{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:33:32Z","timestamp":1790361212104,"version":"4.1.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"vor","delay-in-days":371,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["10.13039\/100000002"],"award-info":[{"award-number":["10.13039\/100000002"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 CA188480-01A1"],"award-info":[{"award-number":["R01 CA188480-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"crossref","award":["10.13039\/100006108"],"award-info":[{"award-number":["10.13039\/100006108"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"crossref","award":["UL1TR000124"],"award-info":[{"award-number":["UL1TR000124"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"crossref","award":["UL1TR001881-01"],"award-info":[{"award-number":["UL1TR001881-01"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Donna and Jesse Garber Award for Cancer Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1093\/annonc\/mdy490","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T06:58:18Z","timestamp":1541055498000},"page":"76-84","source":"Crossref","is-referenced-by-count":40,"title":["Quantitative lymph node burden as a \u2018very-high-risk\u2019 factor identifying head and neck cancer patients benefiting from postoperative chemoradiation"],"prefix":"10.1016","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7484-3631","authenticated-orcid":false,"given":"Z.S.","family":"Zumsteg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Luu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Tighiouart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.S.","family":"Scher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.J.","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.L.","family":"Shiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mallen-St. Clair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5423-509X","authenticated-orcid":false,"given":"A.S.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/annonc\/mdy490_bb0010","unstructured":"NCCN Guidelines - Head and Neck Cancers. 2018; version 1.2018. https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/head-and-neck.pdf."},{"issue":"19","key":"10.1093\/annonc\/mdy490_bb0015","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1056\/NEJMoa032646","article-title":"Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck","volume":"350","author":"Cooper","year":"2004","journal-title":"N Engl J Med"},{"issue":"19","key":"10.1093\/annonc\/mdy490_bb0020","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1056\/NEJMoa032641","article-title":"Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer","volume":"350","author":"Bernier","year":"2004","journal-title":"N Engl J Med"},{"issue":"10","key":"10.1093\/annonc\/mdy490_bb0025","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/hed.20279","article-title":"Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501)","volume":"27","author":"Bernier","year":"2005","journal-title":"Head Neck"},{"issue":"5","key":"10.1093\/annonc\/mdy490_bb0030","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.ijrobp.2012.05.008","article-title":"Long-term follow-up of the RTOG 9501\/intergroup phase III trial: postoperative concurrent radiation therapy and chemotherapy in high-risk squamous cell carcinoma of the head and neck","volume":"84","author":"Cooper","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"31","key":"10.1093\/annonc\/mdy490_bb0035","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1200\/JCO.2016.71.1176","article-title":"Metastatic lymph node burden and survival in oral cavity cancer","volume":"35","author":"Ho","year":"2017","journal-title":"J Clin Oncol"},{"issue":"7","key":"10.1093\/annonc\/mdy490_bb0040","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1001\/jamaoncol.2017.3852","article-title":"Association of quantitative metastatic lymph node burden with survival in hypopharyngeal and laryngeal cancer","volume":"4","author":"Ho","year":"2017","journal-title":"JAMA Oncol"},{"issue":"404","key":"10.1093\/annonc\/mdy490_bb0045","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1080\/01621459.1988.10478722","article-title":"A test of missing completely at random for multivariate data with missing values","volume":"83","author":"Little","year":"1988","journal-title":"J Am Stat Assoc"},{"issue":"3","key":"10.1093\/annonc\/mdy490_bb0050","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/0962280206074463","article-title":"Multiple imputation of discrete and continuous data by fully conditional specification","volume":"16","author":"van Buuren","year":"2007","journal-title":"Stat Methods Med Res"},{"issue":"6","key":"10.1093\/annonc\/mdy490_bb0055","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1002\/sim.6004","article-title":"A