{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:57:02Z","timestamp":1777593422046,"version":"3.51.4"},"reference-count":26,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T00:00:00Z","timestamp":1572825600000},"content-version":"vor","delay-in-days":917,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"crossref","award":["SAF2015-64885-R"],"award-info":[{"award-number":["SAF2015-64885-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Generalitat de Catalunya Suport Grups de Recerca","award":["AGAUR 2014-SGR-795"],"award-info":[{"award-number":["AGAUR 2014-SGR-795"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1093\/annonc\/mdx133","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T21:26:45Z","timestamp":1490390805000},"page":"918-920","source":"Crossref","is-referenced-by-count":1,"title":["Refining the prognostic impact of the cell of origin in diffuse large B-cell lymphoma"],"prefix":"10.1016","volume":"28","author":[{"given":"O.","family":"Balagu\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Campo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1093\/annonc\/mdx133_bb0010","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1182\/blood-2004-07-2947","article-title":"Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response","volume":"105","author":"Monti","year":"2005","journal-title":"Blood"},{"issue":"25","key":"10.1093\/annonc\/mdx133_bb0015","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1056\/NEJMoa012914","article-title":"The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma","volume":"346","author":"Rosenwald","year":"2002","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1093\/annonc\/mdx133_bb0020","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1053\/j.seminhematol.2015.01.005","article-title":"The genetic landscape of diffuse large B-cell lymphoma","volume":"52","author":"Pasqualucci","year":"2015","journal-title":"Semin Hematol"},{"issue":"6","key":"10.1093\/annonc\/mdx133_bb0025","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1177\/2040620711419001","article-title":"The molecular biology of diffuse large B-cell lymphoma","volume":"2","author":"Frick","year":"2011","journal-title":"Ther Adv Hematol"},{"issue":"1","key":"10.1093\/annonc\/mdx133_bb0030","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.beha.2012.01.003","article-title":"New insights into the biology of molecular subtypes of diffuse large B-cell lymphoma and Burkitt lymphoma","volume":"25","author":"Frick","year":"2012","journal-title":"Best Pract Res Clin Haematol"},{"issue":"1","key":"10.1093\/annonc\/mdx133_bb0035","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/nrclinonc.2013.197","article-title":"Diffuse large B-cell lymphoma-treatment approaches in the molecular era","volume":"11","author":"Roschewski","year":"2014","journal-title":"Nat Rev Clin Oncol"},{"issue":"1","key":"10.1093\/annonc\/mdx133_bb0040","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.pathol.2015.11.017","article-title":"Molecular subtyping of diffuse large B-cell lymphoma: update on biology, diagnosis and emerging platforms for practising pathologists","volume":"48","author":"Gifford","year":"2016","journal-title":"Pathology"},{"issue":"20","key":"10.1093\/annonc\/mdx133_bb0045","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1182\/blood-2016-01-643569","article-title":"The 2016 revision of the World Health Organization classification of lymphoid neoplasms","volume":"127","author":"Swerdlow","year":"2016","journal-title":"Blood"},{"issue":"24","key":"10.1093\/annonc\/mdx133_bb0050","doi-asserted-by":"crossref","first-page":"7785","DOI":"10.1158\/1078-0432.CCR-11-0267","article-title":"BCL2 predicts survival in germinal center B-cell-like diffuse large B-cell lymphoma treated with CHOP-like therapy and rituximab","volume":"17","author":"Iqbal","year":"2011","journal-title":"Clin Cancer Res"},{"issue":"24","key":"10.1093\/annonc\/mdx133_bb0055","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.1182\/blood-2013-05-498329","article-title":"Understanding MYC-driven aggressive B-cell lymphomas: pathogenesis and classification","volume":"122","author":"Ott","year":"2013","journal-title":"Blood"},{"issue":"3","key":"10.1093\/annonc\/mdx133_bb0060","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1182\/blood-2016-02-636316","article-title":"Approach to the diagnosis and treatment of high-grade B-cell lymphomas with MYC and BCL2 and\/or BCL6 rearrangements","volume":"129","author":"Sesques","year":"2017","journal-title":"Blood"},{"issue":"24","key":"10.1093\/annonc\/mdx133_bb0065","doi-asserted-by":"crossref","first-page":"6686","DOI":"10.1158\/1078-0432.CCR-13-1482","article-title":"Poor concordance among nine immunohistochemistry classifiers of cell-of-origin for diffuse large B-cell lymphoma: implications for therapeutic strategies","volume":"19","author":"Coutinho","year":"2013","journal-title":"Clin Cancer Res"},{"issue":"6","key":"10.1093\/annonc\/mdx133_bb0070","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.clml.2014.05.002","article-title":"Evaluating cell-of-origin subtype methods for predicting diffuse large B-cell lymphoma survival: a meta-analysis of gene expression profiling and immunohistochemistry algorithms","volume":"14","author":"Read","year":"2014","journal-title":"Clin