{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:04:19Z","timestamp":1792202659855,"version":"4.4.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T00:00:00Z","timestamp":1588982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Genitourinary syndrome of menopause (GSM) is a major problem in many post- or perimenopausal women. Lipofilling has long been considered to be an effective technique for restoring volume, but the discovery of its trophic proprieties has made it the most widely utilized method in regenerative medicine.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The authors aimed to assess the safety and efficacy of microfat and nanofat grafting for vulvovaginal rejuvenation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Women with GSM who met the inclusion criteria were enrolled. Women received microfat in the labia majora and nanofat in the vagina; follow-up was conducted 1, 3, 6, 12, and 18 months. The vaginal health index (VHI) and Female Sexual Distress (FSD) were utilized to assess improvement in vulvovaginal atrophy, orgasm, and sexual desire posttreatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Fifty women were included; their average age was 53 years (range, 45-63 years). The VHI score significantly increased at 1 and 3 months after treatment (P &amp;lt; 0.0001). Moreover, the average FSD score showed a significant improvement at 1 and 3 months posttreatment. This score stabilized from 6 to 12 months but showed further improvement at 18 months. At 6 months posttreatment, for both scales, data pertaining to 80% of patients appeared normalized. There was a particular benefit noted for dryness and dyspareunia. At 18 months, the results remained stable for all of patients. No major side effects were observed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>There are now many ways to rejuvenate the intimate sphere, but microfat and nanofat grafting seem to offer good results with an autologous procedure. Their utilization appears promising for genital rejuvenation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Level of Evidence: 4<\/jats:title>\n                  <jats:p\/>\n               <\/jats:sec>","DOI":"10.1093\/asj\/sjaa118","type":"journal-article","created":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T11:08:42Z","timestamp":1589022522000},"page":"1060-1067","source":"Crossref","is-referenced-by-count":21,"title":["Microfat and Nanofat Grafting in Genital Rejuvenation"],"prefix":"10.1093","volume":"41","author":[{"given":"Sophie","family":"Menkes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounia","family":"SidAhmed-Mezi","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial and Plastic & Reconstructive Surgery, Henri Mondor Hospital , Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Paul","family":"Meningaud","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial and Plastic & Reconstructive Surgery, Henri Mondor Hospital , Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Benadiba","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial and Plastic & Reconstructive Surgery, Henri Mondor Hospital , Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Magalon","sequence":"additional","affiliation":[{"name":"Plastic Surgery Department, Assistance Publique H\u00f4pitaux de Marseille (APHM), Aix Marseille University , Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Hersant","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial and Plastic & Reconstructive Surgery, Henri Mondor Hospital , Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,9]]},"reference":[{"issue":"7","key":"2022112719401868300_CIT0001","first-page":"481","article-title":"Genitourinary syndrome of menopause","volume":"46","author":"Farrell","year":"2017","journal-title":"Aust Fam Physician"},{"key":"2022112719401868300_CIT0002","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3109\/13697137.2015.1079100","article-title":"Treatment of the genitourinary syndrome of menopause","volume":"18","author":"Palacios","year":"2015","journal-title":"Climacteric"},{"issue":"6","key":"2022112719401868300_CIT0003","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1136\/jcp.55.6.446","article-title":"The effect of Replens on vaginal cytology in the treatment of postmenopausal atrophy: cytomorphology versus computerised cytometry","volume":"55","author":"van der Laak","year":"2002","journal-title":"J Clin Pathol"},{"issue":"2","key":"2022112719401868300_CIT0004","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1258\/175404507780796424","article-title":"Women\u2019s attitudes to hormone replacement therapy, alternative therapy and sexual health: a web-based survey","volume":"13","author":"Cumming","year":"2007","journal-title":"Menopause Int"},{"issue":"4","key":"2022112719401868300_CIT0005","first-page":"180","article-title":"Genitourinary syndrome of menopause treatment using lasers and temperature-controlled radiofrequency","volume":"17","author":"Wa\u0144czyk-Baszak","year":"2018","journal-title":"Prz