{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T03:10:03Z","timestamp":1758856203446,"version":"3.44.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Midwest Center for Occupational Health and Safety, Education and Research Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Antineoplastic drugs can persist on surfaces in human and veterinary oncology clinics where they are administered, resulting in potentially hazardous exposures for healthcare workers and cancer patient caregivers. To assess potential surface contamination in occupational settings, a new liquid chromatography-selected reaction monitoring-mass spectrometry (LC-SRM-MS\/MS) method was developed to simultaneously detect six commonly used antineoplastic drugs. A surface wipe and desorption method was optimized for cyclophosphamide, doxorubicin, methotrexate, etoposide, paclitaxel, and 5-fluorouracil with drug desorption recoveries ranging from 49% to 79%. The limit of detection (LOD) and limit of quantitation (LOQ) ranged from 0.01 to 0.12 ng\/ml and 0.01 to 1.33 ng\/ml, respectively. This method was used to quantify cyclophosphamide and doxorubicin surface contamination from wipe samples collected at a veterinary clinic following drug administration to canine-patients. Specific areas in the oncology treatment room identified as frequently contacted were sampled to determine the antineoplastic drug surface contamination that could lead to worker exposure through dermal contact, with cyclophosphamide and doxorubicin levels ranging from 6.68 to 17.4 pg cm-2 and 13.5 to 40.3 pg cm-2. Additionally, cyclophosphamide and doxorubicin wipe samples (n = 50) were obtained from two kennel surfaces and 10 canine-patients after chemotherapy. Samples were collected from the patients\u2019 coats before leaving the clinic and day after in the home environment to investigate the potential for dogs to be a source of household contamination. Cyclophosphamide was identified in samples collected at home in 4\/5 canine-patients at levels ranging from 2.61 to 368 ng\/sample, while doxorubicin was identified on kennel surfaces wiped post-treatment at levels ranging from 3.53 to 1655 pg cm-2. These findings support the ability of this method to detect contamination of these drugs in both occupational clinics and homes. The results set the stage for investigating contamination levels in various settings, such as human and veterinary clinics and home environments, as well as evaluating the effectiveness of decontamination products and protocols toward reducing workplace and environmental exposures.<\/jats:p>","DOI":"10.1093\/annweh\/wxaf058","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T05:54:54Z","timestamp":1757051694000},"page":"843-854","source":"Crossref","is-referenced-by-count":0,"title":["Investigating antineoplastic drug surface contamination in veterinary settings and on canine patients"],"prefix":"10.1093","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1671-4820","authenticated-orcid":false,"given":"Andrew","family":"Floeder","sequence":"first","affiliation":[{"name":"Division of Environmental Health Sciences, School of Public Health, University of Minnesota Twin Cities , Minneapolis, MN 55455 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingfang","family":"Huang","sequence":"additional","affiliation":[{"name":"Minnesota Department of Health , St. Paul, MN 55164 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Bergsrud","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Clinical Investigation Center, University of Minnesota Twin Cities , St. Paul, MN 55108 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachael","family":"Lilly","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Veterinary Medical Center, University of Minnesota Twin Cities , St. Paul, MN 55108 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Borgatti","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Clinical Investigation Center, University of Minnesota Twin Cities , St. Paul, MN 55108 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1465-3761","authenticated-orcid":false,"given":"Susan","family":"Arnold","sequence":"additional","affiliation":[{"name":"Division of Environmental Health Sciences, School of Public Health, University of Minnesota Twin Cities , Minneapolis, MN 55455 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7686-0504","authenticated-orcid":false,"given":"Silvia","family":"Balbo","sequence":"additional","affiliation":[{"name":"Division of Environmental Health Sciences, School of Public Health, University of Minnesota Twin Cities , Minneapolis, MN 55455 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,9,5]]},"reference":[{"volume-title":"AIHA hazardous drug surface contamination guidance document. Publication No. 