{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:07:57Z","timestamp":1792595277500,"version":"4.5.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"vor","delay-in-days":2684,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1093\/annonc\/mds300","type":"journal-article","created":{"date-parts":[[2012,9,17]],"date-time":"2012-09-17T08:24:49Z","timestamp":1347870289000},"page":"x111-x117","source":"Crossref","is-referenced-by-count":262,"special_numbering":"S10","title":["New insights into ovarian cancer pathology"],"prefix":"10.1016","volume":"23","author":[{"given":"J.","family":"Prat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/annonc\/mds300_bb0010","series-title":"Pathology of the Ovary","author":"Prat","year":"2004"},{"key":"10.1093\/annonc\/mds300_bb0015","series-title":"World Health Organization classification of tumours: pathology and genetics of tumours of the breast and female genital organs","first-page":"117","article-title":"Surface epithelial-stromal tumours (Ch 2: tumours of the ovary and peritoneum)","author":"Lee","year":"2003"},{"key":"10.1093\/annonc\/mds300_bb0020","series-title":"World Cancer Report","author":"Stewart","year":"2003"},{"key":"10.1093\/annonc\/mds300_bb0025","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00428-012-1203-5","article-title":"Ovarian carcinomas: five distinct diseases with different origins, genetic alterations, and clinicopathological features","volume":"460","author":"Prat","year":"2012","journal-title":"Virchows Arch"},{"key":"10.1093\/annonc\/mds300_bb0030","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1038\/sj.bjc.6603116","article-title":"Clear cell carcinoma of the ovary: a retrospective multicentre experience of 254 patients with complete surgical staging","volume":"94","author":"Takano","year":"2006","journal-title":"Br J Cancer"},{"key":"10.1093\/annonc\/mds300_bb0035","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1093\/jnci\/djg036","article-title":"A randomized clinical trial of cisplatin\/paclitaxel versus carboplatin\/paclitaxel as first-line treatment of ovarian cancer","volume":"95","author":"du Bois","year":"2003","journal-title":"J Natl Cancer Inst"},{"key":"10.1093\/annonc\/mds300_bb0040","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1016\/j.ygyno.2006.08.022","article-title":"Summary and discussion of session recommendations","volume":"103","author":"Fountain","year":"2006","journal-title":"Gynecol Oncol"},{"key":"10.1093\/annonc\/mds300_bb0045","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/PAS.0b013e3181cf3d79","article-title":"The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory","volume":"34","author":"Kurman","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"10.1093\/annonc\/mds300_bb0050","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/path.1000","article-title":"Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer","volume":"195","author":"Piek","year":"2001","journal-title":"J Pathol"},{"key":"10.1093\/annonc\/mds300_bb0055","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/S0140-6736(01)05992-X","article-title":"Tubal ligation and risk of ovarian cancer","volume":"358","author":"Piek","year":"2001","journal-title":"Lancet"},{"key":"10.1093\/annonc\/mds300_bb0060","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/01.pas.0000180854.28831.77","article-title":"The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome","volume":"30","author":"Medeiros","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"10.1093\/annonc\/mds300_bb0065","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/01.pas.0000213335.40358.47","article-title":"Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: evidence for a causal relationship","volume":"31","author":"Kindelberger","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"10.1093\/annonc\/mds300_bb0070","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/path.2091","article-title":"A candidate precursor to serous carcinoma that originates in the distal fallopian tube","volume":"211","author":"Lee","year":"2007","journal-title":"J Pathol"},{"key":"10.1093\/annonc\/mds300_bb0075","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ygyno.2008.01.012","article-title":"A candidate precursor to pelvic serous cancer (p53 signature) and its prevalence in ovaries and fallopian tubes from women with BRCA mutations","volume":"109","author":"Folkins","year":"2008","journal-title":"Gynecol Oncol"},{"key":"10.1093\/annonc\/mds300_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/pgp.0b013e31814b191f","article-title":"Serous carcinogenesis in the fallopian tube: a descriptive classification","volume":"27","author":"Jarboe","year":"2008","journal-title":"Int J Gynecol Pathol"},{"key":"10.1093\/annonc\/mds300_bb0085","first-page":"2095","article-title":"Frequent PTEN\/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors","volume":"58","author":"Obata","year":"1998","journal-title":"Cancer Res"},{"key":"10.1093\/annonc\/mds300_bb0090","first-page":"7052","article-title":"Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary","volume":"60","author":"Sato","year":"2000","journal-title":"Cancer Res"},{"key":"10.1093\/annonc\/mds300_bb0095","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1093\/jnci\/95.6.484","article-title":"Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma","volume":"95","author":"Singer","year":"2003","journal-title":"J Nat Cancer Inst"},{"key":"10.1093\/annonc\/mds300_bb0100","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/01.pas.0000146025.91953.8d","article-title":"Patterns of p53 mutations separate ovarian serous borderline tumors and low- and high-grade