{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:45:01Z","timestamp":1790667901097,"version":"4.1.0"},"reference-count":17,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"vor","delay-in-days":646,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"AIRC","doi-asserted-by":"publisher","award":["IG 14750"],"award-info":[{"award-number":["IG 14750"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"AIRC","doi-asserted-by":"publisher","award":["IG 18519"],"award-info":[{"award-number":["IG 18519"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"AIRC","doi-asserted-by":"publisher","award":["IG 10173"],"award-info":[{"award-number":["IG 10173"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1093\/annonc\/mdy013","type":"journal-article","created":{"date-parts":[[2018,1,13]],"date-time":"2018-01-13T12:08:04Z","timestamp":1515845284000},"page":"985-991","source":"Crossref","is-referenced-by-count":42,"title":["Activity and safety of afatinib in a window preoperative EORTC study in patients with squamous cell carcinoma of the head and neck (SCCHN)"],"prefix":"10.1016","volume":"29","author":[{"given":"J.-P.","family":"Machiels","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Bossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Menis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Fortpied","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Lhommel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lemort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Canevari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"De Cecco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Guzzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Quattrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Crippa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Duprez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Lalami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Quiriny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"de Saint Aubain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.M.","family":"Clement","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Coropciuc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Hauben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.F.","family":"Licitra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1093\/annonc\/mdy013_bb0010","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1056\/NEJMoa053422","article-title":"Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck","volume":"354","author":"Bonner","year":"2006","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1093\/annonc\/mdy013_bb0015","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1056\/NEJMoa0802656","article-title":"Platinum-based chemotherapy plus cetuximab in head and neck cancer","volume":"359","author":"Vermorken","year":"2008","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1093\/annonc\/mdy013_bb0020","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S1470-2045(15)70124-5","article-title":"Afatinib versus methotrexate as second-line treatment in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck progressing on or after platinum-based therapy (LUX-Head & Neck 1): an open-label, randomised phase 3 trial","volume":"16","author":"Machiels","year":"2015","journal-title":"Lancet Oncol"},{"issue":"15","key":"10.1093\/annonc\/mdy013_bb0025","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.1158\/1078-0432.CCR-15-2547","article-title":"Functional genomics uncover the biology behind the responsiveness of head and neck squamous cell cancer patients to cetuximab","volume":"22","author":"Bossi","year":"2016","journal-title":"Clin Cancer Res"},{"issue":"13","key":"10.1093\/annonc\/mdy013_bb0030","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0959-8049(99)00229-4","article-title":"Measurement of clinical and subclinical tumor response using [18F]-Fluorodeoxyglucose and positron emission tomography: review and 1999 EORTC recommendations","volume":"35","author":"Young","year":"1999","journal-title":"Eur J Cancer"},{"key":"10.1093\/annonc\/mdy013_bb0035","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New response evaluation criteria in solid tumors: revised RECIST guideline (Version1.1)","volume":"45","author":"Eisenhauer","year":"2009","journal-title":"Eur J Cancer"},{"issue":"1","key":"10.1093\/annonc\/mdy013_bb0040","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00259-009-1297-4","article-title":"FDG PET and PET\/CT: EANM procedure guidelines for tumor PET imaging: version 1.0","volume":"37","author":"Boellaard","year":"2010","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"10","key":"10.1093\/annonc\/mdy013_bb0045","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1093\/annonc\/mdx344","article-title":"Biomarkers predict enhanced clinical outcomes with afatinib versus methotrexate in patients with second-line recurrent and\/or metastatic head and neck cancer","volume":"28","author":"Cohen","year":"2017","journal-title":"Ann Oncol"},{"issue":"36","key":"10.1093\/annonc\/mdy013_bb0050","doi-asserted-by":"crossref","first-page":"5630","DOI":"10.1200\/JCO.2005.04.6136","article-title":"High-risk human papillomavirus affects prognosis in patients with surgically treated oropharyngeal squamous cell carcinoma","volume":"24","author":"Licitra","year":"2006","journal-title":"J Clin Oncol"},{"issue":"9","key":"10.1093\/annonc\/mdy013_bb0055","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1093\/annonc\/mdt180","article-title":"Tumor response and safety of cetuximab in a window pre-operative study in patients with squamous cell carcinoma of the head and neck","volume":"24","author":"Schmitz","year":"2013","journal-title":"Ann Oncol"},{"key":"10.1093\/annonc\/mdy013_bb0060","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2017.35.15_suppl.6021","article-title":"PREDICTOR (UNICANCER GEP11): randomized phase II study of preoperative afatinib in untreated head and neck squamous cell carcinoma (HNSCC) patients","author":"Le Tourneau","year":"2017","journal-title":"J Clin Oncol"},{"issue":"23","key":"10.1093\/annonc\/mdy013_bb0065","doi-asserted-by":"crossref","first-page":"7086","DOI":"10.1158\/1078-0432.CCR-07-1370","article-title":"Pilot study of neoadjuvant treatment with erlotinib in nonmetastatic head and neck squamous cell carcinoma","volume":"13","author":"Thomas","year":"2007","journal-title":"Clin Cancer Res"},{"issue":"5","key":"10.1093\/annonc\/mdy013_bb0070","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/bjc.2011.237","article-title":"Effects of lapatinib monotherapy: results of a randomised phase II study in therapy-naive patients with locally advanced squamous cell carcinoma of the head and neck","volume":"105","author":"Del Campo","year":"2011","journal-title":"Br J Cancer"},{"issue":"22","key":"10.1093\/annonc\/mdy013_bb0075","doi-asserted-by":"crossref","first-page":"7071","DOI":"10.1158\/0008-5472.CAN-11-0128","article-title":"p53 modulates acquired resistance to EGFR inhibitors and radiation","volume":"71","author":"Huang","year":"2011","journal-title":"Cancer Res"},{"issue":"25","key":"10.1093\/annonc\/mdy013_bb0080","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1056\/NEJMoa073770","article-title":"TP53 mutations and survival in squamous-cell carcinoma of the head and neck","volume":"357","author":"Poeta","year":"2007","journal-title":"N Engl J Med"},{"issue":"12","key":"10.1093\/annonc\/mdy013_bb0085","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1093\/annonc\/mdv378","article-title":"Designs of preoperative biomarkers trials in oncology: a systematic review of the literature","volume":"26","author":"Marous","year":"2015","journal-title":"Ann Oncol"},{"issue":"2","key":"10.1093\/annonc\/mdy013_bb0090","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1200\/JCO.2015.61.5906","article-title":"Survival impact of increasing time to treatment initiation for patients with head and neck cancer in the United States","volume":"34","author":"Murphy","year":"2016","journal-title":"J Clin Oncol"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092375341945463X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092375341945463X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/29\/4\/985\/24702579\/mdy013.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T09:40:30Z","timestamp":1624700430000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092375341945463X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S092375341945463X"],"URL":"https:\/\/doi.org\/10.1093\/annonc\/mdy013","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]}}}