{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:57:59Z","timestamp":1790855879939,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"vor","delay-in-days":5637,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[2004,8]]},"DOI":"10.1093\/annonc\/mdh308","type":"journal-article","created":{"date-parts":[[2004,7,26]],"date-time":"2004-07-26T18:40:48Z","timestamp":1090867248000},"page":"1179-1186","source":"Crossref","is-referenced-by-count":313,"title":["Patterns of failure, prognostic factors and survival in locoregionally advanced head and neck cancer treated with concomitant chemoradiotherapy: a 9-year, 337-patient, multi-institutional experience"],"prefix":"10.1016","volume":"15","author":[{"given":"B.","family":"Brockstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.J.","family":"Haraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.W.","family":"Rademaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.S.","family":"Kies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.M.","family":"Stenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.B.","family":"Mittal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Pelzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.B.","family":"Fung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.-E.","family":"Witt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Wenig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Portugal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.W.","family":"Weichselbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.E.","family":"Vokes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/annonc\/mdh308_bb0010","author":"American Cancer Society"},{"key":"10.1093\/annonc\/mdh308_bb0015","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJM199106133242402","article-title":"Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer","volume":"324","author":"The Department of Veterans Affairs Cancer Study Group","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1093\/annonc\/mdh308_bb0020","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1093\/jnci\/88.13.890","article-title":"Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase II trial","volume":"88","author":"Lefebvre","year":"1996","journal-title":"J Natl Cancer Inst"},{"key":"10.1093\/annonc\/mdh308_bb0025","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1056\/NEJMoa031317","article-title":"Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer","volume":"349","author":"Forastiere","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1093\/annonc\/mdh308_bb0030","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1056\/NEJMra001375","article-title":"Head and neck cancer","volume":"345","author":"Forastiere","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1093\/annonc\/mdh308_bb0035","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0140-6736(00)90011-4","article-title":"Chemotherapy added to locoregional treatment for head and neck squamous cell carcinoma: three meta-analyses of updated individual patient data","volume":"355","author":"Pignon","year":"2000","journal-title":"Lancet"},{"key":"10.1093\/annonc\/mdh308_bb0040","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S0002-9610(97)81724-2","article-title":"Recurrence patterns with concurrent platinum based chemotherapy and accelerated hyperfractionated radiotherapy in stage III and IV head and neck cancer","volume":"174","author":"Koness","year":"1997","journal-title":"Am J Surg"},{"key":"10.1093\/annonc\/mdh308_bb0045","first-page":"891","article-title":"Preliminary results of RTOG 9703\u2014a phase II randomized trial of concurrent radiation (RT) and chemotherapy for advanced squamous cell carcinoma of the head and neck","volume":"20","author":"Garden","year":"2001","journal-title":"Proc Am Soc Clin Oncol"},{"key":"10.1093\/annonc\/mdh308_bb0050","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0360-3016(97)00092-8","article-title":"Efficacy of targeted supradose cisplatin and concomitant radiation therapy for advanced head and neck cancer: the Memphis Experience","volume":"38","author":"Robbins","year":"1997","journal-title":"Int J Radiation Oncol Biol Phys"},{"key":"10.1093\/annonc\/mdh308_bb0055","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1200\/JCO.2000.18.8.1652","article-title":"Concomitant chemoradiotherapy as primary therapy for locoregionally advanced head and neck cancer","volume":"18","author":"Vokes","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdh308_bb0060","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1200\/JCO.2001.19.7.1961","article-title":"Concomitant infusional paclitaxel and fluorouracil, oral hydroxyurea, and hyperfractionated radiation for locally advanced squamous head and neck cancer","volume":"19","author":"Kies","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdh308_bb0065","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1200\/JCO.20.5.1405","article-title":"Maximizing local control and organ preservation in stage IV squamous cell head and neck cancer with hyperfractionated radiation and concurrent chemotherapy","volume":"20","author":"Adelstein","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdh308_bb0070","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1200\/JCO.1989.7.6.761","article-title":"Hydroxyurea, fluorouracil, and concomitant radiotherapy in poor-prognosis head and neck cancer","volume":"7","author":"Vokes","year":"1989","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdh308_bb0075","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1200\/JCO.1984.2.5.406","article-title":"Phase I and II trial of five-day infused 5-fluorouracil and radiation in advanced cancer of the head and neck","volume":"2","author":"Byfield","year":"1984","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdh308_bb0080","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1200\/JCO.1989.7.7.846","article-title":"Combined simultaneous cisplatin\/fluorouracil chemotherapy and split course radiation in head and neck cancer","volume":"7","author":"Taylor","year":"1989","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdh308_bb0085","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1200\/JCO.1995.13.4.876","article-title":"Induction chemotherapy followed by concomitant chemoradiotherapy for advanced head and neck cancer: impact on the natural history of the disease","volume":"13","author":"Vokes","year":"1995","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdh308_bb0090","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1200\/JCO.1998.16.8.2715","article-title":"Induction chemotherapy followed by concurrent chemoradiation for advanced head and neck cancer: improved disease control and