{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T07:57:42Z","timestamp":1772179062746,"version":"3.50.1"},"reference-count":53,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"vor","delay-in-days":3160,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1093\/annonc\/mdq411","type":"journal-article","created":{"date-parts":[[2010,9,23]],"date-time":"2010-09-23T03:45:27Z","timestamp":1285213527000},"page":"754-760","source":"Crossref","is-referenced-by-count":49,"title":["Gastric atrophy and risk of oesophageal cancer and gastric cardia adenocarcinoma\u2014a systematic review and meta-analysis"],"prefix":"10.1016","volume":"22","author":[{"given":"F.","family":"Islami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Sheikhattari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.S.","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Kamangar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/annonc\/mdq411_bb0010","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1200\/JCO.2005.05.2308","article-title":"Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world","volume":"24","author":"Kamangar","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdq411_bb0015","series-title":"Cancer Epidemiology and Prevention","first-page":"697","article-title":"Esophageal Cancer","author":"Blot","year":"2006"},{"key":"10.1093\/annonc\/mdq411_bb0020","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.bpg.2006.04.008","article-title":"Gastric cancer: global pattern of the disease and an overview of environmental risk factors","volume":"20","author":"Forman","year":"2006","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1093\/annonc\/mdq411_bb0025","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1136\/gut.49.3.347","article-title":"Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts","volume":"49","author":"Helicobacter and Cancer Collaborative Group","year":"2001","journal-title":"Gut"},{"key":"10.1093\/annonc\/mdq411_bb0030","doi-asserted-by":"crossref","first-page":"537","DOI":"10.7326\/0003-4819-93-4-537","article-title":"Serum pepsinogen I as a predictor of stomach cancer","volume":"93","author":"Nomura","year":"1980","journal-title":"Ann Intern Med"},{"key":"10.1093\/annonc\/mdq411_bb0035","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0009-8981(87)90022-2","article-title":"Serum pepsinogens I and II and stomach cancer","volume":"163","author":"Stemmermann","year":"1987","journal-title":"Clin Chim Acta"},{"key":"10.1093\/annonc\/mdq411_bb0040","first-page":"461","article-title":"Helicobacter pylori, pepsinogen, and risk for gastric adenocarcinoma","volume":"2","author":"Parsonnet","year":"1993","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1093\/annonc\/mdq411_bb0045","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1055-3207(02)00002-9","article-title":"Epidemiologic trends in esophageal and gastric cancer in the United States","volume":"11","author":"Brown","year":"2002","journal-title":"Surg Oncol Clin N Am"},{"key":"10.1093\/annonc\/mdq411_bb0050","first-page":"669","article-title":"Trends in incidence of oesophageal and stomach cancer subtypes in Europe","volume":"22","author":"Steevens","year":"2010","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1093\/annonc\/mdq411_bb0055","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/1097-0142(19930201)71:3<745::AID-CNCR2820710316>3.0.CO;2-1","article-title":"Pernicious anemia and subsequent cancer. A population-based cohort study","volume":"71","author":"Hsing","year":"1993","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdq411_bb0060","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/00004836-199307000-00020","article-title":"Atrophic chronic gastritis in patients with epidermoid carcinoma of the esophagus","volume":"17","author":"Rakic","year":"1993","journal-title":"J Clin Gastroenterol"},{"key":"10.1093\/annonc\/mdq411_bb0065","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1093\/jnci\/djh057","article-title":"Helicobacter pylori infection and gastric atrophy: risk of adenocarcinoma and squamous-cell carcinoma of the esophagus and adenocarcinoma of the gastric cardia","volume":"96","author":"Ye","year":"2004","journal-title":"J Natl Cancer Inst"},{"key":"10.1093\/annonc\/mdq411_bb0070","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1093\/ije\/30.6.1415","article-title":"Oesophageal