{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:00:14Z","timestamp":1788872414114,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T00:00:00Z","timestamp":1575331200000},"content-version":"vor","delay-in-days":3715,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Susan B. Komen Foundation"},{"name":"Ethel F. Donaghue Women's Health Investigator Program at Yale"},{"name":"Patterson Trust and Breast Cancer Alliance"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1093\/annonc\/mdp051","type":"journal-article","created":{"date-parts":[[2009,6,4]],"date-time":"2009-06-04T17:44:16Z","timestamp":1244137456000},"page":"1653-1659","source":"Crossref","is-referenced-by-count":55,"title":["Breast cancer in young women (YBC): prevalence of BRCA1\/2 mutations and risk of secondary malignancies across diverse racial groups"],"prefix":"10.1016","volume":"20","author":[{"given":"B.G.","family":"Haffty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.H.","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Goyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Silber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ranieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Matloff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.H.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Nissenblatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Toppmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.S.","family":"Moran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/annonc\/mdp051_bb0010","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S1072-7515(98)00305-6","article-title":"Age at presentation of African-American and Caucasian breast cancer patients","volume":"188","author":"El-Tamer","year":"1999","journal-title":"J Am Coll Surg"},{"key":"10.1093\/annonc\/mdp051_bb0015","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3322\/canjclin.56.2.106","article-title":"Cancer statistics, 2006","volume":"56","author":"Jemal","year":"2006","journal-title":"CA Cancer J Clin"},{"key":"10.1093\/annonc\/mdp051_bb0020","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1001\/archsurg.139.1.31-a","article-title":"Clinical characteristics of breast cancer patients in Korea in 2000","volume":"139","author":"Ahn","year":"2004","journal-title":"Arch Surg"},{"key":"10.1093\/annonc\/mdp051_bb0025","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1002\/ijc.21404","article-title":"Epidemiology and the causes of breast cancer","volume":"118","author":"MacMahon","year":"2006","journal-title":"Int J Cancer"},{"key":"10.1093\/annonc\/mdp051_bb0030","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s004390000290","article-title":"Prevalence of BRCA1 and BRCA2 mutations among clinic-based African American families with breast cancer","volume":"107","author":"Gao","year":"2000","journal-title":"Hum Genet"},{"key":"10.1093\/annonc\/mdp051_bb0035","doi-asserted-by":"crossref","DOI":"10.1136\/jmg.2005.034744","article-title":"Racial differences in the incidence of BRCA1 and BRCA2 mutations in a cohort of early onset breast cancer patients: African American compared to White Women","author":"Haffty","year":"2005","journal-title":"J Med Genet"},{"key":"10.1093\/annonc\/mdp051_bb0040","doi-asserted-by":"crossref","first-page":"8297","DOI":"10.1158\/0008-5472.CAN-06-0503","article-title":"Prevalence and predictors of BRCA1 and BRCA2 mutations in a population-based study of breast cancer in white and black American women ages 35 to 64 years","volume":"66","author":"Malone","year":"2006","journal-title":"Cancer Res"},{"key":"10.1093\/annonc\/mdp051_bb0045","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1158\/1055-9965.1794.13.11","article-title":"BRCA1 and BRCA2 mutations in a study of African American breast cancer patients","volume":"13","author":"Pal","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1093\/annonc\/mdp051_bb0050","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1001\/jama.298.24.2910","article-title":"Genetic testing in diverse populations: are researchers doing enough to get out the correct message?","volume":"298","author":"Huo","year":"2007","journal-title":"JAMA"},{"key":"10.1093\/annonc\/mdp051_bb0055","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1001\/jama.298.24.2869","article-title":"Prevalence of pathogenic BRCA1 mutation carriers in 5 US racial\/ethnic groups","volume":"298","author":"John","year":"2007","journal-title":"JAMA"},{"key":"10.1093\/annonc\/mdp051_bb0060","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1001\/jama.294.15.1925","article-title":"Genetic testing in an ethnically diverse cohort of high-risk women: a comparative analysis of BRCA1 and BRCA2 mutations in American families of European and African ancestry","volume":"294","author":"Nanda","year":"2005","journal-title":"JAMA"},{"key":"10.1093\/annonc\/mdp051_bb0065","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.canlet.2005.12.031","article-title":"BRCA1 and BRCA2 germline mutations in Korean breast cancer patients at high risk of carrying mutations","volume":"245","author":"Ahn","year":"2007","journal-title":"Cancer Lett"},{"key":"10.1093\/annonc\/mdp051_bb0070","doi-asserted-by":"crossref","DOI":"10.1007\/s10549-007-9878-z","article-title":"The CHEK2 