{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T07:50:14Z","timestamp":1780645814872,"version":"3.54.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["Dnr: 2019-02081"],"award-info":[{"award-number":["Dnr: 2019-02081"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Benzodiazepines, gabapentinoids, hypnotics, and opioids can depress respiration, alter sleep, and potentially affect outcomes in individuals treated with home mechanical ventilation (HMV) for obesity hypoventilation syndrome (OHS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To analyze the association of benzodiazepines, gabapentinoids, hypnotics, and opioid use with hospitalization-free survival and mortality after starting HMV for OHS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Population-based longitudinal study on patients with OHS starting HMV in the DISCOVERY cohort between 2005 and 2022, cross-linked with data on dispensed outpatient drugs, hospitalizations, comorbidities, and socioeconomics. The primary outcome was a composite of all-cause hospitalization or death within 1\u2009year. Secondary outcomes were hospitalization and death, respectively. Associations with hospitalization and mortality were analyzed using Cox regression models, adjusting for age, sex, body mass index, place of birth (Sweden), Charlson Comorbidity Index, civil status, education level, and use of other drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>Of 3004 included patients (50% female; mean age 63.3\u2009\u00b1\u200912.7\u2009years), 15% were using benzodiazepines, 10% gabapentinoids, 26% hypnotics, and 25% opioids. Drug treatments associated with a higher risk of hospitalization or death were benzodiazepines (adjusted hazard ratio, 1.23; 95% CI, 1.08-1.41), gabapentinoids (1.17; 1.00-1.36), and opioids (1.25; 1.12-1.40), while hypnotics (1.07; 0.96-1.21) were not clearly associated. The associations were mainly driven by increased risks of hospitalizations, with a similar pattern as for the primary outcome. None of the drug treatments was associated with mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The use of benzodiazepines, gabapentinoids, and opioids was associated with increased risk of hospitalization or mortality in patients with OHS starting treatment with HMV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/annalsats\/aaoag048","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T08:13:56Z","timestamp":1772525636000},"page":"964-972","source":"Crossref","is-referenced-by-count":1,"title":["Impact of central nervous system depressants on prognosis in obesity hypoventilation syndrome\u2014the population-based DISCOVERY study"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2548-0236","authenticated-orcid":false,"given":"Jonas","family":"Einarsson","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences in Lund, Division of Respiratory Medicine, Allergology and Palliative Medicine, Lund University , Lund,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0590-0417","authenticated-orcid":false,"given":"Andreas","family":"Palm","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University , Uppsala,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7227-5113","authenticated-orcid":false,"given":"Magnus","family":"Ekstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences in Lund, Division of Respiratory Medicine, Allergology and Palliative Medicine, Lund University , Lund,","place":["Sweden"]},{"name":"Department of Health, Blekinge Institute of Technology , Karlskrona,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"key":"2026060414422648400_aaoag048-B1","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1513\/pats.200708-122MG","article-title":"Assessment and management of patients with obesity hypoventilation syndrome","volume":"5","author":"Mokhlesi","year":"2008","journal-title":"Proc Am Thorac Soc"},{"key":"2026060414422648400_aaoag048-B2","doi-asserted-by":"publisher","first-page":"e6-24","DOI":"10.1164\/rccm.201905-1071ST","article-title":"Evaluation and management of obesity hypoventilation syndrome. 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