{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:08:50Z","timestamp":1791295730165,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T00:00:00Z","timestamp":1572912000000},"content-version":"vor","delay-in-days":1769,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1093\/annonc\/mdu225","type":"journal-article","created":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T01:44:24Z","timestamp":1407289464000},"page":"47-57","source":"Crossref","is-referenced-by-count":305,"title":["Estimates of benefits and harms of prophylactic use of aspirin in the general population"],"prefix":"10.1016","volume":"26","author":[{"given":"J.","family":"Cuzick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Thorat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bosetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.H.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Burn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.R.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.G.","family":"Ford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.J.","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.A.","family":"Jankowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"La Vecchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Law","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Meyskens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.M.","family":"Rothwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.J.","family":"Senn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Umar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/annonc\/mdu225_bb0010","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/S0140-6736(09)60503-1","article-title":"Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials","volume":"373","author":"Baigent","year":"2009","journal-title":"Lancet"},{"key":"10.1093\/annonc\/mdu225_bb0015","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0140-6736(10)62110-1","article-title":"Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials","volume":"377","author":"Rothwell","year":"2011","journal-title":"Lancet"},{"key":"10.1093\/annonc\/mdu225_bb0020","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/S0140-6736(11)61720-0","article-title":"Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials","volume":"379","author":"Rothwell","year":"2012","journal-title":"Lancet"},{"key":"10.1093\/annonc\/mdu225_bb0025","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/S0140-6736(10)61543-7","article-title":"Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials","volume":"376","author":"Rothwell","year":"2010","journal-title":"Lancet"},{"key":"10.1093\/annonc\/mdu225_bb0030","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/S0140-6736(12)60209-8","article-title":"Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials","volume":"379","author":"Rothwell","year":"2012","journal-title":"Lancet"},{"key":"10.1093\/annonc\/mdu225_bb0035","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/S1470-2045(12)70112-2","article-title":"Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials","volume":"13","author":"Algra","year":"2012","journal-title":"Lancet Oncol"},{"key":"10.1093\/annonc\/mdu225_bb0040","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1093\/annonc\/mds113","article-title":"Aspirin and cancer risk: a quantitative review to 2011","volume":"23","author":"Bosetti","year":"2012","journal-title":"Ann Oncol"},{"key":"10.1093\/annonc\/mdu225_bb0045","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1056\/NEJMra052717","article-title":"Low-dose aspirin for the prevention of atherothrombosis","volume":"353","author":"Patrono","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1093\/annonc\/mdu225_bb0050","doi-asserted-by":"crossref","first-page":"361","DOI":"10.7326\/0003-4819-146-5-200703060-00008","article-title":"Routine aspirin or nonsteroidal anti-inflammatory drugs for the primary prevention of colorectal cancer: U.S. Preventive Services Task Force recommendation statement","volume":"146","author":"USPSTF","year":"2007","journal-title":"Ann Intern Med"},{"key":"10.1093\/annonc\/mdu225_bb0055","doi-asserted-by":"crossref","first-page":"396","DOI":"10.7326\/0003-4819-150-6-200903170-00008","article-title":"Aspirin for the prevention of cardiovascular disease: U.S. Preventive Services Task Force recommendation statement","volume":"150","author":"USPSTF","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1093\/annonc\/mdu225_bb0060","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1007\/s11606-013-2465-6","article-title":"Effect of including cancer mortality on the cost-effectiveness of aspirin for primary prevention in men","volume":"28","author":"Pignone","year":"2013","journal-title":"J Gen Intern Med"},{"key":"10.1093\/annonc\/mdu225_bb0065","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S1470-2045(09)70035-X","article-title":"Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement","volume":"10","author":"Cuzick","year":"2009","journal-title":"Lancet Oncol"},{"key":"10.1093\/annonc\/mdu225_bb0070","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/S0140-6736(07)60747-8","article-title":"Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies","volume":"369","author":"Flossmann","year":"2007","journal-title":"Lancet"},{"key":"10.1093\/annonc\/mdu225_bb0075","doi-asserted-by":"crossref","first-page":"77","DOI":"10.7326\/0003-4819-159-2-201307160-00002","article-title":"Alternate-day, low-dose aspirin and cancer risk: long-term observational follow-up of a randomized trial","volume":"159","author":"Cook","year":"2013","journal-title":"Ann Intern Med"},{"key":"10.1093\/annonc\/mdu225_bb0080","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1093\/jnci\/djs318","article-title":"Daily aspirin use and