{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:35:53Z","timestamp":1787582153069,"version":"build-2736575974"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Bronchiectasis is a chronic, progressive airway disease with rising global prevalence. However, no population-based epidemiologic study of adult bronchiectasis has been published from Canada, leaving the national burden, outcomes, and costs undefined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the incidence, prevalence, mortality, health care utilization, and direct health care costs of bronchiectasis among adults in Alberta, overall and by airway disease phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a population-based retrospective cohort study (2010\u20132025) using linked Alberta provincial administrative health datasets. Adults (\u226518 years) with bronchiectasis were identified using validated ICD-9\/10 codes (ICD-10-CA J47; ICD-9 494), excluding cystic fibrosis. Patients were stratified by co-existing COPD or asthma. We estimated incidence, prevalence, health-care utilization, mortality, and direct health-care costs overall and by phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 12,169 adults with bronchiectasis (median age 65 years; 56% female). Prevalence increased to 311.6 per 100,000 adults in 2024, more than double that in 2010, while annual incidence remained stable at 25.1 (95% CI 24.4\u201325.7) per 100,000 adults. After age- and sex-standardization to the 2021 Canadian reference population, the standardized average annual incidence was 29.6 and the standardized 2024 prevalence was 433.2 (95% CI 426.3\u2013440.2) per 100,000 adults. Bronchiectasis with comorbid COPD (27%) had the most severe outcomes, including high mortality (55% during follow-up; 17% within one year), the highest hospitalization rate (0.62 per person-year), and the greatest lifetime health-care costs (mean \u223c$88,400 CAD). Bronchiectasis with comorbid asthma (13%) occurred in younger, predominantly female patients and was marked by frequent exacerbations (44%) but lower mortality (16%). Overall, patients experienced 0.42 hospital admissions per person-year and mean 5-year direct health-care costs exceeded $36,000 CAD per patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this first Canadian population-based study of adult bronchiectasis, prevalence more than doubled over 15 years despite stable incidence, indicating a growing chronic respiratory disease burden. Bronchiectasis was associated with substantial mortality, acute care use and direct health-care costs, with especially poor outcomes among those with COPD overlap. These findings provide foundational Canadian data to inform disease recognition with phenotype-specific management and future health-system planning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/annalsats\/aaoag258","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T13:54:21Z","timestamp":1787579661000},"source":"Crossref","is-referenced-by-count":0,"title":["Epidemiology and Outcomes of Bronchiectasis in Alberta, Canada: A 15-Year Population-Based Study"],"prefix":"10.1093","author":[{"given":"Ranjani","family":"Somayaji","sequence":"first","affiliation":[{"name":"University of Calgary Cumming School of Medicine, , 3330 Hospital Dr NW, Calgary, AB T2N 2T8"},{"name":"University of Calgary Department of Community Health Sciences, Cumming School of Medicine, , Calgary, Alberta,","place":["Canada"]},{"name":"University of Calgary Department of Medicine, , Calgary, AB,","place":["Canada"]},{"name":"University of Calgary Department Microbiology, Immunology and Infectious Diseases, , Calgary, AB,","place":["Canada"]},{"name":"Snyder Institute for Chronic Diseases, University of Calgary , Calgary, AB,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason E","family":"Black","sequence":"additional","affiliation":[{"name":"University of Calgary Department of Community Health Sciences, Cumming School of Medicine, , Calgary, Alberta,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara A","family":"Whitten","sequence":"additional","affiliation":[{"name":"Provincial Research Data Services, Health Shared Services , Edmonton, Alberta,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mackenzie W","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"University of Calgary Cumming School of Medicine, , 3330 Hospital Dr NW, Calgary, AB T2N 2T8"},{"name":"University of Calgary Department Microbiology, Immunology and Infectious Diseases, , Calgary, AB,","place":["Canada"]},{"name":"Snyder Institute for Chronic Diseases, University of Calgary , Calgary, AB,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Burke-Gaffney","sequence":"additional","affiliation":[{"name":"University of Calgary Department Microbiology, Immunology and Infectious Diseases, , Calgary, AB,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Cooper","sequence":"additional","affiliation":[{"name":"University of Alberta Department of Medicine, , Edmonton, AB,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Jarand","sequence":"additional","affiliation":[{"name":"University of Calgary Cumming School of Medicine, , 3330 Hospital Dr NW, Calgary, AB T2N 2T8"},{"name":"University of Calgary Department of Medicine, , Calgary, AB,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Leigh","sequence":"additional","affiliation":[{"name":"University of Calgary Cumming School of Medicine, , 3330 Hospital Dr NW, Calgary, AB T2N 2T8"},{"name":"University of Calgary Department of Medicine, , Calgary, AB,","place":["Canada"]},{"name":"Snyder Institute for Chronic Diseases, University of Calgary , Calgary, AB,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maeve","family":"Smith","sequence":"additional","affiliation":[{"name":"University of Alberta Department of Medicine, , Edmonton, AB,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina S","family":"Thornton","sequence":"additional","affiliation":[{"name":"University of Calgary Cumming School of Medicine, , 3330 Hospital Dr NW, Calgary, AB T2N 2T8"},{"name":"University of Calgary Department of Medicine, , Calgary, AB,","place":["Canada"]},{"name":"University of Calgary Department Microbiology, Immunology and Infectious Diseases, , Calgary, AB,","place":["Canada"]},{"name":"Snyder Institute for Chronic Diseases, University of Calgary , Calgary, AB,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,24]]},"container-title":["Annals of the American Thoracic Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/annalsats\/advance-article-pdf\/doi\/10.1093\/annalsats\/aaoag258\/70770685\/aaoag258.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/annalsats\/advance-article-pdf\/doi\/10.1093\/annalsats\/aaoag258\/70770685\/aaoag258.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T13:54:21Z","timestamp":1787579661000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/annalsats\/advance-article\/doi\/10.1093\/annalsats\/aaoag258\/8769494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,24]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/annalsats\/aaoag258","relation":{},"ISSN":["2325-6621"],"issn-type":[{"value":"2325-6621","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,24]]},"article-number":"aaoag258"}}