{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:31:27Z","timestamp":1789439487873,"version":"build-2803163510"},"reference-count":109,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T00:00:00Z","timestamp":1577145600000},"content-version":"vor","delay-in-days":6931,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[2001]]},"DOI":"10.1093\/annonc\/12.suppl_2.s3","type":"journal-article","created":{"date-parts":[[2012,1,20]],"date-time":"2012-01-20T01:58:19Z","timestamp":1327024699000},"page":"S3-S11","source":"Crossref","is-referenced-by-count":11,"special_numbering":"S2","title":["Deregulation of genetic pathways in neuroendocrine tumors"],"prefix":"10.1016","volume":"12","author":[{"given":"A.","family":"Calender","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Vercherat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Gaudray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.A.","family":"Chayvialle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0010","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000051850","article-title":"Molecular genetics of neuroendocrine tumors","volume":"62","author":"Calender","year":"2000","journal-title":"Digestion"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0015","doi-asserted-by":"crossref","first-page":"6159","DOI":"10.1038\/sj.onc.1203968","article-title":"Lessons learned from BRCA1 and BRCA2","volume":"19","author":"Zheng","year":"2000","journal-title":"Oncogene"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0020","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1001\/archsurg.1991.01410320017001","article-title":"The natural history of multiple endocrine neoplasia type 1: Highly uncommon or highly unrecognized?","volume":"126","author":"Shepherd","year":"1991","journal-title":"Arch Surg"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0025","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1001\/archderm.1997.03890430067009","article-title":"Multiple facial angiofibromas and collagenomas in patients with multiple endocrine neoplasia type 1","volume":"133","author":"Darling","year":"1997","journal-title":"Arch Dermatol"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0030","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/1097-0215(20000815)87:4<463::AID-IJC1>3.0.CO;2-8","article-title":"Malignant melanoma in patients with multiple endocrine neoplasia type 1 and involvement of the MEN1 gene in sporadic melanoma","volume":"87","author":"Nord","year":"2000","journal-title":"Int J Cancer"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0035","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2169\/internalmedicine.35.285","article-title":"Multiple Endocrine Neoplasia type 1 associated with spinal ependymoma","volume":"35","author":"Kato","year":"1996","journal-title":"Jpn Intern Med"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0040","doi-asserted-by":"crossref","unstructured":"Giraud S, Choplin H, Teh BT et al. A large multiple endocrine neoplasia type 1 family with clinical expression suggestive of anticipation. J Clin Endocrinol Metab 82: 3487\u201392.","DOI":"10.1210\/jc.82.10.3487"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0045","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/332085a0","article-title":"Multiple Endocrine Neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma","volume":"332","author":"Larsson","year":"1988","journal-title":"Nature"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0050","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1126\/science.276.5311.404","article-title":"Positional cloning of the gene for Multiple Endocrine Neoplasia type 1","volume":"276","author":"Chandrasekharappa","year":"1997","journal-title":"Science"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0055","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/hmg\/6.7.1177","article-title":"Identification of the Multiple Endocrine Neoplasia type 1 (MEN1) gene","volume":"6","year":"1997","journal-title":"Hum Mol Genet"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0060","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1073\/pnas.95.4.1630","article-title":"Menin, the product of the MEN1 gene, is a nuclear protein","volume":"95","author":"Guru","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0065","first-page":"301","article-title":"Nuclear\/cytoplasmic localization of the multiple endocrine neoplasia type 1 gene product, menin","volume":"79","author":"Huang","year":"1999","journal-title":"Lab Invest"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0070","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/(SICI)1097-0215(20000315)85:6<877::AID-IJC23>3.0.CO;2-F","article-title":"Expression analysis of endogenous menin, the product of the multiple endocrine neoplasia type 1 gene, in cell lines and human tissues","volume":"85","author":"Wautot","year":"2000","journal-title":"Int J Cancer"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0075","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0092-8674(00)80967-8","article-title":"Menin interacts with the API transcription factor JunD and represses JunD-activated transcription","volume":"96","author":"Agarwal","year":"1999","journal-title":"Cell"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0080","doi-asserted-by":"crossref","first-page":"4706","DOI":"10.1038\/sj.onc.1203832","article-title":"Identification and characterization of JunD missense mutants that lack menin binding","volume":"19","author":"Knapp","year":"2000","journal-title":"Oncogene"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0085","first-page":"51","article-title":"Menin