cancer mortality in a large US cohort","volume":"104","author":"Jacobs","year":"2012","journal-title":"J Natl Cancer Inst"},{"key":"10.1093\/annonc\/mdu225_bb0085","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1001\/archinte.167.6.562","article-title":"Long-term aspirin use and mortality in women","volume":"167","author":"Chan","year":"2007","journal-title":"Arch Intern Med"},{"key":"10.1093\/annonc\/mdu225_bb0090","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1001\/jama.294.1.47","article-title":"Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial","volume":"294","author":"Cook","year":"2005","journal-title":"JAMA"},{"key":"10.1093\/annonc\/mdu225_bb0095","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1002\/ijc.25811","article-title":"Long-term aspirin use and the risk of total, high-grade, regionally advanced and lethal prostate cancer in a prospective cohort of health professionals, 1988\u20132006","volume":"128","author":"Dhillon","year":"2011","journal-title":"Int J Cancer"},{"key":"10.1093\/annonc\/mdu225_bb0100","series-title":"CancerStats\u2014Cancer Statistics for the UK","author":"Cancer Research UK","year":"2011"},{"key":"10.1093\/annonc\/mdu225_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta7310","article-title":"Lowering blood pressure to prevent myocardial infarction and stroke: a new preventive strategy","volume":"7","author":"Law","year":"2003","journal-title":"Health Technol Assess"},{"key":"10.1093\/annonc\/mdu225_bb0110","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1056\/NEJMoa0908610","article-title":"Population trends in the incidence and outcomes of acute myocardial infarction","volume":"362","author":"Yeh","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1093\/annonc\/mdu225_bb0115","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1161\/CIR.0b013e3182456d46","article-title":"Executive summary: heart disease and stroke statistics\u20132012 update: a report from the American Heart Association","volume":"125","author":"Roger","year":"2012","journal-title":"Circulation"},{"key":"10.1093\/annonc\/mdu225_bb0120","unstructured":"Thorat MA, Cuzick J. Prophylactic use of aspirin: systematic review of harms and approaches to mitigation in the general population. (Manuscript submitted)."},{"key":"10.1093\/annonc\/mdu225_bb0125","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1053\/j.gastro.2007.09.035","article-title":"Aspirin dose and duration of use and risk of colorectal cancer in men","volume":"134","author":"Chan","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1093\/annonc\/mdu225_bb0130","first-page":"3177","article-title":"Aspirin use and mortality from cancer in a prospective cohort study","volume":"24","author":"Ratnasinghe","year":"2004","journal-title":"Anticancer Res"},{"key":"10.1093\/annonc\/mdu225_bb0135","first-page":"1322","article-title":"Aspirin use and risk of fatal cancer","volume":"53","author":"Thun","year":"1993","journal-title":"Cancer Res"},{"key":"10.1093\/annonc\/mdu225_bb0140","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1093\/jnci\/djh084","article-title":"Aspirin use and pancreatic cancer mortality in a large United States cohort","volume":"96","author":"Jacobs","year":"2004","journal-title":"J Natl Cancer Inst"},{"key":"10.1093\/annonc\/mdu225_bb0145","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1093\/jnci\/85.15.1220","article-title":"Low-dose aspirin and incidence of colorectal tumors in a randomized trial","volume":"85","author":"Gann","year":"1993","journal-title":"J Natl Cancer Inst"},{"key":"10.1093\/annonc\/mdu225_bb0150","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1001\/jama.2009.1112","article-title":"Aspirin use and survival after diagnosis of colorectal cancer","volume":"302","author":"Chan","year":"2009","journal-title":"JAMA"},{"key":"10.1093\/annonc\/mdu225_bb0155","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1200\/JCO.2009.22.7918","article-title":"Aspirin intake and survival after breast cancer","volume":"28","author":"Holmes","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdu225_bb0160","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/S0140-6736(11)61049-0","article-title":"Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial","volume":"378","author":"Burn","year":"2011","journal-title":"Lancet"},{"key":"10.1093\/annonc\/mdu225_bb0165","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1056\/NEJMoa0801297","article-title":"Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome","volume":"359","author":"Burn","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1093\/annonc\/mdu225_bb0170","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/sj.bjc.6600760","article-title":"A population-based cohort study of the risk of colorectal and other cancers among users of low-dose aspirin","volume":"88","author":"Friis","year":"2003","journal-title":"Br J Cancer"},{"key":"10.1093\/annonc\/mdu225_bb0175","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1056\/NEJMoa021735","article-title":"A randomized trial of aspirin to prevent colorectal adenomas","volume":"348","author":"Baron","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1093\/annonc\/mdu225_bb0180","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/jnci\/djn485","article-title":"Aspirin for the chemoprevention of colorectal adenomas: meta-analysis of the randomized trials","volume":"101","author":"Cole","year":"2009","journal-title":"J Natl Cancer Inst"},{"key":"10.1093\/annonc\/mdu225_bb0185","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1056\/NEJM198907203210301","article-title":"Final report on the aspirin component of the ongoing Physicians' Health Study","volume":"321","author":"Steering Committee of the Physicians' Health Study Research