and gastric cardia adenocarcinomas: analysis of regional variation using the Cancer Incidence in Five Continents database","volume":"30","author":"Corley","year":"2001","journal-title":"Int J Epidemiol"},{"key":"10.1093\/annonc\/mdq411_bb0075","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.dld.2008.02.030","article-title":"OLGA staging for gastritis: a tutorial","volume":"40","author":"Rugge","year":"2008","journal-title":"Dig Liver Dis"},{"key":"10.1093\/annonc\/mdq411_bb0080","first-page":"215","article-title":"Pepsinogens, pepsins, and peptic ulcer","volume":"10","author":"Samloff","year":"1987","journal-title":"Clin Invest Med"},{"key":"10.1093\/annonc\/mdq411_bb0085","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/ijc.21822","article-title":"A prospective study of dietary salt intake and gastric cancer incidence in a defined Japanese population: the Hisayama study","volume":"119","author":"Shikata","year":"2006","journal-title":"Int J Cancer"},{"key":"10.1093\/annonc\/mdq411_bb0090","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1111\/j.1572-0241.2007.01257.x","article-title":"Extensive gastric atrophy: an increased risk factor for superficial esophageal squamous cell carcinoma in Japan","volume":"102","author":"Iijima","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"10.1093\/annonc\/mdq411_bb0095","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1053\/j.gastro.2008.01.071","article-title":"Gastric cancer risk in patients with premalignant gastric lesions: a nationwide cohort study in the Netherlands","volume":"134","author":"de Vries","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1093\/annonc\/mdq411_bb0100","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1111\/j.1349-7006.1995.tb03317.x","article-title":"Sensitivity and specificity of mass screening for gastric cancer using the measurement of serum pepsinogens","volume":"86","author":"Hattori","year":"1995","journal-title":"Jpn J Cancer Res"},{"key":"10.1093\/annonc\/mdq411_bb0105","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1349-7006.1995.tb02989.x","article-title":"Helicobacter pylori infection, serum pepsinogen level and gastric cancer: a case-control study in Japan","volume":"86","author":"Fukuda","year":"1995","journal-title":"Jpn J Cancer Res"},{"key":"10.1093\/annonc\/mdq411_bb0110","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1136\/gut.2004.055400","article-title":"Predicting the development of gastric cancer from combining Helicobacter pylori antibodies and serum pepsinogen status: a prospective endoscopic cohort study","volume":"54","author":"Watabe","year":"2005","journal-title":"Gut"},{"key":"10.1093\/annonc\/mdq411_bb0115","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1086\/430353","article-title":"Helicobacter pylori, pepsinogen, and gastric adenocarcinoma in Hawaii","volume":"191","author":"Nomura","year":"2005","journal-title":"J Infect Dis"},{"key":"10.1093\/annonc\/mdq411_bb0120","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1093\/aje\/kwj088","article-title":"The serum pepsinogen test as a predictor of gastric cancer: the Hisayama study","volume":"163","author":"Oishi","year":"2006","journal-title":"Am J Epidemiol"},{"key":"10.1093\/annonc\/mdq411_bb0125","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/ijc.21884","article-title":"Helicobacter pylori IgA and IgG antibodies, serum pepsinogen I and the risk of gastric cancer: changes in the risk with extended follow-up period","volume":"119","author":"Knekt","year":"2006","journal-title":"Int J Cancer"},{"key":"10.1093\/annonc\/mdq411_bb0130","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/ijc.22435","article-title":"CagA+ Helicobacter pylori infection and gastric cancer risk in the EPIC-EURGAST study","volume":"120","author":"Palli","year":"2006","journal-title":"Int J Cancer"},{"key":"10.1093\/annonc\/mdq411_bb0135","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1136\/gut.2006.114504","article-title":"Two distinct aetiologies of cardia cancer; evidence from premorbid serological markers of gastric atrophy and Helicobacter pylori status","volume":"56","author":"Hansen","year":"2007","journal-title":"Gut"},{"key":"10.1093\/annonc\/mdq411_bb0140","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1136\/gut.2007.132662","article-title":"Relationship between Helicobacter