{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T18:30:13Z","timestamp":1771007413147,"version":"3.50.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T00:00:00Z","timestamp":1589328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Blindness is a rare but catastrophic complication of facial hyaluronic acid (HA) injection. Although various means to rescue visual impairment have been employed, no consensus regarding effective treatment has yet been reached. We organized a multidisciplinary team to address this emergency situation by means of endovascular hyaluronidase application.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The aim of this study was to investigate the direct delivery of hyaluronidase to ophthalmic artery occlusion through endovascular cannulation to resolve HA-induced blindness.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Four patients with visual impairments caused by HA filler embolization were subjected to sequential treatments. Through superselective angiography, a microcatheter was introduced along a guidewire from the femoral artery to the ophthalmic artery to directly deliver hyaluronidase to the HA embolism. The safety and efficiency of this treatment were systematically analyzed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Selective cerebral angiography demonstrated that the endovascular application of hyaluronidase significantly alleviated occlusion in 3 patients. One patient showed slight visual improvement, whereas the other patients showed no improvement in their visual function during a follow-up period of more than 3 months. One patient suffered from cerebral infarction in the left middle cerebral artery during the intervention surgery. Moreover, 2 patients showed multiple lacunar cerebral infarctions after the operation, whereas none exhibited symptoms of hemiplegia during follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Although the endovascular application of hyaluronidase could partially recanalize the occluded branches of the ophthalmic artery, it had limited effects on restoring vision. Considering the risks of vascular intervention surgery, this approach should be considered with caution.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Level of Evidence: 5<\/jats:title>\n                  <jats:p\/>\n               <\/jats:sec>","DOI":"10.1093\/asj\/sjaa036","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T01:29:14Z","timestamp":1589419754000},"page":"344-355","source":"Crossref","is-referenced-by-count":26,"title":["Endovascular Hyaluronidase Application Through Superselective Angiography to Rescue Blindness Caused by Hyaluronic Acid Injection"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5545-4614","authenticated-orcid":false,"given":"Lei","family":"Zhang","sequence":"first","affiliation":[{"name":"Zhejiang Provincial People\u2019s Hospital, affiliated with Hangzhou Medical College , Hangzhou, Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuyan","family":"Luo","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial People\u2019s Hospital, affiliated with Hangzhou Medical College , Hangzhou, Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial People\u2019s Hospital, affiliated with Hangzhou Medical College , Hangzhou, Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial People\u2019s Hospital, affiliated with Hangzhou Medical College , Hangzhou, Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Xu","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial People\u2019s Hospital, affiliated with Hangzhou Medical College , Hangzhou, Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miaoqin","family":"Wu","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial People\u2019s Hospital, affiliated with Hangzhou Medical College , Hangzhou, Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sufan","family":"Wu","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial People\u2019s Hospital, affiliated with Hangzhou Medical College , Hangzhou, Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,5,13]]},"reference":[{"issue":"6","key":"2023012809082500200_CIT0001","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1097\/PRS.0000000000000754","article-title":"Blindness caused by cosmetic filler injection: a review of cause and therapy","volume":"134","author":"Carruthers","year":"2014","journal-title":"Plast Reconstr Surg."},{"issue":"6","key":"2023012809082500200_CIT0002","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1001\/jamaophthalmol.2013.8204","article-title":"Iatrogenic occlusion of the ophthalmic artery after cosmetic facial filler injections: a national survey by the Korean Retina Society","volume":"132","author":"Park","year":"2014","journal-title":"JAMA Ophthalmol."},{"issue":"6","key":"2023012809082500200_CIT0003","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1093\/asj\/sjz053","article-title":"Update on avoiding and treating blindness from fillers: a recent review of the world literature","volume":"39","author":"Beleznay","year":"2019","journal-title":"Aesthet Surg J."},{"issue":"1","key":"2023012809082500200_CIT0004","doi-asserted-by":"crossref","first-page":"28e","DOI":"10.1097\/PRS.0000000000005702","article-title":"Natural course of ophthalmoplegia after iatrogenic ophthalmic artery occlusion caused by cosmetic filler injections","volume":"144","author":"Yang","year":"2019","journal-title":"Plast Reconstr Surg."},{"issue":"12","key":"2023012809082500200_CIT0005","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1136\/bjo.64.12.896","article-title":"Experimental occlusion of the central artery of the retina. 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