{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:59:09Z","timestamp":1790283549555,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T00:00:00Z","timestamp":1577145600000},"content-version":"vor","delay-in-days":5531,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[2004,11]]},"DOI":"10.1093\/annonc\/mdh434","type":"journal-article","created":{"date-parts":[[2004,11,2]],"date-time":"2004-11-02T15:30:00Z","timestamp":1099409400000},"page":"1633-1639","source":"Crossref","is-referenced-by-count":61,"title":["Minimal and small size invasive breast cancer with no axillary lymph node involvement: the need for tailored adjuvant therapies"],"prefix":"10.1016","volume":"15","author":[{"given":"M.","family":"Colleoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Rotmensz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Peruzzotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Maisonneuve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Viale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Renne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Casadio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Veronesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Intra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Torrisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Goldhirsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/annonc\/mdh434_bb0010","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1200\/JCO.1992.10.5.696","article-title":"Factors predicting treatment responsiveness and prognosis in node-negative breast cancer","volume":"10","author":"Neville","year":"1992","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdh434_bb0015","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1200\/JCO.1995.13.3.697","article-title":"Biologic and clinicopathologic factors as indicators of specific relapse types in node-negative breast cancer","volume":"13","author":"Silvestrini","year":"1995","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdh434_bb0020","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/S0140-6736(97)11423-4","article-title":"Tamoxifen for early breast cancer: an overview of the randomised trials","volume":"351","author":"Early Breast Cancer Trialists' Collaborative Groups","year":"1998","journal-title":"Lancet"},{"key":"10.1093\/annonc\/mdh434_bb0025","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/S0140-6736(98)03301-7","article-title":"Polychemotherapy for early breast cancer: an overview of the randomised trials","volume":"352","author":"Early Breast Cancer Trialists' Collaborative Group","year":"1998","journal-title":"Lancet"},{"key":"10.1093\/annonc\/mdh434_bb0030","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/S0140-6736(96)05023-4","article-title":"Ovarian ablation in early breast cancer: overview of the randomised trials","volume":"348","author":"Early Breast Cancer Trialists' Collaborative Group","year":"1996","journal-title":"Lancet"},{"key":"10.1093\/annonc\/mdh434_bb0035","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1200\/JCO.2003.04.576","article-title":"Meeting highlights: updated international expert consensus on the primary therapy of early breast cancer","volume":"21","author":"Goldhirsch","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdh434_bb0040","first-page":"171","article-title":"Joint Committee on Cancer. Cancer Staging Manual","author":"American","year":"1997"},{"key":"10.1093\/annonc\/mdh434_bb0045","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1002\/(SICI)1097-0142(19980615)82:12<2382::AID-CNCR12>3.0.CO;2-L","article-title":"Mammary ductal carcinoma in situ with microinvasion","volume":"82","author":"Susan","year":"1998","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdh434_bb0050","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/00000478-200301000-00009","article-title":"Immunohistochemical distinction of invasive from noninvasive breast lesions: a comparative study of p63 versus calponin and smooth muscle myosin heavy chain","volume":"27","author":"Werling","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"10.1093\/annonc\/mdh434_bb0055","series-title":"Armed Forces Institute of Pathology","article-title":"Tumors of the Mammary Gland","author":"Rosen","year":"1993"},{"key":"10.1093\/annonc\/mdh434_bb0060","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1046\/j.1365-2559.2002.14691.x","article-title":"Pathological prognostic factors in breast cancer, I: the value of histological grade in breast cancer: experience from a large study with long-term follow-up","volume":"41","author":"Elston","year":"2002","journal-title":"Histopathology"},{"key":"10.1093\/annonc\/mdh434_bb0065","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/S0959-8049(99)00005-2","article-title":"Prediction of response to primary chemotherapy for operable breast cancer","volume":"35","author":"Colleoni","year":"1999","journal-title":"Eur J Cancer"},{"key":"10.1093\/annonc\/mdh434_bb0070","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1056\/NEJMoa012782","article-title":"A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer","volume":"349","author":"Veronesi","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1093\/annonc\/mdh434_bb0075","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1093\/jnci\/87.19.1441","article-title":"Meeting highlights: International Consensus Panel on the Treatment of Primary Breast Cancer","volume":"87","author":"Goldhirsch","year":"1995","journal-title":"J Natl Cancer Inst"},{"key":"10.1093\/annonc\/mdh434_bb0080","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1093\/jnci\/90.21.1601","article-title":"Meeting highlights: International Consensus Panel on the Treatment of Primary Breast Cancer","volume":"90","author":"Goldhirsch","year":"1998","journal-title":"J Natl Cancer Inst"},{"key":"10.1093\/annonc\/mdh434_bb0085","first-page":"3817","article-title":"Meeting highlights: International Consensus Panel on the Treatment of