{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T05:26:27Z","timestamp":1783661187679,"version":"3.55.0"},"reference-count":15,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T00:00:00Z","timestamp":1573776000000},"content-version":"vor","delay-in-days":1293,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["(1 RO1 CA157823-)1A1"],"award-info":[{"award-number":["(1 RO1 CA157823-)1A1"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["(1 RO1 CA157823-)1A1"],"award-info":[{"award-number":["(1 RO1 CA157823-)1A1"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1093\/annonc\/mdw045","type":"journal-article","created":{"date-parts":[[2016,2,10]],"date-time":"2016-02-10T01:46:00Z","timestamp":1455068760000},"page":"875-879","source":"Crossref","is-referenced-by-count":40,"title":["Prognostic factors in patients with poor-risk germ-cell tumors: a retrospective analysis of the Indiana University experience from 1990 to 2014"],"prefix":"10.1016","volume":"27","author":[{"given":"N.","family":"Adra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.K.","family":"Althouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J.","family":"Brames","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.H.","family":"Hanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.H.","family":"Einhorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Albany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/annonc\/mdw045_bb0010","first-page":"2630","article-title":"Testicular cancer: an oncological success story","volume":"3","author":"Einhorn","year":"1997","journal-title":"Clin Cancer Res"},{"key":"10.1093\/annonc\/mdw045_bb0015","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/01.ju.0000053866.68623.da","article-title":"Increasing incidence of testicular cancer worldwide: a review","volume":"170","author":"Huyghe","year":"2003","journal-title":"J Urol"},{"key":"10.1093\/annonc\/mdw045_bb0020","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nrc1568","article-title":"Testicular germ-cell tumours in a broader perspective","volume":"5","author":"Oosterhuis","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"10.1093\/annonc\/mdw045_bb0025","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1200\/JCO.1997.15.2.594","article-title":"International Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers. International Germ Cell Cancer Collaborative Group","volume":"15","year":"1997","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdw045_bb0030","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1056\/NEJM198706043162302","article-title":"Treatment of disseminated germ-cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide","volume":"316","author":"Williams","year":"1987","journal-title":"N Engl J Med"},{"key":"10.1093\/annonc\/mdw045_bb0035","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1002\/cncr.11271","article-title":"Cisplatin, etoposide and either bleomycin or ifosfamide in the treatment of disseminated germ cell tumors: final analysis of an intergroup trial","volume":"97","author":"Hinton","year":"2003","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdw045_bb0040","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/00000421-199610000-00012","article-title":"A phase II trial of VP-16, ifosfamide, cisplatin, vinblastine, and bleomycin in advanced germ-cell tumors","volume":"19","author":"Blanke","year":"1996","journal-title":"Am J Clin Oncol"},{"key":"10.1093\/annonc\/mdw045_bb0045","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1200\/JCO.2005.05.4528","article-title":"Phase III randomized trial of conventional-dose chemotherapy with or without high-dose chemotherapy and autologous hematopoietic stem-cell rescue as first-line treatment for patients with poor-prognosis metastatic germ cell tumors","volume":"25","author":"Motzer","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdw045_bb0050","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1056\/NEJMoa067749","article-title":"High-dose chemotherapy and stem-cell rescue for metastatic germ-cell tumors","volume":"357","author":"Einhorn","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1093\/annonc\/mdw045_bb0055","first-page":"4533","article-title":"Germ cell cancer (GCC): long-term survival after treatment with bleomycin (B), etoposide (E), and cisplatin (P) in a large cohort","volume":"31","author":"Gundgaard","year":"2013","journal-title":"ASCO Meeting Abstracts"},{"key":"10.1093\/annonc\/mdw045_bb0060","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1200\/JCO.2010.29.1278","article-title":"Population-based study of treatment guided by tumor marker decline in patients with metastatic nonseminomatous germ cell tumor: a report from the Swedish-Norwegian Testicular Cancer Group","volume":"29","author":"Olofsson","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdw045_bb0065","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1200\/JCO.2001.19.6.1641","article-title":"Second-line chemotherapy in patients with relapsed extragonadal nonseminomatous germ cell tumors: results of an international multicenter analysis","volume":"19","author":"Hartmann","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdw045_bb0070","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1023\/A:1008333229936","article-title":"Identification of prognostic subgroups among patients with metastatic \u2018IGCCCG poor-prognosis\u2019 germ-cell cancer: an explorative analysis using cart modeling","volume":"11","author":"Kollmannsberger","year":"2000","journal-title":"Ann Oncol"},{"key":"10.1093\/annonc\/mdw045_bb0075","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1200\/JCO.1998.16.4.1287","article-title":"Randomized comparison of cisplatin and etoposide and either bleomycin or ifosfamide in treatment of advanced disseminated germ cell tumors: an Eastern Cooperative Oncology Group, Southwest Oncology Group, and Cancer and Leukemia Group B Study","volume":"16","author":"Nichols","year":"1998","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdw045_bb0080","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/S1470-2045(14)70490-5","article-title":"Personalised chemotherapy based on tumour marker decline in poor prognosis germ-cell tumours (GETUG 13): a phase 3, multicentre, randomised trial","volume":"15","author":"Fizazi","year":"2014","journal-title":"Lancet Oncol"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419374265?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419374265?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T09:08:42Z","timestamp":1624698522000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923753419374265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S0923753419374265"],"URL":"https:\/\/doi.org\/10.1093\/annonc\/mdw045","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]}}}