represses JunD-activated transcription by a histone deacetylase-dependent mechanism","volume":"1447","author":"Gobi","year":"1999","journal-title":"Biochem Biophys Acta"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0090","doi-asserted-by":"crossref","first-page":"5936","DOI":"10.1038\/sj.onc.1203005","article-title":"Stable overexpression of MEN1 suppresses tumorigeneicity of Ras","volume":"18","author":"Kim","year":"1999","journal-title":"Oncogene"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0095","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1093\/hmg\/6.7.1169","article-title":"Germline mutations of the MEN1 gene in familial MEN1 and related states","volume":"6","author":"Agarwal","year":"1997","journal-title":"Hum Mol Genet"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0100","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/j.1349-7006.1997.tb00325.x","article-title":"Germline mutations of the MEN1 gene in Japanese kindreds with multiple endocrine neoplasia type 1","volume":"88","author":"Shimizu","year":"1997","journal-title":"Jpn J Cancer"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0105","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1086\/301729","article-title":"Characterization of mutations in patients with multiple endocrine neoplasia type 1","volume":"62","author":"Bassett","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0110","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1086\/301953","article-title":"Germ-line mutation analysis in patients with Multiple Endocrine Neoplasia type 1 and related disorders","volume":"63","author":"Giraud","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0115","first-page":"2621","article-title":"Mutation analysis of the MEN1 gene in Multiple Endocrine Neoplasia type 1, familial acromegaly and familial isolated hyperparathyroidism","volume":"83","author":"Teh","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0120","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/(SICI)1098-1004(1999)13:1<54::AID-HUMU6>3.0.CO;2-K","article-title":"Mutation analysis of the MEN1 gene in Belgian patients with Multiple Endocrine Neoplasia type 1 and related diseases","volume":"13","author":"Poncin","year":"1999","journal-title":"Hum Mutat"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0125","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/(SICI)1098-1004(1999)13:3<175::AID-HUMU1>3.0.CO;2-R","article-title":"Germline mutations in the multiple endocrine neoplasia type 1 gene: Evidence for frequent splicing defects","volume":"13","author":"Mutch","year":"1999","journal-title":"Hum Mutat"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0130","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/ng0897-375","article-title":"Somatic mutation of the MEN1 gene in parathyroid tumours","volume":"16","author":"Heppner","year":"1997","journal-title":"Nat Genet"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0135","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0140-6736(05)63453-8","article-title":"Mutations in the MEN1 gene sporadic neuroendocrine tumours of gastroenteropancreatic system","volume":"350","author":"Toliat","year":"1997","journal-title":"Lancet"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0140","first-page":"4682","article-title":"Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas","volume":"57","author":"Zhuang","year":"1997","journal-title":"Cancer Res"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0145","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1093\/hmg\/6.13.2285","article-title":"Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung","volume":"6","author":"Debelenko","year":"1997","journal-title":"Hum Mol Genet"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0150","first-page":"5446","article-title":"Mutations of the MENI tumor suppressor gene in pituitary tumors","volume":"57","author":"Zhuang","year":"1997","journal-title":"Cancer Res"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0155","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1210\/jcem.83.4.4859","article-title":"Molecular characterization of the MEN1 tumor suppressor gene in sporadic pituitary tumors","volume":"83","author":"Prezant","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0160","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/(SICI)1097-0215(19990129)80:3<373::AID-IJC7>3.0.CO;2-B","article-title":"MENI gene mutation analysis of sporadic adrenocortical lesions","volume":"80","author":"Gortz","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0165","first-page":"730","article-title":"Genotyping of adrenorcortical umors: Very frequent deletions of the MEN1 locus in 11q13 and a 1-centimorgan region in 2p16","volume":"84","author":"Kjellmann","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0170","first-page":"3210","article-title":"The MEN1 gene is rarely downregulated in pituitary adenomas","volume":"83","author":"Asa","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0175","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/(SICI)1098-1004(200001)15:1<86::AID-HUMU16>3.0.CO;2-4","article-title":"UMD (Universal Mutation Database): A generic software to build an analyze locus-specific database","volume":"15","author":"Beroud","year":"2000","journal-title":"Hum Mutat"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0180","first-page":"483","article-title":"Germline mutations in the MENI gene: Creation of a new splice site acceptor site and insertion of 7 intron nucleotides into the mRNA","volume":"4","author":"Engelbach","year":"1999","journal-title":"Int J Mol