{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T19:57:00Z","timestamp":1793390220554,"version":"4.5.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T00:00:00Z","timestamp":1575331200000},"content-version":"vor","delay-in-days":3380,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Novartis Oncology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1093\/annonc\/mdq022","type":"journal-article","created":{"date-parts":[[2010,2,5]],"date-time":"2010-02-05T20:45:38Z","timestamp":1265402738000},"page":"1794-1803","source":"Crossref","is-referenced-by-count":333,"title":["Incidence, patterns of care and prognostic factors for outcome of gastroenteropancreatic neuroendocrine tumors (GEP-NETs): results from the National Cancer Registry of Spain (RGETNE)"],"prefix":"10.1016","volume":"21","author":[{"given":"R.","family":"Garcia-Carbonero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Capdevila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Crespo-Herrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.A.","family":"D\u00edaz-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.P.","family":"Mart\u00ednez del Prado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Alonso Ordu\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Sevilla-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Villabona-Artero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Beguiristain-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Llanos-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Marazuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Alvarez-Escola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Castellano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Vilar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Jim\u00e9nez-Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Teul\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sastre-Valera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Benavent-Vi\u00f1uelas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Monleon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Salazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/annonc\/mdq022_bb0010","first-page":"425","article-title":"Karzinoide tumoren des dunndarms","volume":"1","author":"Obendorfer","year":"1907","journal-title":"Frankf Z Pathol"},{"issue":"1","key":"10.1093\/annonc\/mdq022_bb0015","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S1470-2045(07)70410-2","article-title":"Gastroenteropancreatic neuroendocrine tumours","volume":"9","author":"Modlin","year":"2008","journal-title":"Lancet Oncol"},{"issue":"2","key":"10.1093\/annonc\/mdq022_bb0020","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1159\/000182196","article-title":"ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: towards a standardized approach to the diagnosis of gastroenteropancreatic neuroendocrine tumors and their prognostic stratification","volume":"90","author":"Kl\u00f6ppel","year":"2009","journal-title":"Neuroendocrinology"},{"issue":"2","key":"10.1093\/annonc\/mdq022_bb0025","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1159\/000225950","article-title":"ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: chemotherapy in patients with neuroendocrine tumors","volume":"90","author":"Eriksson","year":"2009","journal-title":"Neuroendocrinology"},{"issue":"2","key":"10.1093\/annonc\/mdq022_bb0030","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1159\/000183751","article-title":"ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: biotherapy","volume":"90","author":"Oberg","year":"2009","journal-title":"Neuroendocrinology"},{"issue":"2","key":"10.1093\/annonc\/mdq022_bb0035","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1159\/000225952","article-title":"ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: follow-up and documentation","volume":"90","author":"Arnold","year":"2009","journal-title":"Neuroendocrinology"},{"issue":"18","key":"10.1093\/annonc\/mdq022_bb0040","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1200\/JCO.2007.15.4377","article-title":"One hundred years after \u201ccarcinoid\u201d: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States","volume":"26","author":"Yao","year":"2008","journal-title":"J Clin Oncol"},{"issue":"10","key":"10.1093\/annonc\/mdq022_bb0045","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1002\/cncr.23883","article-title":"Neuroendocrine tumor epidemiology: contrasting Norway and North America","volume":"113","author":"Hauso","year":"2008","journal-title":"Cancer"},{"issue":"8","key":"10.1093\/annonc\/mdq022_bb0050","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1002\/1097-0142(20011015)92:8<2204::AID-CNCR1564>3.0.CO;2-R","article-title":"Incidence