comparison of 12 algorithms for matching on the propensity score","volume":"33","author":"Austin","year":"2014","journal-title":"Stat Med"},{"issue":"8","key":"10.1093\/annonc\/mdy490_bb0060","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1890\/02-0472","article-title":"Piecewise regression: a tool for identifying ecological thresholds","volume":"84","author":"Toms","year":"2003","journal-title":"Ecology"},{"issue":"21","key":"10.1093\/annonc\/mdy490_bb0065","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1056\/NEJMsr077003","article-title":"Statistics in medicine\u2013reporting of subgroup analyses in clinical trials","volume":"357","author":"Wang","year":"2007","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1093\/annonc\/mdy490_bb0070","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1056\/NEJMoa0912217","article-title":"Human papillomavirus and survival of patients with oropharyngeal cancer","volume":"363","author":"Ang","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1093\/annonc\/mdy490_bb0075","first-page":"7536576","article-title":"Comprehensive genomic characterization of head and neck squamous cell carcinomas","volume":"517","author":"Cancer Genome Atlas","year":"2015","journal-title":"Nature"},{"issue":"2","key":"10.1093\/annonc\/mdy490_bb0080","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3322\/caac.21389","article-title":"Head and neck cancers\u2014major changes in the American Joint Committee on cancer eighth edition cancer staging manual","volume":"67","author":"Lydiatt","year":"2017","journal-title":"CA Cancer J Clin"},{"issue":"4","key":"10.1093\/annonc\/mdy490_bb0085","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/S1470-2045(15)00560-4","article-title":"Development and validation of a staging system for HPV-related oropharyngeal cancer by the International Collaboration on Oropharyngeal cancer Network for Staging (ICON-S): a multicentre cohort study","volume":"17","author":"O'Sullivan","year":"2016","journal-title":"Lancet Oncol"},{"issue":"8","key":"10.1093\/annonc\/mdy490_bb0090","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1001\/jamaoto.2016.1162","article-title":"Patterns of care and comparative effectiveness of intensified adjuvant therapy for resected oropharyngeal squamous cell carcinoma in the human papillomavirus era","volume":"142","author":"Sher","year":"2016","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"7","key":"10.1093\/annonc\/mdy490_bb0095","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1001\/jamaoto.2016.0882","article-title":"Association of extracapsular spread with survival according to human papillomavirus status in oropharynx squamous cell carcinoma and carcinoma of unknown primary site","volume":"142","author":"Kharytaniuk","year":"2016","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"14","key":"10.1093\/annonc\/mdy490_bb0100","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1002\/cncr.26671","article-title":"Extracapsular spread and adjuvant therapy in human papillomavirus-related, p16-positive oropharyngeal carcinoma","volume":"118","author":"Sinha","year":"2012","journal-title":"Cancer"},{"issue":"8","key":"10.1093\/annonc\/mdy490_bb0105","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1002\/hed.24824","article-title":"Impact of positive margins on outcomes of oropharyngeal squamous cell carcinoma according to p16 status","volume":"39","author":"Molony","year":"2017","journal-title":"Head Neck"},{"issue":"12","key":"10.1093\/annonc\/mdy490_bb0110","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1093\/annonc\/mdw428","article-title":"Phase II trial of post-operative radiotherapy with concurrent cisplatin plus panitumumab in patients with high-risk, resected head and neck cancer","volume":"27","author":"Ferris","year":"2016","journal-title":"Ann Oncol"},{"issue":"18","key":"10.1093\/annonc\/mdy490_bb0115","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1200\/JCO.2009.27.4498","article-title":"Critical impact of radiotherapy protocol compliance and quality in the treatment of advanced head and neck cancer: results from TROG 02.02","volume":"28","author":"Peters","year":"2010","journal-title":"J Clin Oncol"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419309949?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419309949?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/30\/1\/76\/28768607\/mdy490.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T08:46:05Z","timestamp":1624697165000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923753419309949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S0923753419309949"],"URL":"https:\/\/doi.org\/10.1093\/annonc\/mdy490","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]}}}