{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:48:52Z","timestamp":1770986932537,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"vor","delay-in-days":6215,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[2003,1]]},"DOI":"10.1093\/annonc\/mdg031","type":"journal-article","created":{"date-parts":[[2002,12,17]],"date-time":"2002-12-17T22:16:46Z","timestamp":1040163406000},"page":"42-47","source":"Crossref","is-referenced-by-count":53,"title":["Unlicensed and off label drug use in acute lymphoblastic leukaemia and other malignancies in children"],"prefix":"10.1016","volume":"14","author":[{"given":"S.","family":"Conroy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Newman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Gudka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/annonc\/mdg031_bb0010","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0140-6736(96)91182-4","article-title":"Use of \u2018off label\u2019 and unlicensed drugs in paediatric intensive care unit","volume":"347","author":"Turner","year":"1996","journal-title":"Lancet"},{"key":"10.1093\/annonc\/mdg031_bb0015","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1136\/bmj.316.7128.343","article-title":"Unlicensed and off label drug use in paediatric wards: prospective study","volume":"316","author":"Turner","year":"1998","journal-title":"BMJ"},{"key":"10.1093\/annonc\/mdg031_bb0020","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1136\/adc.83.6.498","article-title":"Unlicensed and off label prescribing of drugs in general practice","volume":"83","author":"McIntyre","year":"2000","journal-title":"Arch Dis Child"},{"key":"10.1093\/annonc\/mdg031_bb0025","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1136\/bmj.320.7227.79","article-title":"Unlicensed and off label drug use in paediatric wards in different European countries","volume":"320","author":"Conroy","year":"2000","journal-title":"BMJ"},{"key":"10.1093\/annonc\/mdg031_bb0030","doi-asserted-by":"crossref","first-page":"F142","DOI":"10.1136\/fn.80.2.F142","article-title":"Unlicensed and off label drug use in neonates","volume":"80","author":"Conroy","year":"1999","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1093\/annonc\/mdg031_bb0035","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1001\/jama.1991.03470210064033","article-title":"Reimbursement policies constrain the practice of oncology","volume":"266","author":"Laetz","year":"1991","journal-title":"JAMA"},{"key":"10.1093\/annonc\/mdg031_bb0040","first-page":"52","article-title":"Unlicensed drug use in children in the UK","volume":"1","author":"Turner","year":"1997","journal-title":"Paediat Perinatal Drug Ther"},{"key":"10.1093\/annonc\/mdg031_bb0045","series-title":"ABPI Compendium of Data Sheets and Summaries of Product Characteristics 1999\u20132000","year":"1999"},{"key":"10.1093\/annonc\/mdg031_bb0050","series-title":"British National Formulary No 39","year":"2000"},{"key":"10.1093\/annonc\/mdg031_bb0055","series-title":"Medicines for Children","year":"1999"},{"key":"10.1093\/annonc\/mdg031_bb0060","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1136\/bmj.313.7067.1219","article-title":"Non-compliance with oral chemotherapy in childhood leukaemia","volume":"313","author":"Lilleyman","year":"1996","journal-title":"BMJ"},{"key":"10.1093\/annonc\/mdg031_bb0065","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1177\/104345429901600205","article-title":"Palatability and cost comparison of five liquid corticosteroid formulations","volume":"16","author":"Hutto","year":"1999","journal-title":"J Pediat Oncol Nurs"},{"key":"10.1093\/annonc\/mdg031_bb0070","series-title":"From compliance to concordance: towards shared goals on medicine taking","year":"1997"},{"key":"10.1093\/annonc\/mdg031_bb0075","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1097\/00043764-199706000-00013","article-title":"Occupational exposure to antineoplastic agents and self-reported infertility among nurses and pharmacists","volume":"39","author":"Valanis","year":"1997","journal-title":"J Occup Environ Med"},{"key":"10.1093\/annonc\/mdg031_bb0080","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1097\/00043764-199908000-00004","article-title":"Occupational exposure to antineoplastic agents: self-reported miscarriages and stillbirths among nurses and pharmacists","volume":"41","author":"Valanis","year":"1999","journal-title":"J Occup Environ Med"},{"key":"10.1093\/annonc\/mdg031_bb0085","first-page":"162","article-title":"Concern over Glaxo Wellcome discontinuations","volume":"265","author":"Ballantine","year":"2000","journal-title":"Pharm J"},{"key":"10.1093\/annonc\/mdg031_bb0090","first-page":"396","volume":"265","author":"Ballantine","year":"2000","journal-title":"Pharm J"},{"key":"10.1093\/annonc\/mdg031_bb0095","series-title":"Ensuring Best Practice in the Notification of Product Discontinuations","year":"2001"},{"key":"10.1093\/annonc\/mdg031_bb0100","series-title":"Alder Hey Book of Children\u2019s Doses","year":"1994"},{"key":"10.1093\/annonc\/mdg031_bb0105","first-page":"613","article-title":"Drug trials in paediatric oncology: a multi-facetted problem","volume":"36","author":"Boos","year":"1998","journal-title":"Int J Clin Pharmacol Ther"},{"key":"10.1093\/annonc\/mdg031_bb0110","series-title":"Note for Guidance on Clinical Investigation of Medicinal Products in Children","year":"1997"},{"key":"10.1093\/annonc\/mdg031_bb0115","year":"2000"},{"key":"10.1093\/annonc\/mdg031_bb0120","series-title":"Pub. L. 105-115 Section 111 of (21 USC 355A)","year":"1997"},{"key":"10.1093\/annonc\/mdg031_bb0125","first-page":"6631","article-title":"Regulations requiring manufacturers to assess the safety and effectiveness of new drugs and biological products in pediatric patients","volume":"63","year":"1998","journal-title":"Federal Drug Register"},{"key":"10.1093\/annonc\/mdg031_bb0130","series-title":"January 2001 Status Report to Congress","year":"2001"},{"key":"10.1093\/annonc\/mdg031_bb0135","first-page":"9","article-title":"The Pediatric Pharmacology Research Unit Network: proof of concept","volume":"3","author":"Kearns","year":"1999","journal-title":"Paediat Perinatal Drug Ther"},{"key":"10.1093\/annonc\/mdg031_bb0140","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1046\/j.1365-2125.1999.00981.x","article-title":"Status of new medicines approved by the European Medicines Evaluation Agency regarding paediatric use","volume":"48","author":"Impicciatore","year":"1999","journal-title":"Br J Clin Pharmacol"},{"key":"10.1093\/annonc\/mdg031_bb0145","author":"European Commission"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419639219?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419639219?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/14\/1\/42\/303163\/mdg031.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T02:10:28Z","timestamp":1582251028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923753419639219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["S0923753419639219"],"URL":"https:\/\/doi.org\/10.1093\/annonc\/mdg031","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[2003,1]]}}}