Med"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0185","first-page":"611","article-title":"Internally shortened menin protein as a consequence of alternative RNA splicing due to a germline deletion in the multiple endocrine neoplasia type 1 gene","volume":"5","author":"Roijers","year":"2000","journal-title":"Int J Mol Med"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0190","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1038\/sj.onc.1202164","article-title":"Characterization of the mouse MEN1 gene and its expression during development","volume":"17","author":"Stewart","year":"1998","journal-title":"Oncogene"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0195","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1359\/jbmr.1999.14.1.3","article-title":"Studies of the murine homolog of the multiple endocrine neoplasia type 1 (MEN1) gene, men1","volume":"14","author":"Bassett","year":"1999","journal-title":"J Bone Miner Res"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0200","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S0167-4781(99)00089-5","article-title":"Primary structure, gene expression and chromosomal mapping of rodents homologs of the MEN1 tumor suppressor gene","volume":"1446","author":"Karges","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0205","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0303-7207(99)00150-1","article-title":"Structure and distribution of rat menin mRNA","volume":"156","author":"Maruyama","year":"1999","journal-title":"Mol Cell Endocrinol"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0210","doi-asserted-by":"crossref","first-page":"33718","DOI":"10.1074\/jbc.M003555200","article-title":"Regulation of API (Jun\/Fos) factor expression and activation in ovarian granulosa cells. Relation of JunD and Fra2 to terminal differentiation","volume":"275","author":"Sharma","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0215","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1006\/bbrc.1999.1529","article-title":"Characterization of the MEN1 ortholog in zebrafish","volume":"264","author":"Khodaei","year":"1999","journal-title":"Biochem Biophys Res Coram"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0220","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0303-7207(00)00307-5","article-title":"Complementary DNA structure and genomic organization of drosophila menin","volume":"168","author":"Maruyama","year":"2000","journal-title":"Mol Cell Endocrinol"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0225","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1073\/pnas.87.5.1968","article-title":"Localization of the MEN1 gene to a small region within chromosome 11q13 by deletion mapping in tumors","volume":"87","author":"Bystrom","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0230","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1073\/pnas.68.4.820","article-title":"Mutation and cancer: Statistical study of retinoblastoma","volume":"68","author":"Knudson","year":"1971","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0235","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1073\/pnas.98.3.1118","article-title":"A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors","volume":"98","author":"Crabtree","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0240","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1001\/archsurg.1996.01430230112020","article-title":"Sporadic primary hyperparathyroidism in the setting of multiple endocrine neoplasia type 1","volume":"131","author":"Teh","year":"1996","journal-title":"Arch Surg"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0245","first-page":"486","article-title":"A kindred with a variant of multiple enodocrine neoplasia type 1 demonstrating frequent expression of pituitary tumors but not linked to the multiple endocrine type 1 locus at chromosome region 11q13","volume":"82","author":"Stock","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0250","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1006\/bbrc.2000.3471","article-title":"Heterogeneity at the 5\u2019-end of MEN1 transcripts","volume":"276","author":"Khodaei-O\u2019Brien","year":"2000","journal-title":"Biochem Biophys Res Comm"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1349-7006.1998.tb00470.x","article-title":"A large germline deletion of the MEN1 gene in a family with multipl endocrine neoplasia type 1","volume":"89","author":"Kishi","year":"1998","journal-title":"Jpn J Cancer Res"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0260","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1093\/hmg\/2.7.851","article-title":"Mutations in the RET proto-oncogene are associated with MEN2A and FMTC","volume":"2","author":"Donis-Keller","year":"1993","journal-title":"Hum Mol Genet"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0265","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/363458a0","article-title":"Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A","volume":"363","author":"Mulligan","year":"1993","journal-title":"Nature"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0270","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/bjs.1800730411","article-title":"Familial medullary thyroid carcinoma without associated endocrinopathies: A distinct clinical entity","volume":"73","author":"Farndon","year":"1986","journal-title":"Br J Surg"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0275","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0002-9343(96)00330-0","article-title":"Familial medullary thyroid carcinoma: Not a distinct entity? Genotype\u2013phenotype correlations in a