Primary Breast Cancer","volume":"19","author":"Goldhirsch","year":"2001","journal-title":"Seventh International Conference on Adjuvant Therapy of Primary Breast Cancer. J Clin Oncol"},{"key":"10.1093\/annonc\/mdh434_bb0090","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s10434-999-0591-5","article-title":"Six-year follow-up of patients with microinvasive, T1a, and T1b breast carcinoma","volume":"6","author":"Mann","year":"1999","journal-title":"Ann Surg Oncol"},{"key":"10.1093\/annonc\/mdh434_bb0095","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1200\/JCO.1995.13.5.1144","article-title":"Natural history of node-negative breast cancer: a study of 826 patients with long-term follow-up","volume":"13","author":"Quiet","year":"1995","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdh434_bb0100","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF00662138","article-title":"Predicting recurrence in axillary-node negative breast cancer patients","volume":"25","author":"Rosner","year":"1993","journal-title":"Breast Cancer Res Treat"},{"key":"10.1093\/annonc\/mdh434_bb0105","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1054\/brst.2002.0462","article-title":"Natural history of node-negative breast cancer: are conventional prognostic factors predictors of time to relapse?","volume":"11","author":"Hery","year":"2002","journal-title":"Breast"},{"key":"10.1093\/annonc\/mdh434_bb0110","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0022-4731(89)90075-7","article-title":"Prognostic factors for recurrence and survival in axillary node-negative breast cancer","volume":"34","author":"McGuire","year":"1989","journal-title":"J Steroid Biochem"},{"key":"10.1093\/annonc\/mdh434_bb0115","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1200\/JCO.1999.17.5.1474","article-title":"Estrogen receptor status by immunohistochemistry is superior to the ligand-binding assay for predicting response to adjuvant endocrine therapy in breast cancer","volume":"17","author":"Harvey","year":"1999","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdh434_bb0120","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1002\/(SICI)1097-0142(19970215)79:4<761::AID-CNCR13>3.0.CO;2-Y","article-title":"Lymph node negative invasive breast carcinoma1 centimeter or less in size (T1a,bN0M0)","volume":"79","author":"Lee","year":"1997","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdh434_bb0125","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1002\/1097-0142(19910315)67:6<1498::AID-CNCR2820670606>3.0.CO;2-I","article-title":"Ductal carcinoma in situ with microinvasion: a curable entity using surgery alone without need for adjuvant therapy","volume":"67","author":"Rosner","year":"1991","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdh434_bb0130","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1002\/1097-0142(19810615)47:12<2769::AID-CNCR2820471202>3.0.CO;2-7","article-title":"Management and survival of female patients with \u201cminimal\u201d breast cancer: as observed in the long-term and short-term surveys of the American College of Surgeons","volume":"47","author":"Bedwani","year":"1981","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdh434_bb0135","first-page":"384","article-title":"Minimal breast cancer: a clinically meaningful term?","volume":"13","author":"Jotti","year":"1986","journal-title":"Semin Oncol"},{"key":"10.1093\/annonc\/mdh434_bb0140","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0002-9610(80)90293-7","article-title":"Minimal breast carcinoma","volume":"139","author":"Nevin","year":"1980","journal-title":"Am J Surg"},{"key":"10.1093\/annonc\/mdh434_bb0145","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1001\/archsurg.1990.01410220082011","article-title":"The impact of microinvasion on axillary node metastases and survival in patients with intraductal breast cancer","volume":"125","author":"Wong","year":"1990","journal-title":"Arch Surg"},{"key":"10.1093\/annonc\/mdh434_bb0150","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/0360-3016(92)90900-3","article-title":"Microinvasive ductal carcinoma of the breast treated with breast-conserving surgery and definitive irradiation","volume":"23","author":"Solin","year":"1992","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1093\/annonc\/mdh434_bb0155","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/bjs.4051","article-title":"Value of the Van Nuys Prognostic Index in prediction of recurrence of ductal carcinoma in situ after breast-conserving surgery","volume":"90","author":"Boland","year":"2003","journal-title":"Br J Surg"},{"key":"10.1093\/annonc\/mdh434_bb0160","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/S0360-3016(02)03747-1","article-title":"Correlation of clinical and pathologic features with outcome in patients with ductal carcinoma in situ of the breast treated with breast-conserving surgery and radiotherapy","volume":"54","author":"Rodrigues","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1093\/annonc\/mdh434_bb0165","doi-asserted-by":"crossref","first-page":"4141","DOI":"10.1200\/JCO.2002.11.101","article-title":"National Surgical Adjuvant Breast and Bowel Project. Tamoxifen, radiation therapy, or both for prevention of ipsilateral breast tumor recurrence after lumpectomy in women with invasive breast cancers of one centimeter or less","volume":"20","author":"Fisher","year":"2002","journal-title":"J Clin Oncol"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419475285?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419475285?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/15\/11\/1633\/536937\/mdh434.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T11:51:37Z","timestamp":1582199497000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923753419475285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["S0923753419475285"],"URL":"https:\/\/doi.org\/10.1093\/annonc\/mdh434","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[2004,11]]}}}