{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:47:42Z","timestamp":1793317662318,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"vor","delay-in-days":1651,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1093\/annonc\/mdv062","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T04:45:22Z","timestamp":1423802722000},"page":"1019-1025","source":"Crossref","is-referenced-by-count":99,"title":["Molecular phenotypes of DCIS predict overall and invasive recurrence"],"prefix":"10.1016","volume":"26","author":[{"given":"K.E.","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.L.P.","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Cheema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Howe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.J.","family":"Bundred","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/annonc\/mdv062_bb0010","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1002\/1097-0142(19951001)76:7<1197::AID-CNCR2820760715>3.0.CO;2-0","article-title":"Continued local recurrence of carcinoma 15\u201325 years after a diagnosis of low grade ductal carcinoma in situ of the breast treated only by biopsy","volume":"76","author":"Page","year":"1995","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdv062_bb0015","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1002\/cncr.20979","article-title":"Outcome of patients with ductal carcinoma in situ untreated after diagnostic biopsy: results from the Nurses' Health Study","volume":"103","author":"Collins","year":"2005","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdv062_bb0020","first-page":"223","article-title":"Long-term follow-up of in situ carcinoma of the breast","volume":"11","author":"Eusebi","year":"1994","journal-title":"Semin Diagn Pathol"},{"key":"10.1093\/annonc\/mdv062_bb0025","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1200\/JCO.1998.16.2.441","article-title":"Lumpectomy and radiation therapy for the treatment of intraductal breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-17","volume":"16","author":"Fisher","year":"1998","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdv062_bb0030","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/S0140-6736(99)06341-2","article-title":"EORTC Breast Cancer Cooperative Group and EORTC Radiotherapy Group","volume":"355","author":"Julien","year":"2000","journal-title":"Lancet"},{"key":"10.1093\/annonc\/mdv062_bb0035","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S0959-8049(02)00666-4","article-title":"Biological markers that predict clinical recurrence in ductal carcinoma in situ of the breast","volume":"39","author":"Provenzano","year":"2003","journal-title":"Eur J Cancer"},{"key":"10.1093\/annonc\/mdv062_bb0040","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1200\/JCO.2010.34.0141","article-title":"Adjuvant tamoxifen reduces subsequent breast cancer in women with estrogen receptor-positive ductal carcinoma in situ: a study based on NSABP protocol B-24","volume":"30","author":"Allred","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdv062_bb0045","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/jnci\/djh069","article-title":"Trends in the treatment of ductal carcinoma in situ of the breast","volume":"96","author":"Baxter","year":"2004","journal-title":"J Natl Cancer Inst"},{"key":"10.1093\/annonc\/mdv062_bb0050","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/sj.bjc.6603945","article-title":"Radiotherapy following breast-conserving surgery for screen-detected ductal carcinoma in situ: indications and utilisation in the UK. Interim findings from the Sloane Project","volume":"97","author":"Dodwell","year":"2007","journal-title":"Br J Cancer"},{"key":"10.1093\/annonc\/mdv062_bb0055","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1093\/jnci\/djr027","article-title":"Long-term outcomes of invasive ipsilateral breast tumor recurrences after lumpectomy in NSABP B-17 and B-24 randomized clinical trials for DCIS","volume":"103","author":"Wapnir","year":"2011","journal-title":"J Natl Cancer Inst"},{"key":"10.1093\/annonc\/mdv062_bb0060","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S1470-2045(10)70266-7","article-title":"Effect of tamoxifen and radiotherapy in women with locally excised ductal carcinoma in situ: long-term results from the UK\/ANZ DCIS trial","volume":"12","author":"Cuzick","year":"2010","journal-title":"Lancet Oncol"},{"key":"10.1093\/annonc\/mdv062_bb0065","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1016\/S0959-8049(01)00165-4","article-title":"Cell biological factors in ductal carcinoma in situ (DCIS) of the breast-relationship to ipsilateral local recurrence and histopathological characteristics","volume":"37","author":"Ringberg","year":"2001","journal-title":"Eur J Cancer"},{"key":"10.1093\/annonc\/mdv062_bb0070","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/jnci\/djq101","article-title":"Biomarker expression and risk of subsequent tumors after initial ductal carcinoma in situ diagnosis","volume":"102","author":"Kerlikowske","year":"2010","journal-title":"J Natl Cancer Inst"},{"key":"10.1093\/annonc\/mdv062_bb0075","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/cncr.25399","article-title":"Biologic and immunologic effects of preoperative trastuzumab for ductal carcinoma in situ of the