large family","volume":"101","author":"Moers","year":"1996","journal-title":"Am J Med"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0280","first-page":"571","article-title":"Cloning and expression of the RET proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains","volume":"3","author":"Takahashi","year":"1988","journal-title":"Oncogene"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0285","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/mcne.1999.0754","article-title":"GDNF family neurotrophic factors signalling: Four masters, one servant?","volume":"13","author":"Airaksinen","year":"1999","journal-title":"Mol Cell Neurosci"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0290","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1242\/dev.126.12.2785","article-title":"Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system","volume":"126","author":"Taraviras","year":"1999","journal-title":"Development"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0295","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1006\/bbrc.1997.7225","article-title":"Characterization of Ret-Shc-Grb2 complex induced by GDNF, MEN2A and MEN2B mutations","volume":"237","author":"Ohiwa","year":"1997","journal-title":"Biochem Biophys Res Comm"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0300","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1074\/jbc.275.5.3568","article-title":"Transforming ability of MEN2A-RET requires activation of the phosphatidyl-inositol 3-kinase\/AKT signaling pathway","volume":"275","author":"Segouffin-Cariou","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0305","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/367380a0","article-title":"Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret","volume":"367","author":"Schuchardt","year":"1994","journal-title":"Nature"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0310","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/382070a0","article-title":"Renal agenesis and the absence of enteric neurons in mice lacking GDNF","volume":"382","author":"Sanchez","year":"1996","journal-title":"Nature"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0315","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0896-6273(00)80541-3","article-title":"GFR alphal-deficient mice have deficits in the enteric nervous system and kidneys","volume":"21","author":"Enomoto","year":"1998","journal-title":"Neuron"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0320","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/path.1711720305","article-title":"Expression of the ret proto-oncogene product in human normal and neoplastic tissues of neural crest origin","volume":"172","author":"Nakamura","year":"1994","journal-title":"J Pathol"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0325","first-page":"305","article-title":"Developmental expression of the RET protooncogene","volume":"5","author":"Avantaggiato","year":"1994","journal-title":"Cell Growth Differ"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0330","first-page":"3727","article-title":"Tyrosine 1062 of RET-MEN2A mediates activation of Akt (protein kinase B) and mitogen-activated protein kinase pathways leading to PC12 cell survival","volume":"60","author":"De Vita","year":"2000","journal-title":"Cancer Res"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0335","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0168-9525(96)10012-3","article-title":"RET mutations in human disease","volume":"12","author":"Pasini","year":"1996","journal-title":"Trends Genet"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0340","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1001\/jama.1996.03540190047028","article-title":"The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis","volume":"276","author":"Eng","year":"1996","journal-title":"JAMA"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0345","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1073\/pnas.94.7.3330","article-title":"Development of medullary thyroid carcinoma in transgenic mice expressing the RET protooncogene altered by a multiple endocrine neoplasia type 2A mutation","volume":"94","author":"Michiels","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0350","first-page":"5254","article-title":"Tissue-specific carcinogenesis in transgenic mice expressing the RET proto-oncogene with a multiple endocrine neoplasia type 2A mutation","volume":"60","author":"Kawai","year":"2000","journal-title":"Cancer Res"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0355","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1126\/science.7824936","article-title":"Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B","volume":"267","author":"Santoro","year":"1995","journal-title":"Science"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0360","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/sj.onc.1200831","article-title":"Distinct biological properties of two RET isoforms activated by MEN 2A and MEN 2B mutations","volume":"14","author":"Rossel","year":"1997","journal-title":"Oncogene"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0365","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1038\/sj.onc.1202742","article-title":"Biological and biochemical properties of Ret with kinase domains mutations identified in multiple endocrine neoplasia type 2B and familial thyroid carcinoma","volume":"18","author":"IwashitaT","year":"1999","journal-title":"Oncogene"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0370","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/gcc.2870120308","article-title":"Mutation