{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T09:52:49Z","timestamp":1771926769966,"version":"3.50.1"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T00:00:00Z","timestamp":1585180800000},"content-version":"vor","delay-in-days":146,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Loxo Oncology Inc.,"},{"name":"Eli Lilly and Company, Stamford, Connecticut"},{"name":"Bayer AG, Berlin"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1093\/annonc\/mdz382","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T15:27:23Z","timestamp":1567610843000},"page":"viii31-viii35","source":"Crossref","is-referenced-by-count":29,"special_numbering":"S8","title":["Rapid, complete and sustained tumour response to the TRK inhibitor larotrectinib in an infant with recurrent, chemotherapy-refractory infantile fibrosarcoma carrying the characteristic ETV6-NTRK3 gene fusion"],"prefix":"10.1016","volume":"30","author":[{"given":"S.S.","family":"Bielack","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.C.","family":"Cox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Nathrath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Apel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Blattmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Holl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Jenewein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Klenk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Klothaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"M\u00fcller-Abt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ortega-Lawerenz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Scheer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Simon-Klingenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Stegmaier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Tupper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Vokuhl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"von Kalle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1093\/annonc\/mdz382_bb0010","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1097\/00000478-200007000-00005","article-title":"Molecular detection of the ETV6-NTRK3 gene fusion differentiates congenital fibrosarcoma from other childhood spindle cell tumors","volume":"24","author":"Bourgeois","year":"2000","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"10.1093\/annonc\/mdz382_bb0015","first-page":"1","article-title":"Analysis of NTRK alterations in pan-cancer adult and pediatric malignancies: implications for NTRK-targeted therapeutics","volume":"2","author":"Okamura","year":"2018","journal-title":"JCO Precis Oncol 2018"},{"issue":"8","key":"10.1093\/annonc\/mdz382_bb0020","doi-asserted-by":"crossref","first-page":"e26433","DOI":"10.1002\/pbc.26433","article-title":"Identification of NTRK fusions in pediatric mesenchymal tumors","volume":"64","author":"Pavlick","year":"2017","journal-title":"Pediatr Blood Cancer"},{"issue":"2","key":"10.1093\/annonc\/mdz382_bb0025","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/ng0298-184","article-title":"A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma","volume":"18","author":"Knezevich","year":"1998","journal-title":"Nat Genet"},{"key":"10.1093\/annonc\/mdz382_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejca.2015.12.028","article-title":"Conservative strategy in infantile fibrosarcoma is possible: the European paediatric Soft tissue sarcoma Study Group experience","volume":"57","author":"Orbach","year":"2016","journal-title":"Eur J Cancer"},{"issue":"2","key":"10.1093\/annonc\/mdz382_bb0035","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1200\/JCO.2009.21.9972","article-title":"Infantile fibrosarcoma: management based on the European experience","volume":"28","author":"Orbach","year":"2010","journal-title":"J Clin Oncol"},{"issue":"21","key":"10.1093\/annonc\/mdz382_bb0040","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1002\/cncr.31701","article-title":"The use of neoadjuvant larotrectinib in the management of children with locally advanced TRK fusion sarcomas","volume":"124","author":"DuBois","year":"2018","journal-title":"Cancer"},{"issue":"8","key":"10.1093\/annonc\/mdz382_bb0045","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/pbc.26026","article-title":"Infantile fibrosarcoma with NTRK3-ETV6 fusion successfully treated with the tropomyosin-related kinase inhibitor LOXO-101","volume":"63","author":"Nagasubramanian","year":"2016","journal-title":"Pediatr Blood Cancer"},{"issue":"8","key":"10.1093\/annonc\/mdz382_bb0050","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1056\/NEJMoa1714448","article-title":"Efficacy of larotrectinib in TRK fusion-positive cancers in adults and children","volume":"378","author":"Drilon","year":"2018","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1093\/annonc\/mdz382_bb0055","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)","volume":"45","author":"Eisenhauer","year":"2009","journal-title":"Eur J Cancer"},{"issue":"2","key":"10.1093\/annonc\/mdz382_bb0060","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ejca.2008.10.028","article-title":"Evaluation of lymph nodes with RECIST 1.1","volume":"45","author":"Schwartz","year":"2009","journal-title":"Eur J Cancer"},{"issue":"1","key":"10.1093\/annonc\/mdz382_bb0065","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s13045-018-0622-4","article-title":"Basket trial of TRK inhibitors demonstrates efficacy in TRK fusion-positive cancers","volume":"11","author":"Chen","year":"2018","journal-title":"J Hematol Oncol"},{"issue":"2","key":"10.1093\/annonc\/mdz382_bb0070","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s40265-018-1044-x","article-title":"Larotrectinib: first global approval","volume":"79","author":"Scott","year":"2019","journal-title":"Drugs"},{"key":"10.1093\/annonc\/mdz382_bb0075","author":"U.S. Food and Drug Administration"},{"issue":"5","key":"10.1093\/annonc\/mdz382_bb0080","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S1470-2045(18)30119-0","article-title":"Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1\/2 study","volume":"19","author":"Laetsch","year":"2018","journal-title":"Lancet Oncol"},{"issue":"6","key":"10.1093\/annonc\/mdz382_bb0085","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41416-018-0251-2","article-title":"Brief report: potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma","volume":"119","author":"Ziegler","year":"2018","journal-title":"Br J Cancer"},{"key":"10.1093\/annonc\/mdz382_bb0090","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/978-3-642-45106-5_5","article-title":"Trk receptors","volume":"220","author":"Deinhardt","year":"2014","journal-title":"Handb Exp Pharmacol"},{"key":"10.1093\/annonc\/mdz382_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-7571-6_1","article-title":"Neurotrophic factors: an overview","volume":"1727","author":"Skaper","year":"2018","journal-title":"Methods Mol Biol"},{"issue":"3","key":"10.1093\/annonc\/mdz382_bb0100","doi-asserted-by":"crossref","first-page":"231","DOI":"10.18388\/pb.2018_135","article-title":"Neurotrophins: evolution of concepts on rational therapeutic approaches","volume":"64","author":"Skup","year":"2018","journal-title":"Postepy Biochem"},{"issue":"10","key":"10.1093\/annonc\/mdz382_bb0105","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1158\/1535-7163.MCT-16-0909","article-title":"Mechanisms of resistance to NTRK inhibitors and therapeutic strategies in NTRK1-rearranged cancers","volume":"16","author":"Fuse","year":"2017","journal-title":"Mol Cancer Ther"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092375341955116X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092375341955116X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/30\/Supplement_8\/viii31\/30959856\/mdz382.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/30\/Supplement_8\/viii31\/30959856\/mdz382.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T12:10:40Z","timestamp":1585224640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092375341955116X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":20,"alternative-id":["S092375341955116X"],"URL":"https:\/\/doi.org\/10.1093\/annonc\/mdz382","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]}}}