{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:48:36Z","timestamp":1792802916931,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T00:00:00Z","timestamp":1575504000000},"content-version":"vor","delay-in-days":4721,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1093\/annonc\/mdl327","type":"journal-article","created":{"date-parts":[[2006,10,4]],"date-time":"2006-10-04T02:44:58Z","timestamp":1159929898000},"page":"149-157","source":"Crossref","is-referenced-by-count":245,"title":["Incidence and risk factors of central nervous system recurrence in aggressive lymphoma\u2014a survey of 1693 patients treated in protocols of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL)"],"prefix":"10.1016","volume":"18","author":[{"given":"V.","family":"Boehme","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Zeynalova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kloess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Loeffler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Pfreundschuh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/annonc\/mdl327_bb0010","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/1097-0142(19800201)45:3<545::AID-CNCR2820450322>3.0.CO;2-6","article-title":"CNS involvement in the non-Hodgkin's lymphomas","volume":"45","author":"Levitt","year":"1980","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdl327_bb0015","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/0002-9343(88)90262-8","article-title":"Central nervous system metastases from non-Hodgkin's lymphoma: treatment and prophylaxis","volume":"84","author":"Recht","year":"1988","journal-title":"Am J Med"},{"key":"10.1093\/annonc\/mdl327_bb0020","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/1097-0142(19820201)49:3<586::AID-CNCR2820490331>3.0.CO;2-C","article-title":"Central nervous system involvement in non-Hodgkin's lymphoma: an analysis of 105 cases","volume":"49","author":"MacKintosh","year":"1982","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdl327_bb0025","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1182\/blood.V91.4.1178","article-title":"Risk factors, treatment, and outcome of central nervous system recurrence in adults with intermediate-grade and immunoblastic lymphoma","volume":"91","author":"van Besien","year":"1998","journal-title":"Blood"},{"key":"10.1093\/annonc\/mdl327_bb0030","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1023\/A:1008394827806","article-title":"Incidence and risk factors of central nervous system relapse in histologically aggressive non-Hodgkin's lymphoma uniformly treated and receiving intrathecal central nervous system prophylaxis: a GELA study on 974 patients","volume":"11","author":"Haioun","year":"2000","journal-title":"Ann Oncol"},{"key":"10.1093\/annonc\/mdl327_bb0035","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1023\/A:1008260120532","article-title":"For which patients with aggressive non-Hodgkin's lymphoma is prophylaxis for central nervous system disease mandatory?","volume":"9","author":"Bos","year":"1998","journal-title":"Ann Oncol"},{"key":"10.1093\/annonc\/mdl327_bb0040","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1093\/annonc\/mdf175","article-title":"Central nervous system involvement following diagnosis of non-Hodgkin's lymphoma: a risk model","volume":"13","author":"Hollender","year":"2002","journal-title":"Ann Oncol"},{"key":"10.1093\/annonc\/mdl327_bb0045","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1182\/blood.V84.5.1361.1361","article-title":"A revised European\u2013American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group","volume":"84","author":"Harris","year":"1994","journal-title":"Blood"},{"key":"10.1093\/annonc\/mdl327_bb0050","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1200\/JCO.1999.17.12.3835","article-title":"World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting\u2014Airlie House, Virginia, November 1997","volume":"17","author":"Harris","year":"1999","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdl327_bb0055","doi-asserted-by":"crossref","first-page":"4413","DOI":"10.1200\/JCO.2002.07.075","article-title":"Randomized study to evaluate the use of high-dose therapy as part of primary treatment for \u2018aggressive\u2019 lymphoma","volume":"20","author":"Kaiser","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdl327_bb0060","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1182\/blood-2003-06-2094","article-title":"Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of young patients with good-prognosis (normal LDH) aggressive lymphomas: results of the NHL-B1 trial of the DSHNHL","volume":"104","author":"Pfreundschuh","year":"2004","journal-title":"Blood"},{"key":"10.1093\/annonc\/mdl327_bb0065","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1182\/blood-2003-06-2095","article-title":"Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of elderly patients with aggressive lymphomas: results of the NHL-B2 trial of the DSHNHL","volume":"104","author":"Pfreundschuh","year":"2004","journal-title":"Blood"},{"key":"10.1093\/annonc\/mdl327_bb0070","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/oxfordjournals.annonc.a058690","article-title":"Randomised comparison of CHOEP versus alternating hCHOP\/IVEP for high-grade non-Hodgkin's lymphomas: treatment results and prognostic factor analysis in a multi-centre trial","volume":"5","author":"Koppler","year":"1994","journal-title":"Ann