pylori infection and gastric atrophy and the stages of the oesophageal inflammation, metaplasia, adenocarcinoma sequence: results from the FINBAR case-control study","volume":"57","author":"Anderson","year":"2008","journal-title":"Gut"},{"key":"10.1093\/annonc\/mdq411_bb0145","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1136\/gut.2007.137364","article-title":"Combination of gastric atrophy, reflux symptoms and histological subtype indicates two distinct aetiologies of gastric cardia cancer","volume":"57","author":"Derakhshan","year":"2008","journal-title":"Gut"},{"key":"10.1093\/annonc\/mdq411_bb0150","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1007\/s10620-009-0853-x","article-title":"Gastric hyposecretion in esophageal squamous-cell carcinomas","volume":"55","author":"Iijima","year":"2009","journal-title":"Dig Dis Sci"},{"key":"10.1093\/annonc\/mdq411_bb0155","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1111\/j.1530-0277.2009.00908.x","article-title":"Chronic atrophic gastritis and metachronous gastric cancer in Japanese alcoholic men with esophageal squamous cell carcinoma","volume":"33","author":"Yokoyama","year":"2009","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1093\/annonc\/mdq411_bb0160","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/ijc.23918","article-title":"Serum pepsinogens and risk of esophageal squamous dysplasia","volume":"124","author":"Kamangar","year":"2009","journal-title":"Int J Cancer"},{"key":"10.1093\/annonc\/mdq411_bb0165","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1136\/gut.2008.168641","article-title":"Serum pepsinogens and risk of gastric and oesophageal cancers in the general population nutrition intervention trial cohort","volume":"58","author":"Ren","year":"2009","journal-title":"Gut"},{"key":"10.1093\/annonc\/mdq411_bb0170","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1002\/ijc.23955","article-title":"Increased risk of esophageal squamous cell carcinoma in patients with gastric atrophy: independent of the severity of atrophic changes","volume":"124","author":"de Vries","year":"2009","journal-title":"Int J Cancer"},{"key":"10.1093\/annonc\/mdq411_bb0175","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1471-230X-9-34","article-title":"Macroscopic extent of gastric mucosal atrophy: increased risk factor for esophageal squamous cell carcinoma in Japan","volume":"9","author":"Akiyama","year":"2009","journal-title":"BMC Gastroenterol"},{"key":"10.1093\/annonc\/mdq411_bb0180","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/ijc.23539","article-title":"Association of Helicobacter pylori infection with chronic atrophic gastritis: meta-analyses according to type of disease definition","volume":"123","author":"Weck","year":"2008","journal-title":"Int J Cancer"},{"key":"10.1093\/annonc\/mdq411_bb0185","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1136\/gut.51.3.457","article-title":"Gastric cancer and H. pylori","volume":"51","author":"Dawsey","year":"2002","journal-title":"Gut"},{"key":"10.1093\/annonc\/mdq411_bb0190","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1158\/1940-6207.CAPR-08-0109","article-title":"Helicobacter pylori and esophageal cancer risk: a meta-analysis","volume":"1","author":"Islami","year":"2008","journal-title":"Cancer Prev Res (Phila Pa)"},{"key":"10.1093\/annonc\/mdq411_bb0195","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1038\/sj.bjc.6605372","article-title":"Pickled vegetables and the risk of oesophageal cancer: a meta-analysis","volume":"101","author":"Islami","year":"2009","journal-title":"Br J Cancer"},{"key":"10.1093\/annonc\/mdq411_bb0200","first-page":"3554","article-title":"A human model of gastric carcinogenesis","volume":"48","author":"Correa","year":"1988","journal-title":"Cancer Res"},{"key":"10.1093\/annonc\/mdq411_bb0205","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1111\/j.1572-0241.2007.01417.x","article-title":"Sporadic gastric cancer; a complex interaction of genetic and environmental risk factors","volume":"102","author":"McColl","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"10.1093\/annonc\/mdq411_bb0210","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1080\/00365520212500","article-title":"Ethanol-derived microbial production of carcinogenic acetaldehyde in achlorhydric atrophic gastritis","volume":"37","author":"Vakevainen","year":"2002","journal-title":"Scand