{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:08:17Z","timestamp":1790816897726,"version":"4.1.0"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2020,5,2]],"date-time":"2020-05-02T00:00:00Z","timestamp":1588377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Mechanically isolated stromal vascular fraction (tSVF, tissue SVF) is a potent regenerative solution, increasingly used as a therapeutic modality for a variety of pathologies. With recent evidence conclusively favoring mechanical isolation over enzymatic alternatives, the therapeutic share and indications of tSVF are expected to grow even further.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The aim of this study was to provide a systematic review of all studies reporting on the use of tSVF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A systematic search was undertaken of the Embase, PubMed, Web of Science, and Cochrane Central Register of Controlled Trials databases. Outcome measures included clinical indications, such as recipient area, adverse events, clinical results recipient area, method of application, follow-up duration and evaluation methods.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the total of 4505 articles identified, 186 full-texts were screened. Thirty-four studies, reporting on 1443 patients were included. tSVF-based therapy was observed for 10 different pathologies, including aged skin (8 studies), scars (5), wounds (6), osteoarthritis (6), tendinopathy (2), temporomandibular joint disorders (1), androgenic alopecia (1), perianal fistula (3), migraine (1), and vocal fold scarring (1). Across all studies, tSVF-based therapy resulted in favorable clinical results. Overall, 50 (3.43%) minor and one (0.07%) major adverse events were observed, mainly related to the liposuction procedure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>tSVF offers a safe, easy and legal treatment modality for a range of indications. Future research is indicated to identify the optimal isolation protocol, dose and timing. In addition, basic research remains crucial to identify the mechanism of action of SVF within different pathologies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Level of Evidence: 4<\/jats:title>\n                  <jats:p\/>\n               <\/jats:sec>","DOI":"10.1093\/asj\/sjaa111","type":"journal-article","created":{"date-parts":[[2020,5,2]],"date-time":"2020-05-02T09:38:59Z","timestamp":1588412339000},"page":"NP546-NP560","source":"Crossref","is-referenced-by-count":49,"title":["Expanding Clinical Indications of Mechanically Isolated Stromal Vascular Fraction: A Systematic Review"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4311-1600","authenticated-orcid":false,"given":"Mohammad","family":"Ghiasloo","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Ghent University Hospital , Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo C","family":"Lobato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan M","family":"D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kashika","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of General and Visceral Surgery, Evangelical Hospital Bethel , Bielefeld, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Verpaele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Tonnard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,2]]},"reference":[{"issue":"9","key":"2022122114462292500_CIT0001","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nrd.2016.75","article-title":"Targeting adipose tissue in the treatment of obesity-associated diabetes","volume":"15","author":"Kusminski","year":"2016","journal-title":"Nat Rev Drug Discov."},{"issue":"1","key":"2022122114462292500_CIT0002","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cmet.2017.12.002","article-title":"Anatomical, physiological, and functional diversity of adipose tissue","volume":"27","author":"Zwick","year":"2018","journal-title":"Cell Metab."},{"issue":"4","key":"2022122114462292500_CIT0003","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/cbf.2950","article-title":"Novel aspects of parenchymal-mesenchymal interactions: from cell types to molecules and beyond","volume":"31","author":"Bluguermann","year":"2013","journal-title":"Cell Biochem Funct."},{"issue":"12","key":"2022122114462292500_CIT0004","doi-asserted-by":"crossref","first-page":"4279","DOI":"10.1091\/mbc.e02-02-0105","article-title":"Human adipose tissue is a source of multipotent stem cells","volume":"13","author":"Zuk","year":"2002","journal-title":"Mol Biol Cell."},{"issue":"2","key":"2022122114462292500_CIT0005","doi-asserted-by":"crossref","first-page":"e1237","DOI":"10.1002\/term.2524","article-title":"Cell-assisted lipotransfer: friend or foe in fat grafting? 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