Menopauzalny"},{"issue":"4","key":"2022112719401868300_CIT0006","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1097\/PRS.0000000000001123","article-title":"Antiaging treatment of the facial skin by fat graft and adipose-derived stem cells","volume":"135","author":"Charles-de-Sa","year":"2015","journal-title":"Plast Reconstr Surg"},{"issue":"3","key":"2022112719401868300_CIT0007","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.stem.2008.07.003","article-title":"A perivascular origin for mesenchymal stem cells in multiple human organs","volume":"3","author":"Crisan","year":"2008","journal-title":"Cell Stem Cell"},{"key":"2022112719401868300_CIT0008","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/0378-5122(95)00956-6","article-title":"Urogenital ageing: an old problem newly recognized","volume":"22","author":"Bachmann","year":"1995","journal-title":"Maturitas"},{"issue":"2","key":"2022112719401868300_CIT0009","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1743-6109.2007.00672.x","article-title":"Validation of the Female Sexual Distress Scale-Revised for assessing distress in women with hypoactive sexual desire disorder","volume":"5","author":"Derogatis","year":"2008","journal-title":"J Sex Med"},{"key":"2022112719401868300_CIT0010","doi-asserted-by":"crossref","first-page":"108S","DOI":"10.1097\/01.prs.0000234610.81672.e7","article-title":"Structural fat grafting: more than a permanent filler","volume":"118","author":"Coleman","year":"2006","journal-title":"Plast Reconstr Surg"},{"issue":"4","key":"2022112719401868300_CIT0011","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1097\/PRS.0b013e31829fe1b0","article-title":"Nanofat grafting: basic research and clinical applications","volume":"132","author":"Tonnard","year":"2013","journal-title":"Plast Reconstr Surg"},{"issue":"4","key":"2022112719401868300_CIT0012","doi-asserted-by":"crossref","first-page":"273","DOI":"10.4161\/21623945.2014.957987","article-title":"Particle size in fat graft retention: a review on the impact of harvesting technique in lipofilling surgical outcomes","volume":"3","author":"Gause","year":"2014","journal-title":"Adipocyte"},{"issue":"9","key":"2022112719401868300_CIT0013","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.bjps.2013.04.015","article-title":"Conventional vs. micro-fat harvesting: how fat harvesting technique affects tissue-engineering approaches using adipose tissue-derived stem\/stromal cells","volume":"66","author":"Alharbi","year":"2013","journal-title":"J Plast Reconstr Aesthet Surg"},{"issue":"1","key":"2022112719401868300_CIT0014","doi-asserted-by":"crossref","first-page":"e2550","DOI":"10.1097\/GOX.0000000000002550","article-title":"Subcutaneous injections of nanofat adipose-derived stem cell grafting in facial rejuvenation","volume":"8","author":"Menkes","year":"2020","journal-title":"Plast Reconstr Surg Glob Open"},{"issue":"4","key":"2022112719401868300_CIT0015","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1177\/1090820X14528000","article-title":"Harvest of superficial layers of fat with a microcannula and isolation of adipose tissue-derived stromal and vascular cells","volume":"34","author":"Trivisonno","year":"2014","journal-title":"Aesthet Surg J"},{"issue":"1","key":"2022112719401868300_CIT0016","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1186\/s40064-016-2840-y","article-title":"Novel technique of vulvo-vaginal rejuvenation by lipofilling and injection of combined platelet-rich-plasma and hyaluronic acid: a case-report","volume":"5","author":"Aguilar","year":"2016","journal-title":"Springerplus"},{"issue":"1","key":"2022112719401868300_CIT0017","doi-asserted-by":"crossref","first-page":"63","DOI":"10.6118\/jmm.2017.23.1.63","article-title":"Rejuvenation using platelet-rich plasma and lipofilling for vaginal atrophy and lichen sclerosus","volume":"23","author":"Kim","year":"2017","journal-title":"J Menopausal Med"},{"issue":"40","key":"2022112719401868300_CIT0018","doi-asserted-by":"crossref","first-page":"68542","DOI":"10.18632\/oncotarget.19721","article-title":"Nanofat-derived stem cells with platelet-rich fibrin improve facial contour remodeling and skin rejuvenation after autologous structural fat transplantation","volume":"8","author":"Wei","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"2022112719401868300_CIT0019","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.anplas.2017.10.004","article-title":"Treatment of wrinkles of the upper lip by emulsified fat or \u201cnanofat\u201d: biological and clinical study about 4 cases","volume":"63","author":"Mesguich Batel","year":"2018","journal-title":"Ann Chir Plast Esthet"},{"issue":"1","key":"2022112719401868300_CIT0020","doi-asserted-by":"crossref","first-page":"63","DOI":"10.6118\/jmm.2017.23.1.63","article-title":"Rejuvenation using platelet-rich plasma and lipofilling for vaginal atrophy and lichen sclerosus","volume":"23","author":"Kim","year":"2017","journal-title":"J Menopausal