{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:02:51Z","timestamp":1792785771824,"version":"4.5.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T00:00:00Z","timestamp":1571875200000},"content-version":"vor","delay-in-days":480,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100012742","name":"Peregrine Pharmaceuticals","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012742","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"crossref","award":["10.13039\/100000054"],"award-info":[{"award-number":["10.13039\/100000054"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Midcareer Investigator Award","award":["K24CA201543-01"],"award-info":[{"award-number":["K24CA201543-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1093\/annonc\/mdy177","type":"journal-article","created":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T15:10:16Z","timestamp":1525792216000},"page":"1548-1553","source":"Crossref","is-referenced-by-count":39,"title":["Randomized phase III study of docetaxel plus bavituximab in previously treated advanced non-squamous non-small-cell lung cancer"],"prefix":"10.1016","volume":"29","author":[{"given":"D.E.","family":"Gerber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Horn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Boyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Sanborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Natale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Palmero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Bidoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Bondarenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Germonpre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Ghizdavescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kotsakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Lena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Losonczy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W -C","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.L.","family":"Kallinteris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.S.","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Reck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.R.","family":"Spigel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1093\/annonc\/mdy177_bb0010","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1172\/JCI1112","article-title":"Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine\/paracrine mechanisms involving TGF-beta, PGE2, and PAF","volume":"101","author":"Fadok","year":"1998","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1093\/annonc\/mdy177_bb0015","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1194\/jlr.R200019-JLR200","article-title":"Regulation of transbilayer plasma membrane phospholipid asymmetry","volume":"44","author":"Daleke","year":"2003","journal-title":"J Lipid Res"},{"issue":"21","key":"10.1093\/annonc\/mdy177_bb0020","first-page":"6132","article-title":"Increased exposure of anionic phospholipids on the surface of tumor blood vessels","volume":"62","author":"Ran","year":"2002","journal-title":"Cancer Res"},{"key":"10.1093\/annonc\/mdy177_bb0025","first-page":"493","article-title":"Tumor-specific targeting by bavituximab, a phosphatidylserine-targeting monoclonal antibody with vascular targeting and immune modulating properties, in lung cancer xenografts","volume":"5","author":"Gerber","year":"2015","journal-title":"Am J Nucl Med Mol Imaging"},{"issue":"22","key":"10.1093\/annonc\/mdy177_bb0030","doi-asserted-by":"crossref","first-page":"6871","DOI":"10.1158\/1078-0432.CCR-09-1499","article-title":"Antiphosphatidylserine antibody combined with irradiation damages tumor blood vessels and induces tumor immunity in a rat model of glioblastoma","volume":"15","author":"He","year":"2009","journal-title":"Clin Cancer Res"},{"issue":"10","key":"10.1093\/annonc\/mdy177_bb0035","doi-asserted-by":"crossref","first-page":"4408","DOI":"10.1158\/0008-5472.CAN-05-0031","article-title":"A monoclonal antibody that binds anionic phospholipids on tumor blood vessels enhances the antitumor effect of docetaxel on human breast tumors in mice","volume":"65","author":"Huang","year":"2005","journal-title":"Cancer Res"},{"issue":"17","key":"10.1093\/annonc\/mdy177_bb0040","doi-asserted-by":"crossref","first-page":"5211","DOI":"10.1158\/1078-0432.CCR-07-0793","article-title":"Radiation-enhanced vascular targeting of human lung cancers in mice with a monoclonal antibody that binds anionic phospholipids","volume":"13","author":"He","year":"2007","journal-title":"Clin Cancer Res"},{"issue":"12","key":"10.1093\/annonc\/mdy177_bb0045","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1200\/JCO.2000.18.12.2354","article-title":"Randomized