{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T14:08:15Z","timestamp":1784815695028,"version":"3.55.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"Abstract<\/jats:title>\n \n Rationale<\/jats:title>\n Evidence on adherence to adaptive servo-ventilation (ASV), sleep architecture, and patient-reported outcomes in patients with central sleep apnea (CSA) in routine clinical practice is limited.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n The primary objective was to assess adherence to ASV in a real-world population with CSA; secondary objectives were to evaluate longitudinal changes in sleep fragmentation, polysomnographic sleep architecture, and patient-reported outcomes.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The multicenter, prospective, observational AutoSV Registry (NCT03421704, 2018-2023) enrolled adult patients with CSA, who were prescribed ASV (Philips DreamStation BiPAP auto SV). The follow-up period was up to 24 months. Adherence data were collected via telemonitoring software (Philips EncoreAnywhere\u2122). Polysomnography (PSG) was performed at diagnosis, during ineffective continuous positive airway pressure with residual CSA (CPAPrCSA) and on ASV. Sleepiness (Epworth Sleepiness Scale, ESS) and subjective sleep quality (Pittsburgh Sleep Quality Index, PSQI) were measured.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of the 125 enrolled patients, 66% had impaired subjective sleep quality (PSQI&gt;5) and 33% were sleepy (ESS&gt;10). Adherence to ASV therapy was at least 4\u2009hours\/night in 67% of patients. Median adherence was 5.3 (3.1; 6.7) hours\/day (n\u2009=\u2009103, median (IQR) follow-up 16 months). Sleep fragmentation was reduced during ASV, with decreased sleep stage N1 and increased sleep stage N3 and rapid eye movement sleep compared with diagnostic PSG and CPAPrCSA therapy. The global PSQI (mean [95%CI]) score improved by -1.7 (-2.9; -0.6) (p\u2009&lt;\u20090.001; n\u2009=\u200955), and the ESS score (mean [95%CI]) improved by -1.9 (-3.2; -0.6) (p\u2009&lt;\u20090.001; n\u2009=\u200957) from baseline to 24 months.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n ASV therapy in a sleep-clinic population with CPAPrCSA was associated with high adherence, possibly reflecting clinically meaningful benefits, including reduced sleep fragmentation, improved objective and subjective sleep quality, and reduced sleepiness.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/annalsats\/aaoag187","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T13:31:23Z","timestamp":1784813483000},"source":"Crossref","is-referenced-by-count":0,"title":["Adaptive servo-ventilation for central sleep apnea: usage and effect on sleep and symptoms\u2013a multicenter registry study"],"prefix":"10.1093","author":[{"given":"Anett","family":"Lindner","sequence":"first","affiliation":[{"name":"University Hospital Regensburg Department of Internal Medicine II, , Regensburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Jasko","sequence":"additional","affiliation":[{"name":"Philips Respironics , Murrysville, PA,","place":["US"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandhya","family":"Matthes","sequence":"additional","affiliation":[{"name":"University of Cologne Bethanien Hospital, Clinic of Pneumology and Allergology, Center for Sleep Medicine and Respiratory Care, Institute of Pneumology, , Solingen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winfried","family":"Randerath","sequence":"additional","affiliation":[{"name":"University of Cologne Bethanien Hospital, Clinic of Pneumology and Allergology, Center for Sleep Medicine and Respiratory Care, Institute of Pneumology, , Solingen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Fietze","sequence":"additional","affiliation":[{"name":"Charit\u00e9 University Hospital Berlin Centre of Sleep Medicine, , Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Barleben","sequence":"additional","affiliation":[{"name":"Helios Hospital Schwerin Department of Pneumology, , Schwerin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Gr\u00fcning","sequence":"additional","affiliation":[{"name":"Helios Hospital Schwerin Department of Pneumology, , Schwerin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Fox","sequence":"additional","affiliation":[{"name":"Center for Interdisciplinary Management of Advanced Heart Failure, Herz- und Diabeteszentrum NRW, Ruhr-Universit\u00e4t Bochum Clinic for Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum NRW, Ruhr-Universit\u00e4t Bochum, Bad Oeynhausen, Germany; , Bad Oeynhausen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Velasquez-Silva","sequence":"additional","affiliation":[{"name":"Center for Interdisciplinary Management of Advanced Heart Failure, Herz- und Diabeteszentrum NRW, Ruhr-Universit\u00e4t Bochum Clinic for Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum NRW, Ruhr-Universit\u00e4t Bochum, Bad Oeynhausen, Germany; , Bad Oeynhausen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Domanski","sequence":"additional","affiliation":[{"name":"Helios Klinik Hagen-Ambrock , Hagen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Galetke","sequence":"additional","affiliation":[{"name":"VAMED Klinik Hagen-Ambrock Department for Pulmonolgy, , Hagen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Arzt","sequence":"additional","affiliation":[{"name":"University Hospital Regensburg Department of Internal Medicine II, , Regensburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,23]]},"container-title":["Annals of the American Thoracic Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/annalsats\/advance-article-pdf\/doi\/10.1093\/annalsats\/aaoag187\/69867259\/aaoag187.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/annalsats\/advance-article-pdf\/doi\/10.1093\/annalsats\/aaoag187\/69867259\/aaoag187.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T13:31:23Z","timestamp":1784813483000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/annalsats\/advance-article\/doi\/10.1093\/annalsats\/aaoag187\/8740486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,23]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/annalsats\/aaoag187","relation":{},"ISSN":["2325-6621"],"issn-type":[{"value":"2325-6621","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,23]]},"article-number":"aaoag187"}}