{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:37:34Z","timestamp":1789778254769,"version":"4.0.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"vor","delay-in-days":2746,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1093\/annonc\/mdr568","type":"journal-article","created":{"date-parts":[[2012,1,7]],"date-time":"2012-01-07T06:27:28Z","timestamp":1325917648000},"page":"1795-1802","source":"Crossref","is-referenced-by-count":61,"title":["Prognostic significance of L1CAM in ovarian cancer and its role in constitutive NF-\u03baB activation"],"prefix":"10.1016","volume":"23","author":[{"given":"S.","family":"Bondong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kiefel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Hielscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.G.","family":"Zeimet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Zeillinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Pils","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Schuster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.C.","family":"Castillo-Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Cadron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Vergote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Braicu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sehouli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mahner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Altevogt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/annonc\/mdr568_bb0010","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.critrevonc.2006.03.004","article-title":"Ovarian cancer","volume":"60","author":"Colombo","year":"2006","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1093\/annonc\/mdr568_bb0015","doi-asserted-by":"crossref","first-page":"7273","DOI":"10.1158\/1078-0432.CCR-05-0755","article-title":"Molecular pathogenesis of ovarian borderline tumors: new insights and old challenges","volume":"11","author":"Shih Ie","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1093\/annonc\/mdr568_bb0020","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/S0002-9440(10)63708-X","article-title":"Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis","volume":"164","author":"Shih Ie","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1093\/annonc\/mdr568_bb0025","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3322\/canjclin.54.1.8","article-title":"Cancer statistics, 2004","volume":"54","author":"Jemal","year":"2004","journal-title":"CA Cancer J Clin"},{"key":"10.1093\/annonc\/mdr568_bb0030","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1016\/S0090-8258(03)00472-4","article-title":"First-line treatment regimens and the role of consolidation therapy in advanced ovarian cancer","volume":"90","author":"Stuart","year":"2003","journal-title":"Gynecol Oncol"},{"key":"10.1093\/annonc\/mdr568_bb0035","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/334701a0","article-title":"Neural adhesion molecule L1 as a member of the immunoglobulin superfamily with binding domains similar to fibronectin","volume":"334","author":"Moos","year":"1988","journal-title":"Nature"},{"key":"10.1093\/annonc\/mdr568_bb0040","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0955-0674(97)80115-9","article-title":"Neural recognition molecules and synaptic plasticity","volume":"9","author":"Schachner","year":"1997","journal-title":"Curr Opin Cell Biol"},{"key":"10.1093\/annonc\/mdr568_bb0045","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0959-4388(98)80012-3","article-title":"Neural cell recognition molecule L1: from cell biology to human hereditary brain malformations","volume":"8","author":"Brummendorf","year":"1998","journal-title":"Curr Opin Neurobiol"},{"key":"10.1093\/annonc\/mdr568_bb0050","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nn1827","article-title":"Neural recognition molecules of the immunoglobulin superfamily: signaling transducers of axon guidance and neuronal migration","volume":"10","author":"Maness","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1093\/annonc\/mdr568_bb0055","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.canlet.2008.12.021","article-title":"L1 cell adhesion molecule (L1CAM) in invasive tumors","volume":"282","author":"Raveh","year":"2009","journal-title":"Cancer Lett"},{"key":"10.1093\/annonc\/mdr568_bb0060","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1007\/s00018-010-0339-1","article-title":"L1CAM malfunction in the nervous system and human carcinomas","volume":"67","author":"Schafer","year":"2010","journal-title":"Cell Mol Life Sci"},{"key":"10.1093\/annonc\/mdr568_bb0065","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0140-6736(03)14342-5","article-title":"L1 expression as a predictor of progression and survival in patients with uterine and ovarian carcinomas","volume":"362","author":"Fogel","year":"2003","journal-title":"Lancet"},{"key":"10.1093\/annonc\/mdr568_bb0070","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1158\/0008-5472.CAN-07-2897","article-title":"The differential role of L1 in ovarian carcinoma and normal ovarian surface epithelium","volume":"68","author":"Zecchini","year":"2008","journal-title":"Cancer