1100delC mutation is not present in Korean patients with breast cancer cases tested for BRCA1 and BRCA2 mutation","author":"Choi","year":"2008","journal-title":"Breast Cancer Res Treat"},{"key":"10.1093\/annonc\/mdp051_bb0075","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1200\/JCO.2004.04.179","article-title":"Incidence of BRCA1 and BRCA2 mutations in young Korean breast cancer patients","volume":"22","author":"Choi","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdp051_bb0080","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1200\/JCO.1998.16.7.2417","article-title":"Sequence analysis of BRCA1 and BRCA2: correlation of mutations with family history and ovarian cancer risk","volume":"16","author":"Frank","year":"1998","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdp051_bb0085","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.5858\/1999-123-1023-LDOHST","article-title":"Laboratory determination of hereditary susceptibility to breast and ovarian cancer","volume":"123","author":"Frank","year":"1999","journal-title":"Arch Pathol Lab Med"},{"key":"10.1093\/annonc\/mdp051_bb0090","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/1098-1004(200008)16:2<123::AID-HUMU4>3.0.CO;2-Y","article-title":"The breast cancer information core: database design, structure, and scope","volume":"16","author":"Szabo","year":"2000","journal-title":"Hum Mutat"},{"key":"10.1093\/annonc\/mdp051_bb0095","doi-asserted-by":"crossref","first-page":"R66","DOI":"10.1186\/bcr1622","article-title":"Molecular subtypes of breast cancer in relation to paclitaxel response and outcomes in women with metastatic disease: results from CALGB 9342","volume":"8","author":"Harris","year":"2006","journal-title":"Breast Cancer Res"},{"issue":"2","key":"10.1093\/annonc\/mdp051_bb0100","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s10549-008-9926-3","article-title":"Race and triple negative threats to breast cancer survival: a population-based study in Atlanta, GA","volume":"113","author":"Lund","year":"2009","journal-title":"Breast Cancer Res Treat"},{"issue":"36","key":"10.1093\/annonc\/mdp051_bb0105","doi-asserted-by":"crossref","first-page":"5652","DOI":"10.1200\/JCO.2006.06.5664","article-title":"Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer","volume":"24","author":"Haffty","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdp051_bb0110","first-page":"1310","article-title":"The Breast Cancer Linkage Consortium","volume":"91","author":"Cancer risks in BRCA2 mutation carriers","year":"1999","journal-title":"J Natl Cancer Inst"},{"key":"10.1093\/annonc\/mdp051_bb0115","first-page":"678","article-title":"Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium","volume":"52","author":"Easton","year":"1993","journal-title":"Am J Hum Genet"},{"key":"10.1093\/annonc\/mdp051_bb0120","first-page":"1457","article-title":"Estimates of the gene frequency of BRCA1 and its contribution to breast and ovarian cancer incidence","volume":"57","author":"Ford","year":"1995","journal-title":"Am J Hum Genet"},{"key":"10.1093\/annonc\/mdp051_bb0125","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3816\/CBC.2004.n.029","article-title":"Breast cancer surveillance in women with hereditary risk due to BRCA1 or BRCA2 mutations","volume":"5","author":"Robson","year":"2004","journal-title":"Clin Breast Cancer"},{"key":"10.1093\/annonc\/mdp051_bb0130","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1053\/j.seminhematol.2006.04.005","article-title":"Fanconi anemia","volume":"43","author":"Bagby","year":"2006","journal-title":"Semin Hematol"},{"key":"10.1093\/annonc\/mdp051_bb0135","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/nrc2054","article-title":"Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations","volume":"7","author":"Fackenthal","year":"2007","journal-title":"Nat Rev Cancer"},{"issue":"Suppl 6","key":"10.1093\/annonc\/mdp051_bb0140","doi-asserted-by":"crossref","first-page":"vi93","DOI":"10.1093\/annonc\/mdm234","article-title":"Founder mutations in BRCA1 and BRCA2 genes","volume":"18","author":"Ferla","year":"2007","journal-title":"Ann Oncol"},{"key":"10.1093\/annonc\/mdp051_bb0145","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1200\/JCO.2007.11.3449","article-title":"Risk-reducing salpingo-oophorectomy in patients with germline mutations in BRCA1 or BRCA2","volume":"25","author":"Kauff","year":"2007","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.1093\/annonc\/mdp051_bb0150","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/sj.bjc.6604830","article-title":"Breast cancer risks in women with a family history of breast or ovarian cancer who have tested negative for a BRCA1 or BRCA2 mutation","volume":"100","author":"Metcalfe","year":"2009","journal-title":"Br J Cancer"},{"key":"10.1093\/annonc\/mdp051_bb0155","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.genom.9.081307.164339","article-title":"Genetic predisposition to breast cancer: past, present, and future","volume":"9","author":"Turnbull","year":"2008","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"10.1093\/annonc\/mdp051_bb0160","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1200\/JCO.2003.03.189","article-title":"American Society of Clinical Oncology policy statement update: genetic