{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T06:45:37Z","timestamp":1782715537526,"version":"3.54.5"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Multiple pulmonary nodules (MPNs) are commonly encountered in patients at elevated risk for thoracic malignancy and represent a spectrum of disease states and stages. We evaluated the safety, and procedural outcomes of a combined robotic assisted bronchoscopy (RaB) and linear endobronchial ultrasound (EBUS) approach to patients with MPNs during a single bronchoscopic procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter observational registry included patients who underwent RaB for evaluation of MPNs. Data were prospectively collected from six centers between 2019 and 2025. Demographics, imaging characteristics, safety events, and procedural outcomes were analyzed and associated with final diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 191 patients underwent RaB with biopsy of MPN during a single procedure; 167 patients also underwent linear EBUS lymph node sampling. The strict per nodule diagnostic yield was 71.5% overall (first nodule 70.7%, second 74.3%, third 71.4%). At least one malignant nodule was identified in 127 patients (66.8%), and 85 patients (44.5%) had two or more malignant nodules; 15 patients (17.6%) demonstrated heterogeneous histopathology between malignant nodules. Among patients with non\u2013small cell lung cancer, adequate cellularity for next generation sequencing was achieved in 82.6% of nodules. Malignant lymph nodes were identified in 10.8% (18\/167). No patients with two pure ground glass nodules (0\/8) had malignant nodal involvement. Pneumothorax occurred in 7.3% of cases, with 2.1% requiring chest tube placement; unplanned admissions occurred in 3.7%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides a large multisite registry evaluation of performance of simultaneous bronchoscopic sampling of multiple pulmonary nodules with EBUS staging during a single anesthesia event demonstrating an acceptable safety profile and adequacy for molecular profiling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/annalsats\/aaoag142","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T05:59:49Z","timestamp":1782712789000},"source":"Crossref","is-referenced-by-count":0,"title":["Robotic Assisted Bronchoscopy with Endobronchial Ultrasound for the Evaluation of Multiple Pulmonary Nodules: A Multi-Center Registry"],"prefix":"10.1093","author":[{"given":"Christopher M","family":"Kapp","sequence":"first","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Department of Medicine, , Chicago, IL,","place":["USA"]},{"name":"Northwestern University Feinberg School of Medicine Section of Interventional Pulmonology, Division of Pulmonary and Critical Care, , Chicago, IL,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momen M","family":"Wahidi","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Department of Medicine, , Chicago, IL,","place":["USA"]},{"name":"Northwestern University Feinberg School of Medicine Section of Interventional Pulmonology, Division of Pulmonary and Critical Care, , Chicago, IL,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie H","family":"Rowell","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Department of Medicine, , Chicago, IL,","place":["USA"]},{"name":"Northwestern University Feinberg School of Medicine Section of Interventional Pulmonology, Division of Pulmonary and Critical Care, , Chicago, IL,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia S","family":"Yong","sequence":"additional","affiliation":[{"name":"Vanderbilt University Section of Interventional Pulmonology, Division of Pulmonary and Critical Care Medicine, , Nashville, TN,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J","family":"Seides","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Section of Interventional Pulmonology, Division of Pulmonary and Critical Care, , Chicago, IL,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean B","family":"Smith","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Department of Medicine, , Chicago, IL,","place":["USA"]},{"name":"Northwestern University Feinberg School of Medicine Section of Interventional Pulmonology, Division of Pulmonary and Critical Care, , Chicago, IL,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharat","family":"Balan","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Section of Interventional Pulmonology, Division of Pulmonary and Critical Care, , Chicago, IL,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Dibardino","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Section of Interventional Pulmonology, Division of Pulmonary, Allergy and Critical Care, , Philadelphia, PA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Haas","sequence":"additional","affiliation":[{"name":"University of Illinois-Chicago Division of Pulmonary and Critical Care Medicine, , Chicago, IL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"White","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Section of Interventional Pulmonology, Division of Pulmonary and Critical Care, , Chicago, IL,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy J","family":"Kim","sequence":"additional","affiliation":[{"name":"University of California Division of Pulmonary and Critical Care Medicine, , Davis, Sacramento, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Riestra Guiance","sequence":"additional","affiliation":[{"name":"Hartford HealthCare Medical Group Section of Interventional Pulmonary, Division of Pulmonary and Critical Care, , Norwich, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Bhargava","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Department of Medicine, , Chicago, IL,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia H","family":"Diaz","sequence":"additional","affiliation":[{"name":"Johns Hopkins University Division of Pulmonary and Critical Care Medicine, , Baltimore, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra Y","family":"Lee-Mateus","sequence":"additional","affiliation":[{"name":"Mayo Clinic Jacksonville Division of Pulmonary and Critical Care Medicine, Department of Medicine, , Jacksonville, FL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Abia Trujillo","sequence":"additional","affiliation":[{"name":"Mayo Clinic Jacksonville Division of Pulmonary and Critical Care Medicine, Department of Medicine, , Jacksonville, FL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard A","family":"Silvestri","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina Thoracic Oncology Research Group, Division of Pulmonary and Critical Care Medicine, Department of Medicine, , Charleston, SC,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yupeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Department of Medicine, , Chicago, IL,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Pfister","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Department of Medicine, , Chicago, IL,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Thiboutot","sequence":"additional","affiliation":[{"name":"Johns Hopkins University Division of Pulmonary and Critical Care Medicine, , Baltimore, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,27]]},"container-title":["Annals of the American Thoracic Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/annalsats\/advance-article-pdf\/doi\/10.1093\/annalsats\/aaoag142\/68641188\/aaoag142.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/annalsats\/advance-article-pdf\/doi\/10.1093\/annalsats\/aaoag142\/68641188\/aaoag142.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T05:59:49Z","timestamp":1782712789000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/annalsats\/advance-article\/doi\/10.1093\/annalsats\/aaoag142\/8721290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,27]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/annalsats\/aaoag142","relation":{},"ISSN":["2325-6621"],"issn-type":[{"value":"2325-6621","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,27]]},"article-number":"aaoag142"}}