z","timestamp":1769876044000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/annalsats\/advance-article\/doi\/10.1093\/annalsats\/aaoag018\/8450241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,30]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/annalsats\/aaoag018","relation":{},"ISSN":["2325-6621"],"issn-type":[{"value":"2325-6621","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,30]]},"article-number":"aaoag018"}}