testing for cancer susceptibility","volume":"21","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdp051_bb0165","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1056\/NEJMoa020119","article-title":"Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation","volume":"346","author":"Kauff","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1093\/annonc\/mdp051_bb0170","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1016\/S0140-6736(00)03258-X","article-title":"Tamoxifen and risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers: a case-control study. Hereditary Breast Cancer Clinical Study Group","volume":"356","author":"Narod","year":"2000","journal-title":"Lancet"},{"key":"10.1093\/annonc\/mdp051_bb0175","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1056\/NEJM200111153452014","article-title":"Prophylactic mastectomy in carriers of BRCA mutations","volume":"345","author":"Offit","year":"2001","journal-title":"N Engl J Med"},{"issue":"Suppl 1","key":"10.1093\/annonc\/mdp051_bb0180","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1111\/j.1524-4741.2004.101S3.x","article-title":"Efficacy of risk-reducing salpingo-oophorectomy in women with BRCA-1 and BRCA-2 mutations","volume":"10","author":"Olopade","year":"2004","journal-title":"Breast J"},{"key":"10.1093\/annonc\/mdp051_bb0185","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1200\/JCO.2005.02.7888","article-title":"Ten-year multi-institutional results of breast-conserving surgery and radiotherapy in BRCA1\/2-associated stage I\/II breast cancer","volume":"24","author":"Pierce","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdp051_bb0190","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1200\/JCO.2004.04.188","article-title":"Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group","volume":"22","author":"Rebbeck","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdp051_bb0195","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/cncr.20728","article-title":"Appropriateness of breast-conserving treatment of breast carcinoma in women with germline mutations in BRCA1 or BRCA2: a clinic-based series","volume":"103","author":"Robson","year":"2005","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdp051_bb0200","doi-asserted-by":"crossref","first-page":"4635","DOI":"10.1200\/JCO.2006.10.4703","article-title":"BRCA1 and BRCA2 genetic testing in Hispanic patients: mutation prevalence and evaluation of the BRCAPRO risk assessment model","volume":"25","author":"Vogel","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdp051_bb0205","doi-asserted-by":"crossref","first-page":"R19","DOI":"10.1186\/bcr1865","article-title":"Evaluation of unclassified variants in the breast cancer susceptibility genes BRCA1 and BRCA2 using five methods: results from a population-based study of young breast cancer patients","volume":"10","author":"Lee","year":"2008","journal-title":"Breast Cancer Res"},{"key":"10.1093\/annonc\/mdp051_bb0210","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1002\/humu.20896","article-title":"Classification of rare missense substitutions, using risk surfaces, with genetic- and molecular-epidemiology applications","volume":"29","author":"Tavtigian","year":"2008","journal-title":"Hum Mutat"},{"key":"10.1093\/annonc\/mdp051_bb0215","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1002\/humu.20899","article-title":"Assessment of functional effects of unclassified genetic variants","volume":"29","author":"Couch","year":"2008","journal-title":"Hum Mutat"},{"key":"10.1093\/annonc\/mdp051_bb0220","first-page":"1739","article-title":"Pathological features and BRCA1 mutation screening in premenopausal breast cancer patients","volume":"7","author":"Chang","year":"2001","journal-title":"Clin Cancer Res"},{"issue":"29","key":"10.1093\/annonc\/mdp051_bb0225","doi-asserted-by":"crossref","first-page":"4752","DOI":"10.1200\/JCO.2008.16.8310","article-title":"Performance of BRCA1\/2 mutation prediction models in Asian Americans","volume":"26","author":"Kurian","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdp051_bb0230","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1158\/1055-9965.2078.13.12","article-title":"Prevalence of BRCA1 mutation carriers among U.S. non-Hispanic Whites","volume":"13","author":"Whittemore","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1093\/annonc\/mdp051_bb0235","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1054\/bjoc.2000.1407","article-title":"Prevalence and penetrance of BRCA1 and BRCA2 mutations in a population-based series of breast cancer cases. Anglian Breast Cancer Study Group","volume":"83","year":"2000","journal-title":"Br J Cancer"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419408454?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419408454?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/20\/10\/1653\/610111\/mdp051.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T02:38:34Z","timestamp":1710383914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923753419408454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":46,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S0923753419408454"],"URL":"https:\/\/doi.org\/10.1093\/annonc\/mdp051","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]}}}