of the RET protooncogene in sporadic medullary thyroid carcinoma","volume":"12","author":"Eng","year":"1995","journal-title":"Genes Chrom Cancer"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0375","first-page":"3740","article-title":"Relevance of RET protooncogene mutations in sporadic medullary thyroid carcinoma","volume":"81","author":"Wohllk","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0380","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/S0022-3468(98)90656-X","article-title":"Prophylactic thyroidectomy for medullary thyroid carcinoma in gene-carriers of MEN2 syndrome","volume":"33","author":"Lallier","year":"1998","journal-title":"J Pediatr Surg"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0385","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1053\/gast.2000.18143","article-title":"Pancreatic involvement in von Hippel Lindau disease","volume":"119","author":"Hammel","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0390","first-page":"452","article-title":"Von Hippel\u2013Lindau disease: Recent genetic progress and patient management","volume":"59","author":"Richard","year":"1998","journal-title":"Ann Endocrinol"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0395","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0025-6196(11)65031-3","article-title":"Von Hippel Lindau disease","volume":"75","author":"Couch","year":"2000","journal-title":"Mayo Clin Proc"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0400","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1126\/science.8493574","article-title":"Identification of the von Hippel\u2013Lindau disease tumor suppressor gene","volume":"260","author":"Latif","year":"1993","journal-title":"Science"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0405","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1126\/science.7660129","article-title":"Elongin (SIII): A multisubunit regulator of elongation by RNA polymerase II","volume":"269","author":"Aso","year":"1995","journal-title":"Science"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0410","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1126\/science.7660130","article-title":"Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C","volume":"269","author":"Kibel","year":"1995","journal-title":"Science"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0415","doi-asserted-by":"crossref","first-page":"5629","DOI":"10.1128\/MCB.17.9.5629","article-title":"The von Hippel-Lindau tumor suppressor gene product interacts with Spl to repress vascular endothelial growth factor promoter activity","volume":"17","author":"Mukhopadhyay","year":"1997","journal-title":"Mol Cell Biol"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0420","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S1097-2765(00)80096-9","article-title":"The von Hippel Lindau suppressor protein is required for proper assembly of an extracellular fibronectin matrix","volume":"1","author":"Ohh","year":"1998","journal-title":"Mol Cell"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0425","doi-asserted-by":"crossref","first-page":"12436","DOI":"10.1073\/pnas.96.22.12436","article-title":"Identification of the von Hippel Lindau tumor suppressor protein as part of an active E3 ubiquitin ligase complex","volume":"96","author":"Iwai","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0430","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1074\/jbc.M008295200","article-title":"Role of exon 2 \u2013 encoded beta domain of the von Hippel Lindau tumor suppressor protein","volume":"276","author":"Bonicalzi","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0435","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1067\/msy.2000.110239","article-title":"Clinical and genetic analysis of patients with pancreatic neuroendocrine tumors associated with von Hippel Lindau disease","volume":"128","author":"Libutti","year":"2000","journal-title":"Surgery"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0440","first-page":"1231","article-title":"Neuroendocrine tumors and von Hippel Lindau disease \u2013 3 cases","volume":"28","author":"Aubert-Petit","year":"1999","journal-title":"Presse Med"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0445","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1046\/j.1365-2265.1997.00149.x","article-title":"Molecular diagnosis of von Hippel Lindau disease in a kindred with a predominance of familial pheochromocytoma","volume":"46","author":"Garcia","year":"1997","journal-title":"Clin Endocrinol"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0450","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/00005792-198507000-00007","article-title":"The complex of myxomas, spotty pigmentation and endocrine overactivity","volume":"64","author":"Carney","year":"1985","journal-title":"Medicine"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0455","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1172\/JCI118467","article-title":"Carney complex, a familial multiple neoplasia and lentiginosis syndrome. Analysis of 11 kindreds and linkage to the short arm of chromosome 2","volume":"97","author":"Stratakis","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0460","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1161\/01.CIR.98.23.2560","article-title":"Identification of a novel genetic locus for familial cardiac myxomas and Carney complex","volume":"98","author":"Casey","year":"1998","journal-title":"Circulation"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0465","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/79238","article-title":"Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex","volume":"26","author":"Kirschner","year":"2000","journal-title":"Nat