survival","volume":"16","author":"Kies","year":"1998","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdh308_bb0095","first-page":"1689","article-title":"Multicenter randomized phase II study of paclitaxel (1-hour infusion), fluorouracil, hydroxyurea and concomitant twice daily radiation with or without erythropoietin for advanced head and neck cancer","volume":"9","author":"Rosen","year":"2003","journal-title":"Clin Cancer Res"},{"key":"10.1093\/annonc\/mdh308_bb0100","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0360-3016(97)00366-0","article-title":"Concurrent platinum based chemotherapy and hyperfractionated radiotherapy with late intensification in advanced head and neck cancer","volume":"39","author":"Glicksman","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1093\/annonc\/mdh308_bb0105","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1200\/JCO.1994.12.9.1876","article-title":"Rapidly alternating chemotherapy and hyperfractionated radiotherapy in the management of locally advanced head and neck carcinoma; four year results of a phase I\/II study","volume":"12","author":"Leyvraz","year":"1994","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdh308_bb0110","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1002\/(SICI)1097-0142(20000215)88:4<876::AID-CNCR19>3.0.CO;2-Y","article-title":"Mature results of a phase III randomized trial comparing concurrent chemoradiotherapy with radiation therapy alone in patients with stage III and IV squamous cell carcinoma of the head and neck","volume":"88","author":"Adelstein","year":"2000","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdh308_bb0115","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1200\/JCO.1997.15.9.3100","article-title":"Induction chemotherapy with cisplatin, fluorouracil, and high-dose leucovorin for squamous cell carcinoma of the head and neck: long-term results","volume":"15","author":"Clark","year":"1997","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdh308_bb0120","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1002\/cncr.2820690526","article-title":"Prognostic factors for survival and tumor control in cervical lymph node metastases from head and neck cancer. A multivariate study of 492 cases","volume":"69","author":"Cerezo","year":"1992","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdh308_bb0125","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/S0002-9610(05)80109-6","article-title":"Lymph node prognostic factors in head and neck squamous cell carcinomas","volume":"68","author":"Mamelle","year":"1994","journal-title":"Am J Surg"},{"key":"10.1093\/annonc\/mdh308_bb0130","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1200\/JCO.2001.19.21.4107","article-title":"Does histologic grade have a role in the management of head and neck cancers?","volume":"19","author":"Fortin","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdh308_bb0135","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1200\/JCO.1994.12.2.385","article-title":"Randomized comparison of neoadjuvant cisplatin and fluorouracil infusion followed by radiation versus concomitant treatment in advanced head and neck cancer","volume":"12","author":"Taylor","year":"1994","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdh308_bb0140","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/1097-0142(19930115)71:2<452::AID-CNCR2820710228>3.0.CO;2-B","article-title":"Regional lymph node involvement and its significance in the development of distant metastases in head and neck carcinoma","volume":"71","author":"Leemans","year":"1993","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdh308_bb0145","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/hed.2890060305","article-title":"Failure at distant sites following multimodality treatment for advanced head and neck cancer","volume":"6","author":"Vikram","year":"1984","journal-title":"Head Neck Surg"},{"key":"10.1093\/annonc\/mdh308_bb0150","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/0360-3016(92)90642-U","article-title":"Adjuvant chemotherapy for resectable squamous cell carcinomas of the head and neck: report on Intergroup study 0034","volume":"23","author":"Laramore","year":"1992","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1093\/annonc\/mdh308_bb0155","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/jnci\/86.4.265","article-title":"Phase III trial of initial chemotherapy in stage III or IV head and neck cancers: a study by the Gruppo di Studio Sui Tumori della Testa e del Collo","volume":"86","author":"Paccagnella","year":"1994","journal-title":"J Natl Cancer Inst"},{"key":"10.1093\/annonc\/mdh308_bb0160","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/1097-0142(19870801)60:3<301::AID-CNCR2820600306>3.0.CO;2-V","article-title":"Adjuvant chemotherapy for advanced head and neck squamous carcinoma. Final report of the head and neck contracts program","volume":"60","author":"Head and Neck Contracts Program","year":"1987","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdh308_bb0165","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1288\/00005537-198811000-00011","article-title":"Preoperative chemotherapy in advanced resectable head and neck cancer: final report of the Southwest Oncology Group","volume":"98","author":"Schuller","year":"1988","journal-title":"Laryngoscope"},{"key":"10.1093\/annonc\/mdh308_bb0170","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1054\/bjoc.2000.1512","article-title":"Randomized trial of neoadjuvant chemotherapy in oropharyngeal carcinoma","volume":"83","author":"Domenge","year":"2000","journal-title":"Br J Cancer"},{"key":"10.1093\/annonc\/mdh308_bb0175","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1200\/JCO.2003.06.006","article-title":"Weekly carboplatin and paclitaxel followed by concomitant paclitaxel, fluorouracil, and hydroxyurea chemoradiotherapy: curative and organ-preserving therapy for advanced head and neck cancer","volume":"21","author":"Vokes","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdh308_bb0180","first-page":"5936","article-title":"Induction chemotherapy followed by concomitant TFHX chemoradiotherapy with reduced dose radiation in advanced head and neck cancer","volume":"9","author":"Haraf","year":"2003","journal-title":"Clin Cancer Res"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753420310449?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753420310449?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/15\/8\/1179\/335213\/mdh308.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T22:31:17Z","timestamp":1582237877000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923753420310449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2004,8]]}},"alternative-id":["S0923753420310449"],"URL":"https:\/\/doi.org\/10.1093\/annonc\/mdh308","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[2004,8]]}}}