carcinomas and provide support for a new model of ovarian carcinogenesis","volume":"29","author":"Singer","year":"2005","journal-title":"Am J Surg Pathol"},{"key":"10.1093\/annonc\/mds300_bb0105","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1097\/00000478-200404000-00009","article-title":"Grading ovarian serous carcinoma using a two-tier system","volume":"28","author":"Malpica","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"10.1093\/annonc\/mds300_bb0110","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/PAS.0b013e3181788546","article-title":"A limited panel of immunomarkers can reliably distinguish between clear cell and high-grade serous carcinoma of the ovary","volume":"33","author":"K\u00f6bel","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"10.1093\/annonc\/mds300_bb0115","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1093\/jnci\/djj465","article-title":"Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: a kin-cohort study in Ontario, Canada","volume":"98","author":"Risch","year":"2006","journal-title":"J. Natl Cancer Inst"},{"key":"10.1093\/annonc\/mds300_bb0120","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1146\/annurev.pathol.3.121806.151422","article-title":"Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment","volume":"4","author":"Venkitaraman","year":"2009","journal-title":"Annu. Rev Pathol"},{"key":"10.1093\/annonc\/mds300_bb0125","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/jnci\/94.1.61","article-title":"Frequency of BRCA1 dysfunction in ovarian cancer","volume":"94","author":"Geisler","year":"2002","journal-title":"J Natl Cancer Inst"},{"key":"10.1093\/annonc\/mds300_bb0130","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/jnci\/92.7.564","article-title":"Promoter hypermethylation is a cause of BRCA1 inactivation in sporadic breast and ovarian tumors","volume":"92","author":"Esteller","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"10.1093\/annonc\/mds300_bb0135","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nrc2946","article-title":"The genesis and evolution of high-grade serous ovarian cancer","volume":"10","author":"Bowtell","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"10.1093\/annonc\/mds300_bb0140","doi-asserted-by":"crossref","first-page":"e10358","DOI":"10.1371\/journal.pone.0010358","article-title":"Genetic analysis of the early natural history of epithelial ovarian carcinoma","volume":"5","author":"Pothuri","year":"2010","journal-title":"PLoS One"},{"key":"10.1093\/annonc\/mds300_bb0145","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.1002\/cncr.25439","article-title":"The molecular pathogenesis of hereditary ovarian carcinoma: alterations in the tubal epithelium of women with BRCA1 and BRCA2 mutations","volume":"116","author":"Norquist","year":"2010","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mds300_bb0150","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1097\/01.AOG.0000227787.24587.d1","article-title":"Clinical behavior of stage II-IV low-grade serous carcinoma of the ovary","volume":"108","author":"Gershenson","year":"2006","journal-title":"Obstet Gynecol"},{"key":"10.1093\/annonc\/mds300_bb0155","doi-asserted-by":"crossref","first-page":"e232","DOI":"10.1371\/journal.pmed.0050232","article-title":"Ovarian carcinoma subtypes are different diseases: implications for biomarker studies","volume":"5","author":"K\u00f6bel","year":"2008","journal-title":"PLoS Med"},{"key":"10.1093\/annonc\/mds300_bb0160","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/path.3967","article-title":"Low-grade serous carcinomas of the ovary contain very few point mutations","volume":"226","author":"Jones","year":"2012","journal-title":"J Pathol"},{"key":"10.1093\/annonc\/mds300_bb0165","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/00000478-200202000-00001","article-title":"Mucinous tumors of the ovary. A clinicopathologic analysis of 75 borderline tumors (of intestinal type) and carcinomas","volume":"26","author":"Rodriguez","year":"2002","journal-title":"Am J Surg Pathol"},{"key":"10.1093\/annonc\/mds300_bb0170","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1097\/00000478-200011000-00001","article-title":"Mucinous tumors of the ovary. A clinicopathologic study of 196 borderline tumors (of intestinal type) and carcinomas, including an evaluation of 11 cases with \u201cpseudomyxomaperitonei\u201d","volume":"24","author":"Lee","year":"2000","journal-title":"Am J Surg Pathol"},{"key":"10.1093\/annonc\/mds300_bb0175","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.humpath.2004.03.003","article-title":"Borderline ovarian tumors: key points and workshop summary","volume":"35","author":"Silverberg","year":"2004","journal-title":"Hum Pathol"},{"key":"10.1093\/annonc\/mds300_bb0180","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/sj.bjc.6603003","article-title":"A distinct molecular profile associated with mucinous epithelial ovarian cancer","volume":"94","author":"Heinzelmann-Schwarz","year":"2006","journal-title":"Br J Cancer"},{"key":"10.1093\/annonc\/mds300_bb0185","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1002\/(SICI)1097-0142(19970415)79:8<1581::AID-CNCR21>3.0.CO;2-T","article-title":"K-ras mutations in mucinous ovarian tumors. A clinicopathologic and molecular study of 95 cases","volume":"79","author":"Cuatrecasas","year":"1997","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mds300_bb0190","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1053\/hupa.2002.129422","article-title":"Expression of cytokeratins 7 and 20 in primary carcinomas of the stomach and colorectum and their value in the differential diagnosis of