{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:44:24Z","timestamp":1791996264152,"version":"4.4.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale and Objective<\/jats:title>\n                    <jats:p>We assessed whether an FDA-cleared quantitative CT (qCT) tool (Brainomix, e-Lung) identifies progressive pulmonary fibrosis (PPF) earlier than routine clinical diagnosis and evaluated the prognostic value of baseline and serial imaging biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multicentre retrospective study involving University of Alabama (UAB), Weill Cornell Medicine (WCM) and University of Chicago (UChicago); n\u2009=\u2009509. HRCTs were analysed with e-Lung to derive Weighted Reticulovascular Score (WRVS, %), Total Disease Extent (TDE, %), and e-Lung Volume (mL). Prespecified progression thresholds were an absolute WRVS increase of\u2009\u2265\u20093 percentage points, an absolute TDE increase of\u2009\u2265\u20091.5 percentage points, and a relative e-Lung Volume decline of\u2009\u2265\u200910%, over less than 2 years. We compared the earliest qCT progression date with recorded clinical PPF diagnoses, assessed clinically stable controls, and modelled associations with future PPF and mortality using adjusted time-varying Cox models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 200 patients with PPF and serial HRCTs meeting the prespecified timing criterion, qCT identified progression earlier in 78% (UAB), 83% (WCM), and 47% (UChicago), with mean lead times of 434, 847, and 220 days, respectively. Among 187 clinically stable patients meeting the same serial-imaging criterion, progression thresholds were met in 67%, 56%, and 42%, respectively. High-risk baseline WRVS (\u226515%) predicted future PPF (OR 4.09, 2.48, and 2.30) and mortality (HR 2.03 pooled UAB\/WCM; 2.75 UChicago). Per 1-percentage-point increase, adjusted mortality HRs were 1.15 and 1.19 for WRVS and 1.05 and 1.04 for TDE in pooled UAB\/WCM and UChicago, respectively. Threshold crossings were also associated with mortality (WRVS: HR 6.50 pooled UAB\/WCM, 4.05 UChicago; TDE: 7.60 and 3.26; e-Lung Volume: 8.20 and 2.59).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>qCT detects radiological progression months to years before clinical PPF diagnoses. Integrating e-Lung into ILD pathways could accelerate treatment decisions and personalize follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/annalsats\/aaoag320","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:45:05Z","timestamp":1791992705000},"source":"Crossref","is-referenced-by-count":0,"title":["Quantitative CT in the real-world evaluation of progressive pulmonary fibrosis; the REVISE PPF multicentre observational study"],"prefix":"10.1093","author":[{"given":"Ayodeji","family":"Adegunsoye","sequence":"first","affiliation":[{"name":"University of Chicago Department of Medicine, , Chicago, IL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna J","family":"Podolanczuk","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College Department of Medicine, , New York, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teja","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"The University of Alabama at Birmingham Heersink School of Medicine , Birmingham, Alabama,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Rennison-Jones","sequence":"additional","affiliation":[{"name":"Brainomix , Oxford","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Rothenberg","sequence":"additional","affiliation":[{"name":"The University of Alabama at Birmingham Heersink School of Medicine , Birmingham, Alabama,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Berger","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College Department of Medicine, , New York, NY,","place":["United 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States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iazsmin Bauer","family":"Ventura","sequence":"additional","affiliation":[{"name":"University of Chicago Department of Medicine, , Chicago, IL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E","family":"Strek","sequence":"additional","affiliation":[{"name":"University of Chicago Department of Medicine, , Chicago, IL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finja","family":"Ottink","sequence":"additional","affiliation":[{"name":"Brainomix , Oxford","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wassim","family":"Bou-Zeid","sequence":"additional","affiliation":[{"name":"Brainomix , Oxford","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Joly","sequence":"additional","affiliation":[{"name":"Brainomix , Oxford","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"White","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim Pharmaceuticals, Inc ., Ridgefield, CT,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George WJ","family":"Harston","sequence":"additional","affiliation":[{"name":"Brainomix , Oxford","place":["UK"]},{"name":"Oxford University Hospitals NHS Foundation Trust ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Brainomix , Oxford","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Devaraj","sequence":"additional","affiliation":[{"name":"Brainomix , Oxford","place":["UK"]},{"name":"Royal Brompton Hospital London ,","place":["UK"]},{"name":"National Heart and Lung Institute , ,","place":["UK"]},{"name":"Imperial College London , ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M","family":"George","sequence":"additional","affiliation":[{"name":"Brainomix , Oxford","place":["UK"]},{"name":"Royal Brompton Hospital London ,","place":["UK"]},{"name":"National Heart and Lung Institute , ,","place":["UK"]},{"name":"Imperial College London , ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,14]]},"container-title":["Annals of the American Thoracic 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