{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:39:14Z","timestamp":1790689154774,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T00:00:00Z","timestamp":1558569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Dust Diseases Board"},{"name":"Western Australia Department of Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>An asbestos job-exposure matrix (AsbJEM) has been developed to systematically and cost-effectively evaluate occupational exposures in population-based studies. The primary aim of this study was to examine the accuracy of the AsbJEM in determining exposure\u2013response relationships between asbestos exposure estimates and malignant mesothelioma (MM) incidence (indirect validation). The secondary aim was to investigate whether the assumptions used in the development of the original AsbJEM provided accurate asbestos exposure estimates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study population consisted of participants in an annual health surveillance program, who had at least 3-month occupational asbestos exposure. Calculated asbestos exposure indices included cumulative asbestos exposure and the average exposure intensity, estimated using the AsbJEM and duration of employment. Asbestos and MM exposure\u2013response relationships were compared between the original AsbJEM and its variations based on manipulations of the intensity, duration and frequency of exposure. Twenty-four exposure estimates were calculated for both cumulative asbestos exposure and the average exposure intensity using three exposure intensities (50th, 75th and 90th percentile of the range of mode exposure), four peak durations (15, 30, 60 and 120 min) and two patterns of peak frequency (original and doubled). Cox proportional hazards models were used to describe the associations between MM incidence and each of the cumulative and average intensity estimates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data were collected from 1602 male participants. Of these, 40 developed MM during the study period. There were significant associations between MM incidence and both cumulative and average exposure intensity for all estimates. The strongest association, based on the regression-coefficient from the models, was found for the 50th percentile of mode exposure, 15-min peak duration and the doubled frequency of peak exposure. Using these assumptions, the hazard ratios for mesothelioma were 1 (reference), 1.91, 3.24 and 5.37 for the quartiles of cumulative asbestos exposure and 1 (reference), 1.84, 2.31 and 4.40 for the quartiles of the average exposure intensity, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The well-known positive exposure\u2013response relationship between MM incidence and both estimated cumulative asbestos exposure and average exposure intensity was confirmed. The strongest relationship was found when the frequency of peak exposure in the AsbJEM was doubled from the originally published estimates.<\/jats:p><\/jats:sec>","DOI":"10.1093\/annweh\/wxz038","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T11:07:11Z","timestamp":1556708831000},"page":"719-728","source":"Crossref","is-referenced-by-count":9,"title":["Validation of an Asbestos Job-Exposure Matrix (AsbJEM) in Australia: Exposure\u2013Response Relationships for Malignant Mesothelioma"],"prefix":"10.1093","volume":"63","author":[{"given":"Hiroyuki","family":"Kamiya","sequence":"first","affiliation":[{"name":"School of Population and Global Health, University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Peters","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, University of Western Australia, Perth, Western Australia, Australia"},{"name":"Environmental Epidemiology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nita","family":"Sodhi-Berry","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Reid","sequence":"additional","affiliation":[{"name":"School of Public Health, Curtin University, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Len","family":"Gordon","sequence":"additional","affiliation":[{"name":"Caltex Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"de Klerk","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, University of 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Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Franklin","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,5,23]]},"reference":[{"key":"2019080801144170700_CIT0001","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/bjc.2012.23","article-title":"Malignant mesotheliomas in former miners and millers of crocidolite at Wittenoom (Western Australia) after more than 50 years follow-up","volume":"106","author":"Berry","year":"2012","journal-title":"Br J Cancer"},{"key":"2019080801144170700_CIT0002","doi-asserted-by":"crossref","first-page":"265","DOI":"10.5271\/sjweh.36","article-title":"Performance of odds ratios obtained with a job-exposure matrix and individual exposure assessment with special reference to 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