metastatic carcinomas to the ovary","volume":"33","author":"Park","year":"2002","journal-title":"Hum Pathol"},{"key":"10.1093\/annonc\/mds300_bb0195","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.humpath.2005.03.005","article-title":"Synchronous endometrioid carcinomas of the uterine corpus and ovary: Alterations in the beta-catenin (CTNNB1) pathway are associated with independent primary tumors and favorable prognosis","volume":"36","author":"Irving","year":"2005","journal-title":"Hum Pathol"},{"key":"10.1093\/annonc\/mds300_bb0200","doi-asserted-by":"crossref","first-page":"5198","DOI":"10.1158\/1078-0432.CCR-08-0196","article-title":"Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome","volume":"14","author":"Tothill","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.1093\/annonc\/mds300_bb0205","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1006\/gyno.1996.0032","article-title":"Histologic transformation of benign endometriosis to early epithelial ovarian cancer","volume":"60","author":"Sainz de la Cuesta","year":"1996","journal-title":"Gynecol Oncol"},{"key":"10.1093\/annonc\/mds300_bb0210","first-page":"1707","article-title":"Allelotyping of endometriosis with adjacent ovarian carcinoma reveals evidence of a common lineage","volume":"58","author":"Jiang","year":"1998","journal-title":"Cancer Res"},{"key":"10.1093\/annonc\/mds300_bb0215","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1056\/NEJMoa1008433","article-title":"ARID1A mutations in endometriosis-associated ovarian carcinomas","volume":"363","author":"Wiegand","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1093\/annonc\/mds300_bb0220","first-page":"1344","article-title":"Mutations in the beta-catenin gene (CTNNB1) in endometrioid ovarian carcinomas","volume":"58","author":"Palacios","year":"1998","journal-title":"Cancer Res"},{"key":"10.1093\/annonc\/mds300_bb0225","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.humpath.2004.07.019","article-title":"Molecular genetic alterations in endometrioid carcinomas of the ovary: Similar frequency of beta-catenin abnormalities but lower rate of microsatellite instability and PTEN alterations than in uterine endometrioid carcinomas","volume":"35","author":"Catas\u00fas","year":"2004","journal-title":"Hum Pathol"},{"key":"10.1093\/annonc\/mds300_bb0230","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0002-9440(10)65148-6","article-title":"Beta-catenin expression pattern in stage I and II ovarian carcinomas: relationship withbeta-catenin gene mutations, clinicopathological features, and clinical outcome","volume":"155","author":"Gamallo","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1093\/annonc\/mds300_bb0235","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1002\/1097-0142(20011201)92:11<2829::AID-CNCR10094>3.0.CO;2-3","article-title":"Microsatellite instability, MLH-1 promoter hypermethylation, and frameshift mutations at coding mononucleotide repeat microsatellites in ovarian tumors","volume":"92","author":"Gras","year":"2001","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mds300_bb0240","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1097\/00019606-200106000-00008","article-title":"Beta-catenin expression pattern, beta-catenin gene mutations, and microsatellite instability in endometrioid ovarian carcinomas and synchronous endometrial carcinomas","volume":"10","author":"Moreno-Bueno","year":"2001","journal-title":"Diagn Mol Pathol"},{"key":"10.1093\/annonc\/mds300_bb0245","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1002\/1097-0142(20000601)88:11<2584::AID-CNCR22>3.0.CO;2-5","article-title":"Clinical characteristics of clear cell carcinoma of the ovary: a distinct histologic type with poor prognosis and resistance to platinum based chemotherapy","volume":"88","author":"Sugiyama","year":"2000","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mds300_bb0250","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1006\/gyno.1998.5284","article-title":"Prognosis of Japanese patients with ovarian clear cell carcinoma associated with pelvic endometriosis: clinicopathologic evaluation","volume":"72","author":"Komiyama","year":"1999","journal-title":"Gynecol Oncol"},{"key":"10.1093\/annonc\/mds300_bb0255","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-2407-8-17","article-title":"Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities","volume":"8","author":"Press","year":"2008","journal-title":"BMC Cancer"},{"key":"10.1093\/annonc\/mds300_bb0260","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/modpathol.3800492","article-title":"Expression of hepatocyte nuclear factor-1beta (HNF-1beta) in clear cell tumors and endometriosis of the ovary","volume":"19","author":"Kato","year":"2006","journal-title":"Mod Pathol"},{"key":"10.1093\/annonc\/mds300_bb0265","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/IGC.0b013e3181a19eca","article-title":"The role of hepatocyte nuclear factor-1beta in the pathogenesis of clear cell carcinoma of the ovary","volume":"19","author":"Kobayashi","year":"2009","journal-title":"Int J Gynecol Cancer"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419417535?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419417535?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/23\/suppl_10\/x111\/6674285\/mds300.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T13:30:55Z","timestamp":1582205455000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923753419417535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":52,"alternative-id":["S0923753419417535"],"URL":"https:\/\/doi.org\/10.1093\/annonc\/mds300","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}