Res"},{"key":"10.1093\/annonc\/mdr568_bb0075","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/path.2673","article-title":"Up-regulation of L1CAM is linked to loss of hormone receptors and E-cadherin in aggressive subtypes of endometrial carcinomas","volume":"220","author":"Huszar","year":"2010","journal-title":"J Pathol"},{"key":"10.1093\/annonc\/mdr568_bb0080","first-page":"26","article-title":"L1 (CAM) (CD171) in ovarian serous neoplasms","volume":"29","author":"Daponte","year":"2008","journal-title":"Eur J Gynaecol Oncol"},{"issue":"Pt 16","key":"10.1093\/annonc\/mdr568_bb0085","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1242\/jcs.112.16.2667","article-title":"Metalloproteinase-mediated release of the ectodomain of L1 adhesion molecule","volume":"112","author":"Beer","year":"1999","journal-title":"J Cell Sci"},{"key":"10.1093\/annonc\/mdr568_bb0090","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1096\/fj.02-0430fje","article-title":"ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles","volume":"17","author":"Gutwein","year":"2003","journal-title":"FASEB J"},{"key":"10.1093\/annonc\/mdr568_bb0095","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1083\/jcb.200101099","article-title":"Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins","volume":"155","author":"Mechtersheimer","year":"2001","journal-title":"J Cell Biol"},{"key":"10.1093\/annonc\/mdr568_bb0100","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.ygyno.2006.08.038","article-title":"L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells","volume":"104","author":"Stoeck","year":"2007","journal-title":"Gynecol Oncol"},{"key":"10.1093\/annonc\/mdr568_bb0105","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","article-title":"Immunity, inflammation, and cancer","volume":"140","author":"Grivennikov","year":"2010","journal-title":"Cell"},{"key":"10.1093\/annonc\/mdr568_bb0110","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nrc780","article-title":"NF-kappaB in cancer: from innocent bystander to major culprit","volume":"2","author":"Karin","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1093\/annonc\/mdr568_bb0115","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"key":"10.1093\/annonc\/mdr568_bb0120","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.ccr.2011.03.018","article-title":"The unholy trinity: inflammation, cytokines, and STAT3 shape the cancer microenvironment","volume":"19","author":"Li","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1093\/annonc\/mdr568_bb0125","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1365-2559.2010.03544.x","article-title":"Expression of classical NF-kappaB pathway effectors in human ovarian carcinoma","volume":"56","author":"Darb-Esfahani","year":"2010","journal-title":"Histopathology"},{"key":"10.1093\/annonc\/mdr568_bb0130","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1593\/neo.101720","article-title":"Cancer-associated fibroblasts and their putative role in potentiating the initiation and development of epithelial ovarian cancer","volume":"13","author":"Schauer","year":"2011","journal-title":"Neoplasia"},{"key":"10.1093\/annonc\/mdr568_bb0135","doi-asserted-by":"crossref","first-page":"4766","DOI":"10.1038\/onc.2010.230","article-title":"L1CAM-integrin interaction induces constitutive NF-kappaB activation in pancreatic adenocarcinoma cells by enhancing IL-1beta expression","volume":"29","author":"Kiefel","year":"2010","journal-title":"Oncogene"},{"key":"10.1093\/annonc\/mdr568_bb0140","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1242\/jcs.069542","article-title":"Nuclear factor-kappaB signaling and ezrin are essential for L1-mediated metastasis of colon cancer cells","volume":"123","author":"Gavert","year":"2010","journal-title":"J Cell Sci"},{"key":"10.1093\/annonc\/mdr568_bb0145","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.molmed.2010.11.005","article-title":"Linking L1CAM-mediated signaling to NF-\u03baB activation","volume":"17","author":"Kiefel","year":"2011","journal-title":"Trends Mol Med"},{"key":"10.1093\/annonc\/mdr568_bb0150","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/jnci\/92.3.205","article-title":"New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada","volume":"92","author":"Therasse","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"10.1093\/annonc\/mdr568_bb0155","doi-asserted-by":"crossref","first-page":"187s","DOI":"10.1200\/JCO.2003.01.223","article-title":"Use of CA-125 to assess response to new agents in ovarian cancer trials","volume":"21","author":"Rustin","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdr568_bb0160","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.humpath.2006.03.014","article-title":"Expression profile analysis in multiple human tumors identifies L1 (CD171) as a molecular marker for differential diagnosis and targeted therapy","volume":"37","author":"Huszar","year":"2006","journal-title":"Hum Pathol"},{"key":"10.1093\/annonc\/mdr568_bb0165","doi-asserted-by":"crossref","first-page":"28880","DOI":"10.1074\/jbc.M404075200","article-title":"Extracellular signal-regulated kinase (ERK)-dependent gene expression