{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:35:53Z","timestamp":1783470953621,"version":"3.55.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"vor","delay-in-days":2320,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"ERAWEB"},{"name":"European Community"},{"name":"Fondazione Veronesi"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1093\/annonc\/mdt184","type":"journal-article","created":{"date-parts":[[2013,5,16]],"date-time":"2013-05-16T02:13:20Z","timestamp":1368670400000},"page":"1907-1911","source":"Crossref","is-referenced-by-count":50,"title":["Prevalence and risk factors of extrapancreatic malignancies in a large cohort of patients with intraductal papillary mucinous neoplasm (IPMN) of the pancreas"],"prefix":"10.1016","volume":"24","author":[{"given":"A.","family":"Larghi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Panic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Capurso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Leoncini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Arzani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Salvia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Del Chiaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Frulloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.G.","family":"Arcidiacono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Zerbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Manta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Fabbri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ventrucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Tarantino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Piciucchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Carnuccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Boggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Costamagna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Delle Fave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Pezzilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bulajic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Ricciardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Boccia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/annonc\/mdt184_bb0010","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00428-007-0512-6","article-title":"Pancreatic intraductal papillary-mucinous neoplasms: a new and evolving entity","volume":"451","author":"Andrejevic-Blant","year":"2007","journal-title":"Virchows Arch"},{"key":"10.1093\/annonc\/mdt184_bb0015","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1002\/1097-0142(19890915)64:6<1329::AID-CNCR2820640627>3.0.CO;2-S","article-title":"Intraductal papillary neoplasms of the pancreas. A clinicopathologic study of six patients","volume":"64","author":"Morohoshi","year":"1989","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdt184_bb0020","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1097\/mpa.0b013e31806da090","article-title":"Characteristic clinicopathological features of the types of intraductal papillary-mucinous neoplasms of the pancreas","volume":"35","author":"Ishida","year":"2007","journal-title":"Pancreas"},{"key":"10.1093\/annonc\/mdt184_bb0025","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000090023","article-title":"International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas","volume":"6","author":"Tanaka","year":"2006","journal-title":"Pancreatology"},{"key":"10.1093\/annonc\/mdt184_bb0030","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1097\/SLA.0b013e3181a189a8","article-title":"Intraductal papillary mucinous neoplasms of the pancreas: differentiation of malignant and benign tumors by endoscopic ultrasound findings of mural nodules","volume":"249","author":"Ohno","year":"2009","journal-title":"Ann Surg"},{"key":"10.1093\/annonc\/mdt184_bb0035","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.pan.2012.04.004","article-title":"International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas","volume":"12","author":"Tanaka","year":"2012","journal-title":"Pancreatology"},{"key":"10.1093\/annonc\/mdt184_bb0040","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.cgh.2006.01.018","article-title":"Natural history of intraductal papillary mucinous tumors of the pancreas: actuarial risk of malignancy","volume":"4","author":"Levy","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1093\/annonc\/mdt184_bb0045","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.pan.2012.03.056","article-title":"The long term risk of malignancy in patients with branch duct intraductal papillary mucinous neoplasms