{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:59:31Z","timestamp":1790917171118,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2002,7,1]],"date-time":"2002-07-01T00:00:00Z","timestamp":1025481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"vor","delay-in-days":6399,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[2002,7]]},"DOI":"10.1093\/annonc\/mdf175","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T22:39:17Z","timestamp":1027895957000},"page":"1099-1107","source":"Crossref","is-referenced-by-count":232,"title":["Central nervous system involvement following diagnosis ofnon-Hodgkin\u2019s lymphoma: a risk model"],"prefix":"10.1016","volume":"13","author":[{"given":"A.","family":"Hollender","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kvaloy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Nome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Skovlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Lote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Holte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/annonc\/mdf175_bb0010","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/1097-0142(197901)43:1<390::AID-CNCR2820430155>3.0.CO;2-U","article-title":"Involvement of the central nervous system by non-Hodgkin\u2019s lymphoma. The Southwest Oncology Group Experience","volume":"43","author":"Herman","year":"1979","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdf175_bb0015","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/1097-0142(19800201)45:3<545::AID-CNCR2820450322>3.0.CO;2-6","article-title":"CNS involvement in the non-Hodgkin\u2019s lymphomas","volume":"45","author":"Levitt","year":"1980","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdf175_bb0020","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/1097-0142(19820201)49:3<586::AID-CNCR2820490331>3.0.CO;2-C","article-title":"Central nervous system involvement in non-Hodgkin\u2019s lymphoma: an analysis of 105 cases","volume":"49","author":"Mackintosh","year":"1982","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdf175_bb0025","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/0002-9343(88)90262-8","article-title":"Central nervous system metastases from non-Hodgkin\u2019s lymphoma: treatment and prophylaxis","volume":"84","author":"Recht","year":"1988","journal-title":"Am J Med"},{"key":"10.1093\/annonc\/mdf175_bb0030","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/00000421-199112000-00004","article-title":"Central nervous system involvement in patients with diffuse aggressive non-Hodgkin\u2019s lymphoma","volume":"14","author":"Bashir","year":"1991","journal-title":"Am J Clin Oncol"},{"key":"10.1093\/annonc\/mdf175_bb0035","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/S0959-8049(00)00171-4","article-title":"Prognostic factors in 140 adult patients with non-Hodgkin\u2019s lymphoma with systemic central nervous system (CNS) involvement: a single centre analysis","volume":"36","author":"Hollender","year":"2000","journal-title":"Eur J Cancer"},{"key":"10.1093\/annonc\/mdf175_bb0040","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1182\/blood.V91.4.1178","article-title":"Risk factors, treatment, and outcome of central nervous system recurrence in adults with intermediate-grade and immunoblastic lymphoma","volume":"91","author":"van Besien","year":"1998","journal-title":"Blood"},{"key":"10.1093\/annonc\/mdf175_bb0045","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/0002-9343(79)91065-9","article-title":"Central nervous system complications of non-Hodgkin\u2019s lymphoma. The potential role for prophylactic therapy","volume":"66","author":"Young","year":"1979","journal-title":"Am J Med"},{"key":"10.1093\/annonc\/mdf175_bb0050","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0140-6736(84)91235-2","article-title":"Central nervous system relapse in unfavourable-histology non-Hodgkin\u2019s lymphoma: is prophylaxis indicated?","volume":"2","author":"Johnson","year":"1984","journal-title":"Lancet"},{"key":"10.1093\/annonc\/mdf175_bb0055","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/hon.2900080305","article-title":"Secondary central nervous system involvement by non-Hodgkin\u2019s lymphoma: the risk factors","volume":"8","author":"Liang","year":"1990","journal-title":"Hematol Oncol"},{"key":"10.1093\/annonc\/mdf175_bb0060","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-1-4615-3084-8_5","article-title":"Optimal therapy for small noncleaved cell lymphoma","volume":"66","author":"Butler","year":"1993","journal-title":"Cancer Treat Res"},{"key":"10.1093\/annonc\/mdf175_bb0065","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/1097-0142(19860301)57:5<971::AID-CNCR2820570516>3.0.CO;2-X","article-title":"Central nervous system prophylaxis with combined intravenous and intrathecal methotrexate in diffuse lymphoma of aggressive histologic type","volume":"57","author":"Perez-Soler","year":"1986","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdf175_bb0070","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1002\/1097-0142(19840601)53:11<2404::AID-CNCR2820531107>3.0.CO;2-F","article-title":"Treatment of diffuse poorly differentiated lymphocytic lymphoma: an analysis of prognostic variables","volume":"53","author":"Al-Katib","year":"1984","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdf175_bb0075","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1177\/030089168106700108","article-title":"Involvement