{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T21:12:23Z","timestamp":1769116343514,"version":"3.49.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["ZO1ES102945"],"award-info":[{"award-number":["ZO1ES102945"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01ES027027-01"],"award-info":[{"award-number":["R01ES027027-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01ES030210-01"],"award-info":[{"award-number":["R01ES030210-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DMS-1513654"],"award-info":[{"award-number":["DMS-1513654"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["IIS-1562303"],"award-info":[{"award-number":["IIS-1562303"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DMS-1916349"],"award-info":[{"award-number":["DMS-1916349"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000125","name":"National Institute for Occupational Safety and Health","doi-asserted-by":"publisher","award":["K01OH011191"],"award-info":[{"award-number":["K01OH011191"]}],"id":[{"id":"10.13039\/100000125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Our objectives were to (i) determine correlations between measurements of THC and of BTEX-H, (ii) apply these linear relationships to predict BTEX-H from measured THC, (iii) use these correlations as informative priors in Bayesian analyses to estimate exposures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We used a Bayesian left-censored bivariate framework for all 3 objectives. First, we modeled the relationships (i.e. correlations) between THC and each BTEX-H chemical for various overarching groups of measurements using linear regression to determine if correlations derived from linear relationships differed by various exposure determinants. We then used the same linear regression relationships to predict (or impute) BTEX-H measurements from THC when only THC measurements were available. Finally, we used the same linear relationships as priors for the final exposure models that used real and predicted data to develop exposure estimate statistics for each individual exposure group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Correlations between measurements of THC and each of the BTEX-H chemicals (n = 120 for each of BTEX, 36 for n-hexane) differed substantially by area of the Gulf of Mexico and by time period that reflected different oil-spill related exposure opportunities. The correlations generally exceeded 0.5. Use of regression relationships to impute missing data resulted in the addition of &amp;gt;23 000 n-hexane and 541 observations for each of BTEX. The relationships were then used as priors for the calculation of exposure statistics while accounting for censored measurement data.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Taking advantage of observed relationships between THC and BTEX-H allowed us to develop robust exposure estimates where a large amount of data were missing, strengthening our exposure estimation process for the epidemiologic study.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/annweh\/wxab064","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T03:22:51Z","timestamp":1627615371000},"page":"i71-i88","source":"Crossref","is-referenced-by-count":15,"title":["Linear Relationships Between Total Hydrocarbons and Benzene, Toluene, Ethylbenzene, Xylene, and <i>n<\/i>-Hexane during the <i>Deepwater Horizon<\/i> Response and Clean-up"],"prefix":"10.1093","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9444-0207","authenticated-orcid":false,"given":"Caroline P","family":"Groth","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, WVU School of Public Health, West Virginia University , One Medical Center Drive, Morgantown, WV 26506 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran B","family":"Huynh","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, Dornsife School of Public Health, Drexel University , 3215 Market St, Philadelphia, PA 19104 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudipto","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, UCLA Fielding School of Public Health, University of California \u2013Los Angeles , 650 Charles E. Young Drive, Los Angeles, CA 90095 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9869-284X","authenticated-orcid":false,"given":"Gurumurthy","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University , 615 N Wolfe St, Baltimore, MD 21205 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A","family":"Stewart","sequence":"additional","affiliation":[{"name":"Stewart Exposure Assessments, LLC , 6045 N. 27th. St., Arlington, VA 22207 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harrison","family":"Quick","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University , 3215 Market St, Philadelphia, PA 19104 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6776-0018","authenticated-orcid":false,"given":"Dale P","family":"Sandler","sequence":"additional","affiliation":[{"name":"Epidemiology Branch, National Institute of Environmental Health Sciences , 111 T.W. Alexander Drive MD A3-05, P.O. Box 12233, Research Triangle Park, NC 27709 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Blair","sequence":"additional","affiliation":[{"name":"National Cancer Institute , 9609 Medical Center Drive, Building 9609 MSC 9760, Bethesda, MD 20892-9760 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence S","family":"Engel","sequence":"additional","affiliation":[{"name":"Epidemiology Branch, National Institute of Environmental Health Sciences , 111 T.W. Alexander Drive MD A3-05, P.O. Box 12233, Research Triangle Park, NC 27709 , USA"},{"name":"Department of Epidemiology, University of North Carolina at Chapel Hill , 35 Dauer Drive, Chapel Hill, NC 27599 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6794-8360","authenticated-orcid":false,"given":"Richard K","family":"Kwok","sequence":"additional","affiliation":[{"name":"Epidemiology Branch, National Institute of Environmental Health Sciences , 111 T.W. Alexander Drive MD A3-05, P.O. Box 12233, Research Triangle Park, NC 27709 , USA"},{"name":"Office of the Director, National Institute of Environmental Health Sciences , 9000 Rockville Pike, Bethesda, MD 20892 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7840-234X","authenticated-orcid":false,"given":"Mark R","family":"Stenzel","sequence":"additional","affiliation":[{"name":"Exposure Assessment Applications, LLC , 6045 N. 27th. 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