2023-1","year":"2023","author":"American Industrial Hygiene Association (AIHA)","key":"2025092522370086800_CIT0001"},{"key":"2025092522370086800_CIT0003","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1177\/10781552221118535","article-title":"Developing wipe sampling strategy guidance for assessing environmental contamination of antineoplastic drugs","volume":"29","author":"Arnold","year":"2023","journal-title":"J Oncol Pharm Pract"},{"key":"2025092522370086800_CIT0004","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1080\/15459624.2019.1667502","article-title":"Assessing variability of antineoplastic drugs handling practices in clinical settings","volume":"16","author":"Arnold","year":"2019","journal-title":"J Occup Environ Hyg"},{"key":"2025092522370086800_CIT0005","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1520\/STP49740S","article-title":"Review of standards for surface and dermal sampling","volume":"8","author":"Ashley","year":"2011","journal-title":"J ASTM Int"},{"key":"2025092522370086800_CIT0006","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1080\/15459624.2020.1777296","article-title":"The application of novel field measurement and field evaluation protocols for assessing health care workers\u2019 exposure risk to antineoplastic drugs","volume":"17","author":"Astrakianakis","year":"2020","journal-title":"J Occup Environ Hyg"},{"article-title":"2023 AVMA report on the economic state of the veterinary profession","year":"2023","author":"Bain","key":"2025092522370086800_CIT0069"},{"key":"2025092522370086800_CIT0007","doi-asserted-by":"publisher","first-page":"2713","DOI":"10.1093\/ajhp\/53.22.2713","article-title":"Monitoring occupational exposure to cancer chemotherapy drugs","volume":"53","author":"Baker","year":"1996","journal-title":"Am J Health-Syst Pharm"},{"year":"2014","author":"[BAuA] Federal Institute for Occupational Safety and Health","key":"2025092522370086800_CIT0022"},{"volume-title":"Occupational employment and wage statistics","year":"2023","author":"[BLS] Bureau of Labor Statistics","key":"2025092522370086800_CIT0009"},{"article-title":"Capillary-flow LC-MS: combining high sensitivity, robustness, and throughput","year":"2017","author":"Boychenko","key":"2025092522370086800_CIT0066"},{"key":"2025092522370086800_CIT0067","first-page":"SG-2","article-title":"Surface sampling guidance, considerations, and methods in occupational hygiene","volume-title":"NIOSH manual of analytical methods","author":"Broadwater","year":"2022","edition":"5"},{"key":"2025092522370086800_CIT0061","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1111\/vco.12271","article-title":"A literature review of reports of the stability and storage of common injectable chemotherapy agents used in veterinary patients","volume":"15","author":"Chan","year":"2016","journal-title":"Vet Comp Oncol"},{"key":"2025092522370086800_CIT0012","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.3390\/molecules25051254","article-title":"Liquid chromatography\u2013tandem mass spectrometry for the simultaneous determination of doxorubicin and its metabolites doxorubicinol, doxorubicinone, doxorubicinolone, and 7-deoxydoxorubicinone in mouse plasma","volume":"25","author":"Choi","year":"2020","journal-title":"Molecules"},{"key":"2025092522370086800_CIT0013","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1056\/NEJMoa011795","article-title":"CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma","volume":"346","author":"Coiffier","year":"2002","journal-title":"N Engl J Med"},{"key":"2025092522370086800_CIT0014","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1093\/annweh\/wxx070","article-title":"Wipe sampling method and evaluation of environmental variables for assessing surface contamination of 10 antineoplastic drugs by liquid chromatography\/tandem mass spectrometry","volume":"61","author":"Colombo","year":"2017","journal-title":"Ann. Work Expo. Health"},{"key":"2025092522370086800_CIT0015","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1093\/ajhp\/56.14.1427","article-title":"Surface contamination with antineoplastic agents in six cancer treatment centers in Canada and the United States","volume":"56","author":"Connor","year":"1999","journal-title":"Am J Health-Syst Pharm"},{"key":"2025092522370086800_CIT0016","doi-asserted-by":"publisher","first-page":"354","DOI":"10.3322\/canjclin.56.6.354","article-title":"Preventing occupational exposures to antineoplastic drugs in health care settings","volume":"56","author":"Connor","year":"2006","journal-title":"CA Cancer J Clin"},{"key":"2025092522370086800_CIT0064","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/1078155207082350","article-title":"Preface","volume":"13","author":"Connor","year":"2007","journal-title":"J Oncol Pharm Pract."