Genet"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0470","doi-asserted-by":"crossref","first-page":"R31","DOI":"10.1172\/JCI10841","article-title":"Mutations in the protein kinase A Riot regulatory subunit cause familial cardiac myxomas and Carney complex","volume":"106","author":"Casey","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0475","first-page":"139","article-title":"Cyclic AMP, PKA, and the physiological regulation of adiposity","volume":"53","author":"McKnight","year":"1998","journal-title":"Recent Progr Horm Res"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0480","first-page":"202","article-title":"Ampullary carcinoid and neurofibromatosis: Case report and review of the literature","volume":"44","author":"Van Basten","year":"1994","journal-title":"Neth J Med"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0485","first-page":"1543","article-title":"The association between tuberous sclerosis and insulinoma","volume":"16","author":"Kim","year":"1995","journal-title":"Am J Neuroradiol"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0490","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.277.5327.805","article-title":"Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34","volume":"277","author":"van Slegtenhorst","year":"1997","journal-title":"Science"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0495","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1074\/jbc.272.10.6097","article-title":"The tuberous sclerosis 2 gene product, tubenn, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis","volume":"272","author":"Xiao","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0500","first-page":"3425","article-title":"Prognostic markers in patients with typical bronchial carcinoid tumors","volume":"85","author":"Granberg","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0505","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/BF01659123","article-title":"Expression of a potential metastasis suppressor gene nm23 in thyroid neoplasms","volume":"17","author":"Farley","year":"1993","journal-title":"World J Surg"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0510","first-page":"285","article-title":"Natural history, clinicopathologic classification and prognosis of gastric ECL cell tumors","volume":"71","author":"Solcia","year":"1998","journal-title":"Yale J Biol Med"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0515","first-page":"311","article-title":"Deletion of chromosome 1 predicts prognosis in pancreatic endocrine tumors","volume":"59","author":"Ebrahimi","year":"1999","journal-title":"Cancer Res"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0520","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1172\/JCI119547","article-title":"A novel pancreatic endocrine tumor suppressor gene locus on chromosome 3p with clinical prognostic implications","volume":"100","author":"Chung","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0525","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/(SICI)1098-2264(199806)22:2<130::AID-GCC7>3.0.CO;2-Y","article-title":"Deletion mapping of endocrine tumors localizes a second tumor suppressor gene on chromosome band 11q13","volume":"22","author":"Chakrabarti","year":"1998","journal-title":"Genes Chrom Cancer"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0530","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/(SICI)1098-2264(199911)26:3<258::AID-GCC11>3.0.CO;2-2","article-title":"Genetic alterations on 3p, 11q13, and 18q in non familial and MEN1-associated pancreatic endocrine tumors","volume":"26","author":"Hessmann","year":"1999","journal-title":"Genes Chrom Cancer"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0535","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/ijc.2910600514","article-title":"Expression of transforming growth factor alpha and its receptor in human neuroendocrine tumors","volume":"60","author":"Nilsson","year":"1995","journal-title":"Int J Cancer"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0540","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1046\/j.1471-4159.1995.64062622.x","article-title":"Nerve growth factor as a mitogen for a pancreatic carcinoid cell line","volume":"64","author":"Bold","year":"1995","journal-title":"J Neurochem"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0545","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1101\/gr.6.2.124","article-title":"Cloning and characterization of a novel human gene related to vascular endothelial growth factor","volume":"6","author":"Grimmond","year":"1996","journal-title":"Genome Res"},{"key":"10.1093\/annonc\/12.suppl_2.S3_bb0550","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1006\/bbrc.1995.2832","article-title":"Melanoma cell lines express VEGF receptor KDR and respond to exogenously added VEGF","volume":"217","author":"Liu","year":"1995","journal-title":"Biochim Biophys Res Commun"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092375341954491X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092375341954491X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/12\/suppl_2\/S3\/787318\/12-suppl_2-S3.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,26]],"date-time":"2021-12-26T09:28:35Z","timestamp":1640510915000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092375341954491X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":109,"alternative-id":["S092375341954491X"],"URL":"https:\/\/doi.org\/10.1093\/annonc\/12.suppl_2.s3","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[2001]]}}}