{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T15:19:24Z","timestamp":1776093564974,"version":"3.50.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:00:00Z","timestamp":1581897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Malignant pleural mesothelioma (MPM) due to environmental and familial (domestic) asbestos exposure is well recognized. However, information on cumulative asbestos dose in subjects affected by MPM is limited.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To evaluate the residual lung asbestos fibre and asbestos body burden in women with MPM with past environmental and\/or familial asbestos exposure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We collected lung samples from autopsies regarding 15 non-occupationally asbestos-exposed MPM cases, divided in three groups: (i) familial exposure from the Fincantieri shipyards in Monfalcone (No. 7), (ii) environmental and familial asbestos exposure from the asbestos-cement plant Fibronit in Broni (No. 6), and (iii) environmental exposure from the Fibronit plant (No. 2). Asbestos body (AB) and fibres (AF) per gram of dry lung tissue were counted by optical and scanning electron microscopy, respectively, and expressed as geometric means and standard deviations (GM, GSD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>GM\/GSD of AB counts were 6123\/9.6 (Group 1), 13 800\/10.4 (Group 2), and 8400\/1.1 (Group 3); GM\/GSD of AF were 0.6\/2.1 (Group 1), 7.9\/2.1 (Group 2), and 6.0\/2.3 (Group 3) million. Pleural plaques were observed in 12 cases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Exclusive familial exposure to asbestos determined cumulative doses close to those observed in moderate occupational exposure circumstances. Our results also suggest that combined environmental and familial exposures may cause unexpectedly high cumulative fibre doses.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/annweh\/wxaa009","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T15:10:18Z","timestamp":1579792218000},"page":"297-310","source":"Crossref","is-referenced-by-count":12,"title":["Lung Asbestos Fibre Burden and Pleural Mesothelioma in Women with Non-occupational Exposure"],"prefix":"10.1093","volume":"64","author":[{"given":"Pietro Gino","family":"Barbieri","sequence":"first","affiliation":[{"name":"Formerly Mesothelioma Registry, Occupational Health Unit, Local Health Authority, Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Somigliana","sequence":"first","affiliation":[{"name":"Centre of Electronic Microscopy, Lombardy Environmental Protection Agency (ARPA), Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Chen","sequence":"first","affiliation":[{"name":"Public Health Department, Forensic Medical Unit, University of Pavia, Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8935-3843","authenticated-orcid":false,"given":"Dario","family":"Consonni","sequence":"first","affiliation":[{"name":"Epidemiology Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Vignola","sequence":"first","affiliation":[{"name":"Occupational Health Unit, Local Health Authority, Broni (PV), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Finotto","sequence":"first","affiliation":[{"name":"Occupational Health Unit, Local Health Authority, Monfalcone (GO), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,2,17]]},"reference":[{"key":"2020031013372019500_CIT0001","first-page":"660","article-title":"Asbestos fibre burden in the lungs of patients with mesothelioma who lived near asbestos-cement factories","volume":"56","author":"Barbieri","year":"2012","journal-title":"Ann Occup Hyg"},{"key":"2020031013372019500_CIT0002","first-page":"315","article-title":"Patologie asbesto-correlate e indicatori biologici di dose cumulativa in lavoratori di cantiere navale (1996\u20132015)","volume":"107","author":"Barbieri","year":"2016","journal-title":"Med Lav"},{"key":"2020031013372019500_CIT0003","first-page":"21","article-title":"Carico polmonare di fibre di asbesto e indici di esposizione cumulativa in lavoratori del cemento-amianto","volume":"99","author":"Barbieri","year":"2008","journal-title":"Med Lav"},{"key":"2020031013372019500_CIT0004","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4103\/0019-5278.55124","article-title":"Malignant pleural mesothelioma in Italy","volume":"13","author":"Bianchi","year":"2009","journal-title":"Indian J Occup Environ Med"},{"key":"2020031013372019500_CIT0005","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1023\/A:1007691003600","article-title":"Environmental exposure to asbestos and risk of pleural mesothelioma: review and meta-analysis","volume":"16","author":"Bourd\u00e8s","year":"2000","journal-title":"Eur J Epidemiol"},{"key":"2020031013372019500_CIT0006","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1186\/s12885-015-1301-2","article-title":"Epidemiological patterns of asbestos exposure and spatial clusters of incident cases of malignant mesothelioma from the Italian national registry","volume":"15","author":"Corfiati","year":"2015","journal-title":"BMC Cancer"},{"key":"2020031013372019500_CIT0007","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.21037\/jtd.2017.03.164","article-title":"Pleural and peritoneal mesotheliomas in the Friuli Venezia Giulia register: data analysis from 1995 to 2015 in Northeastern Italy","volume":"9","author":"D\u2019Agostin","year":"2017","journal-title":"J Thorac Dis"},{"key":"2020031013372019500_CIT0008","first-page":"419","article-title":"Pleural mesothelioma in household members of asbestos-exposed workers in Friuli Venezia Giulia, Italy","volume":"30","author":"D\u2019Agostin","year":"2017","journal-title":"Int J Occup Med Environ Health"},{"key":"2020031013372019500_CIT0009","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1136\/thx.48.3.269","article-title":"Malignant mesothelioma in women","volume":"48","author":"Dawson","year":"1993","journal-title":"Thorax"},{"key":"2020031013372019500_CIT0010","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1183\/09031936.98.11061416","article-title":"Guidelines for mineral fibre analyses in biological samples: report of the ERS Working Group. 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