of the central nervous system in non-Hodgkin\u2019s lymphoma","volume":"67","author":"Cetto","year":"1981","journal-title":"Tumori"},{"key":"10.1093\/annonc\/mdf175_bb0080","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1001\/archneur.1997.00550190044013","article-title":"Central nervous system relapse in non-Hodgkin\u2019s lymphoma","volume":"54","author":"Bollen","year":"1997","journal-title":"Arch Neurol"},{"key":"10.1093\/annonc\/mdf175_bb0085","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3109\/02841869609084002","article-title":"Risk factors for central nervous system involvement in non-Hodgkin\u2019s lymphoma. A multivariate analysis","volume":"35","author":"Keldsen","year":"1996","journal-title":"Acta Oncol"},{"key":"10.1093\/annonc\/mdf175_bb0090","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1182\/blood.V86.6.2091.bloodjournal8662091","article-title":"The value of high-dose systemic chemotherapy and intrathecal therapy for central nervous system prophylaxis in different risk groups of adult acute lymphoblastic leukemia","volume":"86","author":"Cortes","year":"1995","journal-title":"Blood"},{"key":"10.1093\/annonc\/mdf175_bb0095","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1002\/1097-0142(19940615)73:12<3037::AID-CNCR2820731223>3.0.CO;2-6","article-title":"Myelopathy after intrathecal chemotherapy","volume":"73","author":"McLean","year":"1994","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdf175_bb0100","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1182\/blood.V54.6.1249.1249","article-title":"Central nervous system relapse in malignant lymphomas: risk factors and implications for prophylaxis","volume":"54","author":"Litam","year":"1979","journal-title":"Blood"},{"key":"10.1093\/annonc\/mdf175_bb0105","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1023\/A:1008260120532","article-title":"For which patients with aggressive non-Hodgkin\u2019s lymphoma is prophylaxis for central nervous system disease mandatory?","volume":"9","author":"Bos","year":"1998","journal-title":"Ann Oncol"},{"key":"10.1093\/annonc\/mdf175_bb0110","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1600-0609.1985.tb02817.x","article-title":"Meningeal involvement in non-Hodgkin\u2019s lymphoma: symptoms, incidence","volume":"35","author":"Ersboll","year":"1985","journal-title":"risk factors and treatment. Scand J Haematol"},{"key":"10.1093\/annonc\/mdf175_bb0115","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3109\/10428199909058415","article-title":"Isolated central nervous system relapse in aggressive non-Hodgkin\u2019s lymphoma: the Bologna experience","volume":"32","author":"Zinzani","year":"1999","journal-title":"Leuk Lymphoma"},{"key":"10.1093\/annonc\/mdf175_bb0120","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3109\/10428190009087024","article-title":"Predictive factors for central nervous system involvement in non-Hodgkin\u2019s lymphoma: significance of very high serum LDH concentrations","volume":"38","author":"Tomita","year":"2000","journal-title":"Leuk Lymphoma"},{"key":"10.1093\/annonc\/mdf175_bb0125","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0140-6736(88)90367-4","article-title":"Updated Kiel classification for lymphomas","volume":"1","author":"Stansfeld","year":"1988","journal-title":"Lancet"},{"key":"10.1093\/annonc\/mdf175_bb0130","first-page":"1860","article-title":"Report of the Committee on Hodgkin\u2019s Disease Staging Classification","volume":"31","author":"Carbone","year":"1971","journal-title":"Cancer Res"},{"key":"10.1093\/annonc\/mdf175_bb0135","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1023\/A:1008392528248","article-title":"CHOP versus MACOP-B in aggressive lymphoma\u2014a Nordic Lymphoma Group randomised trial","volume":"10","author":"Jerkeman","year":"1999","journal-title":"Ann Oncol"},{"key":"10.1093\/annonc\/mdf175_bb0140","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1093\/annonc\/2.suppl_2.181","article-title":"Autologous bone marrow transplantation for advanced stage adult lymphoblastic lymphoma in first complete remission","volume":"2","author":"Santini","year":"1991","journal-title":"Ann Oncol"},{"key":"10.1093\/annonc\/mdf175_bb0145","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJM199309303291402","article-title":"A predictive model for aggressive non-Hodgkin\u2019s lymphoma","volume":"329","author":"Shipp","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1093\/annonc\/mdf175_bb0150","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Stat Assoc"},{"key":"10.1093\/annonc\/mdf175_bb0155","doi-asserted-by":"crossref","first-page":"579","DOI":"10.2307\/2529177","article-title":"Conservatism of the approximation \u2211(O \u2013 E)2\/E in the log-rank test for survival data or tumor incidence data","volume":"29","author":"Peto","year":"1973","journal-title":"Biometrics"},{"key":"10.1093\/annonc\/mdf175_bb0160","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life tables","volume":"34","author":"Cox","year":"1972","journal-title":"J R Stat Soc"},{"key":"10.1093\/annonc\/mdf175_bb0165","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1182\/blood.V79.9.2432.2432","article-title":"Neural cell adhesion molecule-positive peripheral T-cell lymphoma: a rare variant with a propensity for unusual sites of