{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T12:43:11Z","timestamp":1772196191582,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2003,6,1]],"date-time":"2003-06-01T00:00:00Z","timestamp":1054425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"vor","delay-in-days":6044,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[2003,6]]},"DOI":"10.1093\/annonc\/mdg741","type":"journal-article","created":{"date-parts":[[2003,6,23]],"date-time":"2003-06-23T21:22:17Z","timestamp":1056403337000},"page":"iii4-iii10","source":"Crossref","is-referenced-by-count":20,"special_numbering":"S3","title":["Intracranial metastases: therapeutic options"],"prefix":"10.1016","volume":"14","author":[{"given":"M.","family":"Westphal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Heese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"de Wit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/annonc\/mdg741_bb0005","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1470-2045(01)00622-2","article-title":"The seed soil hypothesis: vascularisation and brain metastasis","volume":"3","author":"Fidler","year":"2002","journal-title":"Lancet Oncol"},{"key":"10.1093\/annonc\/mdg741_bb0010","first-page":"477","article-title":"Management of brain metastases","volume":"148","author":"Posner","year":"1992","journal-title":"Rev Neurol"},{"key":"10.1093\/annonc\/mdg741_bb0015","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1001\/archneur.1988.00520310047016","article-title":"Distribution of brain metastases","volume":"45","author":"Delattre","year":"1988","journal-title":"Arch Neurol"},{"key":"10.1093\/annonc\/mdg741_bb0020","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1056\/NEJM199002223220802","article-title":"A randomized trial of surgery in the treatment of single metastasis to the brain","volume":"322","author":"Patchell","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1093\/annonc\/mdg741_bb0025","first-page":"1205","article-title":"An overview of radiotherapy trials for the treatment of brain metastases","volume":"9","author":"Berk","year":"1995","journal-title":"Oncology"},{"key":"10.1093\/annonc\/mdg741_bb0030","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0360-3016(98)00447-7","article-title":"Radiosurgery for brain metastases: is whole brain radiotherapy necessary?","volume":"43","author":"Sneed","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1093\/annonc\/mdg741_bb0035","first-page":"1886","article-title":"Practice parameter: anticonvulsant prophylaxis in patients with newly diagnosed brain tumors","volume":"54","author":"Glantz","year":"2000","journal-title":"Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology"},{"key":"10.1093\/annonc\/mdg741_bb0040","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/BF00165714","article-title":"Brain metastasis from melanoma","volume":"1","author":"Byrne","year":"1983","journal-title":"J Neurooncol"},{"key":"10.1093\/annonc\/mdg741_bb0045","series-title":"Neurologic complications of cancer","author":"Posner","year":"1995"},{"key":"10.1093\/annonc\/mdg741_bb0050","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S1042-3680(18)30371-1","article-title":"Medical management of cerebral metastases","volume":"7","author":"Batchelor","year":"1996","journal-title":"Neurosurg Clin North Am"},{"key":"10.1093\/annonc\/mdg741_bb0055","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1212\/WNL.44.4.675","article-title":"Dose\u2013effect relationship of dexamethasone on Karnofsky performance in metastatic brain tumors: a randomized study of doses of 4, 8 and 16 milligrams per day","volume":"44","author":"Vecht","year":"1994","journal-title":"Neurology"},{"key":"10.1093\/annonc\/mdg741_bb0060","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1056\/NEJM196907032810108","article-title":"Interference in the effect of dexamethasone by diphenylhydantoin","volume":"281","author":"Werk","year":"1969","journal-title":"N Engl J Med"},{"key":"10.1093\/annonc\/mdg741_bb0065","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S1042-3680(18)30378-4","article-title":"Chemotherapy of cerebral metastases from solid tumors","volume":"7","author":"Lesser","year":"1996","journal-title":"Neurosurg Clin North Am"},{"key":"10.1093\/annonc\/mdg741_bb0070","first-page":"3400","article-title":"Treatment of brain metastases of small-cell lung cancer: comparing teniposide and teniposide with whole-brain irradiation therapy","volume":"18","author":"Postmus","year":"2000","journal-title":"A phase III study of the European Organization for the Research and Treatment of Cancer Lung Cancer Cooperative Group. J Clin