{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:21:57Z","timestamp":1789690917754,"version":"4.0.1"},"reference-count":18,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006436","name":"Celgene","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006436","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1093\/annonc\/mdy522","type":"journal-article","created":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T20:18:16Z","timestamp":1543263496000},"page":"297-302","source":"Crossref","is-referenced-by-count":197,"title":["OPTIMA: a phase II dose and volume de-escalation trial for human papillomavirus-positive oropharyngeal cancer"],"prefix":"10.1016","volume":"30","author":[{"given":"T.Y.","family":"Seiwert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.C.","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.A.","family":"Blair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.G.","family":"Karrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Melotek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Portugal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.J.","family":"Brisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Dekker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kochanny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Gooi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.W.","family":"Lingen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.M.","family":"Villaflor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.T.","family":"Ginat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.J.","family":"Haraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.E.","family":"Vokes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1093\/annonc\/mdy522_bb0010","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1056\/NEJMoa0912217","article-title":"Human papillomavirus and survival of patients with oropharyngeal cancer","volume":"363","author":"Ang","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1093\/annonc\/mdy522_bb0015","doi-asserted-by":"crossref","first-page":"5793","DOI":"10.1002\/cncr.27631","article-title":"Late dysphagia after radiotherapy-based treatment of head and neck cancer","volume":"11","author":"Hutcheson","year":"2012","journal-title":"Cancer"},{"issue":"4","key":"10.1093\/annonc\/mdy522_bb0020","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.ijrobp.2012.08.030","article-title":"Toxicities affecting quality of life after chemo-IMRT of oropharyngeal cancer: prospective study of patient-reported, observer-rated, and objective outcomes","volume":"85","author":"Hunter","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1093\/annonc\/mdy522_bb0025","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJM199106133242402","article-title":"Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. The Department of Veterans Affairs Laryngeal Cancer Study Group","volume":"324","author":"Wolf","year":"1991","journal-title":"N Eng J Med"},{"issue":"5","key":"10.1093\/annonc\/mdy522_bb0030","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1093\/annonc\/mdw051","article-title":"Response-adapted volume de-escalation (RAVD) in locally advanced head and neck cancer","volume":"27","author":"Villaflor","year":"2016","journal-title":"Ann Oncol"},{"issue":"5","key":"10.1093\/annonc\/mdy522_bb0035","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1200\/JCO.2016.68.3300","article-title":"E1308: phase II trial of induction chemotherapy followed by reduced-dose radiation and weekly cetuximab in patients with HPV-associated resectable squamous cell carcinoma of the oropharynx \u2013 ECOG-ACRIN Cancer Research Group","volume":"35","author":"Marur","year":"2017","journal-title":"J Clin Oncol"},{"issue":"6","key":"10.1093\/annonc\/mdy522_bb0040","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S1470-2045(17)30246-2","article-title":"Reduced-dose radiotherapy for human papillomavirus-associated squamous-cell carcinoma of the oropharynx: a single-arm, phase 2 study","volume":"18","author":"Chen","year":"2017","journal-title":"Lancet Oncol"},{"issue":"2","key":"10.1093\/annonc\/mdy522_bb0045","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)","volume":"45","author":"Eisenhauer","year":"2009","journal-title":"Eur J Cancer"},{"issue":"2","key":"10.1093\/annonc\/mdy522_bb0050","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1200\/JCO.2003.06.006","article-title":"Weekly carboplatin and paclitaxel followed by concomitant paclitaxel, fluorouracil, and hydroxyurea chemoradiotherapy: curative and organ-preserving therapy for advanced head and neck cancer","volume":"21","author":"Vokes","year":"2003","journal-title":"J Clin Oncol"},{"issue":"16 Pt 1","key":"10.1093\/annonc\/mdy522_bb0055","first-page":"5936","article-title":"Induction chemotherapy followed by concomitant TFHX chemoradiotherapy with reduced dose radiation in advanced head and neck cancer","volume":"9","author":"Haraf","year":"2003","journal-title":"Clin Cancer Res"},{"issue":"13","key":"10.1093\/annonc\/mdy522_bb0060","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.1158\/1078-0432.CCR-07-4592","article-title":"Randomized crossover pharmacokinetic study of solvent-based paclitaxel and nab-paclitaxel","volume":"14","author":"Gardner","year":"2008","journal-title":"Clin Cancer Res"},{"issue":"11","key":"10.1093\/annonc\/mdy522_bb0065","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1002\/cncr.31338","article-title":"Mature results of a prospective study of deintensified chemoradiotherapy for low-risk human papillomavirus-associated oropharyngeal squamous cell carcinoma","volume":"124","author":"Chera","year":"2018","journal-title":"Cancer"},{"key":"10.1093\/annonc\/mdy522_bb0070","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ijrobp.2016.04.030","article-title":"Final results of a randomized phase 2 trial investigating the addition of cetuximab to induction chemotherapy and accelerated or hyperfractionated chemoradiation for locoregionally advanced head and neck cancer","volume":"9","author":"Seiwert","year":"2016","journal-title":"Int J Radiat Biol Oncol Phys"},{"issue":"9","key":"10.1093\/annonc\/mdy522_bb0075","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1002\/lary.24712","article-title":"A systematic review of transoral robotic surgery and radiotherapy for early oropharynx cancer: a systematic review","volume":"124","author":"de Almeida","year":"2014","journal-title":"Laryngoscope"},{"issue":"6","key":"10.1093\/annonc\/mdy522_bb0080","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1001\/jamaoncol.2015.6587","article-title":"Human papillomavirus genotype association with survival in head and neck squamous cell carcinoma","volume":"2","author":"Bratman","year":"2016","journal-title":"JAMA Oncol"},{"key":"10.1093\/annonc\/mdy522_bb0085","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1002\/ijc.28580","article-title":"Molecular characterization of p16-immunopositive but HPV DNA-negative oropharyngeal carcinomas","volume":"134","author":"Reitbergen","year":"2014","journal-title":"Int J Cancer"},{"key":"10.1093\/annonc\/mdy522_bb0090","author":"National Cancer Institute"},{"issue":"14","key":"10.1093\/annonc\/mdy522_bb0095","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1200\/JCO.2004.12.012","article-title":"Preliminary results of Radiation Therapy Oncology Group 97-03: a randomized phase II trial of concurrent radiation and chemotherapy for advanced squamous cell carcinomas of the head and neck","volume":"22","author":"Garden","year":"2004","journal-title":"J Clin Oncol"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419310294?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419310294?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/30\/2\/297\/28549854\/mdy522.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T08:54:37Z","timestamp":1624697677000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923753419310294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S0923753419310294"],"URL":"https:\/\/doi.org\/10.1093\/annonc\/mdy522","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]}}}