involvement","volume":"79","author":"Kern","year":"1992","journal-title":"Blood"},{"key":"10.1093\/annonc\/mdf175_bb0170","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/35000501","article-title":"Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling","volume":"403","author":"Alizadeh","year":"2000","journal-title":"Nature"},{"issue":"Suppl","key":"10.1093\/annonc\/mdf175_bb0175","first-page":"S11","article-title":"Late CNS relapse of systemic non-Hodgkin\u2019s lymphoma (NHL) a residual primary disease or a second novel lymphoma Abstracts from the Fourth Congress of the European Association of Neuro-Oncology Copenhagen Denmark June 3-6 2000","volume":"2","author":"Lossos","year":"2000","journal-title":"Neuro-oncol"},{"key":"10.1093\/annonc\/mdf175_bb0180","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1023\/A:1008394827806","article-title":"Incidence and risk factors of central nervous system relapse in histologically aggressive non-Hodgkin\u2019s lymphoma uniformly treated and receiving intrathecal central nervous system prophylaxis: a GELA study on 974 patients","volume":"11","author":"Haioun","year":"2000","journal-title":"Ann Oncol"},{"key":"10.1093\/annonc\/mdf175_bb0185","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1445-5994.1985.tb02724.x","article-title":"Non-Hodgkin\u2019s lymphoma involving the central nervous system","volume":"15","author":"Wolf","year":"1985","journal-title":"Aust NZ J Med"},{"key":"10.1093\/annonc\/mdf175_bb0190","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/(SICI)1097-0142(20000101)88:1<154::AID-CNCR21>3.0.CO;2-T","article-title":"Testicular lymphoma is associated with a high incidence of extranodal recurrence","volume":"88","author":"Fonseca","year":"2000","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdf175_bb0195","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1056\/NEJM199811193392104","article-title":"Volker D. A prognostic score for advanced Hodgkin\u2019s disease","volume":"339","author":"Hasenclever","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1093\/annonc\/mdf175_bb0200","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1023\/A:1008248315859","article-title":"Central nervous system relapse of lymphoid malignancies in adults: the role of high-dose chemotherapy","volume":"8","author":"van Besien","year":"1997","journal-title":"Ann Oncol"},{"key":"10.1093\/annonc\/mdf175_bb0205","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1200\/JCO.1996.14.3.941","article-title":"CNS involvement in mantle-cell lymphoma","volume":"14","author":"Montserrat","year":"1996","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdf175_bb0210","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1200\/JCO.1998.16.12.3803","article-title":"Hyper-CVAD and high-dose methotrexate\/cytarabine followed by stem-cell transplantation: an active regimen for aggressive mantle-cell lymphoma","volume":"16","author":"Khouri","year":"1998","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdf175_bb0215","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1080\/028418600750063631","article-title":"Stage I high-grade non-Hodgkin\u2019s lymphoma","volume":"39","author":"Lote","year":"2000","journal-title":"Acta Oncol"},{"key":"10.1093\/annonc\/mdf175_bb0220","series-title":"and","first-page":"823","article-title":"The Non-Hodgkin\u2019s Lymphomas","volume":"802","author":"Magrath I (ed)","year":"1997"},{"key":"10.1093\/annonc\/mdf175_bb0225","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1182\/blood.V84.2.355.355","article-title":"Prevention and treatment of meningeal leukemia in children","volume":"84","author":"Pinkel","year":"1994","journal-title":"Blood"},{"key":"10.1093\/annonc\/mdf175_bb0230","first-page":"3294","article-title":"Improved treatment results in childhood B-cell neoplasms with tailored intensification of therapy: a report of the Berlin\u2013Frankfurt\u2013Munster Group Trial NHL-BFM 90","volume":"94","author":"Reiter","year":"1999","journal-title":"Blood"},{"key":"10.1093\/annonc\/mdf175_bb0235","unstructured":"H Tilly, E Lepage, B Coiffier et al. A randomized comparison of ACVBP and CHOP in the treatment of advanced aggressive non-Hodgkin\u2019s lymphoma: the LNH93-5 study. In Abstracts of the 42nd Annual Meeting of the American Society of Hematology, December 1\u20135, 2000, The Moscone Center, San Francisco, CA (Abstr 3596)."},{"key":"10.1093\/annonc\/mdf175_bb0240","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/annonc\/8.suppl_1.S71","article-title":"Long-term survival advantage of MACOP-B over CHOP in intermediate-grade non-Hodgkin\u2019s lymphoma","volume":"8","author":"Wolf","year":"1997","journal-title":"Ann Oncol"},{"key":"10.1093\/annonc\/mdf175_bb0245","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1056\/NEJM199304083281404","article-title":"Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin\u2019s lymphoma","volume":"328","author":"Fisher","year":"1993","journal-title":"N Engl J Med"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419638664?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419638664?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/13\/7\/1099\/437403\/mdf175.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T05:55:39Z","timestamp":1733723739000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923753419638664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2002,7]]}},"alternative-id":["S0923753419638664"],"URL":"https:\/\/doi.org\/10.1093\/annonc\/mdf175","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[2002,7]]}}}