contributes to L1 cell adhesion molecule-dependent motility and invasion","volume":"279","author":"Silletti","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1093\/annonc\/mdr568_bb0170","doi-asserted-by":"crossref","first-page":"4918","DOI":"10.1523\/JNEUROSCI.22-12-04918.2002","article-title":"The neural cell adhesion molecule L1 potentiates integrin-dependent cell migration to extracellular matrix proteins","volume":"22","author":"Thelen","year":"2002","journal-title":"J Neurosci"},{"key":"10.1093\/annonc\/mdr568_bb0175","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1083\/jcb.200408051","article-title":"L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers","volume":"168","author":"Gavert","year":"2005","journal-title":"J Cell Biol"},{"key":"10.1093\/annonc\/mdr568_bb0180","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/ijc.21880","article-title":"The adhesion molecule L1 (CD171) promotes melanoma progression","volume":"119","author":"Meier","year":"2006","journal-title":"Int J Cancer"},{"key":"10.1093\/annonc\/mdr568_bb0185","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1038\/sj.onc.1210747","article-title":"The cytoplasmic part of L1-CAM controls growth and gene expression in human tumors that is reversed by therapeutic antibodies","volume":"27","author":"Gast","year":"2008","journal-title":"Oncogene"},{"key":"10.1093\/annonc\/mdr568_bb0190","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1158\/0008-5472.CAN-05-1818","article-title":"Efficient inhibition of intra-peritoneal tumor growth and dissemination of human ovarian carcinoma cells in nude mice by anti-L1-cell adhesion molecule monoclonal antibody treatment","volume":"66","author":"Arlt","year":"2006","journal-title":"Cancer Res"},{"key":"10.1093\/annonc\/mdr568_bb0195","doi-asserted-by":"crossref","first-page":"9040","DOI":"10.1128\/MCB.25.20.9040-9053.2005","article-title":"L1 is sequentially processed by two differently activated metalloproteases and presenilin\/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth","volume":"25","author":"Maretzky","year":"2005","journal-title":"Mol Cell Biol"},{"key":"10.1093\/annonc\/mdr568_bb0200","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1042\/BJ20051013","article-title":"A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44","volume":"393","author":"Stoeck","year":"2006","journal-title":"Biochem J"},{"key":"10.1093\/annonc\/mdr568_bb0205","doi-asserted-by":"crossref","first-page":"24602","DOI":"10.1074\/jbc.274.35.24602","article-title":"Integrin and neurocan binding to L1 involves distinct Ig domains","volume":"274","author":"Oleszewski","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1093\/annonc\/mdr568_bb0210","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/j.biocel.2009.01.006","article-title":"The soluble form of the cancer-associated L1 cell adhesion molecule is a pro-angiogenic factor","volume":"41","author":"Friedli","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1093\/annonc\/mdr568_bb0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2004.11.013","article-title":"Elevated levels of neural recognition molecule L1 in the cerebrospinal fluid of patients with Alzheimer disease and other dementia syndromes","volume":"27","author":"Strekalova","year":"2006","journal-title":"Neurobiol Aging"},{"issue":"189","key":"10.1093\/annonc\/mdr568_bb0220","first-page":"181","article-title":"Circulating levels of cell adhesion molecule L1 as a prognostic marker in gastrointestinal stromal tumor patients","volume":"11","author":"Zander","year":"2011","journal-title":"BMC Cancer"},{"key":"10.1093\/annonc\/mdr568_bb0225","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/jbm.a.30590","article-title":"Activation of cell-survival transcription factor NFkappaB in L1Ig6-stimulated endothelial cells","volume":"77","author":"Reidy","year":"2006","journal-title":"J Biomed Mater Res A"},{"key":"10.1093\/annonc\/mdr568_bb0230","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1158\/1078-0432.CCR-04-1688","article-title":"Cleavage of L1 in exosomes and apoptotic membrane vesicles released from ovarian carcinoma cells","volume":"11","author":"Gutwein","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1093\/annonc\/mdr568_bb0235","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1038\/sj.onc.1210076","article-title":"Drug-induced expression of the cellular adhesion molecule L1CAM confers anti-apoptotic protection and chemoresistance in pancreatic ductal adenocarcinoma cells","volume":"26","author":"Sebens Muerkoster","year":"2007","journal-title":"Oncogene"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419380160?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419380160?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/23\/7\/1795\/16703437\/mdr568.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T09:11:41Z","timestamp":1624698701000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923753419380160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":46,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0923753419380160"],"URL":"https:\/\/doi.org\/10.1093\/annonc\/mdr568","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}