of the pancreas","volume":"12","author":"Khannoussi","year":"2012","journal-title":"Pancreatology"},{"key":"10.1093\/annonc\/mdt184_bb0050","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1097\/01.sla.0000128306.90650.aa","article-title":"Intraductal papillary mucinous neoplasms of the pancreas: an updated experience","volume":"239","author":"Sohn","year":"2004","journal-title":"Ann Surg"},{"key":"10.1093\/annonc\/mdt184_bb0055","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cgh.2011.12.029","article-title":"The clinical relevance of the increasing incidence of intraductal papillary mucinous neoplasm","volume":"10","author":"Klibansky","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1093\/annonc\/mdt184_bb0060","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.gastrohep.2010.07.001","article-title":"Incidence and characteristics of pancreatic cystic neoplasms","volume":"33","author":"Adet","year":"2010","journal-title":"Gastroenterol Hepatol"},{"key":"10.1093\/annonc\/mdt184_bb0065","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1159\/000064716","article-title":"Intraductal papillary-mucinous tumor of the pancreas concomitant with ductal carcinoma of the pancreas","volume":"2","author":"Yamaguchi","year":"2002","journal-title":"Pancreatology"},{"key":"10.1093\/annonc\/mdt184_bb0070","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.1572-0241.1999.879_h.x","article-title":"Extrapancreatic neoplasms occur with unusual frequency in patients with intraductal papillary mucinous tumors of the pancreas","volume":"94","author":"Sugiyama","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1093\/annonc\/mdt184_bb0075","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1001\/archsurg.141.1.51","article-title":"High incidence of extrapancreatic neoplasms in patients with intraductal papillary mucinous neoplasms","volume":"141","author":"Choi","year":"2006","journal-title":"Arch Surg"},{"key":"10.1093\/annonc\/mdt184_bb0080","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.surg.2005.11.008","article-title":"Patients with pancreatic intraductal papillary mucinous neoplasms are at high risk of colorectal cancer development","volume":"139","author":"Eguchi","year":"2006","journal-title":"Surgery"},{"key":"10.1093\/annonc\/mdt184_bb0085","first-page":"162","article-title":"[Extrapancreatic tumors in intraductal papillary mucinous neoplasm of the pancreas] Korean","volume":"54","author":"Oh","year":"2009","journal-title":"J Gastroenterol"},{"key":"10.1093\/annonc\/mdt184_bb0090","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1245\/s10434-008-0143-4","article-title":"Extrapancreatic malignancies in patients with intraductal papillary mucinous neoplasm of the pancreas: prevalence, associated factors, and comparison with patients with other pancreatic cystic neoplasms","volume":"15","author":"Yoon","year":"2008","journal-title":"Ann Surg Oncol"},{"key":"10.1093\/annonc\/mdt184_bb0095","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.jamcollsurg.2007.01.015","article-title":"Incidence of additional primary cancers in patients with invasive intraductal papillary mucinous neoplasms and sporadic pancreatic adenocarcinomas","volume":"204","author":"Riall","year":"2007","journal-title":"J Am Coll Surg"},{"key":"10.1093\/annonc\/mdt184_bb0100","doi-asserted-by":"crossref","first-page":"5688","DOI":"10.3748\/wjg.v11.i36.5688","article-title":"Malignancies associated with intraductal papillary mucinous neoplasm of the pancreas","volume":"11","author":"Kamisawa","year":"2005","journal-title":"World J Gastroenterol"},{"key":"10.1093\/annonc\/mdt184_bb0105","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/SLA.0b013e3181b5ad1e","article-title":"Frequency of extrapancreatic neoplasms in intraductal papillary mucinous neoplasm of the pancreas: implications for management","volume":"251","author":"Reid-Lombardo","year":"2010","journal-title":"Ann Surg"},{"key":"10.1093\/annonc\/mdt184_bb0110","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1111\/j.1572-0241.2008.02142.x","article-title":"Prevalence of extrapancreatic cancers in patients with histologically proven intraductal papillary mucinous neoplasms of the pancreas: a case\u2013control study","volume":"103","author":"Baumgaertner","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1093\/annonc\/mdt184_bb0115","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1159\/000159844","article-title":"Synchronous and metachronous extrapancreatic malignant neoplasms in patients with intraductal papillary-mucinous neoplasm of the