Oncol"},{"key":"10.1093\/annonc\/mdg741_bb0075","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1002\/(SICI)1097-0142(19990401)85:7<1599::AID-CNCR23>3.0.CO;2-#","article-title":"Front-line chemotherapy with cisplatin and etoposide for patients with brain metastases from breast carcinoma, non-small cell lung cancer or malignant melanoma: a prospective study","volume":"85","author":"Franciosi","year":"1999","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdg741_bb0080","first-page":"75b","article-title":"Concomitant temozolamide (TMZ) and radiotherapy (RT) followed by adjuvant treatment with temozolamide in patients with brain metastases from solid tumors","volume":"20","author":"Dardoufas","year":"2001","journal-title":"Proc Am Soc Clin Oncol"},{"key":"10.1093\/annonc\/mdg741_bb0085","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1200\/JCO.2002.04.140","article-title":"Temozolamide enhances radiation treatment efficacy in brain metastases: a randomized phase II study","volume":"20","author":"Antonadou","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdg741_bb0090","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/1097-0142(19860815)58:4<832::AID-CNCR2820580404>3.0.CO;2-W","article-title":"Chemotherapy induces regression of brain metastases in breast carcinoma","volume":"58","author":"Rosner","year":"1986","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdg741_bb0095","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1002\/1097-0142(19920215)69:4<972::AID-CNCR2820690423>3.0.CO;2-P","article-title":"Response of brain metastases from breast cancer to systemic chemotherapy","volume":"69","author":"Boogerd","year":"1992","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdg741_bb0100","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1200\/JCO.1997.15.3.1063","article-title":"TPDC-FuHu chemotherapy for the treatment of recurrent metastatic brain tumors","volume":"15","author":"Kaba","year":"1997","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdg741_bb0105","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00432-001-0303-4","article-title":"Regression of brain metastases from breast carcinoma after chemotherapy with bendamustine","volume":"128","author":"Zulkowski","year":"2002","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1093\/annonc\/mdg741_bb0110","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1002\/(SICI)1097-0142(19990215)85:4<988::AID-CNCR29>3.0.CO;2-R","article-title":"Treatment outcome in patients with brain metastases from malignant germ cell tumors","volume":"85","author":"Fossa","year":"1999","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdg741_bb0115","first-page":"3057","article-title":"Intrathecal chemotherapy in carcinomatous meningitis from breast cancer","volume":"22","author":"Orlando","year":"2002","journal-title":"Anticancer Res"},{"key":"10.1093\/annonc\/mdg741_bb0120","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00432-002-0354-1","article-title":"Long-term survival in patients with brain metastases","volume":"128","author":"Lutterbach","year":"2002","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1093\/annonc\/mdg741_bb0125","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3171\/jns.2000.93.1.0009","article-title":"Surgical treatment of brain metastases from melanoma: a retrospective study of 91 patients","volume":"93","author":"Wronski","year":"2000","journal-title":"J Neurosurg"},{"key":"10.1093\/annonc\/mdg741_bb0130","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0360-3016(02)02770-0","article-title":"A multi-institutional review of radio-surgery alone vs. radiosurgery vs. radiosurgery with whole brain radiotherapy as the initial management of brain metastasis","volume":"53","author":"Sneed","year":"2002","journal-title":"Int J Radiat Oncol"},{"key":"10.1093\/annonc\/mdg741_bb0135","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0360-3016(01)02645-1","article-title":"Risk of symptomatic brain tumor recurrence and neurologich deficit after radiosurgery alone in patients with newly diagnosed brain metastasis: results and implications","volume":"52","author":"Regine","year":"2002","journal-title":"Int J Radiat Oncol"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092375341947717X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092375341947717X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/14\/suppl_3\/iii4\/398857\/mdg741.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T15:53:39Z","timestamp":1589471619000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092375341947717X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6]]},"references-count":27,"alternative-id":["S092375341947717X"],"URL":"https:\/\/doi.org\/10.1093\/annonc\/mdg741","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[2003,6]]}}}