},{"key":"2025092522370086800_CIT0017","doi-asserted-by":"publisher","first-page":"D45","DOI":"10.1080\/15459624.2013.766561","article-title":"Case study: evaluation of chemotherapy drug exposure at a veterinary teaching hospital in michigan","volume":"10","author":"Couch","year":"2013","journal-title":"J Occup Environ Hyg"},{"key":"2025092522370086800_CIT0018","first-page":"941275","article-title":"Breed-predispositions to cancer in pedigree dogs","volume":"2013","author":"Dobson","year":"2013","journal-title":"Int Sch Res Notices"},{"volume-title":"Preventing occupational and environmental exposure to cytotoxic drugs in veterinary medicine","year":"2007","author":"ECVIM","key":"2025092522370086800_CIT0019"},{"key":"2025092522370086800_CIT0020","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1200\/JOP.0723601","article-title":"Future supply and demand for oncologists: challenges to assuring access to oncology services","volume":"3","author":"Erikson","year":"2007","journal-title":"J Oncol Pract"},{"key":"2025092522370086800_CIT0068","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1016\/S0140-6736(79)91939-1","article-title":"Mutagenicity in urine of nurses handling cytostatic drugs","volume":"313","author":"Falck","year":"2003","journal-title":"The Lancet"},{"volume-title":"Q2(R1) Validation of Analytical Procedures: Text and Methodology Guidance for Industry","year":"2021","author":"[FDA] U.S. Food & Drug Administration","key":"2025092522370086800_CIT0055"},{"key":"2025092522370086800_CIT0023","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1056\/NEJM199304083281404","article-title":"Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin\u2019s lymphoma","volume":"328","author":"Fisher","year":"1993","journal-title":"N Engl J Med"},{"key":"2025092522370086800_CIT0024","doi-asserted-by":"publisher","first-page":"e0115686","DOI":"10.1371\/journal.pone.0115686","article-title":"Effects of 5-fluorouracil on morphology, cell cycle, proliferation, apoptosis, autophagy and ROS production in endothelial cells and cardiomyocytes","volume":"10","author":"Focaccetti","year":"2015","journal-title":"PLoS One"},{"key":"2025092522370086800_CIT0025","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1097\/01.ede.0000246827.44093.c1","article-title":"Nurses with dermal exposure to antineoplastic drugs: reproductive outcomes","volume":"18","author":"Fransman","year":"2007","journal-title":"Epidemiology"},{"key":"2025092522370086800_CIT0026","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1111\/avj.12515","article-title":"Regulatory verification on safe use of cytotoxic drugs in veterinary clinics and animal hospitals","volume":"94","author":"Fung","year":"2016","journal-title":"Aust Vet J"},{"key":"2025092522370086800_CIT0028","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1146\/annurev-animal-022114-110911","article-title":"Dogs as a model for cancer","volume":"4","author":"Gardner","year":"2016","journal-title":"Annu Rev Anim Biosci"},{"key":"2025092522370086800_CIT0029","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1892\/0891-6640(2002)016&lt;0704:eoacpw&gt;2.3.co;2","article-title":"Evaluation of a 6-month chemotherapy protocol with no maintenance therapy for dogs with lymphoma","volume":"16","author":"Garrett","year":"2002","journal-title":"J Vet Intern Med"},{"key":"2025092522370086800_CIT0027","doi-asserted-by":"publisher","first-page":"E10","DOI":"10.1188\/17.ONF.E10-E19","article-title":"Testing an intervention to decrease healthcare workers\u2019 exposure to antineoplastic agents","volume":"44","author":"Graeve","year":"2017","journal-title":"Oncol Nurs Forum"},{"key":"2025092522370086800_CIT0030","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1093\/jat\/34.3.142","article-title":"Determination of drug residues in urine of dogs receiving anti-cancer chemotherapy by liquid chromatography-electrospray ionization-tandem mass spectrometry: is there an environmental or occupational risk","volume":"34","author":"Hamscher","year":"2010","journal-title":"J Anal Toxicol"},{"key":"2025092522370086800_CIT0031","doi-asserted-by":"publisher","first-page":"8221","DOI":"10.1007\/s00216-016-9932-y","article-title":"Micro-liquid chromatography mass spectrometry for the analysis of antineoplastic drugs from wipe samples","volume":"408","author":"Hetzel","year":"2016","journal-title":"Anal Bioanal Chem"},{"key":"2025092522370086800_CIT0033","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1111\/vco.12049","article-title":"Determination of platinum surface contamination in veterinary and human oncology centres using inductively coupled plasma mass spectrometry","volume":"13","author":"Janssens","year":"2015","journal-title":"Vet Comp