trends and risk factors of carcinoid tumors: a nationwide epidemiologic study from Sweden","volume":"92","author":"Hemminki","year":"2001","journal-title":"Cancer"},{"issue":"3","key":"10.1093\/annonc\/mdq022_bb0055","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1053\/j.gastro.2007.01.006","article-title":"Survival from malignant digestive endocrine tumors in England and Wales: a population-based study","volume":"132","author":"Lepage","year":"2007","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1093\/annonc\/mdq022_bb0060","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/bjs.6051","article-title":"Clinical outcome and long-term survival in 118 consecutive patients with neuroendocrine tumours of the pancreas","volume":"95","author":"Fischer","year":"2008","journal-title":"Br J Surg"},{"issue":"12","key":"10.1093\/annonc\/mdq022_bb0065","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1245\/s10434-007-9566-6","article-title":"Population-based study of islet cell carcinoma","volume":"14","author":"Yao","year":"2007","journal-title":"Ann Surg Oncol"},{"issue":"7","key":"10.1093\/annonc\/mdq022_bb0070","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1001\/archsurg.143.7.664","article-title":"Analysis of 900 appendiceal carcinoid tumors for a proposed predictive staging system","volume":"143","author":"Landry","year":"2008","journal-title":"Arch Surg"},{"issue":"7","key":"10.1093\/annonc\/mdq022_bb0075","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1111\/j.1572-0241.2007.01185.x","article-title":"A three-decade analysis of 3,911 small intestinal neuroendocrine tumors: the rapid pace of no progress","volume":"102","author":"Modlin","year":"2007","journal-title":"Am J Gastroenterol"},{"issue":"10","key":"10.1093\/annonc\/mdq022_bb0080","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1093\/annonc\/mdn351","article-title":"Pancreatic neuroendocrine tumors (PNETs): incidence, prognosis and recent trend toward improved survival","volume":"19","author":"Halfdanarson","year":"2008","journal-title":"Ann Oncol"},{"key":"10.1093\/annonc\/mdq022_bb0085","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1196\/annals.1294.002","article-title":"The gastroenteropancreatic neuroendocrine cell system and its tumors: the WHO classification","volume":"1014","author":"Kl\u00f6ppel","year":"2004","journal-title":"Ann N Y Acad Sci"},{"issue":"8","key":"10.1093\/annonc\/mdq022_bb0090","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1093\/annonc\/mdm009","article-title":"New drug development in digestive neuroendocrine tumors","volume":"18","author":"Dur\u00e1n","year":"2007","journal-title":"Ann Oncol"},{"issue":"2","key":"10.1093\/annonc\/mdq022_bb0095","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1677\/ERC-06-0074","article-title":"Chemotherapy and role of the proliferation marker Ki-67 in digestive neuroendocrine tumors","volume":"14","author":"Vilar","year":"2007","journal-title":"Endocr Relat Cancer"},{"issue":"15","key":"10.1093\/annonc\/mdq022_bb0100","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1517\/14656566.9.15.2617","article-title":"Pharmacotherapy of neuroendocrine cancers","volume":"9","author":"Modlin","year":"2008","journal-title":"Expert Opin Pharmacother"},{"issue":"28","key":"10.1093\/annonc\/mdq022_bb0105","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.1200\/JCO.2009.22.8510","article-title":"Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group","volume":"27","author":"Rinke","year":"2009","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1093\/annonc\/mdq022_bb0110","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1200\/JCO.2009.24.2669","article-title":"Daily oral everolimus activity in patients with metastatic pancreatic neuroendocrine tumors after failure of cytotoxic chemotherapy: a phase II trial","volume":"28","author":"Yao","year":"2010","journal-title":"J Clin Oncol"},{"issue":"4","key":"10.1093\/annonc\/mdq022_bb0115","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s11523-009-0130-0","article-title":"Sunitinib paves the way for targeted therapies in neuroendocrine tumors","volume":"4","author":"Raymond","year":"2009","journal-title":"Target Oncol"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419400483?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419400483?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/21\/9\/1794\/338434\/mdq022.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T05:37:12Z","timestamp":1624685832000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923753419400483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S0923753419400483"],"URL":"https:\/\/doi.org\/10.1093\/annonc\/mdq022","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]}}}