{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:54:15Z","timestamp":1792133655803,"version":"4.4.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"vor","delay-in-days":1528,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000969","name":"American Institute for Cancer Research","doi-asserted-by":"crossref","award":["#09A051"],"award-info":[{"award-number":["#09A051"]}],"id":[{"id":"10.13039\/100000969","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["S10RR027047"],"award-info":[{"award-number":["S10RR027047"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1093\/annonc\/mdv271","type":"journal-article","created":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T01:45:04Z","timestamp":1435283104000},"page":"1960-1966","source":"Crossref","is-referenced-by-count":87,"title":["High anabolic potential of essential amino acid mixtures in advanced nonsmall cell lung cancer"],"prefix":"10.1016","volume":"26","author":[{"given":"M.P.K.J.","family":"Engelen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Safar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Bartter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Koeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.E.P.","family":"Deutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/annonc\/mdv271_bb0010","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/sj.bjc.6600466","article-title":"The systemic inflammatory response, weight loss, performance status and survival in patients with inoperable non-small-cell lung cancer","volume":"87","author":"Scott","year":"2002","journal-title":"Br J Cancer"},{"key":"10.1093\/annonc\/mdv271_bb0015","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/00006199-200311000-00007","article-title":"A cluster of symptoms over time in patients with lung cancer","volume":"52","author":"Gift","year":"2003","journal-title":"Nurs Res"},{"key":"10.1093\/annonc\/mdv271_bb0020","doi-asserted-by":"crossref","first-page":"1133S","DOI":"10.3945\/ajcn.2010.28608C","article-title":"Body composition in patients with non-small cell lung cancer: a contemporary view of cancer cachexia with the use of computed tomography image analysis","volume":"91","author":"Baracos","year":"2010","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/annonc\/mdv271_bb0025","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.clnu.2012.05.003","article-title":"Normal protein anabolic response to hyperaminoacidemia in insulin-resistant patients with lung cancer cachexia","volume":"31","author":"Winter","year":"2012","journal-title":"Clin Nutr"},{"key":"10.1093\/annonc\/mdv271_bb0030","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1139\/apnm-2013-0403","article-title":"The association between body composition and toxicities from the combination of Doxil and trabectedin in patients with advanced relapsed ovarian cancer","volume":"39","author":"Prado","year":"2014","journal-title":"Appl Physiol Nutr Metab"},{"key":"10.1093\/annonc\/mdv271_bb0035","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.clnu.2007.07.004","article-title":"Amino acid metabolism and inflammatory burden in ovarian cancer patients undergoing intense oncological therapy","volume":"26","author":"Dillon","year":"2007","journal-title":"Clin Nutr"},{"key":"10.1093\/annonc\/mdv271_bb0040","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.clnu.2011.05.008","article-title":"Muscle protein synthesis in cancer patients can be stimulated with a specially formulated medical food","volume":"30","author":"Deutz","year":"2011","journal-title":"Clin Nutr"},{"key":"10.1093\/annonc\/mdv271_bb0045","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.3945\/ajcn.113.060228","article-title":"Central tenet of cancer cachexia therapy: do patients with advanced cancer have exploitable anabolic potential?","volume":"98","author":"Prado","year":"2013","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/annonc\/mdv271_bb0050","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/ajcn\/78.2.250","article-title":"Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults","volume":"78","author":"Volpi","year":"2003","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/annonc\/mdv271_bb0055","doi-asserted-by":"crossref","first-page":"E381","DOI":"10.1152\/ajpendo.00488.2005","article-title":"A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly","volume":"291","author":"Katsanos","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1093\/annonc\/mdv271_bb0060","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.jcf.2012.12.011","article-title":"Dietary essential amino acids are highly anabolic in pediatric patients with cystic fibrosis","volume":"12","author":"Engelen","year":"2013","journal-title":"J Cyst Fibros"},{"key":"10.1093\/annonc\/mdv271_bb0065","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.clnu.2013.06.014","article-title":"Hydrolyzed casein and whey protein meals comparably stimulate net whole-body protein synthesis in COPD patients with nutritional depletion without an additional effect of leucine co-ingestion","volume":"33","author":"Jonker","year":"2014","journal-title":"Clin Nutr"},{"key":"10.1093\/annonc\/mdv271_bb0070","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1093\/ajcn\/71.3.733","article-title":"Skeletal muscle weakness is associated with wasting of extremity fat-free mass but not with airflow obstruction in patients with chronic obstructive pulmonary disease","volume":"71","author":"Engelen","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/annonc\/mdv271_bb0075","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/0026-0495(81)90074-3","article-title":"Use of a heated superficial hand vein as an alternative site for the measurement of amino acid concentrations and for the study of glucose and alanine kinetics in man","volume":"30","author":"Abumrad","year":"1981","journal-title":"Metabolism"},{"key":"10.1093\/annonc\/mdv271_bb0080","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.clnu.2014.04.007","article-title":"Protein intake and exercise for optimal muscle function with aging: recommendations from the ESPEN Expert Group","volume":"33","author":"Deutz","year":"2014","journal-title":"Clin Nutr"},{"key":"10.1093\/annonc\/mdv271_bb0085","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/MCO.0b013e328300ecc1","article-title":"Cachexia: prevalence and impact in medicine","volume":"11","author":"Tan","year":"2008","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1093\/annonc\/mdv271_bb0090","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1080\/01635581.2001.9680613","article-title":"Measurement of the systemic inflammatory response predicts cancer-specific and non-cancer survival in patients with cancer","volume":"41","author":"McMillan","year":"2001","journal-title":"Nutr Cancer"},{"key":"10.1093\/annonc\/mdv271_bb0095","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.clnu.2014.03.006","article-title":"Effects of an oral nutritional supplement containing eicosapentaenoic acid on nutritional and clinical outcomes in patients with advanced non-small cell lung cancer: randomised trial","volume":"33","author":"S\u00e1nchez-Lara","year":"2014","journal-title":"Clin Nutr"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419317715?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419317715?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/26\/9\/1960\/16701334\/mdv271.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T07:50:51Z","timestamp":1624521051000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923753419317715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0923753419317715"],"URL":"https:\/\/doi.org\/10.1093\/annonc\/mdv271","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]}}}