phase III trial of docetaxel versus vinorelbine or ifosfamide in patients with advanced non-small-cell lung cancer previously treated with platinum-containing chemotherapy regimens. The TAX 320 Non-Small Cell Lung Cancer Study Group","volume":"18","author":"Fossella","year":"2000","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1093\/annonc\/mdy177_bb0050","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13058-016-0708-2","article-title":"Phosphatidylserine-targeting antibodies augment the anti-tumorigenic activity of anti-PD-1 therapy by enhanging immune activation and downregulating pro-oncogenic factors induced by T-cell checkpoint inhibition in murine triple-negative breast cancers","volume":"18","author":"Gray","year":"2016","journal-title":"Breast Cancer Res"},{"issue":"21","key":"10.1093\/annonc\/mdy177_bb0055","doi-asserted-by":"crossref","first-page":"6888","DOI":"10.1158\/1078-0432.CCR-11-1074","article-title":"Phase I safety and pharmacokinetic study of bavituximab, a chimeric phosphatidylserine-targeting monoclonal antibody, in patients with advanced solid tumors","volume":"17","author":"Gerber","year":"2011","journal-title":"Clin Cancer Res"},{"key":"10.1093\/annonc\/mdy177_bb0060","article-title":"A phase Ib safety and pharmacokinetic study of bavituximab plus chemotherapy in patients with refractory advanced solid tumor malignancies","volume":"26(Suppl 15)","author":"Digumarti","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdy177_bb0065","article-title":"Phase II study of bavituximab plus paclitaxel and carboplatin in untreated locally advanced or metastatic non-small cell lung cancer: interim results","volume":"28(Suppl 15)","author":"Digumarti","year":"2010","journal-title":"J Clin Oncol"},{"issue":"3","key":"10.1093\/annonc\/mdy177_bb0070","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.cllc.2016.02.003","article-title":"Docetaxel combined with bavituximab in previously treated, advanced nonsquamous non-small-cell lung cancer","volume":"17","author":"Gerber","year":"2016","journal-title":"Clin Lung Cancer"},{"issue":"8","key":"10.1093\/annonc\/mdy177_bb0075","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1093\/annonc\/mdv220","article-title":"A randomized phase II study of ganetespib, a heat shock protein 90 inhibitor, in combination with docetaxel in second-line therapy of advanced non-small cell lung cancer (GALAXY-1)","volume":"26","author":"Ramalingam","year":"2015","journal-title":"Ann Oncol"},{"key":"10.1093\/annonc\/mdy177_bb0080","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1200\/JCO.2004.08.163","article-title":"Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy","volume":"22","author":"Hanna","year":"2004","journal-title":"J Clin Oncol"},{"issue":"10","key":"10.1093\/annonc\/mdy177_bb0085","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/S1470-2045(13)70310-3","article-title":"Erlotinib versus docetaxel as second-line treatment of patients with advanced non-small-cell lung cancer and wild-type EGFR tumours (TAILOR): a randomised controlled trial","volume":"14","author":"Garassino","year":"2013","journal-title":"Lancet Oncol"},{"issue":"2","key":"10.1093\/annonc\/mdy177_bb0090","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1182\/blood-2012-03-378646","article-title":"The significance of autoantibodies against beta2-glycoprotein I","volume":"120","author":"de Groot","year":"2012","journal-title":"Blood"},{"issue":"17","key":"10.1093\/annonc\/mdy177_bb0095","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1056\/NEJMoa1507643","article-title":"Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer","volume":"373","author":"Borghaei","year":"2015","journal-title":"N Engl J Med"},{"issue":"15","key":"10.1093\/annonc\/mdy177_bb0100","doi-asserted-by":"crossref","first-page":"4242","DOI":"10.1158\/1078-0432.CCR-16-3133","article-title":"Hyperprogressors after immunotherapy: analysis of genomic alterations associated with accelerated growth rate","volume":"23","author":"Kato","year":"2017","journal-title":"Clin Cancer Res"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092375341932112X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092375341932112X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/29\/7\/1548\/31190847\/mdy177.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/29\/7\/1548\/31190847\/mdy177.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T04:39:22Z","timestamp":1624682362000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092375341932112X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S092375341932112X"],"URL":"https:\/\/doi.org\/10.1093\/annonc\/mdy177","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]}}}