{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T08:53:29Z","timestamp":1785228809700,"version":"3.55.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"OHS Futures program of Alberta Labour"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The Fort McMurray fire in Alberta, Canada, devastated the townsite in May 2016. First responders were heavily exposed to smoke particles. Blood samples taken from firefighters in May and August\/September 2016 were used to measure concentrations of inflammatory markers in plasma and the relation of these markers to exposures and respiratory ill-health.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Blood samples were drawn from firefighters from two fire services, who also completed questionnaires about tasks and exposures during their deployment to the fire and about respiratory symptoms. Plasma was analysed for 42 inflammatory markers in a multiplex assay. At Service A, samples were collected twice, within 19 days of the start of the fire (early sample) and again 14\u201318 weeks later (late sample). At Service B, only late samples were collected, at 16\u201320 weeks. Principal component (PC) scores were extracted from markers in plasma from the early and late samples and, at both time periods, the first two components retained. PC scores were examined against estimated cumulative exposures to PM2.5 particles, self-rated physical stressors during the fire, and time since the last deployment to an active fire. The relation of component scores and exposure estimates to respiratory health were examined, using self-ratings at the time of the blood draw, a validated respiratory screening questionnaire (the European Community Respiratory Health Survey [ECRHS]) some 30 months after the fire, and clinical assessments in 2019\u20132020.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Repeat blood samples were available for 68 non-smoking first responders from Service A and late samples from 160 non-smokers from both services. In the 68 with two samples, marker concentrations decreased from early to late samples for all but 3 of the 42 markers, significantly so (P &amp;lt; 0.05) for 25. The first component extracted from the early samples (C1E) was unrelated to respiratory symptoms but the second (C2E) was weakly related to increased cough (P = 0.079) and breathlessness (P = 0.068) and a lower forced expiratory volume in one second\/forced expiratory capacity (FEV1\/FVC)(\u03b2 = \u20131.63, 95% CI \u20133.11 to \u20130.14) P = 0.032. The first PC at 14\u201320 weeks (C1L) was unrelated to exposure or respiratory health but the second PC (C2L) from these late samples, drawn from both fire services, related to cumulative PM2.5 exposure. In a multivariate model, clustered within fire service, cumulative exposure (\u03b2 = 0.19, 95% CI 0.09\u20130.30), dehydration (\u03b2 = 0.65, 95% CI 0.04\u20131.27) and time since last deployed to a fire (\u03b2 = \u20130.04, 95% CI \u20130.06 to \u20130.01) were all related to the C2L score. This score was also associated with respiratory symptoms of wheezing, chest tightness, and breathlessness at the time of the blood draw but not to symptoms at later follow-up. However, apart from the lower FEV1\/FVC at 15\u201319 days, the marker scores did not add to regression models that also included estimated cumulative PM2.5 exposure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Concentrations of persisting inflammatory markers in the plasma of firefighters deployed to a devastating fire decreased with time and were related to estimates of exposure. Although not a powerful independent predictor of later respiratory ill-health, they may serve as an indicator of previous high exposure in the absence of contemporary exposure estimates.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/annweh\/wxaa142","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T20:41:40Z","timestamp":1608756100000},"page":"635-648","source":"Crossref","is-referenced-by-count":13,"title":["Are Inflammatory Markers an Indicator of Exposure or Effect in Firefighters Fighting a Devastating Wildfire? Follow-up of a Cohort in Alberta, Canada"],"prefix":"10.1093","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3147-1548","authenticated-orcid":false,"given":"Nicola","family":"Cherry","sequence":"first","affiliation":[{"name":"Division of Preventive Medicine, University of Alberta Edmonton, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8788-8406","authenticated-orcid":false,"given":"Jeremy","family":"Beach","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine, University of Alberta Edmonton, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Galarneau","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine, University of Alberta Edmonton, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"key":"2022021211313221500_CIT0001","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1097\/JOM.0000000000001053","article-title":"Impact of work task-related acute occupational smoke exposures on select proinflammatory immune parameters in wildland firefighters","volume":"59","author":"Adetona","year":"2017","journal-title":"J Occup Environ Med"},{"key":"2022021211313221500_CIT0002","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/089583701753403953","article-title":"Rapid decline in sputum IL-10 concentration following occupational smoke exposure","volume":"14","author":"Burgess","year":"2002","journal-title":"Inhal Toxicol"},{"key":"2022021211313221500_CIT0003","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1183\/09031936.94.07050954","article-title":"The European Community Respiratory Health 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