breast","volume":"117","author":"Kuerer","year":"2011","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdv062_bb0080","doi-asserted-by":"crossref","first-page":"232","DOI":"10.7150\/jca.2.232","article-title":"Biological Markers in DCIS and Risk of Breast Recurrence: A Systematic Review","volume":"2","author":"Lari","year":"2011","journal-title":"J Cancer"},{"key":"10.1093\/annonc\/mdv062_bb0085","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1002\/cncr.20260","article-title":"The prognostic significance of multiple morphologic features and biologic markers in ductal carcinoma in situ of the breast: a study of a large cohort of patients treated with surgery alone","volume":"100","author":"Cornfield","year":"2004","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdv062_bb0090","doi-asserted-by":"crossref","first-page":"10869","DOI":"10.1073\/pnas.191367098","article-title":"Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications","volume":"98","author":"Sorlie","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1093\/annonc\/mdv062_bb0095","doi-asserted-by":"crossref","first-page":"R31","DOI":"10.1186\/bcr2261","article-title":"Epidemiology of breast cancer subtypes in two prospective cohort studies of breast cancer survivors","volume":"11","author":"Kwan","year":"2009","journal-title":"Breast Cancer Res"},{"key":"10.1093\/annonc\/mdv062_bb0100","doi-asserted-by":"crossref","first-page":"R67","DOI":"10.1186\/bcr2128","article-title":"Comparison of molecular phenotypes of ductal carcinoma in situ and invasive breast cancer","volume":"10","author":"Tamimi","year":"2008","journal-title":"Breast Cancer Res"},{"key":"10.1093\/annonc\/mdv062_bb0105","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/sj.bjc.6601534","article-title":"COX-2 expression is associated with an aggressive phenotype in ductal carcinoma in situ","volume":"90","author":"Boland","year":"2004","journal-title":"Br J Cancer"},{"key":"10.1093\/annonc\/mdv062_bb0110","unstructured":"NHSBSP. Pathology reporting of breast disease. NHSBSP Publication No. 58, 2005."},{"key":"10.1093\/annonc\/mdv062_bb0115","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/jnci\/djp082","article-title":"Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer","volume":"101","author":"Cheang","year":"2009","journal-title":"J Natl Cancer Inst"},{"key":"10.1093\/annonc\/mdv062_bb0120","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1038\/bjc.2013.147","article-title":"Tailoring treatment for ductal intraepithelial neoplasia of the breast according to Ki-67 and molecular phenotype","volume":"108","author":"Lazzeroni","year":"2013","journal-title":"Br J Cancer"},{"key":"10.1093\/annonc\/mdv062_bb0125","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1158\/0008-5472.SABCS11-S4-6","article-title":"A prospective validation study of the DCIS score from ECOG E5194","volume":"71","author":"Solin","year":"2011","journal-title":"Cancer Res"},{"key":"10.1093\/annonc\/mdv062_bb0130","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/1097-0142(20010101)91:1<9::AID-CNCR2>3.0.CO;2-E","article-title":"Extent of excision margin width required in breast conserving surgery for ductal carcinoma in situ","volume":"91","author":"Chan","year":"2001","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdv062_bb0135","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1158\/1078-0432.CCR-09-1623","article-title":"Cyclooxygenase-2 inhibition does not improve the reduction in ductal carcinoma in situ proliferation with aromatase inhibitor therapy: results of the ERISAC randomized placebo-controlled trial","volume":"16","author":"Bundred","year":"2010","journal-title":"Clin Cancer Res"},{"key":"10.1093\/annonc\/mdv062_bb0140","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1158\/1078-0432.CCR-07-1465","article-title":"Integrated genomic and transcriptomic analysis of ductal carcinoma in situ of the breast","volume":"14","author":"Vincent-Salomon","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.1093\/annonc\/mdv062_bb0145","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/sj.bjc.6606021","article-title":"Molecular subtyping of DCIS: heterogeneity of breast cancer reflected in pre-invasive disease","volume":"104","author":"Clark","year":"2011","journal-title":"Br J Cancer"},{"key":"10.1093\/annonc\/mdv062_bb0150","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1200\/JCO.2001.19.8.2263","article-title":"Risk factors for recurrence and metastasis after breast-conserving therapy for ductal carcinoma-in-situ: analysis of European Organization for Research and Treatment of Cancer Trial 10853","volume":"19","author":"Bijker","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdv062_bb0155","first-page":"362","article-title":"Molecular markers in ductal carcinoma in situ of the breast","volume":"1","author":"Porter","year":"2003","journal-title":"Mol Cancer Res"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419315054?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419315054?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/26\/5\/1019\/10767304\/mdv062.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T15:44:21Z","timestamp":1691250261000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923753419315054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S0923753419315054"],"URL":"https:\/\/doi.org\/10.1093\/annonc\/mdv062","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]}}}