Oncol"},{"key":"10.1093\/annonc\/mdl327_bb0075","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1002\/1097-0142(197610)38:4<1484::AID-CNCR2820380407>3.0.CO;2-I","article-title":"Hydroxyldaunomycin (adriamycin) combination chemotherapy in malignant lymphoma","volume":"38","author":"McKelvey","year":"1976","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdl327_bb0080","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1056\/NEJM199304083281404","article-title":"Comparison of a standard regimen (CHOP) with tree intensive chemotherapy regimens for advanced non-Hodgkin's lymphoma","volume":"328","author":"Fisher","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1093\/annonc\/mdl327_bb0085","first-page":"457","article-title":"Nonparametric estimation from incomplete observations","volume":"55","author":"El","year":"1958","journal-title":"J Am Stat Assoc"},{"key":"10.1093\/annonc\/mdl327_bb0090","series-title":"Data in Medical Research","first-page":"80","author":"Modelling Survival","year":"1999"},{"key":"10.1093\/annonc\/mdl327_bb0095","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3109\/10428199909058415","article-title":"Isolated central nervous system relapse in aggressive non-Hodgkin's lymphoma: the Bologna experience","volume":"32","author":"Zinzani","year":"1999","journal-title":"Leuk Lymphoma"},{"key":"10.1093\/annonc\/mdl327_bb0100","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3109\/02841869609084002","article-title":"Risk factors for central nervous system involvement in non-Hodgkin's lymphoma\u2014a multivariate analysis","volume":"35","author":"Keldsen","year":"1996","journal-title":"Acta Oncol"},{"key":"10.1093\/annonc\/mdl327_bb0105","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1001\/archneur.1997.00550190044013","article-title":"Central nervous system relapse in non-Hodgkin lymphoma. A single-center study of 532 patients","volume":"54","author":"Bollen","year":"1997","journal-title":"Arch Neurol"},{"key":"10.1093\/annonc\/mdl327_bb0110","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/(SICI)1097-0142(20000101)88:1<154::AID-CNCR21>3.0.CO;2-T","article-title":"Testicular lymphoma is associated with a high incidence of extranodal recurrence","volume":"88","author":"Fonseca","year":"2000","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdl327_bb0115","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/hon.2900080305","article-title":"Secondary central nervous system involvement by non-Hodgkin's lymphoma: the risk factors","volume":"8","author":"Liang","year":"1990","journal-title":"Hematol Oncol"},{"key":"10.1093\/annonc\/mdl327_bb0120","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1182\/blood.V54.6.1249.1249","article-title":"Central nervous system relapse in malignant lymphomas: risk factors and implications for prophylaxis","volume":"54","author":"Litam","year":"1979","journal-title":"Blood"},{"key":"10.1093\/annonc\/mdl327_bb0125","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/cncr.10699","article-title":"Prophylactic intrathecal methotrexate and hydrocortisone reduces central nervous system recurrence and improves survival in aggressive non-Hodgkin lymphoma","volume":"95","author":"Tomita","year":"2002","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdl327_bb0130","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1080\/1042819021000006475","article-title":"Intrathecal chemotherapy alone is inadequate central nervous system prophylaxis in patients with intermediate-grade non-Hodgkin's lymphoma","volume":"43","author":"Chua","year":"2002","journal-title":"Leuk Lymphoma"},{"key":"10.1093\/annonc\/mdl327_bb0135","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1200\/JCO.2003.11.141","article-title":"Patterns of outcome and prognostic factors in primary large-cell lymphoma of the testis in a survey by the International Extranodal Lymphoma Study Group","volume":"21","author":"Zucca","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdl327_bb0140","first-page":"83","article-title":"Lack of adhesion molecules in testicular diffuse centroblastic and immunoblastic B cell lymphomas as a contributory factor in malignant behaviour","volume":"429","author":"Horstmann","year":"1996","journal-title":"Virchows Arch"},{"key":"10.1093\/annonc\/mdl327_bb0145","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1182\/blood.V95.6.1900","article-title":"Cell adhesion receptors in lymphoma dissemination","volume":"95","author":"Drillenburg","year":"2000","journal-title":"Blood"},{"key":"10.1093\/annonc\/mdl327_bb0150","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1182\/blood-2004-05-1982","article-title":"High incidence of occult leptomeningeal disease detected by flow cytometry in newly diagnosed aggressive B-cell lymphomas at risk for central nervous system involvement: the role of flow cytometry versus cytology","volume":"105","author":"Hegde","year":"2005","journal-title":"Blood"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419375623?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419375623?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/18\/1\/149\/790682\/mdl327.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T08:19:16Z","timestamp":1624436356000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923753419375623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S0923753419375623"],"URL":"https:\/\/doi.org\/10.1093\/annonc\/mdl327","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}