Med"},{"issue":"5","key":"2022112719401868300_CIT0021","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1097\/PRS.0000000000006155","article-title":"Nanofat cell aggregates: a nearly constitutive stromal cell inoculum for regenerative site-specific therapies","volume":"144","author":"Ses\u00e9","year":"2019","journal-title":"Plast Reconstr Surg"},{"issue":"2","key":"2022112719401868300_CIT0022","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1097\/PRS.0000000000000927","article-title":"Chaput. A novel and effective strategy for the isolation of adipose-derived stem cells: minimally manipulated adipose-derived stem cells for more rapid and safe stem cell therapy","volume":"135","author":"Bertheuil","year":"2015","journal-title":"Plast Reconstr Surg"},{"issue":"12","key":"2022112719401868300_CIT0023","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1002\/sctm.18-0051","article-title":"Higher pericyte content and secretory activity of microfragmented human adipose tissue compared to enzymatically derived stromal vascular fraction","volume":"7","author":"Vezzani","year":"2018","journal-title":"Stem Cells Transl Med"},{"issue":"2","key":"2022112719401868300_CIT0024","doi-asserted-by":"crossref","first-page":"237e","DOI":"10.1097\/PRS.0000000000002356","article-title":"Phenotypic analysis of stromal vascular fraction after mechanical shear reveals stress-induced progenitor populations","volume":"138","author":"Banyard","year":"2016","journal-title":"Plast Reconstr Surg"},{"issue":"6","key":"2022112719401868300_CIT0025","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1097\/PRS.0000000000001288","article-title":"Effects of intersyringe processing on adipose tissue and its cellular components: implications in autologous fat grafting","volume":"135","author":"Osinga","year":"2015","journal-title":"Plast Reconstr Surg"},{"issue":"12","key":"2022112719401868300_CIT0026","doi-asserted-by":"crossref","first-page":"e818","DOI":"10.1016\/j.bjps.2010.07.003","article-title":"Increased survival of free fat grafts with platelet-rich plasma in rabbits","volume":"63","author":"Pires Fraga","year":"2010","journal-title":"J Plast Reconstr Aesthet Surg"},{"issue":"5","key":"2022112719401868300_CIT0027","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/j.1524-4725.2011.01953.x","article-title":"Activated platelet-rich plasma improves fat graft survival in nude mice: a pilot study","volume":"37","author":"Oh","year":"2011","journal-title":"Dermatol Surg"},{"issue":"1","key":"2022112719401868300_CIT0028","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/SAP.0b013e3181b0273c","article-title":"Platelet-rich plasma (PRP) promotes survival of fat-grafts in rats","volume":"65","author":"Nakamura","year":"2010","journal-title":"Ann Plast Surg"},{"issue":"4","key":"2022112719401868300_CIT0029","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/s00266-010-9640-5","article-title":"Influence of platelet-rich plasma on the histologic characteristics of the autologous fat graft to the upper lip of rabbits","volume":"35","author":"Rodr\u00edguez-Flores","year":"2011","journal-title":"Aesthetic Plast Surg"},{"issue":"4","key":"2022112719401868300_CIT0030","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/00008505-200110000-00002","article-title":"Platelet-rich plasma (PRP): what is PRP and what is not PRP?","volume":"10","author":"Marx","year":"2001","journal-title":"Implant Dent"},{"issue":"4","key":"2022112719401868300_CIT0031","first-page":"252","article-title":"Does platelet-rich plasma enhance the survival of grafted fat? An update review","volume":"6","author":"Jin","year":"2013","journal-title":"Int J Clin Exp Med"},{"issue":"5","key":"2022112719401868300_CIT0032","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1097\/PRS.0b013e3181882046","article-title":"Proliferation-promoting effect of platelet-rich plasma on human adipose-derived stem cells and human dermal fibroblasts","volume":"122","author":"Kakudo","year":"2008","journal-title":"Plast Reconstr Surg"}],"container-title":["Aesthetic Surgery Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/asj\/advance-article-pdf\/doi\/10.1093\/asj\/sjaa118\/33197257\/sjaa118.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/asj\/article-pdf\/41\/9\/1060\/47357431\/sjaa118.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/asj\/article-pdf\/41\/9\/1060\/47357431\/sjaa118.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,27]],"date-time":"2022-11-27T19:40:37Z","timestamp":1669578037000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/asj\/article\/41\/9\/1060\/5835048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,9]]},"references-count":32,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,5,9]]},"published-print":{"date-parts":[[2021,8,13]]}},"URL":"https:\/\/doi.org\/10.1093\/asj\/sjaa118","relation":{},"ISSN":["1090-820X","1527-330X"],"issn-type":[{"value":"1090-820X","type":"print"},{"value":"1527-330X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,9,1]]},"published":{"date-parts":[[2020,5,9]]}}}