{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T04:54:04Z","timestamp":1758862444887,"version":"3.37.3"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>In Italy, the highest pleural cancer mortality and incidence have been observed among Italian regions where the 2 largest Italian shipyards were (and are) located. The objective of this study was to assess the exposure\u2013response relationship for mesothelioma among male workers employed in the Monfalcone, Italy, shipyard.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a necropsy-based case\u2013control study. Cases (N = 102) were mesothelioma decedents and controls were those with lung cancer (N = 84). Complete job histories were available; the lung fibre content was measured using a scanning electron microscope with X-ray fluorescence, after sample preparation according to the European Respiratory Society guidelines. Odds ratios and 95% confidence intervals of mesothelioma by fibre type and lung fibre burden, as a categorical or continuous variable, were assessed by unconditional logistic regression, adjusted for age and time since exposure cessation. Analyses for the amphibole and chrysotile lung fibre burden were mutually adjusted. We calculated a cumulative exposure index by applying a job-exposure matrix to the job histories of study cases and assessed its correlation with the lung fibre burden.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We found an odds ratio of 22.0 (confidence intervals 5.66\u201385.7) for the highest lung fibre burden category (mean 43.8 million total asbestos fibres per gram of dry tissue) compared with the reference (mean 0.48). Using log10-transformed lung fibre burden, we found that the odds ratio was 3.71 (confidence intervals 2.03\u20136.79) for a 10-fold lung fibre burden increase. Results for the amphibole lung fibre burden were similar. Odds ratios increased over chrysotile lung fibre burden categories (P-trend = 0.025), and the odds ratio for a 10-fold increase was 4.73 (confidence intervals 0.32\u201370.4).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The cumulative exposure index was correlated with total and amphibole lung fibre burden, but not with chrysotile lung fibre burden. Mesothelioma risk was proportional to total, amphibole, and chrysotile lung fibre burden in shipyard workers.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/annweh\/wxae018","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T04:04:09Z","timestamp":1711512249000},"page":"476-485","source":"Crossref","is-referenced-by-count":2,"title":["Lung fibre burden and risk of malignant mesothelioma in shipyard workers: a necropsy-based case\u2013control study"],"prefix":"10.1093","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2312-1342","authenticated-orcid":false,"given":"Dario","family":"Mirabelli","sequence":"first","affiliation":[{"name":"Unit of Cancer Epidemiology, Department of Medical Sciences, CPO Piemonte and University of Turin , via Santena 7, 10126 Turin , Italy (retired)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Benedetta","family":"Somigliana","sequence":"additional","affiliation":[{"name":"Lombardy Regional Protection Agency (ARPA), Electron Microscopy Centre, Laboratory Department , via Renato Donatelli 5, 20162 Milan , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danila","family":"Azzolina","sequence":"additional","affiliation":[{"name":"Department of Environmental Sciences and Prevention, University of Ferrara , 32 corso Ercole I d'Este 32, 44121 Ferrara , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8935-3843","authenticated-orcid":false,"given":"Dario","family":"Consonni","sequence":"additional","affiliation":[{"name":"Epidemiology Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico , via San Barnaba 8, 20122 Milan , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro Gino","family":"Barbieri","sequence":"additional","affiliation":[{"name":"Formerly Mesothelioma 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