pancreas","volume":"8","author":"Ishida","year":"2008","journal-title":"Pancreatology"},{"key":"10.1093\/annonc\/mdt184_bb0120","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.surg.2011.06.036","article-title":"Intraductal papillary mucinous neoplasm of the pancreas: associated cancers, family history, genetic predisposition?","volume":"151","author":"Lubezky","year":"2012","journal-title":"Surgery"},{"key":"10.1093\/annonc\/mdt184_bb0125","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1136\/gut.2010.227306","article-title":"Incidence of extrapancreatic malignancies in patients with intraductal papillary mucinous neoplasms of the pancreas","volume":"60","author":"Kawakubo","year":"2011","journal-title":"Gut"},{"key":"10.1093\/annonc\/mdt184_bb0130","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/01.mpa.0000202939.40213.fd","article-title":"High expression of intestinal-type mucin (MUC2) in intraductal papillary mucinous neoplasms coexisting with extrapancreatic gastrointestinal cancers","volume":"32","author":"Lee","year":"2006","journal-title":"Pancreas"},{"key":"10.1093\/annonc\/mdt184_bb0135","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1136\/gut.51.3.446","article-title":"Intraductal papillary and mucinous pancreatic tumour: a new extracolonic tumour in familial adenomatous polyposis","volume":"51","author":"Maire","year":"2002","journal-title":"Gut"},{"key":"10.1093\/annonc\/mdt184_bb0140","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1097\/01.sla.0000124386.54496.15","article-title":"Main-duct intraductal papillary mucinous neoplasms of the pancreas: clinical predictors of malignancy and long-term survival following resection","volume":"239","author":"Salvia","year":"2004","journal-title":"Ann Surg"},{"key":"10.1093\/annonc\/mdt184_bb0145","doi-asserted-by":"crossref","DOI":"10.1038\/ajg.2013.42","article-title":"Risk factors for intraductal papillary mucinous neoplasm (IPMN) of the pancreas: results of a multicentre case-control study promoted by AISP (Italian Association for the study of the Pancreas)","author":"Capurso","year":"2013","journal-title":"Amer J Gastr"},{"key":"10.1093\/annonc\/mdt184_bb0150","series-title":"Statistical Methods in Cancer Research. Volume II \u2013 The Design and Analysis of Cohort Studies","author":"Breslow","year":"1987"},{"key":"10.1093\/annonc\/mdt184_bb0155","first-page":"1","article-title":"[Italian cancer figures, report 2011: survival of cancer patients in Italy]","volume":"35","author":"AIRTUM Working Group","year":"2011","journal-title":"Epidemiol Prev"},{"key":"10.1093\/annonc\/mdt184_bb0160","doi-asserted-by":"crossref","first-page":"7737","DOI":"10.1158\/1078-0432.CCR-09-0004","article-title":"Increased prevalence of precursor lesions in familial pancreatic cancer patients","volume":"15","author":"Shi","year":"2009","journal-title":"Clin Can Res"},{"key":"10.1093\/annonc\/mdt184_bb0165","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1158\/0008-5472.CAN-03-3823","article-title":"Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds","volume":"64","author":"Klein","year":"2004","journal-title":"Cancer Res"},{"key":"10.1093\/annonc\/mdt184_bb0170","series-title":"Cancer Mortality Database","author":"World Health Organization (WHO)","year":"2011"},{"key":"10.1093\/annonc\/mdt184_bb0175","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1463-1318.2012.03108.x","article-title":"Impact of family history of gastric cancer on colorectal neoplasias in young Japanese","volume":"15","author":"Hata","year":"2013","journal-title":"Colorectal Dis"},{"key":"10.1093\/annonc\/mdt184_bb0180","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1111\/j.1572-0241.2001.04677.x","article-title":"A systematic review and meta-analysis of familial colorectal cancer risk","volume":"96","author":"Johns","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"10.1093\/annonc\/mdt184_bb0185","first-page":"3","article-title":"International Agency for Research on Cancer","volume":"96","author":"World Health Organization","year":"2010"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419366736?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419366736?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/24\/7\/1907\/13789837\/mdt184.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T07:39:40Z","timestamp":1624693180000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923753419366736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S0923753419366736"],"URL":"https:\/\/doi.org\/10.1093\/annonc\/mdt184","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]}}}