Lymphoma Myeloma Leuk"},{"issue":"7","key":"10.1093\/annonc\/mdx133_bb0075","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1200\/JCO.2006.09.4490","article-title":"Immunohistochemical prognostic markers in diffuse large B-cell lymphoma: validation of tissue microarray as a prerequisite for broad clinical applications\u2014a study from the Lunenburg Lymphoma Biomarker Consortium","volume":"25","author":"de Jong","year":"2007","journal-title":"J Clin Oncol"},{"issue":"31","key":"10.1093\/annonc\/mdx133_bb0080","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.1200\/JCO.2011.35.4423","article-title":"The germinal center\/activated B-cell subclassification has a prognostic impact for response to salvage therapy in relapsed\/refractory diffuse large B-cell lymphoma: a bio-CORAL study","volume":"29","author":"Thieblemont","year":"2011","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1093\/annonc\/mdx133_bb0085","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3816\/CLML.2011.n.003","article-title":"Prognostic relevance of immunohistochemical subclassification of diffuse large B-cell lymphoma in two prospective phase III clinical trials","volume":"11","author":"Rayman","year":"2011","journal-title":"Clin Lymphoma Myeloma Leuk"},{"issue":"1","key":"10.1093\/annonc\/mdx133_bb0090","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1182\/blood-2003-05-1545","article-title":"Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray","volume":"103","author":"Hans","year":"2004","journal-title":"Blood"},{"issue":"5","key":"10.1093\/annonc\/mdx133_bb0095","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1093\/annonc\/mdx022","article-title":"BCL2 expression but not MYC and BCL2 coexpression predicts survival in elderly patients with diffuse large B-cell lymphoma independently of cell of origin in the phase 3 LNH03-6B trial","volume":"28","author":"Petrella","year":"2017","journal-title":"Ann Oncol"},{"key":"10.1093\/annonc\/mdx133_bb0100","doi-asserted-by":"crossref","first-page":"e458","DOI":"10.14694\/EdBook_AM.2015.35.e458","article-title":"Cell-of-origin in diffuse large B-cell lymphoma: are the assays ready for the clinic?","author":"Scott","year":"2015","journal-title":"Am Soc Clin Oncol Educ Book"},{"issue":"10","key":"10.1093\/annonc\/mdx133_bb0105","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.3324\/haematol.2013.086173","article-title":"MYC protein expression and genetic alterations have prognostic impact in patients with diffuse large B-cell lymphoma treated with immunochemotherapy","volume":"98","author":"Valera","year":"2013","journal-title":"Haematologica"},{"issue":"6","key":"10.1093\/annonc\/mdx133_bb0110","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1200\/JCO.2005.03.4264","article-title":"BCL2 expression is a prognostic marker for the activated B-cell-like type of diffuse large B-cell lymphoma","volume":"24","author":"Iqbal","year":"2006","journal-title":"J Clin Oncol"},{"issue":"12","key":"10.1093\/annonc\/mdx133_bb0115","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1182\/blood-2012-06-435842","article-title":"MYC status in concert with BCL2 and BCL6 expression predicts outcome in diffuse large B-cell lymphoma","volume":"121","author":"Horn","year":"2013","journal-title":"Blood"},{"issue":"7","key":"10.1093\/annonc\/mdx133_bb0120","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1038\/leu.2015.43","article-title":"Different biological risk factors in young poor-prognosis and elderly patients with diffuse large B-cell lymphoma","volume":"29","author":"Horn","year":"2015","journal-title":"Leukemia"},{"issue":"8","key":"10.1093\/annonc\/mdx133_bb0125","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1182\/blood-2013-11-536433","article-title":"Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue","volume":"123","author":"Scott","year":"2014","journal-title":"Blood"},{"issue":"11","key":"10.1093\/annonc\/mdx133_bb0130","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1182\/blood-2013-06-508937","article-title":"Molecular classification of mature aggressive B-cell lymphoma using digital multiplexed gene expression on formalin-fixed paraffin-embedded biopsy specimens","volume":"122","author":"Masqu\u00e9-Soler","year":"2013","journal-title":"Blood"},{"key":"10.1093\/annonc\/mdx133_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmoldx.2015.01.007","article-title":"Accurate classification of germinal center B-cell-like\/activated B-cell-like diffuse large B-cell lymphoma using a simple and rapid reverse transcriptase-multiplex ligation-dependent probe amplification assay: a CALYM study","author":"Mareschal","year":"2015","journal-title":"J Mol Diagn"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092375341932037X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092375341932037X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/28\/5\/918\/13942926\/mdx133.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T08:16:18Z","timestamp":1624695378000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092375341932037X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["S092375341932037X"],"URL":"https:\/\/doi.org\/10.1093\/annonc\/mdx133","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]}}}