Group","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1093\/annonc\/mdu225_bb0190","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0140-6736(12)60367-5","article-title":"The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials","volume":"380","author":"Mihaylova","year":"2012","journal-title":"Lancet"},{"key":"10.1093\/annonc\/mdu225_bb0195","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1161\/CIRCULATIONAHA.107.735340","article-title":"Cost-effectiveness of aspirin treatment in the primary prevention of cardiovascular disease events in subgroups based on age, gender, and varying cardiovascular risk","volume":"117","author":"Greving","year":"2008","journal-title":"Circulation"},{"key":"10.1093\/annonc\/mdu225_bb0200","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1001\/archinternmed.2010.525","article-title":"Cost-utility of aspirin and proton pump inhibitors for primary prevention","volume":"171","author":"Earnshaw","year":"2011","journal-title":"Arch Intern Med"},{"key":"10.1093\/annonc\/mdu225_bb0205","doi-asserted-by":"crossref","first-page":"326","DOI":"10.7326\/0003-4819-144-5-200603070-00007","article-title":"Aspirin, statins, or both drugs for the primary prevention of coronary heart disease events in men: a cost-utility analysis","volume":"144","author":"Pignone","year":"2006","journal-title":"Ann Intern Med"},{"key":"10.1093\/annonc\/mdu225_bb0210","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.amjmed.2012.01.017","article-title":"Low-dose aspirin and cancer mortality: a meta-analysis of randomized trials","volume":"125","author":"Mills","year":"2012","journal-title":"Am J Med"},{"key":"10.1093\/annonc\/mdu225_bb0215","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1111\/j.1572-0241.1999.01517.x","article-title":"The risk of acute major upper gastrointestinal bleeding among users of aspirin and ibuprofen at various levels of alcohol consumption","volume":"94","author":"Kaufman","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1093\/annonc\/mdu225_bb0220","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0140-6736(02)07273-2","article-title":"Role of Helicobacter pylori infection and non-steroidal anti-inflammatory drugs in peptic-ulcer disease: a meta-analysis","volume":"359","author":"Huang","year":"2002","journal-title":"Lancet"},{"key":"10.1093\/annonc\/mdu225_bb0225","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.cgh.2005.10.006","article-title":"Effects of Helicobacter pylori and nonsteroidal anti-inflammatory drugs on peptic ulcer disease: a systematic review","volume":"4","author":"Papatheodoridis","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1093\/annonc\/mdu225_bb0230","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/S0140-6736(97)04523-6","article-title":"Randomised trial of eradication of Helicobacter pylori before non-steroidal anti-inflammatory drug therapy to prevent peptic ulcers","volume":"350","author":"Chan","year":"1997","journal-title":"Lancet"},{"key":"10.1093\/annonc\/mdu225_bb0235","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0140-6736(02)07272-0","article-title":"Eradication of Helicobacter pylori and risk of peptic ulcers in patients starting long-term treatment with non-steroidal anti-inflammatory drugs: a randomised trial","volume":"359","author":"Chan","year":"2002","journal-title":"Lancet"},{"key":"10.1093\/annonc\/mdu225_bb0240","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0140-6736(96)01501-2","article-title":"Modelling cost-effectiveness of Helicobacter pylori screening to prevent gastric cancer: a mandate for clinical trials","volume":"348","author":"Parsonnet","year":"1996","journal-title":"Lancet"},{"key":"10.1093\/annonc\/mdu225_bb0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta7060","article-title":"The cost-effectiveness of screening for Helicobacter pylori to reduce mortality and morbidity from gastric cancer and peptic ulcer disease: a discrete-event simulation model","volume":"7","author":"Roderick","year":"2003","journal-title":"Health Technol Assess"},{"key":"10.1093\/annonc\/mdu225_bb0250","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.cgh.2011.05.020","article-title":"Low doses of acetylsalicylic acid increase risk of gastrointestinal bleeding in a meta-analysis","volume":"9","author":"Lanas","year":"2011","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1093\/annonc\/mdu225_bb0255","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1093\/jnci\/djh171","article-title":"Re: cost-effectiveness of aspirin chemoprevention for Barrett's esophagus","volume":"96","author":"Jankowski","year":"2004","journal-title":"J Natl Cancer Inst"},{"key":"10.1093\/annonc\/mdu225_bb0260","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1111\/j.1365-2036.2009.04131.x","article-title":"Uncomplicated peptic ulcer in the UK: trends from 1997 to 2005","volume":"30","author":"Cai","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1093\/annonc\/mdu225_bb0265","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1136\/bmj.331.7528.1310","article-title":"Risk of adverse gastrointestinal outcomes in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis","volume":"331","author":"Hippisley-Cox","year":"2005","journal-title":"BMJ"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419313146?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419313146?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T03:39:19Z","timestamp":1624505959000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923753419313146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S0923753419313146"],"URL":"https:\/\/doi.org\/10.1093\/annonc\/mdu225","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718521764.793509589","asserted-by":"object"}]},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]}}}