J Gastroenterol"},{"key":"10.1093\/annonc\/mdq411_bb0215","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1097\/00042737-200309000-00008","article-title":"Gastric juice nitrite and vitamin C in patients with gastric cancer and atrophic gastritis: is low acidity solely responsible for cancer risk?","volume":"15","author":"Kodama","year":"2003","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1093\/annonc\/mdq411_bb0220","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S1470-2045(09)70326-2","article-title":"A review of human carcinogens\u2014Part E: tobacco, areca nut, alcohol, coal smoke, and salted fish","volume":"10","author":"Secretan","year":"2009","journal-title":"Lancet Oncol"},{"key":"10.1093\/annonc\/mdq411_bb0225","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.gtc.2009.01.004","article-title":"Environmental causes of esophageal cancer","volume":"38","author":"Kamangar","year":"2009","journal-title":"Gastroenterol Clin North Am"},{"key":"10.1093\/annonc\/mdq411_bb0230","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1080\/00365520601101641","article-title":"Pathology findings and validation of gastric and esophageal cancer cases in a European cohort (EPIC\/EUR-GAST)","volume":"42","author":"Carneiro","year":"2007","journal-title":"Scand J Gastroenterol"},{"key":"10.1093\/annonc\/mdq411_bb0235","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.gastro.2005.05.055","article-title":"The perception of cancer risk in patients with prevalent Barrett\u2019s esophagus enrolled in an endoscopic surveillance program","volume":"129","author":"Shaheen","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1093\/annonc\/mdq411_bb0240","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1136\/gut.2007.131375","article-title":"Combined effects of obesity, acid reflux and smoking on the risk of adenocarcinomas of the oesophagus","volume":"57","author":"Whiteman","year":"2008","journal-title":"Gut"},{"key":"10.1093\/annonc\/mdq411_bb0245","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.gie.2008.07.035","article-title":"Diagnosing Barrett\u2019s esophagus: reliability of clinical and pathologic diagnoses","volume":"69","author":"Corley","year":"2009","journal-title":"Gastrointest Endosc"},{"key":"10.1093\/annonc\/mdq411_bb0250","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1053\/j.gastro.2008.12.052","article-title":"Alcohol consumption and the risks of adenocarcinoma and squamous cell carcinoma of the esophagus","volume":"136","author":"Pandeya","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1093\/annonc\/mdq411_bb0255","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1002\/ijc.24623","article-title":"IGF2R polymorphisms and risk of esophageal and gastric adenocarcinomas","volume":"125","author":"Hoyo","year":"2009","journal-title":"Int J Cancer"},{"key":"10.1093\/annonc\/mdq411_bb0260","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/oxfordjournals.aje.a117324","article-title":"Meta-analysis\/Shmeta-analysis","volume":"140","author":"Shapiro","year":"1994","journal-title":"Am J Epidemiol"},{"key":"10.1093\/annonc\/mdq411_bb0265","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1080\/00365520802273025","article-title":"Serum biomarkers provide an accurate method for diagnosis of atrophic gastritis in a general population: the Kalixanda study","volume":"43","author":"Storskrubb","year":"2008","journal-title":"Scand J Gastroenterol"},{"key":"10.1093\/annonc\/mdq411_bb0270","doi-asserted-by":"crossref","first-page":"853","DOI":"10.3748\/wjg.15.853","article-title":"Serum biomarker tests are useful in delineating between patients with gastric atrophy and normal, healthy stomach","volume":"15","author":"Iijima","year":"2009","journal-title":"World J Gastroenterol"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092375341938545X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092375341938545X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/22\/4\/754\/13784513\/mdq411.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T09:23:59Z","timestamp":1624699439000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092375341938545X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S092375341938545X"],"URL":"https:\/\/doi.org\/10.1093\/annonc\/mdq411","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}