Oncol"},{"key":"2025092522370086800_CIT0035","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1093\/annweh\/wxab013","article-title":"Spatial and temporal variability in antineoplastic drug surface contamination in cancer care centers in Alberta and Minnesota","volume":"65","author":"Jeronimo","year":"2021","journal-title":"Ann. Work Expo. Health"},{"key":"2025092522370086800_CIT0034","doi-asserted-by":"publisher","first-page":"7083","DOI":"10.1007\/s00216-015-8868-y","article-title":"A surface wipe sampling and LC\u2013MS\/MS method for the simultaneous detection of six antineoplastic drugs commonly handled by healthcare workers","volume":"407","author":"Jeronimo","year":"2015","journal-title":"Anal Bioanal Chem"},{"key":"2025092522370086800_CIT0036","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1136\/vr.b4871","article-title":"Reduction of workplace contamination with platinum-containing cytostatic drugs in a veterinary hospital by introduction of a closed system","volume":"166","author":"Kandel-Tschiederer","year":"2010","journal-title":"Vet Rec"},{"key":"2025092522370086800_CIT0037","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1080\/15459624.2021.2000617","article-title":"A quantitative LC\u2013MS method to determine surface contamination of antineoplastic drugs by wipe sampling","volume":"19","author":"K\u00e5redal","year":"2022","journal-title":"J Occup Environ Hyg"},{"key":"2025092522370086800_CIT0072","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1345\/aph.1M578","article-title":"Stability of cyclophosphamide in extemporaneous oral suspensions","volume":"44","author":"Kennedy","year":"2010","journal-title":"Ann Pharmac."},{"key":"2025092522370086800_CIT0038","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3390\/pharmacy8010043","article-title":"Oncology pharmacists can reduce the projected shortfall in cancer patient visits: projections for years 2020 to 2025","volume":"8","author":"Knapp","year":"2020","journal-title":"Pharmacy"},{"key":"2025092522370086800_CIT0039","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1080\/15287394.2014.910158","article-title":"Assessment of genotoxic effects in nurses handling cytostatic drugs","volume":"77","author":"Ladeira","year":"2014","journal-title":"J Toxicol Environ Health A"},{"key":"2025092522370086800_CIT0040","doi-asserted-by":"publisher","first-page":"e248","DOI":"10.1093\/jat\/bkac073","article-title":"LC\u2013MS-MS determination of cytostatic drugs on surfaces and in urine to assess occupational exposure","volume":"46","author":"Lema-At\u00e1n","year":"2022","journal-title":"J Anal Toxicol"},{"key":"2025092522370086800_CIT0041","first-page":"ofac525","article-title":"December. A primer on home infusion administration methods","volume-title":"Open forum infectious diseases,","author":"Loriaux","year":"2022"},{"key":"2025092522370086800_CIT0042","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1177\/1078155217726160","article-title":"Survey of guidelines and current practices for safe handling of antineoplastic and other hazardous drugs used in 24 countries","volume":"25","author":"Mathias","year":"2019","journal-title":"J Oncol Pharm Pract"},{"key":"2025092522370086800_CIT0043","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1093\/annhyg\/mel023","article-title":"Exposure to antineoplastic drugs outside the hospital environment","volume":"50","author":"Meijster","year":"2006","journal-title":"Ann Occup Hyg"},{"volume-title":"NIOSH alert: preventing occupational exposures to antineoplastic and other hazardous drugs in health care settings. DHHS (NIOSH) Publication No. 2004-165","year":"2004","author":"National Institute for Occupational Safety and Health (NIOSH)","key":"2025092522370086800_CIT0045"},{"volume-title":"Managing hazardous drug exposures: information for healthcare settings. DHHS (NIOSH) Publication No. 2023-130","year":"2023","author":"National Institute for Occupational Safety and Health (NIOSH)","key":"2025092522370086800_CIT0044"},{"key":"2025092522370086800_CIT0060","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.talanta.2013.04.070","article-title":"Multianalyte determination of 24 cytostatics and metabolites by liquid chromatography\u2013electrospray\u2013tandem mass spectrometry and study of their stability and optimum storage conditions in aqueous solution","volume":"116","author":"Negreira","year":"2013","journal-title":"Talanta."