{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:17:32Z","timestamp":1787865452730,"version":"build-2784847793"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Australian, Medical Research Future","award":["2022\/MRF2023066"],"award-info":[{"award-number":["2022\/MRF2023066"]}]},{"name":"National Health and Medical Research Council of Australia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sepsis survivors may experience ongoing health challenges after hospitalization for sepsis. Patient-reported outcome measures (PROMs) and patient-reported experience measures (PREMs) are important endpoints to assess patient health status and health system performance. This review aimed to (1) identify and describe the PROMs and PREMs used in randomized controlled trials (RCTs) of critically ill adults with sepsis and (2) determine the \u201csurvivor-centricity\u201d of these measures. MEDLINE, Embase, CINAHL Plus, and PsycINFO were searched on November 18, 2024. Studies were included if they (1) were conducted in adult patients admitted to the intensive care unit (ICU) with sepsis; (2) were RCTs (or a follow-up study of an RCT); (3) included at least 1 PROM or PREM; and (4) were published since January 1, 2000, in English, and available in full text. A total of 7667 studies were screened for eligibility. Eighteen studies were included (n\u2009=\u200921\u200a439 patients). Nine (50%) studies were RCTs, and 9 (50%) were RCT follow-up studies. A total of 21 PROMs, and 1 PREM were identified in these 18 studies. The most common PROM was health-related quality of life (HRQoL), measured in 17 (94%) studies, via the EuroQol-5D-5L (n\u2009=\u200910, 56%). Most PROMs (n\u2009=\u200913, 62%) were aligned with the survivor-centricity health domain of psychological impairment. Only 1 study reported a PREM that captured the patient experience of chronic care. In RCTs of patients admitted to the ICU with sepsis, HRQoL was the most frequently measured PROM. Only 1 PREM was identified. Health-related QoL captured the most survivor-centricity domains.<\/jats:p>\n                  <jats:p>INPLASY Registration: INPLASY (International Platform of Registered Systematic Reviewsand Meta-Analysis Protocols), INPLASY Protocol 5756 \u2013 INPLASY, INPLASY202410064<\/jats:p>","DOI":"10.1093\/annalsats\/aaoag102","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:58:30Z","timestamp":1776409110000},"page":"1257-1270","source":"Crossref","is-referenced-by-count":0,"title":["Patient-reported outcomes and experience measures in clinical trials of critically ill adults with sepsis: a scoping review"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9908-224X","authenticated-orcid":false,"given":"Elizabeth","family":"Hibbert","sequence":"first","affiliation":[{"name":"Department of Critical Care, School of Medicine, The University of Melbourne , Melbourne, Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1886-5526","authenticated-orcid":false,"given":"Nina","family":"Leggett","sequence":"additional","affiliation":[{"name":"Department of Critical Care, School of Medicine, The University of Melbourne , Melbourne, Victoria,","place":["Australia"]},{"name":"Department of Physiotherapy, Western Health , Melbourne, Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dasom","family":"Kim","sequence":"additional","affiliation":[{"name":"Emergency Department, Western Health , Melbourne, Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1185-9836","authenticated-orcid":false,"given":"Sheraya","family":"De Silva","sequence":"additional","affiliation":[{"name":"Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University , Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4996-3006","authenticated-orcid":false,"given":"Rose","family":"Messiha","sequence":"additional","affiliation":[{"name":"Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University , Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2307-8076","authenticated-orcid":false,"given":"Brett","family":"Abbenbroek","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health, Sepsis Australia, University of New South Wales , Sydney, New South Wales,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4293-3258","authenticated-orcid":false,"given":"Lewis","family":"Campbell","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Royal Darwin Hospital , Darwin, Northern Territory,","place":["Australia"]},{"name":"Menzies School of Health Research , Darwin, Northern Territory,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7620-5577","authenticated-orcid":false,"given":"Adam","family":"Deane","sequence":"additional","affiliation":[{"name":"Department of Critical Care, School of Medicine, The University of Melbourne , Melbourne, Victoria,","place":["Australia"]},{"name":"Intensive Care Unit, The Royal Melbourne Hospital , Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3469-2792","authenticated-orcid":false,"given":"Jacob","family":"Dye","sequence":"additional","affiliation":[{"name":"Consumer Consultant, Sepsis Australia, The George Institute for Global Health, Sepsis Australia, University of New South Wales , Sydney, New South Wales,","place":["Australia"]},{"name":"Critical Care Program, The George Institute for Global Health, University of New South Wales , Sydney, New South Wales,","place":["Australia"]},{"name":"Collaborative Evaluation Research Centre, Federation University, Churchill, Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7700-9933","authenticated-orcid":false,"given":"Glenn","family":"Eastwood","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Western Health , Melbourne, Victoria,","place":["Australia"]},{"name":"Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University , Victoria,","place":["Australia"]},{"name":"Department of Intensive Care, Austin Hospital , Heidelberg, Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2785-5864","authenticated-orcid":false,"given":"Simon","family":"Finfer","sequence":"additional","affiliation":[{"name":"Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University , Victoria,","place":["Australia"]},{"name":"School of Public Health, Imperial College London , London,","place":["England"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8295-7559","authenticated-orcid":false,"given":"Alisa","family":"Higgins","sequence":"additional","affiliation":[{"name":"Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University , Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9002-2075","authenticated-orcid":false,"given":"Carol L","family":"Hodgson","sequence":"additional","affiliation":[{"name":"Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University , Victoria,","place":["Australia"]},{"name":"Department of Physiotherapy, Alfred Hospital , Melbourne, Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3269-3855","authenticated-orcid":false,"given":"Evelyn","family":"Hutcheon","sequence":"additional","affiliation":[{"name":"Western Health Library Service, Western Health , Melbourne, Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5125-6829","authenticated-orcid":false,"given":"Edward","family":"Litton","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Fiona Stanley Hospital , Perth, Western Australia,","place":["Australia"]},{"name":"School of Medicine, University of Western Australia , Crawley, Western Australia,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mick","family":"O\u2019Dowd","sequence":"additional","affiliation":[{"name":"Consumer Consultant, The George Institute for Global Health, University of New South 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and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University , Victoria,","place":["Australia"]},{"name":"Adelaide Medical School, University of Adelaide , Adelaide, South Australia,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8442-6724","authenticated-orcid":false,"given":"Hallie C","family":"Prescott","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan,","place":["United States"]},{"name":"VA Center for Clinical Management Research, Ann Arbor, Michigan,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0385-6731","authenticated-orcid":false,"given":"Manoj","family":"Saxena","sequence":"additional","affiliation":[{"name":"Critical Care Program, Faculty of Medicine, The George Institute for Global Health, University of New South Wales , Sydney, New South Wales,","place":["Australia"]},{"name":"Department of Intensive Care Medicine, St George's Hospital , Sydney, New South Wales,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1239-7514","authenticated-orcid":false,"given":"Kiran","family":"Shekar","sequence":"additional","affiliation":[{"name":"Adult Intensive Care Services, The Prince Charles Hospital , Brisbane, Queensland,","place":["Australia"]},{"name":"The University of Queensland , Brisbane, Queensland,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Korina","family":"Valentine","sequence":"additional","affiliation":[{"name":"Consumer Consultant, The George Institute for Global Health, University of New South Wales , Sydney, New South 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