{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T19:22:43Z","timestamp":1783106563822,"version":"3.54.6"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Exposure to fine particulate matter (PM2.5), a major component of ambient air pollution, is associated with worse short-term respiratory outcomes in cystic fibrosis (CF). The relationship between air pollution exposure over time and lung disease progression in CF is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To elucidate how PM2.5 affects the rate of age-related decline in forced expiratory volume in one second (FEV1) among adults with CF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective open cohort study of pwCF\u2009\u2265\u200926\u2009years in the U.S. CF Foundation Patient Registry between 2003-2019. Annual average PM2.5 was estimated at the population-weighted center of each participant\u2019s zip code using a spatiotemporal model. We examined the effect of PM2.5 on the age-related change in FEV1 z-score by mixed effects linear regression, adjusting for relevant demographic and clinical covariates, and stratifying by 5-year cohorts of birth year to account for secular improvements in FEV1 and PM2.5 over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>11,392 adults with CF age\u2009\u2265\u200926 contributed 81,944 person-years of follow-up. Mean ambient PM2.5 levels over the study period were 9.1\u2009\u00b5g\/m3 (7.5\u201410.4). The average annual age-related change in FEV1 z-score was -0.057 (95% CI -0.081, -0.033). After covariate adjustment, we did not find evidence of an adverse association between PM2.5 and annual change in FEV1 z-score in the overall cohort [+0.002 per 3\u2009\u00b5g\/m3 change in PM2.5 (95% CI -0.001, 0.005)] or across birth cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this large U.S. study, we did not detect an effect of ambient PM2.5 exposure at the zip code level on long-term lung function trajectory in adults with CF. Consideration of other windows of potential vulnerability to exposure, such as during childhood, may help further explain the relationship between air pollution and long-term outcomes in CF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary Sources of Funding<\/jats:title>\n                    <jats:p>Cystic Fibrosis Foundation, CIR Northwest, Seattle Children\u2019s Research Institute<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/annalsats\/aaoag188","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T19:09:14Z","timestamp":1783105754000},"source":"Crossref","is-referenced-by-count":0,"title":["Fine particulate matter exposure and long-term lung-function trajectory in adults with cystic fibrosis"],"prefix":"10.1093","author":[{"given":"Bob Z","family":"Sun","sequence":"first","affiliation":[{"name":"University of British Columbia Department of Pediatrics, Faculty of Medicine, , Vancouver, BC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D","family":"Cogen","sequence":"additional","affiliation":[{"name":"University of Washington Department of Pediatrics, School of Medicine, , Seattle, WA"},{"name":"Seattle Children\u2019s Research Institute Center for Respiratory Biology and Therapeutics, , Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marshall","family":"Brown","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Research Institute Core for Biostatistics, Epidemiology and Analytics in Research, , Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna V","family":"Faino","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Research Institute Core for Biostatistics, Epidemiology and Analytics in Research, , Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Hinckley Stukovsky","sequence":"additional","affiliation":[{"name":"University of Washington Department of Biostatistics, School of Public Health, , Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam A","family":"Szpiro","sequence":"additional","affiliation":[{"name":"University of Washington Department of Biostatistics, School of Public Health, , Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianne","family":"Sheppard","sequence":"additional","affiliation":[{"name":"University of Washington Department of Biostatistics, School of Public Health, , Seattle, WA"},{"name":"University of Washington Department of Environmental & Occupational Health Sciences, School of Public Health, , Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher H","family":"Goss","sequence":"additional","affiliation":[{"name":"University of Washington Department of Pediatrics, School of Medicine, , Seattle, WA"},{"name":"Seattle Children\u2019s Research Institute Center for Respiratory Biology and Therapeutics, , Seattle, WA"},{"name":"University of Washington Department of Medicine, School of Medicine, , Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Kaufman","sequence":"additional","affiliation":[{"name":"University of Washington Department of Environmental & Occupational Health Sciences, School of Public Health, , Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Rosenfeld","sequence":"additional","affiliation":[{"name":"University of Washington Department of Pediatrics, School of Medicine, , Seattle, WA"},{"name":"Seattle Children\u2019s Research Institute Center for Respiratory Biology and Therapeutics, , Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,3]]},"container-title":["Annals of the American Thoracic Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/annalsats\/advance-article-pdf\/doi\/10.1093\/annalsats\/aaoag188\/68694033\/aaoag188.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/annalsats\/advance-article-pdf\/doi\/10.1093\/annalsats\/aaoag188\/68694033\/aaoag188.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T19:09:15Z","timestamp":1783105755000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/annalsats\/advance-article\/doi\/10.1093\/annalsats\/aaoag188\/8724505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,3]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/annalsats\/aaoag188","relation":{},"ISSN":["2325-6621"],"issn-type":[{"value":"2325-6621","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,3]]},"article-number":"aaoag188"}}