},{"key":"2025092522370086800_CIT0046","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1007\/s00216-011-5157-2","article-title":"Wipe sampling procedure coupled to LC\u2013MS\/MS analysis for the simultaneous determination of 10 cytotoxic drugs on different surfaces","volume":"402","author":"Nussbaumer","year":"2012","journal-title":"Anal Bioanal Chem"},{"volume-title":"Chemotherapy and immunotherapy guidelines: and recommendations for practice","year":"2019","author":"Olsen","key":"2025092522370086800_CIT0047"},{"volume-title":"Evaluation guidelines for surface sampling methods","year":"2001","author":"Occupational Safety and Health Administration (OSHA)","key":"2025092522370086800_CIT0048"},{"key":"2025092522370086800_CIT0049","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.bbadis.2009.02.010","article-title":"Using naturally occurring tumours in dogs and cats to study telomerase and cancer stem cell biology","volume":"1792","author":"Pang","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"2025092522370086800_CIT0063","doi-asserted-by":"publisher","first-page":"1996","DOI":"10.2146\/ajhp180564","article-title":"ASHP guidelines on handling hazardous drugs","volume":"75","author":"Power","year":"2018","journal-title":"Am J Health-Syst Pharm."},{"key":"2025092522370086800_CIT0050","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1186\/s12913-023-09613-2","article-title":"Development of an intravenous chemotherapy intervention for children and adolescents with cancer administered by their parents at home (INTACTatHome)","volume":"23","author":"Roug","year":"2023","journal-title":"BMC Health Serv Res"},{"key":"2025092522370086800_CIT0065","doi-asserted-by":"publisher","DOI":"10.14288\/1.0406089","article-title":"Antineoplastic Drug Handling and Potential for Exposure among Veterinarians","volume-title":"Electronic Theses and Dissertations (ETDs) 2008+. T","author":"Senyk","year":"2021"},{"key":"2025092522370086800_CIT0052","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3322\/caac.21763","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J Clin"},{"key":"2025092522370086800_CIT0053","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1111\/jvim.15077","article-title":"ACVIM small animal consensus statement on safe use of cytotoxic chemotherapeutics in veterinary practice","volume":"32","author":"Smith","year":"2018","journal-title":"J Vet Intern Med"},{"key":"2025092522370086800_CIT0054","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1080\/03067319.2010.494769","article-title":"Development and validation of an LC\u2013MS\/MS procedure for environmental monitoring of eight cytostatic drugs in pharmacies","volume":"91","author":"Tuerk","year":"2011","journal-title":"Int J Environ Analyt Chem"},{"key":"2025092522370086800_CIT0070","article-title":"General Chapter &lt;800&gt; Hazardous drugs \u2013 Handling in healthcare settings","volume-title":"USP Compounding Compendium","author":"The United States Pharmacopeial Convention","year":"2019"},{"key":"2025092522370086800_CIT0057","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1097\/00043764-199908000-00004","article-title":"Occupational exposure to antineoplastic agents: self-reported miscarriages and stillbirths among nurses and pharmacists","volume":"41","author":"Valanis","year":"1999","journal-title":"J Occup Environ Med"},{"key":"2025092522370086800_CIT0058","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1188\/20.onf.263-272","article-title":"Surface contamination with antineoplastic drugs on two inpatient oncology units","volume":"47","author":"Walton","year":"2020","journal-title":"Oncol Nurs Forum"},{"key":"2025092522370086800_CIT0071","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1111\/j.1365-2710.1990.tb00386.x","article-title":"Stability of doxorubicin, daunorubicin and epirubicin in plastic syringes and minibags","volume":"15","author":"Wood","year":"2008","journal-title":"J Clin Pharm Ther."},{"key":"2025092522370086800_CIT0059","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1200\/JOP.2013.001319","article-title":"Projected supply of and demand for oncologists and radiation oncologists through 2025: an aging, better-insured population will result in shortage","volume":"10","author":"Yang","year":"2014","journal-title":"J Oncol Pract"}],"container-title":["Annals of Work Exposures and Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/annweh\/article-pdf\/69\/8\/843\/64212622\/wxaf058.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/annweh\/article-pdf\/69\/8\/843\/64212622\/wxaf058.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T02:37:32Z","timestamp":1758854252000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/annweh\/article\/69\/8\/843\/8248202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,5]]},"references-count":63,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,9,5]]},"published-print":{"date-parts":[[2025,9,26]]}},"URL":"https:\/\/doi.org\/10.1093\/annweh\/wxaf058","relation":{},"ISSN":["2398-7308","2398-7316"],"issn-type":[{"type":"print","value":"2398-7308"},{"type":"electronic","value":"2398-7316"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,9,5]]}}}